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14 Possible Causes for Hepatomegaly, Leukocyte Alkaline Phosphatase Decreased, Occult Malignancy

  • Non-Hodgkin Lymphoma

    Hepatomegaly. Intermediate- and high-grade lymphomas: Most patients present with rapidly growing and bulky lymphadenopathy.[patient.info] Slow growing or indolent lymphomas usually present with lymphadenopathy, hepatomegaly, splenomegaly or different types of cytopenias.[symptoma.com] Intermediate- and high-grade lymphomas may produce the following physical examination findings: Rapidly growing and bulky lymphadenopathy Splenomegaly Hepatomegaly Large abdominal[emedicine.medscape.com]

  • Pancreatic Adenocarcinoma

    Suspicion of pancreatic cancer take a detailed history and perform physical exam, evaluating especially for abdominal distention (ascites), a palpable gallbladder, hepatomegaly[cancertherapyadvisor.com] Patients presenting with or developing advanced intra-abdominal disease may have ascites, a palpable abdominal mass, hepatomegaly from liver metastases, or splenomegaly from[emedicine.medscape.com]

  • Metastatic Adenocarcinoma of the Breast

    We report an exceptional case of metastatic adenocarcinoma of the breast occurring within a benign intradermal nevus. An extensive review of the literature on metastatic breast carcinoma is included.[ncbi.nlm.nih.gov]

  • Hodgkin Lymphoma

    The presenting feature common in all cases was superficial lymphadenopathy followed by hepatomegaly in 17 (20%) cases and splenomegaly in 16 (19%).[ncbi.nlm.nih.gov] Abdomen: Abdominal enlargement may be noted with splenomegaly or hepatomegaly.[symptoma.com] The nodes may also feel rubbery and swollen when examined Splenomegaly: enlargement of the spleen occurs in about 30% of people with Hodgkin's lymphoma Hepatomegaly: enlargement[slideshare.net]

  • Bronchogenic Carcinoma

    The findings of physical examination included cardiac auscultation of a characteristic «bubbling water» systodiastolic murmur and hepatomegaly of 2 cm.[revespcardiol.org] […] metastases from lung cancer may present clinically or as a finding at autopsy. [3] Clinically they present with symptoms of colonic obstruction, lower gastrointestinal bleed (occult[jpgmonline.com] […] the appearance of pan colitis in this case could be from the extensive tumour involvement of colonic mucosa and excessive proliferative activity of a poorly differentiated malignancy[jpgmonline.com]

  • Cecal Adenocarcinoma

    Jaundice and hepatomegaly indicate advanced disease with extensive liver metastases.[patient.info] Most importantly, for patients with blood cultures that grow C. septicum , a comprehensive search for occult malignancy is imperative, especially for adenocarcinomas in the[acgcasereports.gi.org] […] transcatheter arterial embolization (TAE)肝動脈塞栓療法 hepatic trauma肝外傷 hepatitis肝炎 hepatitis AA型肝炎 hepatoblastoma肝芽腫 hepatocellular carcinoma (liver cell carcinoma)肝細胞癌 hepatocyte肝細胞 hepatomegaly[tokyo-med.ac.jp]

  • Renal Cell Carcinoma

    Great mimic" due to associated paraneoplastic syndromes of Cushing syndrome, gynecomastia, hypercalcemia, hypertension, leukemoid reaction, polycythemia, Stauffer syndrome (hepatomegaly[pathologyoutlines.com] We describe a unique case of subcutaneous metastasis of sarcomatoid renal cell carcinoma which was the first manifestation of the occult malignancy.[ncbi.nlm.nih.gov] In cases where the oral lesion represents the initial presentation of an occult primary malignancy, additional workup including full body imaging is recommended to determine[jomfp.in]

  • Malignant Melanoma

    Sonography of the abdomen showed heterogeneous hepatomegaly and splenomegaly with multiple images suggestive of nodular metastatic lesions in the liver and spleen.[scielo.br] FM Solivetti, SA Di Luca, G Pirozzi, etal: Sonographic evaluation of clinically occult in-transit and satellite metastases from cutaneous malignant melanoma Radiol Med (Torino[doi.org] Striking differences were noted in a small subset of patients who had occult nodal metastases treated with IFN versus control.[emedicine.com]

  • Leukoerythroblastic Anemia

    Massive splenomegaly can cause abdominal pressure, early satiety, cachexia, portal hypertension, and left upper quadrant abdominal pain; hepatomegaly may be present.[merckmanuals.com] Increased C-reactive protein suggests but does not secure a diagnosis of reactive thrombocytosis associated with an occult inflammatory or malignant process.[ascopost.com] leukocyte alkaline phosphatase score in CML LAP is absent in neoplastic granulocytes and present in benign granulocytes Treatment of CML imatinib mesylate: oral tyrosine[memorize.com]

  • Bone Marrow Disease

    Erlenmeyer flask deformity 41. 2-Other manifestations : -Spleen : -Massive splenomegaly -Splenic nodules -Splenic infarcts -Liver : -Hepatomegaly 42. c) Differential Diagnosis[slideshare.net] Some of the transplant centers, including ours, use bone marrow aspiration on related donors to exclude occult hematological malignancies.[nature.com] Presence of hepatomegaly, splenomegaly or lymphadenopathy suggests a diagnosis of leukaemia.[patient.info]

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