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18 Possible Causes for Hepatomegaly, Liver Biopsy showing Periportal Necrosis

  • Primary Sclerosing Cholangitis

    Liver disease other than PSC was defined as autoimmune hepatitis, hepatitis, hepatomegaly, liver failure, cirrhosis, portal hypertension, cholangiocarcinoma, or hepatobiliary[ncbi.nlm.nih.gov] Hepatomegaly (may also have splenomegaly at presentation). Later stages: signs of cirrhosis, portal hypertension or hepatic failure.[patient.info] Primary Sclerosing Cholangitis (PSC) is characterized by progressive inflammatory fibrotic destruction of the biliary ducts and patients with PSC often have chronic jaundice, hepatomegaly[sancilio.com]

  • Viral Hepatitis

    Three patients presented only jaundice and hepatomegaly; one also had liver failure.[ncbi.nlm.nih.gov] In the icteric phase, the patients develop jaundice, gastrointestinal disturbance, dark urine, gray-colored stools, right upper quadrant pain, and hepatomegaly.[symptoma.com] Rare manifestations of CMV hepatitis include tender hepatomegaly, granulomatous hepatitis, anicteric or icteric cholestatic hepatitis, and acute hepatitis with massive necrosis[doi.org]

  • Hepatitis A

    The child was deeply icteric and had hepatomegaly. IgM antibodies for hepatitis A virus were positive.[ncbi.nlm.nih.gov] The hepatomegaly continues for another 2-12 weeks and thereafter the liver regains its normal function. Hepatitis A is best diagnosed serologically.[symptoma.com] Common examination findings are hepatomegaly and clinical jaundice with marked elevation of serum transaminases (usually 1000 units/L).[bestpractice.bmj.com]

  • Hepatitis B

    Hepatitis B is a form of viral hepatitis, caused by the hepatitis B virus, a member of the Hepadnavirus family. It is estimated that worldwide, more than 350 million people have chronic hepatitis B virus infection. The course of the disease may be extremely variable, depending on the patient’s age and immune status.[…][symptoma.com]

  • Massive Hepatic Necrosis

    Hepatic involvement is a common finding in cytomegalovirus mononucleosis as manifested by mild hepatomegaly, consistent increases in serum transaminase activity, and variable[annals.org] A, intraoperative (POD 0) wedge biopsy of the native liver showed massive hepatic necrosis and periportal ductular structure (HE, 200 ).[nature.com] Early - features of cholangiohepatitis and cholestasis (increased ALP, AST, direct bilirubin, cholesterol); hepatomegaly, jaundice, and pruritis (destructive phase) Late -[quizlet.com]

  • Aflatoxicosis

    Symptoms include hepatomegaly, abdominal discomfo rt, anorexia, malaise, jaundice and oedema of legs, face and trunk.[aspergillus.org.uk] The affected liver showed hepatomegaly, paleness, wide areas of hemorrhages and necrosis.[khartoumspace.uofk.edu] Patients will appear ill with fever, jaundice, nausea, vomiting, abdominal pain, and hemorrhagic diathesis, hepatomegaly, and elevated liver function tests.[visualdx.com]

  • Autoimmune Hepatitis

    CT Nonspecific, ranging from normal to hepatomegaly and cirrhosis.[radiopaedia.org] In more severe cases, biopsy typically shows periportal necrosis with mononuclear cell infiltrates (piecemeal necrosis) accompanied by variable periportal fibrosis and bile[merckmanuals.com] Abdominal pain 38% Paleness 26% Other symptoms and signs may include: General discomfort or uneasiness Abdominal distension Pruritis Diarrhea Edema Weight loss Spider angiomata Hepatomegaly[symptoma.com]

  • Generalized Lipodystrophy

    The diagnosis is made on the basis of loss of body fat, muscular hypertrophy, acanthosis nigricans, hirsutism, hepatomegaly with fatty liver, hyperlipidemia and hyperglycemia[ncbi.nlm.nih.gov] Hepatomegaly was noticed, and histological examination of a liver biopsy specimen suggested severe hepatic steatosis and periportal necrosis.[ncbi.nlm.nih.gov] The diagnosis is made on the basis of lack of body fat, muscular hypertrophy, acanthosis nigricans, hirsutism, hepatomegaly with fatty liver, hyperlipidemia and hyperglycemia[ncbi.nlm.nih.gov]

  • Primary Biliary Cirrhosis

    The multifactorial analysis identified bilirubinemia and hepatomegaly as independent predictive variables.[nejm.org] Liver biopsy showed lymphocytic and plasmacytic infiltration in the portal and periportal areas, with numerous areas of bridging centrilobular necrosis, indicating AIH.[ncbi.nlm.nih.gov] […] ankles Diarrhea characterized by greasy stools Ascites Skin darkening Abdominal pain experienced in the upper right region Deposition of fat in areas around eyes and eyelids Hepatomegaly[symptoma.com]

  • Isoniazid Hepatitis

    Budd–Chiari syndrome may sometimes mimic DILI, and thus it should be considered, especially if tender hepatomegaly and/or ascites are evident.[gi.org]

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