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649 Possible Causes for Hepatomegaly, Microcytic Anemia

  • Alpha Thalassemia

    Concurrent alpha thalassemia might be a protective trait against significant hepatomegaly in sickle cell anaemia patients more than 60 months of age at Mulago hospital.[ncbi.nlm.nih.gov] Two hundred six patients with hypochromic microcytic anemia were evaluated for alpha thalassemia.[ncbi.nlm.nih.gov] He also had moderate anemia, hepatomegaly and hypospadias.[ncbi.nlm.nih.gov]

  • Thalassemia

    The presence of hepatomegaly was a statistically significant predictor for poor physical QOL (OR   8.5, p   0.02).[ncbi.nlm.nih.gov] On the basis of limited descriptions in the literature, the disease is reported as a mild microcytic anemia with an uncomplicated course.[ncbi.nlm.nih.gov] They also have massive hepatomegaly due to heart failure and extramedullary hematopoiesis.[emedicine.medscape.com]

  • Castleman Disease

    Examination revealed pallor; generalized edema; axillary, cervical, and inguinal lymphadenopathy; hypertension; and hepatomegaly.[ncbi.nlm.nih.gov] Chronic, iron-refractory, microcytic anemia can be a diagnostic and therapeutic challenge.[ncbi.nlm.nih.gov] MCD were more symptomatic (50% vs 96.9%, P   0.001) and sicker than UCD, including more fever, hepatomegaly and/or splenomegaly and hypoalbuminemia.[ncbi.nlm.nih.gov]

  • Erythropoietic Protoporphyria

    Patients can also present with splenomegaly and hepatomegaly. Liver biopsy in such patients may reveal features of appreciable hepatocellular injury.[flipper.diff.org] anemia, thrombocytopenia, and mild hepatic dysfunction.[ncbi.nlm.nih.gov] This patient presented cutaneous photosensitivity similar to the heterozygous cases, but a higher protoporphyrin accumulation in erythrocytes, microcytic anemia, and early[ncbi.nlm.nih.gov]

  • Cooley's Anemia

    Hepatomegaly can result from a number of mechanisms; extramedullary erthyropoiesis, hepatitis due to chronic transfusion associated infections, and iron overload.[pathophys.org] Heterozygous gammabeta(0) mice suffer from microcytic anemia.[ncbi.nlm.nih.gov] The early papers by Cooley 2 described the condition as being characterized by a hypochromic microcytic anemia with many distorted erythrocytes which were usually resistant[jamanetwork.com]

  • Extramedullary Hematopoiesis

    Massive hepatomegaly is a common finding in hydrops fetalis (HF) arising from hemoglobinopathies.[ncbi.nlm.nih.gov] Her admission workup showed microcytic anemia.[ncbi.nlm.nih.gov] […] spherocytosis 5 Radiographic features When involving an organ, extramedullary haematopoiesis causes visceromegaly occurring most often in the spleen ( splenomegaly ) and liver ( hepatomegaly[radiopaedia.org]

  • Plummer-Vinson Syndrome

    People who are having distal metastasis may present with Lymphadenopathy, hepatomegaly, and a pleural effusion.[2].[explainmedicine.com] Blood tests demonstrate a hypochromic microcytic anemia that is consistent with an iron-deficiency anemia.[en.wikipedia.org] Investigations Complete blood cell (CBC) counts: decreased values of hemoglobin, hematocrit, mean corpuscular volume Peripheral blood smears: hypochromic microcytic anemia[slideshare.net]

  • Idiopathic Pulmonary Hemosiderosis

    Severe pallor, cough, hemoptysis, and hepatomegaly were the most common findings on physical examination.[ncbi.nlm.nih.gov] Several previous reports of hemoglobin were as low as 3.6 g/dl with hypochromic and microcytic anemia.[ncbi.nlm.nih.gov] Clubbing, hepatomegaly and splenomegaly was seen in 16 (62%), 15 (58%) and 10 (38%) children, respectively.[ncbi.nlm.nih.gov]

  • Paroxysmal Nocturnal Hemoglobinuria

    […] characterized by episodes of hemolytic anemia, hemoglobinuria (chiefly at night), pallor, icterus or bronzing of the skin, a moderate degree of splenomegaly, and sometimes hepatomegaly[medical-dictionary.thefreedictionary.com] Depending on their localization, thromboses (which affect 30-40 % of untreated patients) may manifest as abdominal pain, hepatomegaly, ascites and headaches.[orpha.net] […] thrombosis abdominal pain, fever, and rectal bleeding (mesenteric vein thrombosis) headache, vomiting, and seizures (cerebral venous sinous thrombosis) fever, jaundice, hepatomegaly[medbullets.com]

  • Lipodystrophy

    Severe dyslipideaemia, hepatomegaly and non-alcoholic steatoheaptitis are almost always noted.[dnatesting.uchicago.edu] anemia, panniculitis-associated (JMP) lipodystrophy syndrome spectrum PSMB8 mutations 9a.[accessmedicine.mhmedical.com] An enlarged liver (hepatomegaly) is also common. Hepatomegaly is caused by the accumulation of fat in the liver (fatty liver or steatosis).[rarediseases.org]

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