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1,773 Possible Causes for Hepatomegaly, Kidney Disease, Splenomegaly

  • Paroxysmal Nocturnal Hemoglobinuria

    […] characterized by episodes of hemolytic anemia, hemoglobinuria (chiefly at night), pallor, icterus or bronzing of the skin, a moderate degree of splenomegaly, and sometimes hepatomegaly[medical-dictionary.thefreedictionary.com] PNH is associated with abdominal vein thrombosis, which can cause splenomegaly and hypersplenism.[ncbi.nlm.nih.gov] The association of Fanconi syndrome (FS) and chronic kidney disease (CKD) has been rarely described during the course of paroxysmal nocturnal hemoglobinuria (PNH).[ncbi.nlm.nih.gov]

  • Congenital Hepatic Fibrosis

    The age at presentation ranged from 1.8-14 years (mean: 7.5 years); clinical manifestations at diagnosis were splenomegaly (12), hepatomegaly (11), failure to thrive (10),[ncbi.nlm.nih.gov] We describe the first case of CHF presenting in an otherwise healthy child, with thrombocytopenia and splenomegaly as the only manifestations of the disease.[ncbi.nlm.nih.gov] […] autosomal-dominant polycystic kidney disease.[ncbi.nlm.nih.gov]

  • Autosomal Dominant Polycystic Kidney Disease

    However, in rare cases the condition may be complicated with massive hepatomegaly leading to compression of the surrounding organs, or acute complications [ 2 ].[omicsonline.org] They may be palpable if the size augmentation is considerable; if the cysts affect other organs as well, palpable viscera may be detected (splenomegaly, hepatomegaly).[symptoma.com] Diagram of autosomal dominant polycystic disease with a normal kidney inset for comparison Abdominal CT scan of an adult with autosomal dominant polycystic kidney disease.[en.wikipedia.org]

  • Congenital Acquired Immune Deficiency Syndrome

    Category A (mildly symptomatic) - Infants or children that present wth 2 or more of the following: dermatitis, hepatomegaly, splenomegaly, lymphadenopathy ( 2 sites involved[symptoma.com] disease tumors or malignant lesions Q: What are our treatment options?[childrenshospital.org] disease sufferers and transplanted persons.[glosbe.com]

  • Tyrosinemia Type 1

    The main manifestations that led to the diagnosis were acute liver failure (55.8%), asymptomatic hepatomegaly (44.1%) and renal tubular dysfunction (29.4%).[ncbi.nlm.nih.gov] Tyrosinemia type I (HT1) is a genetic metabolic disorder characterized by progressive liver disease, kidney disease, and rickets.[ncbi.nlm.nih.gov] Therefore, these products go on to cause liver disease, kidney disease, and even nerve damage. This disease is inherited in an autosomal recessive pattern.[symptoma.com]

  • Extramedullary Hematopoiesis

    Massive hepatomegaly is a common finding in hydrops fetalis (HF) arising from hemoglobinopathies.[ncbi.nlm.nih.gov] These findings thus challenge our understanding of splenomegaly as a marker of disease.[ncbi.nlm.nih.gov] Kidney disease in the setting of a hematologic malignancy is common, with the frequency and type of kidney disease varying depending on the specific malignancy.[ncbi.nlm.nih.gov]

  • Hepatitis E

    It mostly affects adults as this disease mimics hepatic illness with features such as fatigue, jaundice, nausea, emesis, fever, anorexia, hepatomegaly, and abdominal pain.[symptoma.com] Hepatitis E virus (HEV)-related kidney disease and symptomatic cryoglobulinemia have been observed in solid-organ transplant recipients.[ncbi.nlm.nih.gov] […] hepatitis include jaundice (yellow discoloration of the skin and sclera of the eyes, dark urine and pale stools), anorexia (loss of appetite), an enlarged, tender liver (hepatomegaly[hepfi.org]

  • Cystinosis

    The patient was admitted to our hospital because of hepatomegaly, anemia, and thrombocytopenia and underwent a trephine bone marrow biopsy based on a preliminary diagnosis[ncbi.nlm.nih.gov] […] cystine accumulation caused multiple endocrinopathies (including adrenal insufficiency, hypothyroidism and primary hypogonadism), neurological symptoms, pancytopenia owing to splenomegaly[ncbi.nlm.nih.gov] The foundation is focusing on promoting health education to prevent kidney disease.[cystinosisindia.org]

  • Malignant Neoplasm

    Diseases) Understanding Chemotherapy - NIH - Easy-to-Read (National Cancer Institute) What to Know about External Beam Radiation Therapy - NIH - Easy-to-Read (National Cancer[icdlist.com] These subsections include: Adrenal glands, kidneys, ureters Breast Diseases treated by stem cell transplantation or bone marrow transplantation Gall bladder or liver Genital[disability-benefits-help.org] Encyclopedia) Colon cancer screening (Medical Encyclopedia) Large bowel resection (Medical Encyclopedia) Lower GI Series - NIH (National Institute of Diabetes and Digestive and Kidney[icdlist.com]

  • Infectious Mononucleosis

    The patient showed severe hepatomegaly incidentally, and dual positivity of Immunoglobulin (Ig) M to Epstein-Barr virus (EBV) viral capsid antigen (VCA) and cytomegalovirus[ncbi.nlm.nih.gov] Clinical estimates of splenomegaly are fallible.[ncbi.nlm.nih.gov] In severely immunosuppressed patients EBV reactivation and organ dysfunction including viral disease of involving the brain, liver, heart, and lungs, and rarely the kidneys[livescience.com]

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