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191 Possible Causes for Hepatomegaly, Liver Enzymes Abnormal, Steatorrhea

  • Hemochromatosis

    […] transferrin saturation (TS); ALT; AST; GGT; elevated C-reactive protein; ß-thalassemia; neutrophils; lymphocytes; monocytes; platelets; metacarpophalangeal joint hypertrophy; hepatomegaly[ncbi.nlm.nih.gov] The disease is usually diagnosed as a result of family screening or after a blood test indicates a high level of iron or abnormal liver enzymes.[hopkinsmedicine.org] Eight of the 16 homozygous subjects had clinical findings that were consistent with the presence of hereditary hemochromatosis, such as hepatomegaly, skin pigmentation, and[ncbi.nlm.nih.gov]

  • 3Beta-Hydroxy-Delta5-C27-Steroid Oxidoreductase Deficiency

    Hepatomegaly and/or splenomegaly are also commonly observed and pruritus is a rare observation.[symptoma.com] […] jaundice, enlarged liver, abnormal liver enzyme tests), steatorrhea, or complications from decreased fat soluble vitamin absorption; and Cholic acid (Cholbam) is being used[aetna.com] Clinical features include hepatomegaly with or without splenomegaly, jaundice, fat and fat-soluble vitamin malabsorption, and mild steatorrhea.[malacards.org]

  • Amyloidosis

    Hepatic involvement is common, but the clinical manifestations are usually mild with hepatomegaly and an elevated alkaline phosphatase level.[ncbi.nlm.nih.gov] Generally, the amyloid-infiltrated liver feels very hard, and elevated liver enzymes (particularly alkaline phosphatase) and other liver function abnormalities may be detected[rarediseases.org] Microscopic examination of a stool specimen stained with Sudan III showed steatorrhea with no evidence of parasites.[scielo.isciii.es]

  • Galactosemia

    Galactosemia in newborns and infants is associated with the following symptoms: jaundice, hepatomegaly, failure to thrive, feeding difficulties, hypoglycemia, convulsions,[ncbi.nlm.nih.gov] If not treated promptly, infants with type I galactosemia will quickly develop life-threatening conditions such as failure to thrive, liver damage, and abnormal bleeding.[consultant360.com] To the best of our knowledge, there is no case of galactosemia reported in literature which presented with recurrent neonatal sepsis without hepatomegaly, hyperbilirubinemia[ncbi.nlm.nih.gov]

  • Wolman Disease

    Hepatomegaly and/or elevation of liver transaminases are almost always present. Hepatic steatosis often leads to fibrosis and cirrhosis.[ncbi.nlm.nih.gov] The first sign in adults may be elevated liver enzymes seen on a blood test.[liverfoundation.org] Affected infants show signs of lipid storage in most tissues, including hepatosplenomegaly, abdominal distension, vomiting, steatorrhea, failure to thrive, and adrenal calcifications[ncbi.nlm.nih.gov]

  • Biliary Cirrhosis

    With a reference to the signs of PBC, the most prominent include hepatomegaly, hyperpigmentation, splenomegaly, xanthelasma and signs related to cirrhosis and end-stage liver[symptoma.com] PBC is characterized by abnormal high blood levels of the liver enzyme alkaline phosphatase (ALP).[ffpharma.com] Patients usually are asymptomatic at presentation but may experience fatigue or have symptoms of cholestasis (eg, pruritus, steatorrhea) or cirrhosis (eg, portal hypertension[msdmanuals.com]

  • Primary Biliary Cirrhosis

    The multifactorial analysis identified bilirubinemia and hepatomegaly as independent predictive variables.[nejm.org] After starting ursodeoxycholic acid treatment, cholestatic liver enzyme abnormalities improved.[ncbi.nlm.nih.gov] In June 2008, she was admitted with intrahepatic cholestasis, steatorrhea, and spontaneous fractures of various ribs.[ncbi.nlm.nih.gov]

  • Cholestasis

    For diagnosis of BA, clinical evaluation, hepatomegaly, stool color, serum gamma-glutamyltranspeptidase (GGT), duodenal juice color, bile acid in duodenal juice, ultrasonography[ncbi.nlm.nih.gov] Abstract Despite extensive investigations, some patients have no identifiable cause for their cholestatic liver enzyme abnormalities.[ncbi.nlm.nih.gov] Consequently, cholestatic conditions can cause lipid malabsorption, leading to steatorrhea .[pathwaymedicine.org]

  • Shwachman Syndrome

    Other findings included hepatomegaly and/or abnormal liver function test results and skeletal abnormalities.[ncbi.nlm.nih.gov] Some affected children may also have an abnormally large liver (hepatomegaly) and/or increased levels of certain liver enzymes in the blood (serum liver enzymes).[rarediseases.org] Pancreatic lipase secretion was assessed in 3 patients with steatorrhea and 5 without steatorrhea (73% of the surviving patients) using a sensitive assay which used maximum[ncbi.nlm.nih.gov]

  • Secondary Biliary Cirrhosis

    Characterized by progressive weight loss and fatigue, steatorrhea, splenomegaly and hepatomegaly.[medicalformat.com] Acute cellular rejection is often heralded by the onset of abnormalities in cholestatic liver enzyme levels.[clevelandclinicmeded.com] Patients will display the general clinical features of cholestasis such as pruritis, xanthomas, jaundice, steatorrhea, and deficiencies of the fat soluble vitamins A, D, E[pathwaymedicine.org]

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