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466 Possible Causes for Hepatomegaly, Progressive Polyneuropathy

  • Chronic Alcoholism

    Hepatomegaly (in chronic alcoholic liver disease the liver is shrunken). Ascites; gonadal atrophy. Atrial fibrillation and cardiomyopathy.[patient.info] Characteristic ultrasonographic findings include a hyperechoic liver with or without hepatomegaly.[clevelandclinicmeded.com] Most patients with moderate disease are undernourished and present with fatigue, fever, jaundice, right upper quadrant pain, tender hepatomegaly, and sometimes a hepatic bruit[merckmanuals.com]

  • Diabetes Mellitus

    Abstract Glycogenic hepatopathy is a rare condition that causes significant hepatomegaly and elevated liver enzyme levels in uncontrolled type 1 diabetic patients.[ncbi.nlm.nih.gov] Children with diabetic dwarfism syndrome, which was also known as Mauriac's syndrome, suffered from stunted growth, hepatomegaly, and delayed puberty. 4 In 1936, the first[dx.doi.org]

  • Occult Malignancy

    Chest examination revealed scattered crackles over bases and a firm hepatomegaly 4 cm below coastal margin. Investigations revealed normal CBC.[consultant360.com]

  • Amyloidosis

    Hepatic involvement is common, but the clinical manifestations are usually mild with hepatomegaly and an elevated alkaline phosphatase level.[ncbi.nlm.nih.gov] Tafamidis is a TTR stabilizer that is orally administered and, by interfering with amyloid fibril formation and deposition, is capable of slowing progression of TTR polyneuropathy[ncbi.nlm.nih.gov] […] that presents to a cancer care provider with nephrotic range proteinuria, heart failure with preserved ejection fraction, non-diabetic peripheral neuropathy, unexplained hepatomegaly[ncbi.nlm.nih.gov]

  • Pernicious Anemia

    Some people with Pernicious Anemia may have an abnormally enlarged liver (hepatomegaly) or spleen (splenomegaly).[rarediseases.org] Hepatomegaly and splenomegaly may be present.[patient.info]

  • Systemic Amyloidosis

    Examination and tests in this patient also revealed anemia, hepatomegaly, infiltrative cardiomyopathy, polyneuropathy and immunoglobulin l deposition, favoring a diagnosis[ncbi.nlm.nih.gov] Hou X, Aguilar MI, Small DH (2007) Transthyretin and familial amyloidotic polyneuropathy. Recent progress in understanding the molecular mechanism of neurodegeneration.[doi.org] Key words: AL Amyloidosis, Proteinuria, Hepatomegaly Advertisement Journal of Contemporary Medical Education SUBMIT YOUR ARTICLE NOW[scopemed.org]

  • Waldenstrom Macroglobulinemia

    The clinical manifestations of the disorder are hepatomegaly (20%), splenomegaly (15%), and lymphadenopathy (15%) [ 7 ].[pancreas.imedpub.com] Neuropathy is typically slowly progressive, distal, symmetrical, and sensorimotor.[emedicine.medscape.com] (effective October 01, 2015) Signs and Symptoms Adenopathy Confusion Dizziness Easy bruising or bleeding (nosebleeds or bleeding from gums) Feeling very tired Headaches Hepatomegaly[seer.cancer.gov]

  • Secondary Amyloidosis

    Hepatomegaly, splenomegaly, and autonomic neuropathy frequently occur as the disease progresses; cardiomyopathy occurs rarely.[bu.edu] Oedema accompanied by proteinuria was present in 88% of the cases, hepatomegaly in 17%, and splenomegaly in 11%.[ncbi.nlm.nih.gov] Rarely, a more specific symptom, such as abdominal fullness or right upper quadrant discomfort (reflecting hepatomegaly), might bring the patient to the physician.[emedicine.medscape.com]

  • Polyarteritis Nodosa

    The full text of this article hosted at iucr.org is unavailable due to technical difficulties. Hôpital Cochin, Paris 5‐René Descartes University, Assistance Publique Hôpitaux de Paris, France INSERM, UMR‐S 872, Les Cordeliers, Eq. 7 Nutriomique, Paris, France Search for more papers by this author Loïc Guillevin[…][doi.org]

  • Chediak Higashi Syndrome

    […] phagocytes (neutrophils), which thus have poor bactericidal function, leading to susceptibility to infections, abnormalities in nuclear structure of leukocytes, anemia, and hepatomegaly[en.wikipedia.org] peripheral neuropathy and the tendency to develop a life threatening lymphoma like syndrome. 1 Susceptibility to infection from phagocytic dysfunction ranges from mild recurrent[pjms.com.pk] Mild hepatomegaly was noted; however, no lymph nodes were palpable. Complete blood count was within normal limits.[e-ijd.org]

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