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14 Possible Causes for Hepatomegaly, Leukocyte Alkaline Phosphatase Decreased, Occult Malignancy

  • Non-Hodgkin Lymphoma

    Hepatomegaly. Intermediate- and high-grade lymphomas: Most patients present with rapidly growing and bulky lymphadenopathy.[] Slow growing or indolent lymphomas usually present with lymphadenopathy, hepatomegaly, splenomegaly or different types of cytopenias.[] Intermediate- and high-grade lymphomas may produce the following physical examination findings: Rapidly growing and bulky lymphadenopathy Splenomegaly Hepatomegaly Large abdominal[]

  • Pancreatic Adenocarcinoma

    Suspicion of pancreatic cancer take a detailed history and perform physical exam, evaluating especially for abdominal distention (ascites), a palpable gallbladder, hepatomegaly[] Patients presenting with or developing advanced intra-abdominal disease may have ascites, a palpable abdominal mass, hepatomegaly from liver metastases, or splenomegaly from[]

  • Metastatic Adenocarcinoma of the Breast

    We report an exceptional case of metastatic adenocarcinoma of the breast occurring within a benign intradermal nevus. An extensive review of the literature on metastatic breast carcinoma is included.[]

  • Hodgkin Lymphoma

    The presenting feature common in all cases was superficial lymphadenopathy followed by hepatomegaly in 17 (20%) cases and splenomegaly in 16 (19%).[] Abdomen: Abdominal enlargement may be noted with splenomegaly or hepatomegaly.[] The nodes may also feel rubbery and swollen when examined Splenomegaly: enlargement of the spleen occurs in about 30% of people with Hodgkin's lymphoma Hepatomegaly: enlargement[]

  • Bronchogenic Carcinoma

    The findings of physical examination included cardiac auscultation of a characteristic «bubbling water» systodiastolic murmur and hepatomegaly of 2 cm.[] […] metastases from lung cancer may present clinically or as a finding at autopsy. [3] Clinically they present with symptoms of colonic obstruction, lower gastrointestinal bleed (occult[] […] the appearance of pan colitis in this case could be from the extensive tumour involvement of colonic mucosa and excessive proliferative activity of a poorly differentiated malignancy[]

  • Cecal Adenocarcinoma

    Jaundice and hepatomegaly indicate advanced disease with extensive liver metastases.[] Most importantly, for patients with blood cultures that grow C. septicum , a comprehensive search for occult malignancy is imperative, especially for adenocarcinomas in the[] […] transcatheter arterial embolization (TAE)肝動脈塞栓療法 hepatic trauma肝外傷 hepatitis肝炎 hepatitis AA型肝炎 hepatoblastoma肝芽腫 hepatocellular carcinoma (liver cell carcinoma)肝細胞癌 hepatocyte肝細胞 hepatomegaly[]

  • Renal Cell Carcinoma

    Great mimic" due to associated paraneoplastic syndromes of Cushing syndrome, gynecomastia, hypercalcemia, hypertension, leukemoid reaction, polycythemia, Stauffer syndrome (hepatomegaly[] We describe a unique case of subcutaneous metastasis of sarcomatoid renal cell carcinoma which was the first manifestation of the occult malignancy.[] In cases where the oral lesion represents the initial presentation of an occult primary malignancy, additional workup including full body imaging is recommended to determine[]

  • Malignant Melanoma

    Sonography of the abdomen showed heterogeneous hepatomegaly and splenomegaly with multiple images suggestive of nodular metastatic lesions in the liver and spleen.[] FM Solivetti, SA Di Luca, G Pirozzi, etal: Sonographic evaluation of clinically occult in-transit and satellite metastases from cutaneous malignant melanoma Radiol Med (Torino[] Striking differences were noted in a small subset of patients who had occult nodal metastases treated with IFN versus control.[]

  • Leukoerythroblastic Anemia

    Massive splenomegaly can cause abdominal pressure, early satiety, cachexia, portal hypertension, and left upper quadrant abdominal pain; hepatomegaly may be present.[] Increased C-reactive protein suggests but does not secure a diagnosis of reactive thrombocytosis associated with an occult inflammatory or malignant process.[] leukocyte alkaline phosphatase score in CML LAP is absent in neoplastic granulocytes and present in benign granulocytes Treatment of CML imatinib mesylate: oral tyrosine[]

  • Bone Marrow Disease

    Erlenmeyer flask deformity 41. 2-Other manifestations : -Spleen : -Massive splenomegaly -Splenic nodules -Splenic infarcts -Liver : -Hepatomegaly 42. c) Differential Diagnosis[] Some of the transplant centers, including ours, use bone marrow aspiration on related donors to exclude occult hematological malignancies.[] Presence of hepatomegaly, splenomegaly or lymphadenopathy suggests a diagnosis of leukaemia.[]

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