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61 Possible Causes for Hepatomegaly, Microcytic Anemia, Unconjugated Bilirubin Increased

  • Thalassemia

    The presence of hepatomegaly was a statistically significant predictor for poor physical QOL (OR   8.5, p   0.02).[ncbi.nlm.nih.gov] On the basis of limited descriptions in the literature, the disease is reported as a mild microcytic anemia with an uncomplicated course.[ncbi.nlm.nih.gov] They also have massive hepatomegaly due to heart failure and extramedullary hematopoiesis.[emedicine.medscape.com]

  • Congenital Dyserythropoietic Anemia

    Iron overload, as measured by liver iron and serum ferritin levels, was reduced substantially, liver function tests improved, and hepatomegaly decreased.[ncbi.nlm.nih.gov] GS is typified by increased production of both unconjugated and monoconjugated bilirubin, which is more lithogenic.[ncbi.nlm.nih.gov] , due to ALAS2 mutation (hypochromic microcytic anemia that develops within a few months of birth); and congenital dyserythropoietic anemia (CDA) type I , characterized by[oncologynurseadvisor.com]

  • Erythropoietic Porphyria

    […] nucleated red cells, absence of haptoglobin, increased unconjugated bilirubin, increased fecal urobilinogen, and increased plasma iron turnover.[bloodjournal.org] His splenic tip was palpable 3 cm below the left costal margin but he had no hepatomegaly.[nature.com] A hypochromic, microcytic anemia was present from birth, and platelet counts averaged 70 x 10(9)/L (70,000/microL). Erythrocyte UROS activity was 21% of controls.[ncbi.nlm.nih.gov]

  • Hereditary Elliptocytosis

    A large spleen (splenomegaly) and a large liver (hepatomegaly) are also common.[nethealthbook.com] Symptoms of anemia: fatigue, dizziness (MOST PATIENTS HAVE NO ANEMIA) Jaundice : increased unconjugated bilirubin in the blood (due to hemolysis) will result in physical findings[stepwards.com] Structural membrane proteins were studied from erythrocytes (RBC) of a patient with a nonhemolytic form of hereditary elliptocytosis (HE) who developed a microcytic anemia[ncbi.nlm.nih.gov]

  • Hereditary Spherocytosis

    Pallor (100%), icterus (67%), undocumented fever (28%), splenomegaly (96%) and hepatomegaly (73%) were the most frequent findings. Cholelithiasis was observed in 26%.[ncbi.nlm.nih.gov] Newborn babies can present with neonatal jaundice in first week of life. [2] Intermittent nature of jaundice [1] This is due to the haemolysis that increases the unconjugated[explainmedicine.com] anemia of varying degree. [3] Uraninite is a radioactive , uranium-rich mineral and ore with a chemical composition that is largely UO2 , but also contains UO3 and oxides[interhomeopathy.org]

  • Neonatal Isoimmune Neutropenia

    VPS45 AR Bone marrow fibrosis, nephromegaly, extramedullary hematopoiesis Glycogen storage disease type 1b G6PT1 AR Fasting hypoglycemia, lactic acidosis, hyperlipidemia, hepatomegaly[arupconsult.com] bilirubin § Increased retics § Haptoglobins unreliable in neonates § Film § DAT § May be negative in ABO HDN § Heinz body test § Drug induced haemolysis, G6PD § Haemoglobinuria[ihaematology.com] […] according to the size of red cells, Red Cells Indexes, Development of hemoglobin and erythrocyte volume values since birth into adulthood, POSTNATAL CHANGES OF HEMOGLOBIN, Microcytic[mefanet-motol.cuni.cz]

  • Hemolytic Anemia

    In extravascular hemolysis plasma levels of unconjugated bilirubin increase because the hepatocytes cannot process the excess bilirubin.[med-ed.virginia.edu] Following this, a physical examination may reveal hepatomegaly or tenderness in the abdominal region.[symptoma.com] Deficiencies in iron or lead poisoning can produce a microcytic anemia, while B12 and folate deficiencies produce a megaloblastic anemia and can be distinguished by peripheral[pedclerk.bsd.uchicago.edu]

  • Pernicious Anemia

    Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[rarediseases.org] Biochemistry There may be an increase in plasma unconjugated bilirubin due to increased destruction of red cell precursors in the marrow.[patient.info] Diagnostic dilemmas could occur when patients with PA present with spuriously normal or high cobalamin levels, normocytic or microcytic anemia, non-anemic macrocytosis, autoimmune[ncbi.nlm.nih.gov]

  • Autoimmune Hemolytic Anemia

    […] involvement (84% vs 31%, p   0.001), fever (65% vs 26%, p   0.001), weight loss   2 kg (39% vs 6%, p   0.001), reticuloendothelial manifestations (48% vs 8%, p   0.001), hepatomegaly[ncbi.nlm.nih.gov] Jaundice creates problems associated with increased unconjugated bilirubin.[patient.info] Deficiencies in iron or lead poisoning can produce a microcytic anemia, while B12 and folate deficiencies produce a megaloblastic anemia and can be distinguished by peripheral[pedclerk.bsd.uchicago.edu]

  • Cooley's Anemia

    Hepatomegaly can result from a number of mechanisms; extramedullary erthyropoiesis, hepatitis due to chronic transfusion associated infections, and iron overload.[pathophys.org] […] and a decreasing trend in the serum lactate dehydrogenase (LDH) and serum unconjugated bilirubin levels.[onlinelibrary.wiley.com] Heterozygous gammabeta(0) mice suffer from microcytic anemia.[ncbi.nlm.nih.gov]

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