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3,519 Possible Causes for Hepatomegaly, Leukocyte Alkaline Phosphatase Increased, Wide Space Between the First and Second Toe

  • Non-Hodgkin Lymphoma

    Hepatomegaly. Intermediate- and high-grade lymphomas: Most patients present with rapidly growing and bulky lymphadenopathy.[patient.info] Slow growing or indolent lymphomas usually present with lymphadenopathy, hepatomegaly, splenomegaly or different types of cytopenias.[symptoma.com] Intermediate- and high-grade lymphomas may produce the following physical examination findings: Rapidly growing and bulky lymphadenopathy Splenomegaly Hepatomegaly Large abdominal[emedicine.medscape.com]

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  • Portal Cirrhosis

    The presence of this triad in a patient with unexplained hepatomegaly is indicative of portal cirrhosis.[ncbi.nlm.nih.gov] The liver becomes large, even huge (hepatomegaly). The normal liver weighs about 1,200 grams (2.6 lb).[en.wikipedia.org]

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  • Down Syndrome

    Ultrasound features indicative of TAM included hepatomegaly splenomegaly (79.5%), hydrops fetalis (30.8%), pericardial effusion (23.1%) and aberrant liquor volume (15.4%).[ncbi.nlm.nih.gov] A wide space, often with a deep fissure between the first and second toes, is also common.[dx.doi.org] Amongst these features, hepatomegaly, splenomegaly, pericardial/pleural effusions and skin rash are seen more frequently in neonates with TAM compared with neonates without[doi.org]

  • Primary Myelofibrosis

    alkaline phosphatase (LAP) score is increased Treatment Reduced intensity allogeneic stem cell transplant if intermediate to high risk or palliation of extramedullary hematopoiesis[pathologyoutlines.com] The patient, a 62-year-old female, having had primary myelofibrosis for 13 years and a splenectomy 4 years before, was admitted because of high fever, hepatomegaly, thrombocythemia[ncbi.nlm.nih.gov] […] manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly[orpha.net]

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  • Cholestasis

    For diagnosis of BA, clinical evaluation, hepatomegaly, stool color, serum gamma-glutamyltranspeptidase (GGT), duodenal juice color, bile acid in duodenal juice, ultrasonography[ncbi.nlm.nih.gov] Clinical signs of cholestasis (discolored stools, dark urine) usually appear in the first months of life with recurrent or permanent jaundice associated with hepatomegaly[orpha.net] Hepatomegaly is also a common finding. Between episodes patients show no symptoms and the interval between attacks varies from months to years.[orpha.net]

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  • Myeloproliferative Disease

    A myeloproliferative disorder manifested by thrombocytosis, a high leukocyte alkaline phosphatase (LAP) score and an increased red blood cell mass was found in a 64-yr-old[ncbi.nlm.nih.gov] Splenomegaly, hepatomegaly as well as fatigue, malaise or weight loss may appear in advanced stages.[orpha.net] Leukocyte alkaline phosphatase ( 100 units in the absence of fever or infection). There is no staging system for this disease.[northshore.org]

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  • Hepatocellular Carcinoma

    Case: We present a case of a 36 year old woman at 36 weeks of gestation with jaundice and hepatomegaly. She was hepatitis B positive.[journals.co.za] Figures Figure 1: showing massive hepatomegaly with distended veins and the pregnancy Figure 2: fetal head and the hepatomegaly with HCC in ultrasound view References Trichopoulos[panafrican-med-journal.com] Ultrasonography of abdomen showed hepatomegaly (15.9cms), hypoechoeic with no focal lesions. Common bile duct and portal vein seem to be normal on examination.[cancerjournal.net]

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  • Chronic Lymphocytic Leukemia

    0 lymphocytosis in the blood and marrow only (survival 120 months) Stage I lymphocytosis and adenopathy (survival 95 months) Stage II lymphocytosis, splenomegaly and/or hepatomegaly[flexikon.doccheck.com] […] of the left zygomatic region; anterior nasal bleeding; pustulous non-itching lesions at the cervical region and posterior thorax; enlarged bilateral axillary lymph nodes; hepatomegaly[ncbi.nlm.nih.gov] Patients may sometimes present with hepatomegaly, splenomegaly or both and/or a hemolytic anemia.[radiopaedia.org]

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  • Viral Hepatitis

    Three patients presented only jaundice and hepatomegaly; one also had liver failure.[ncbi.nlm.nih.gov] In the icteric phase, the patients develop jaundice, gastrointestinal disturbance, dark urine, gray-colored stools, right upper quadrant pain, and hepatomegaly.[symptoma.com] Rare manifestations of CMV hepatitis include tender hepatomegaly, granulomatous hepatitis, anicteric or icteric cholestatic hepatitis, and acute hepatitis with massive necrosis[doi.org]

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  • Polycythemia Vera

    leukocyte alkaline phosphatase, increased vit.B12 level, decreased folic acid level, elevated alk.phosphatase & conjungated bilirubin, hypercalcemia.[enotes.tripod.com] […] neurological symptoms : dizziness, headache, visual disturbances, tinnitus Hypertension Splenomegaly : associated with early satiety and abdominal discomfort; less commonly hepatomegaly[amboss.com] Symptoms of Budd-Chiari syndrome include pain in the upper right part of the abdomen, an abnormally enlarged liver (hepatomegaly), yellowing of the skin and the whites of[rarediseases.org]

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