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276 Possible Causes for Hepatomegaly, Hypercellular Bone Marrow

  • Chronic Myeloid Leukemia

    Low-grade fever and excessive sweating Elevated white blood cell (WBC) count Splenomegaly Decreased appetite and food intake Left upper quadrant abdominal pain from splenomegaly Hepatomegaly[symptoma.com] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] Hepatomegaly also occurs, although less commonly than splenomegaly. Hepatomegaly is usually part of the extramedullary hematopoiesis occurring in the spleen.[emedicine.medscape.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    […] characterized by episodes of hemolytic anemia, hemoglobinuria (chiefly at night), pallor, icterus or bronzing of the skin, a moderate degree of splenomegaly, and sometimes hepatomegaly[medical-dictionary.thefreedictionary.com] Bone marrow failure is present in all patients with PNH, even when peripheral blood counts are normal and the bone marrow is hypercellular.[emedicine.medscape.com] Depending on their localization, thromboses (which affect 30-40 % of untreated patients) may manifest as abdominal pain, hepatomegaly, ascites and headaches.[orpha.net]

  • Myeloproliferative Disease

    […] mice from two independent transgenic lines and from backcrosses into either the FVB or the C57BL/6 strains succumbed to a similar disease characterized by splenomegaly, hepatomegaly[ncbi.nlm.nih.gov] The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[clinlabnavigator.com] Splenomegaly, hepatomegaly as well as fatigue, malaise or weight loss may appear in advanced stages.[orpha.net]

  • Polycythemia Vera

    […] women) Plethora Pruritus after bathing Splenomegaly Weight loss Weakness Sweating Less Common Bruising/epistaxis Budd-Chiari syndrome Erythromelalgia Gout Hemorrhagic events Hepatomegaly[aafp.org] bone marrow 5.[slideshare.net] , Visual disturbances - 31%, Weight loss - 29%, Paresthesias - 29%, Dyspnea - 26%, Joint symptoms - 26%, Epigastric discomfort - 24% Physical Findings Splenomegaly -70%; Hepatomegaly[enotes.tripod.com]

  • Acute Leukemia

    Extramedullary infiltration by leukemic cells may cause lymphadenopathy, splenomegaly, hepatomegaly, and leukemia cutis (a raised, nonpruritic rash).[merckmanuals.com] ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] Hepatomegaly and/or splenomegaly resulting from leukemic infiltration are present in many patients at diagnosis but are often overlooked.[clinicaladvisor.com]

  • Hepatic Vein Thrombosis

    Eight group II patients (asymptomatic patients) had no ascites, hepatomegaly, or abdominal pain.[ncbi.nlm.nih.gov] Bone marrow was hypercellular with an increase in progenitor cells. The aggregation response of platelets to ADP and to collagen was markedly increased.[ncbi.nlm.nih.gov] Two patients survived, with gradual resolution of hepatomegaly and ascites following discontinuance of the birth control pills.[ncbi.nlm.nih.gov]

  • Extramedullary Hematopoiesis

    Massive hepatomegaly is a common finding in hydrops fetalis (HF) arising from hemoglobinopathies.[ncbi.nlm.nih.gov] The spaces were filled with fat and prominent hypercellular bone marrow, with trilineage hematopoiesis with scattered lymphoid aggregates, some showing reactive follicles.[austinpublishinggroup.com] The patient underwent a bone marrow biopsy which revealed hypercellular bone marrow with erythroid hyperplasia.[biomarkerres.biomedcentral.com]

  • Fetal Erythroblastosis

    Also, the newborn will be anemic and pale and present splenomegaly and hepatomegaly, caused by extramedullary hematopoiesis. Portal hypertension has the same cause.[symptoma.com] Ultrasonography may reveal hepatomegaly, abdominal enlargement, ascites, or signs of hydrops fetalis.[quizlet.com] […] haemolyticus neonatorum (fetal erythroblastosis) with the following symptoms: anemia (due to the hemolysis) splenomegaly (location of the macrophages that destroy the erythrocytes) hepatomegaly[embryology.ch]

  • Sickle Cell Disease

    Additional autopsy findings included cardiomegaly with a heart weight of 450 gm (312 78), right atrial and right ventricular chamber dilatation, and hepatomegaly with a liver[ncbi.nlm.nih.gov]

  • Leukemia

    […] tiredness and fatigue Pain in bone Fever accompanied by chills Excessive sweating especially during night hours Easy prone to infections Bleeding or bruising very easily Hepatomegaly[symptoma.com] […] patient has enlarged lymph nodes Splenomegaly, which is an enlarged spleen Anemia, meaning low levels of red blood cells Thrombocytopenia, meaning low levels of platelets Hepatomegaly[cancer.net] Peripheral Smear Leukocytosis without other secondary cause (or despite treatment) White Blood Cell Count 20,000/mm3 Associated Anemia , Thrombocytopenia or Thrombocytosis Hepatomegaly[fpnotebook.com]

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