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337 Possible Causes for Hepatomegaly, Neonatal Feeding Difficulties

  • Diabetes Mellitus

    Observational studies demonstrate that preterm delivery is associated with increased risks of neonatal morbidity, separation of mother and baby and difficulties in achieving[ncbi.nlm.nih.gov] Abstract Glycogenic hepatopathy is a rare condition that causes significant hepatomegaly and elevated liver enzyme levels in uncontrolled type 1 diabetic patients.[ncbi.nlm.nih.gov] Children with diabetic dwarfism syndrome, which was also known as Mauriac's syndrome, suffered from stunted growth, hepatomegaly, and delayed puberty. 4 In 1936, the first[dx.doi.org]

  • Cardiomyopathy

    1st step in mitochondrial β-oxidation of fatty acids Onset: Early childhood Episodes: Associated with fasting Hypoglycemia, Hypoketotic Cardiac arrest Clinical findings Hepatomegaly[neuromuscular.wustl.edu] […] period. 40 Infants with D CM often present with symptoms of HF 13,39–42 such as tachypnea, dyspnea, tachycardia, feeding difficulty and failure to thrive. 38–41 These symptoms[revportcardiol.org] Additional symptoms may include fluid collection in the abdomen (ascites) and feet due to accumulation of fluid, congestion of the lungs, and an abnormally large liver (hepatomegaly[rarediseases.org]

  • Glycogen Storage Disease Type 3

    Hepatomegaly and growth retardation are other common features.[symptoma.com] […] symptoms, probably because of feeding difficulties. 6, 8, 10– 12 There has been only one reported case of Costello syndrome who showed impaired glucose tolerance. 5 The patient[jmg.bmj.com] GSD III is characterized by fasting hypoglycemia, hepatomegaly, growth retardation, progressive myopathy, and cardiomyopathy due to storage of abnormally structured glycogen[ncbi.nlm.nih.gov]

  • TORCH Syndrome

    On the contrary, findings resembling congenital infectious diseases including neonatal icterus, hyperbilirubinemia, thrombocytopenia, and hepatomegaly, affect less than half[ncbi.nlm.nih.gov] They include hepatosplenomegaly (enlargement of the liver and spleen), fever, lethargy, difficulty feeding, anemia, petechiae, purpurae, jaundice, and chorioretinitis.[en.wikipedia.org] Cytomegalic inclusion disease can include hepatomegaly, splenomegaly, paraventricular calcification, and intrauterine growth retardation.[ncbi.nlm.nih.gov]

  • Medium Chain Acyl CoA Dehydrogenase Deficiency

    When, inadvertently he was given medium-chain triglycerides for 2 days, the excretion of abnormal metabolites of medium-chain fatty acids increased and hepatomegaly became[ncbi.nlm.nih.gov] As breastfeeding rates increase, close management of feeding difficulties is essential for all neonates awaiting NBS results.Genet Med 18 12, 1315-1319.[ncbi.nlm.nih.gov] When an infant presents with hypoglycemia, acidosis, hepatomegaly, and respiratory arrest, the neonatal team must be alert to the possibility of a metabolic disorder.[ncbi.nlm.nih.gov]

  • Hyperammonemia Type 3

    A congenital form occurs in two types: Type 1, due to deficiency of the enzyme ornithine carbamoyltransferase, is marked by vomiting, lethargy, coma, and hepatomegaly; symptoms[medical-dictionary.thefreedictionary.com] Parents of neonates born with NAGS gene defects often claim feeding difficulties; retrospectively, poor feeding can generally be traced back to the first day of the child's[symptoma.com] IVb: neurologic deterioration, energy-deficiency type, without ketoacidosis and without hyperammonemia Type V: predominant liver presentation Type Va: hypoglycemia with hepatomegaly[ommbid.mhmedical.com]

  • Methylmalonic Acidemia

    Two days after her discharge, after having a meal rich in protein, she was brought unconscious with hepatomegaly, severe acidosis, ketonuria, and mild hyperammonemia.[ncbi.nlm.nih.gov] Born after a normal pregnancy, the patient developed general hypotonia and severe feeding difficulties at 5 days of life.[analesdepediatria.elsevier.es] Affected infants can experience vomiting, dehydration, weak muscle tone (hypotonia), developmental delay, excessive tiredness (lethargy), an enlarged liver (hepatomegaly),[ghr.nlm.nih.gov]

  • Zellweger Syndrome

    […] and 9% of control fibroblast dihydroxyacetone phosphate acyltransferase activity, and one with mild facial manifestations, wide sutures, hypotonia, developmental delay, hepatomegaly[ncbi.nlm.nih.gov] ZS patients are characterized by profound hypotonia and neonatal seizures, which – accompanied by feeding difficulties and psychomotor retardation – lead to an early death[dx.doi.org] Liver disease was evident from hepatomegaly and elevated serum liver enzymes and bilirubin.[ncbi.nlm.nih.gov]

  • Galactosemia

    Galactosemia in newborns and infants is associated with the following symptoms: jaundice, hepatomegaly, failure to thrive, feeding difficulties, hypoglycemia, convulsions,[ncbi.nlm.nih.gov] If galactose is not removed from the diet, infants will develop lethargy and jaundice, feeding difficulties and will fail to gain weight. Sepsis and death may occur.[sema4genomics.com] To the best of our knowledge, there is no case of galactosemia reported in literature which presented with recurrent neonatal sepsis without hepatomegaly, hyperbilirubinemia[ncbi.nlm.nih.gov]

  • Beckwith-Wiedemann Syndrome

    […] creases / pits Case of BWS with an enlarged tongue and omphalocele Gross images Images hosted on other servers: Large lobulated adrenal glands Placental mesenchymal dysplasia Hepatomegaly[pathologyoutlines.com] Abnormal growth may also manifest as hemihyperplasia and/or macroglossia (leading to difficulties in feeding, speech and infrequently, sleep apnea).[orpha.net] […] part, is bigger than the other) Apart from these, the infant may have large eyes, undescended testicles (cryptorchidism), small head size (microcephaly), enlarged liver (hepatomegaly[dovemed.com]

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