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7,776 Possible Causes for Hepatomegaly, Mutation in the CDK6 Gene, Personality Change

  • Chronic Alcoholism

    Hepatomegaly (in chronic alcoholic liver disease the liver is shrunken). Ascites; gonadal atrophy. Atrial fibrillation and cardiomyopathy.[patient.info] Liver disease, severe depression, high blood pressure, obvious change in personal appearance… you name it.[allaboutrecoveryinc.com] Characteristic ultrasonographic findings include a hyperechoic liver with or without hepatomegaly.[clevelandclinicmeded.com]

    Missing: Mutation in the CDK6 Gene
  • Pernicious Anemia

    Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[rarediseases.org] Older patients may present with symptoms suggesting senile dementia or Alzheimer disease; memory loss, irritability, and personality changes are commonplace.[web.archive.org] Hepatomegaly and splenomegaly may be present.[patient.info]

    Missing: Mutation in the CDK6 Gene
  • Mucopolysaccharidosis

    The patient was a 2-yr-old girl presenting with skeletal deformity, hepatomegaly, and delayed motor development.[ncbi.nlm.nih.gov] Medical care is directed at treating systemic conditions and improving the person's quality of life.[en.wikipedia.org] […] neurodevelopmental delays, macrocephaly with a prominent forehead, coarse facial features with clear corneas, chronic congestion with snoring, wide-spaced teeth, short thick neck, hepatomegaly[ncbi.nlm.nih.gov]

    Missing: Mutation in the CDK6 Gene
  • Malignant Neoplasm of Pancreas

    Late findings: abdominal mass or ascites (present in 20% of patients), hepatomegaly from liver metastases, splenomegaly from portal vein obstruction, and a palpable rectal[oncolink.org] Psychosocial Assess for the presence of irritability, depression, and personality changes.[medical-dictionary.thefreedictionary.com] : May be the first presentation Palpable gallbladder (ie, Courvoisier sign) Developing, advanced intra-abdominal disease: Presence of ascites, a palpable abdominal mass, hepatomegaly[emedicine.medscape.com]

    Missing: Mutation in the CDK6 Gene
  • Alcohol Dementia

    Hallucinations Delusions Impaired memory Personality changes – ranging from depressed and withdrawn to excited and irritable.[healthhype.com] Personality changes. Neglect. Hoarding.[cleanandsoberlive.com] Alcohol dementia refers to an impairment of cognitive ability and personality changes as a result of alcohol misuse or chronic alcohol abuse and is referred to as alcohol-related[healthhype.com]

    Missing: Mutation in the CDK6 Gene
  • Wilson Disease

    CONCLUSIONS: Wilson disease can present with only significantly increased transaminases activity and hepatomegaly or liver failure, but neurological symptoms are very rare[ncbi.nlm.nih.gov] change, grossly inappropriate behavior and inexplicable deterioration of school or other work, neurosis, and psychosis.[medicinenet.com] Twenty patients were symptomatic, 19 were referred because of abnormal liver function test results and/or hepatomegaly, and 18 received their diagnoses after family screening[ncbi.nlm.nih.gov]

    Missing: Mutation in the CDK6 Gene
  • Malignant Carcinoid Syndrome

    […] wheezing, palpitations, hypotension, dizziness Physical Pay attention to: heart murmur, asthma-like symptoms, pellagra, electrolyte deficieny/dehydration from diarrhea, hepatomegaly[openanesthesia.org] Upon presentation, his evaluation revealed noteworthy changes in his personality since his cancer diagnosis.[healio.com] She was found to have non-tender hepatomegaly.[jmedicalcasereports.biomedcentral.com]

    Missing: Mutation in the CDK6 Gene
  • Mucopolysaccharidosis 3

    […] disorders and loss of speech accompanied by behavioral abnormalities, neuropsychiatric problems, mental retardation, hearing loss, and visceral manifestations, such as mild hepatomegaly[phoenixnestbiotech.com] Individuals with MPS III typically have mildly "coarse" facial features , a large head ( macrocephaly ), a slightly enlarged liver (mild hepatomegaly), and a soft out-pouching[ghr.nlm.nih.gov] Somatic manifestations such as hepatomegaly, dysostosis multiplex, coarse facies and hypertrichosis are relatively mild compared to the other mucopolysaccharidoses.[invitae.com]

    Missing: Mutation in the CDK6 Gene
  • Pancreatic Neoplasm

    Physical examination may reveal jaundice, temporal wasting, peripheral lymphadenopathy, hepatomegaly, and ascites.[ncbi.nlm.nih.gov] Psychosocial Assess for the presence of irritability, depression, and personality changes.[medical-dictionary.thefreedictionary.com] Thus when mutations in the CDKN2A gene disrupt the function of p16(INK4), there is improper progression from the G1 to the S phase, allowing continued, uncontrolled cell proliferation[ncbi.nlm.nih.gov]

  • African Trypanosomiasis

    […] transmission is likely a powerful evolutionary force driving extravasation, suggesting that the generalised tissue penetration underlying pathogenesis (i.e. splenomegaly, hepatomegaly[elifesciences.org] A 33 year old male African patient, a former resident of Cameroon, presented with a 4-month history of progressive personality changes.[ncbi.nlm.nih.gov] The illness progresses after a few weeks to weight loss, as well as personality changes, slurred speech, seizures, difficulty balancing and walking resulting from central[iamat.org]

    Missing: Mutation in the CDK6 Gene

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