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558 Possible Causes for Hepatomegaly, Lactate Dehydrogenase Increased

  • Infectious Mononucleosis

    The patient showed severe hepatomegaly incidentally, and dual positivity of Immunoglobulin (Ig) M to Epstein-Barr virus (EBV) viral capsid antigen (VCA) and cytomegalovirus[ncbi.nlm.nih.gov] Although the complaints at admission did not differ between these two patient groups, the incidence of clinical signs (tonsillopharyngitis, lymphadenopathy, hepatomegaly,[ncbi.nlm.nih.gov] […] splenomegaly possible splenic rupture splenic infarction has been reported 3 generalised lymphadenopathy , including cervical lymphadenopathy tonsillar enlargement possible hepatomegaly[radiopaedia.org]

  • Reye Syndrome

    Serum glutamic oxaloacetic transaminase and lactate dehydrogenase (LDH) values increased strikingly on the third day after the onset of coma.[ncbi.nlm.nih.gov] A 2-year-old boy had acute fever, malaise, and somnolence with hepatomegaly, increased blood ammonia content (338 microM), high SGOT, low blood glucose content, and mild acidosis[ncbi.nlm.nih.gov] Bývá hepatomegalie s výraznou leukocytózou, intermitentní hypoglykemie, ketonemie, acidóza a hypernatremie. (cit.[fpnotebook.com]

  • Gastric Cancer

    Increased lactate within GC TILs was positively correlated with increased lactate dehydrogenase A (LDH)A.[ncbi.nlm.nih.gov] Signs may include a palpable enlarged stomach with succussion splash; hepatomegaly; periumbilical metastasis (Sister Mary Joseph nodule); and enlarged lymph nodes such as[emedicine.medscape.com] Physical exam The most common finding in advanced cases is palpable abdominal mass, which may be accompanied by succussion splash and hepatomegaly.[symptoma.com]

  • Thalassemia

    At the end of the treatment period, Hb and HbF increased by 2.5   1.8 g/dL and 2.5   1.6 g/dL, while bilirubin, lactate dehydrogenase, and the nucleated red blood cell count[ncbi.nlm.nih.gov] The presence of hepatomegaly was a statistically significant predictor for poor physical QOL (OR   8.5, p   0.02).[ncbi.nlm.nih.gov] They also have massive hepatomegaly due to heart failure and extramedullary hematopoiesis.[emedicine.medscape.com]

  • Acute Lymphoblastic Leukemia

    Serum level of lactate dehydrogenase (LDH) predicts increased anaerobic glycolysis and is associated with metabolic modulation in cancer cells.[ncbi.nlm.nih.gov] Bone pain/tenderness, hepatomegaly, and splenomegaly may be present. About 7% of children have CNS involvement at the time of diagnosis.[lecturio.com] Lymphadenopathy, splenomegaly, and hepatomegaly is seen in about 20% of patients with ALL.[cancertherapyadvisor.com]

  • Primary Myelofibrosis

    The latter was associated more frequently with anaemia, thrombocytopenia, peripheral blood blasts and increased lactate dehydrogenase levels.[ncbi.nlm.nih.gov] The patient, a 62-year-old female, having had primary myelofibrosis for 13 years and a splenectomy 4 years before, was admitted because of high fever, hepatomegaly, thrombocythemia[ncbi.nlm.nih.gov] Lactate Dehydrogenase (LDH) Anemia Splenomegaly What Other Diseases Should Be Considered and How Do I Distinguish Between Them?[clinicaladvisor.com]

  • Paroxysmal Nocturnal Hemoglobinuria

    The effect of eculizumab on intravascular hemolysis was demonstrated by a reduction in lactate dehydrogenase levels at all measurements after baseline.[ncbi.nlm.nih.gov] […] characterized by episodes of hemolytic anemia, hemoglobinuria (chiefly at night), pallor, icterus or bronzing of the skin, a moderate degree of splenomegaly, and sometimes hepatomegaly[medical-dictionary.thefreedictionary.com] After approximately 2 years, apart from normalization of the lactate dehydrogenase (LDH) level, there was an increase in glycosylphosphatidylinositol (GPI) negative red cells[nejm.org]

  • Chronic Lymphocytic Leukemia

    […] chemicals measured in blood tests , for example lactate dehydrogenase (LDH) or calcium.[lymphoma-action.org.uk] […] of the left zygomatic region; anterior nasal bleeding; pustulous non-itching lesions at the cervical region and posterior thorax; enlarged bilateral axillary lymph nodes; hepatomegaly[ncbi.nlm.nih.gov] Stage II: Lymphocytosis along with either splenomegaly or hepatomegaly is present. Lymphadenopathy may or may not be present.[symptoma.com]

  • Viral Hepatitis

    Lactate dehydrogenase (LD) – an enzyme released with cell damage; found in cells throughout the body.[labtestsonline.org] Three patients presented only jaundice and hepatomegaly; one also had liver failure.[ncbi.nlm.nih.gov] In the icteric phase, the patients develop jaundice, gastrointestinal disturbance, dark urine, gray-colored stools, right upper quadrant pain, and hepatomegaly.[symptoma.com]

  • Liver Abscess

    We report a case of a 63-year-old male with a history of anorexia for 3 weeks, fever for 4 days and examination findings of tender hepatomegaly with a liver span of 15 cm[ncbi.nlm.nih.gov] The main clinical features were fever (100%), right hypochodric pain (100%), tender hepatomegaly (90%) and intercostal tenderness (60%).[ncbi.nlm.nih.gov] Common clinical findings were fever, abdominal pain, and hepatomegaly. Radionuclide scan was useful in diagnosis of lesions larger than 2 cm.[pediatrics.aappublications.org]

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