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73 Possible Causes for Hepatocyte Iron Increased

  • Iron Deficiency

    , increased dietary iron absorption from enterocytes, and mobilization of storage iron from hepatocytes.[cancertherapyadvisor.com] Plasma iron levels fall and iron-restricted erythropoiesis develops because release of iron from macrophages, enterocytes, and hepatocytes is impeded, increasing the amounts[cancertherapyadvisor.com] […] from enterocytes absorbing dietary iron, and inhibiting release of iron stored in hepatocytes.[cancertherapyadvisor.com]

  • Hemochromatosis

    Generation of free radicals by iron particles may damage hepatocyte DNA, increasing risk of hepatocellular carcinoma.[pathwaymedicine.org] A biopsy will show excess accumulation of iron within hepatocytes.[lecturio.com] By increasing hepcidin production, thiazolidinone compounds may provide a useful alternative for the treatment of iron overload disorders. Received October 21, 2018.[haematologica.org]

  • African Iron Overload

    In the index subjects, increased iron was present in both hepatocytes and cells of the mononuclear-phagocyte system.[ncbi.nlm.nih.gov] Increased stainable liver iron was observed in hepatocytes only in 4 patients, in macrophages only in 8 patients, and in hepatocytes and macrophages in 8 patients.[ncbi.nlm.nih.gov] Increased lipid peroxidation is thought to be a vital contributor to hepatocellular carcinoma in iron overload.[en.wikipedia.org]

  • Colorectal Carcinoma

    The inflammatory cytokine interleukin (IL)-6 increases the synthesis of liver hepcidin, a major iron-regulatory hormone central to iron homeostasis, resulting in reduced duodenal[atm.amegroups.com] […] iron absorption and retention of iron in macrophages and hepatocytes promoting iron storage ( 34 ).[atm.amegroups.com]

  • Cholestasis

    […] and moderately increased iron stores, but no steatosis, fibrosis, necrosis, inflammation, or features of biliary atresia.[pediatrics.aappublications.org] […] life revealed no excretion of tracer from the liver; thus, a liver biopsy was done, which revealed focal intracellular cholestasis with giant cell transformation of some hepatocytes[pediatrics.aappublications.org]

  • Pediatric Crohn Disease

    hepatocytes, hepcidin is induced by IL-6, but not IL-1 or tumor necrosis factor-α. 5, 21 A number of studies have demonstrated increased serum IL-6 levels in CD. 14, 15 We[doi.org] , whereas IL-6-null mice did not. 5 In addition, humans injected with recombinant human IL-6 exhibit increases in urinary hepcidin and reductions in serum iron. 5 In human[doi.org] […] the liver of mice and humans. 34 In a murine model of inflammation, wild-type mice injected with turpentine exhibited increases in hepcidin mRNA and a reduction in serum iron[doi.org]

  • Hepatocellular Carcinoma

    The removal of excess iron by phlebotomy attenuates hepatocyte injury in patients with HCV infection [ 25 ], and reduces the rate of HCC emergence [ 26 ].[doi.org] […] and increases the risk of developing HCC [ 24 ].[doi.org] Excess amounts of iron deposits are frequently observed in the liver of individuals with a chronic hepatitis C infection, and an iron overload induces mitochondrial injury[doi.org]

  • Microcytic Anemia

    Cp knock-out mice display increased iron content in liver and spleen macrophages as well as in hepatocytes. 120 Ferrokinetic studies in Cp / and Cp / mice revealed a striking[dx.doi.org] […] of iron to plasma transferrin.[dx.doi.org] The disease is caused by the absence of ceruloplasmin (Cp), a multi-copper ferroxidase, which catalyzes the oxidation of ferrous to ferric iron, a change required for binding[dx.doi.org]

  • Posthemorrhagic Anaemia of the Newborn

    Il-6 may induce iron uptake in hepatocytes, leading to hypoferraemia.[nataonline.com] Il-1_ and TNF-_ (the latter is usually not found after surgery) increase iron uptake by macrophages and impair iron release from macrophages.[nataonline.com]

  • Primary Sclerosing Cholangitis

    Furthermore, acrolein was also elevated within the nuclei of periportal inflammatory cells whereas MDA staining was increased in hepatocytes across the lobule.[ncbi.nlm.nih.gov] Prussian Blue staining, when compared to the positive controls (ALD, NASH), did not display any evidence of iron accumulation in PSC/IBD livers.[ncbi.nlm.nih.gov]

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