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18 Possible Causes for Hepatocyte Dropout

  • Alpers Syndrome

    Description of the clinical course in a child compound heterozygous for POLG1 mutations, neuropathology findings and results of dietary treatment based on fasting avoidance and long chain triglycerides (LCT) restriction. At 3(1/2) months of age the patient presented with severe hypoglycemia, hyperlactatemia,[…][]

  • Congestive Heart Failure

    Liver biopsy demonstrated marked centrilobular hepatocyte necrosis and dropout accompanied by congestion, some areas of bridging necrosis and focal confluent necrosis which[]

  • Liver Transplant Rejection

    […] arteries due to concentric intimal thickening and lipid rich macrophages Biliary strictures may occur Centrilobular hepatocyte dropout Neeraja Kambham MD Department of Pathology[] […] damage Also loss of bile ducts, arteritis, central ischemic damage with ballooning degeneration and hepatocyte dropout Microscopic (histologic) images Images hosted on other[] Biopsies in this setting typically show centrilobular hepatocyte dropout due to hepatocellular necrosis, with compensatory zone 2 hepatocyte proliferation and bile ductular[]

  • Cholestasis

    The hepatocytes may show Mallory bodies, eosinophilicand pseudoxanthomatous degeneration. There may be foci of cell dropout.[]

  • Pericholangitis

    Definition Damage to the transplanted liver caused by cold or warm ischemia Diagnostic Criteria Centrilobular changes (zone 3) Hepatocyte swelling Cholestasis Hepatocyte dropout[]

  • Crohn's Disease

    Liver biopsy revealed severe perivenular sinusoidal dilation with areas of hepatocyte dropout, bands of hepatocyte atrophy and centrizonal fibrosis, suggestive of BCS.[]

  • Massive Hepatic Necrosis

    Frequent microscopic changes include ballooning degeneration, scattered acidophil bodies, hepatocytes dropout, lobular and sinusoidal inflammatory cell infiltrate, and Kupffer[] Ballooned hepatocytes and dilated canaliculi were seen. E. Pigment was present, but mostly in Kupffer cells, not hepatocytes or as bile plugs. F.[] […] when shown, showed extensive damage, here seen as loss of cytoplasm, and nuclear pleomorphism and hyperchromasia (other degenerative changes, not seen here, include nuclear dropout[]

  • Acute Liver Failure

    […] have already undergone lysis, so-called "cell dropout" or collapse.[] As used in this report, the term necrosis refers not only to hepatic parenchymal cells still in the process of disintegration but also to foci of destruction in which the hepatocytes[]

  • Acute Fatty Liver of Pregnancy

    […] and macrovesicular fat In severe cases, hepatocyte dropout, reticulin collapse, portal tract inflammation Positive stains (frozen tissue) Fat stains ( Oil red O, Sudan black[] […] description Pale, yellow, small liver Microscopic (histologic) description Microvesicular steatosis in zones 2 or 3 (vacuoles may be very small) Also marked ballooning of hepatocytes[]

  • Extrahepatic Cholestasis

    The hepatocytes may show Mallory bodies, eosinophilicand pseudoxanthomatous degeneration. There may be foci of cell dropout.[]

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