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47 Possible Causes for Hepatomegaly, Polychromasia in Peripheral Blood Smear

  • Paroxysmal Cold Hemoglobinuria

    Signs Splenomegaly Hepatomegaly Transient Jaundice Pale fingers, toes, and tip of nose VI.[fpnotebook.com] Tests include complete blood count (CBC) and peripheral smear.[emedicine.com] Typically there was a sudden onset of pallor and malaise; jaundice, splenomegaly and hepatomegaly were found in about half the subjects.[doi.org]

  • Congenital Dyserythropoietic Anemia Type 1

    Case report: The female fetus of a gravida 2 para 1 woman was noted to have hepatomegaly, cardiomegaly, and elevated middle cerebral artery velocity concerning for severe[bloodjournal.org] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[unboundmedicine.com] Many people affected with jaundice and hepatomegaly. This alteration also causes the body to absorb too much iron, which accumulates and can damage tissues and organs.[ivami.com]

  • Autoimmune Hemolytic Anemia

    […] hepatitis B virus, drug usage or cholestatic syndrome and in around 40% of cases its etiology will be defined as autoimmune. 22 One patient from the present sample developed hepatomegaly[scielo.br] Peripheral blood smear showed polychromasia and spherocytosis. Haptoglobin level was 0.06 g/L ( N 0.16-2). Both hemoglobin electrophoresis and G6PD level were normal.[jahjournal.org] H1N1 influenza–associated AIHA in children may respond to treatment with oseltamivir and intravenous immunoglobulin. [6] Fetal splenomegaly and associated hepatomegaly could[emedicine.medscape.com]

  • African Histoplasmosis

    He had generalized lymphadenopathy and non-tender hepatomegaly. Examination of the respiratory system revealed bilateral coarse crackles.[ijstd.org] Peripheral smear showed microcytic hypochromic red blood cells, anisopoikilocytosis, polychromasia and reduced leucocyte count and toxic granules with no evidence of hemolysis[ijstd.org]

  • Myelofibrosis

    […] manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly[orpha.net] The peripheral smear of patients with primary myelofibrosis includes red blood cells of variable shape (including tear drop cells) and size and variable degrees of polychromasia[mpncanada.com] Repeated and preemptive palliative radiotherapy of symptomatic hepatomegaly in a patient with advanced myelofibrosis. Onkologie. 2008;31:325–327.[doi.org]

  • Congenital Dyserythropoietic Anemia

    Iron overload, as measured by liver iron and serum ferritin levels, was reduced substantially, liver function tests improved, and hepatomegaly decreased.[ncbi.nlm.nih.gov] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[ncbi.nlm.nih.gov] CDA I patients have a moderate macrocytic anemia with frequent splenomegaly and occasional hepatomegaly.[orpha.net]

  • Pancytopenia

    The most frequent admission symptoms and findings of the patients with pancytopenia were fever (75%), fatigue (50%), splenomegaly (75%), and hepatomegaly (41%).[ncbi.nlm.nih.gov] blood smear examination for which Leishman stain was used.[mjdrdypu.org] Immediate clinical assessment includes assessment for fever, circulatory compromise, evidence of bleeding, lymphadenopathy, splenomegaly and hepatomegaly.[onlinelibrary.wiley.com]

  • Myeloma-associated Amyloidosis

    Liver biopsy could have rendered the possible cause of hepatomegaly, but patient’s noncompliance hindered the answer whether liver involvement was the consequence of a chronic[eurekaselect.com] A peripheral blood smear showed normocytic normochromic anemia with anisopoikilocytosis and mild polychromasia, as well as mild neutrophilia with slight toxic granulation.[ekjm.org] Unlike others, our patient had no hepatomegaly on examination or on imaging studies.[thefreelibrary.com]

  • Secondary Myelofibrosis

    There was no hepatomegaly.[ijcasereportsandimages.com] The peripheral smear of patients with primary myelofibrosis includes red blood cells of variable shape (including tear drop cells) and size and variable degrees of polychromasia[mpncanada.com] Prognosis is related to factors such as fever, bleeding tendency, ineffective erythropoiesis, hemolysis, hepatomegaly, plasma iron conversion rate and bone marrow cell hyperplasia[healthfrom.com]

  • Zieve's Syndrome

    Symptoms Most common symptoms due to long-term history of chronic alcoholism include: Nausea Vomiting after heavy drinking Anorexia Abdominal pain Hepatomegaly, enlarged spleen[athena.targetwoman.com] The peripheral blood smear revealed polychromasia and nucleated erythrocytes. The parents’ blood counts and smears were normal.[indianpediatrics.net] The patient's peripheral smear showed polychromasia, macrocytosis, tear drop cells, ovalocytes, spur cells, and schistocytes ( Figure 1 ).[ncbi.nlm.nih.gov]

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