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694 Possible Causes for Hepatomegaly, Jaundice, Petechiae

  • Infectious Mononucleosis

    We report a case of infectious mononucleosis in a 72-year old jaundiced gentleman with ferritin level of 2438 that normalised on clinical improvement.[ncbi.nlm.nih.gov] The patient showed severe hepatomegaly incidentally, and dual positivity of Immunoglobulin (Ig) M to Epstein-Barr virus (EBV) viral capsid antigen (VCA) and cytomegalovirus[ncbi.nlm.nih.gov] In adolescent and adult patients presenting with sore throat, the presence of posterior cervical, inguinal or axillary adenopathy, palatine petechiae, splenomegaly, or atypical[ncbi.nlm.nih.gov]

  • Relapsing Fever

    Jaundice was seen in four of the five cases, three of them died. Only twenty cases of neonatal relapsing fever were previously reported.[ncbi.nlm.nih.gov] Malaria and babesiosis cause hemolytic anemia and may be associated with hepatomegaly and splenomegaly. Recurring fever is typical of malaria and Borrelia infection.[mdedge.com] Papules (small lumps), petechiae (small red or purple spots due to bleeding into the skin), purpura (bleeding into the skin, includes petechiae and bruises), and facial flushing[dermnetnz.org]

  • Babesiosis

    Jaundice, hepatosplenomegaly, anemia and conjugated hyperbilirubinemia developed in this preterm infant.[ncbi.nlm.nih.gov] On physical examination, fever, splenomegaly, hepatomegaly, or jaundice may be observed.[aldf.com] Petechiae (small red or purple spots due to bleeding into the skin) and bruises may occur, most likely due to thrombocytopenia (low platelets , which causes abnormal blood[dermnetnz.org]

  • Pernicious Anemia

    Jaundice: There is mild jaundice caused by the excessive breakdown of hemoglobin due to ineffective erythropoiesis in the bone marrow.[symptoma.com] Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[rarediseases.org] Petechiae in the mammillary bodies. WKS, acute lesion. Periaqueductal lesions. WKS, acute lesion. Periaqueductal lesions. WKS, burned out lesion. WKS, burned out lesion.[neuropathology-web.org]

  • Erythropoietic Protoporphyria

    A 21-year-old Japanese man was admitted to our hospital because of severe abdominal pain and jaundice.[ncbi.nlm.nih.gov] Patients can also present with splenomegaly and hepatomegaly. Liver biopsy in such patients may reveal features of appreciable hepatocellular injury.[flipper.diff.org] EPP is characterised by cutaneous manifestations of acute painful photosensitivity with erythema and oedema, sometimes with petechiae, together with stinging and burning sensations[ncbi.nlm.nih.gov]

  • Weil's Disease

    Two patients are described with Weil's disease as a rare cause of jaundice. We discuss some features that can lead to early diagnosis.[ncbi.nlm.nih.gov] Rash O looks like a heart for bradycardia Weil's disease mnemonic "WEILS" Wet due to hemorrhage E is to remind me of epistaxis and other hemorrhagic manifestations like petechiae[medicowesome.com] […] addition, thrombocytopenia and several other factors contribute to hemorrhagic episodes, most frequently in the pulmonary system (presenting as hemoptysis), whereas epistaxis, petechiae[symptoma.com]

  • Congenital Toxoplasmosis

    Because biliary atresia can coexist with either congenital infection or inborn errors of metabolism, evaluation for an obstructive etiology of jaundice in infants with a recognized[ncbi.nlm.nih.gov] During the first month of life, physical examination was normal in 34.5%, and for those with clinical signs and symptoms, the main manifestations were hepatomegaly and/or[ncbi.nlm.nih.gov] The newborn may have a low birth weight, enlarged liver and spleen, jaundice, anemia, petechiae, and eye damage.[clinicaltrials.gov]

  • Typhus

    Most common cause of jaundice in south east Asia is of infective etiology.[ncbi.nlm.nih.gov] The most common CT finding was hepatomegaly (74.4%), followed by splenomegaly (66.7%).[ncbi.nlm.nih.gov] […] myalgia nausea vomiting Physical exam hypotension fever photophobia early rash light rose color and blanches under pressure late rash dull red that does not fade scattered petechiae[step2.medbullets.com]

  • Primary Sclerosing Cholangitis

    Primary sclerosing cholangitis (PSC) is a chronic inflammatory disease of bile ducts..Patients with PSC usually presents with fatigue, jaundice and pruritus.[ncbi.nlm.nih.gov] Liver disease other than PSC was defined as autoimmune hepatitis, hepatitis, hepatomegaly, liver failure, cirrhosis, portal hypertension, cholangiocarcinoma, or hepatobiliary[ncbi.nlm.nih.gov] While CD was well-controlled by immunomodulators, the patient's thrombocytopenia gradually progressed resulting in petechiae (platelet count of 11 10(9) /L) when she was 10[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    Although the severe obstructive jaundice requiring endoscopic therapy following cholecystectomy was complicated, critical intravascular hemolysis and thrombosis were not observed[ncbi.nlm.nih.gov] […] characterized by episodes of hemolytic anemia, hemoglobinuria (chiefly at night), pallor, icterus or bronzing of the skin, a moderate degree of splenomegaly, and sometimes hepatomegaly[medical-dictionary.thefreedictionary.com] […] fatigue, tachycardia, jaundice, and gross hematuria acute hemolytic episodes from activators of complement surgery infection stress alcohol thrombocytopenia: mucosal bleeding, petechiae[medbullets.com]

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