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25 Possible Causes for Hepatocyte Dropout

  • Alpers Syndrome

    dropout, bridging fibrosis or cirrhosis, collapse of liver cell plates, parenchymal lobular architecture, regenerative nodules and oncocytic changes in scattered hepatocytes[nature.com] […] criteria for Alpers syndrome include characteristic liver histopathological changes, namely two of the following: microvesicular steatosis, bile ductular proliferation, hepatocyte[nature.com]

  • Pericholangitis

    Definition Damage to the transplanted liver caused by cold or warm ischemia Diagnostic Criteria Centrilobular changes (zone 3) Hepatocyte swelling Cholestasis Hepatocyte dropout[surgpathcriteria.stanford.edu]

  • Peliosis Hepatis

    There is no hepatocyte dropout, nor is there any cell plate collapse with the intact reticulin framework.[content.sciendo.com] Needle-biopsy histology showed severe sinusoid dilation and dropout of centrilobular hepatocytes consistent with peliosis hepatis.[ncbi.nlm.nih.gov]

  • Acute Fatty Liver of Pregnancy

    […] and macrovesicular fat In severe cases, hepatocyte dropout, reticulin collapse, portal tract inflammation Positive stains (frozen tissue) Fat stains ( Oil red O , Sudan black[pathologyoutlines.com] […] description Pale, yellow, small liver Microscopic (histologic) description Microvesicular steatosis in zones 2 or 3 (vacuoles may be very small) Also marked ballooning of hepatocytes[pathologyoutlines.com]

  • Congestive Heart Failure

    Liver biopsy demonstrated marked centrilobular hepatocyte necrosis and dropout accompanied by congestion, some areas of bridging necrosis and focal confluent necrosis which[ncbi.nlm.nih.gov]

  • Liver Transplant Rejection

    […] arteries due to concentric intimal thickening and lipid rich macrophages Biliary strictures may occur Centrilobular hepatocyte dropout Neeraja Kambham MD Department of Pathology[surgpathcriteria.stanford.edu] […] damage Also loss of bile ducts, arteritis, central ischemic damage with ballooning degeneration and hepatocyte dropout Microscopic (histologic) images Images hosted on other[pathologyoutlines.com] […] ballooning and dropout Due to chronic injury Acute bile duct loss after acute rejection may be reversible Obliterative arteriopathy Requires hepatectomy for diagnosis Occluded[surgpathcriteria.stanford.edu]

  • Budd-Chiari Syndrome

    Liver biopsy revealed severe perivenular sinusoidal dilation with areas of hepatocyte dropout, bands of hepatocyte atrophy and centrizonal fibrosis, suggestive of BCS.[ncbi.nlm.nih.gov] ; (B)), areas of hepatocyte dropout and occasional occlusion of central veins (B, arrow).[casereports.bmj.com] Our patient’s liver biopsy revealed severe perivenular sinusoidal dilation with areas of confluent hepatocyte dropout, bands of hepatocyte atrophy and centrizonal fibrosis[casereports.bmj.com]

  • Hepatic Veno-Occlusive Disease

    dropout centrilobular sinusoidal dilatation (congestion) sinusoidal hemorrhage obliterative fibrosis pericentral fibrosis (perivenular fibrosis) diffuse occlusive lesions[humpath.com] Histological pattern of the liver biopsy specimen: marked centrilobular congestion (arrows) with hepatocyte dropout.[bjmp.org] The perivenular (zone 3) region of the liver, showing centrilobar hepatocyte atrophy, dropout and haemorrhage.[erj.ersjournals.com]

  • Methoxyflurane

    A liver biopsy revealed evidence of resolving acute hepatitis with confluent perivenular hepatocyte dropout and bridging necrosis.[mja.com.au]

  • Liver Dysfunction

    Needle-biopsy histology showed severe sinusoid dilation and dropout of centrilobular hepatocytes consistent with peliosis hepatis.[ncbi.nlm.nih.gov]

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