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61 Possible Causes for Hepatomegaly, Microcytic Anemia, Unconjugated Bilirubin Increased

  • Thalassemia

    The presence of hepatomegaly was a statistically significant predictor for poor physical QOL (OR   8.5, p   0.02).[] On the basis of limited descriptions in the literature, the disease is reported as a mild microcytic anemia with an uncomplicated course.[] They also have massive hepatomegaly due to heart failure and extramedullary hematopoiesis.[]

  • Congenital Dyserythropoietic Anemia

    Iron overload, as measured by liver iron and serum ferritin levels, was reduced substantially, liver function tests improved, and hepatomegaly decreased.[] GS is typified by increased production of both unconjugated and monoconjugated bilirubin, which is more lithogenic.[] , due to ALAS2 mutation (hypochromic microcytic anemia that develops within a few months of birth); and congenital dyserythropoietic anemia (CDA) type I , characterized by[]

  • Erythropoietic Porphyria

    […] nucleated red cells, absence of haptoglobin, increased unconjugated bilirubin, increased fecal urobilinogen, and increased plasma iron turnover.[] His splenic tip was palpable 3 cm below the left costal margin but he had no hepatomegaly.[] A hypochromic, microcytic anemia was present from birth, and platelet counts averaged 70 x 10(9)/L (70,000/microL). Erythrocyte UROS activity was 21% of controls.[]

  • Hereditary Elliptocytosis

    A large spleen (splenomegaly) and a large liver (hepatomegaly) are also common.[] Symptoms of anemia: fatigue, dizziness (MOST PATIENTS HAVE NO ANEMIA) Jaundice : increased unconjugated bilirubin in the blood (due to hemolysis) will result in physical findings[] Structural membrane proteins were studied from erythrocytes (RBC) of a patient with a nonhemolytic form of hereditary elliptocytosis (HE) who developed a microcytic anemia[]

  • Hereditary Spherocytosis

    Pallor (100%), icterus (67%), undocumented fever (28%), splenomegaly (96%) and hepatomegaly (73%) were the most frequent findings. Cholelithiasis was observed in 26%.[] Newborn babies can present with neonatal jaundice in first week of life. [2] Intermittent nature of jaundice [1] This is due to the haemolysis that increases the unconjugated[] anemia of varying degree. [3] Uraninite is a radioactive , uranium-rich mineral and ore with a chemical composition that is largely UO2 , but also contains UO3 and oxides[]

  • Neonatal Isoimmune Neutropenia

    VPS45 AR Bone marrow fibrosis, nephromegaly, extramedullary hematopoiesis Glycogen storage disease type 1b G6PT1 AR Fasting hypoglycemia, lactic acidosis, hyperlipidemia, hepatomegaly[] bilirubin § Increased retics § Haptoglobins unreliable in neonates § Film § DAT § May be negative in ABO HDN § Heinz body test § Drug induced haemolysis, G6PD § Haemoglobinuria[] […] according to the size of red cells, Red Cells Indexes, Development of hemoglobin and erythrocyte volume values since birth into adulthood, POSTNATAL CHANGES OF HEMOGLOBIN, Microcytic[]

  • Hemolytic Anemia

    In extravascular hemolysis plasma levels of unconjugated bilirubin increase because the hepatocytes cannot process the excess bilirubin.[] Following this, a physical examination may reveal hepatomegaly or tenderness in the abdominal region.[] Deficiencies in iron or lead poisoning can produce a microcytic anemia, while B12 and folate deficiencies produce a megaloblastic anemia and can be distinguished by peripheral[]

  • Pernicious Anemia

    Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[] Biochemistry There may be an increase in plasma unconjugated bilirubin due to increased destruction of red cell precursors in the marrow.[] Diagnostic dilemmas could occur when patients with PA present with spuriously normal or high cobalamin levels, normocytic or microcytic anemia, non-anemic macrocytosis, autoimmune[]

  • Autoimmune Hemolytic Anemia

    […] involvement (84% vs 31%, p   0.001), fever (65% vs 26%, p   0.001), weight loss   2 kg (39% vs 6%, p   0.001), reticuloendothelial manifestations (48% vs 8%, p   0.001), hepatomegaly[] Jaundice creates problems associated with increased unconjugated bilirubin.[] Deficiencies in iron or lead poisoning can produce a microcytic anemia, while B12 and folate deficiencies produce a megaloblastic anemia and can be distinguished by peripheral[]

  • Cooley's Anemia

    Hepatomegaly can result from a number of mechanisms; extramedullary erthyropoiesis, hepatitis due to chronic transfusion associated infections, and iron overload.[] […] and a decreasing trend in the serum lactate dehydrogenase (LDH) and serum unconjugated bilirubin levels.[] Heterozygous gammabeta(0) mice suffer from microcytic anemia.[]

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