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81 Possible Causes for Hepatomegaly, Virus Associated Hemophagocytic Syndrome

  • Sickle Cell Disease

    Additional autopsy findings included cardiomegaly with a heart weight of 450 gm (312 78), right atrial and right ventricular chamber dilatation, and hepatomegaly with a liver[] Hepatomegaly was seen in 28.6% of the subjects.[] […] sex, the genotypes of both patient and donor, the number of transfusions received, the incidence of red-cell alloimmunization, previous chelation therapy, the presence of hepatomegaly[]

  • Malignant Histiocytosis

    Most patients presented with systemic symptoms and lymphadenopathy (92%), splenomegaly (100%) and hepatomegaly (67%).[] The differential diagnosis among hemophagocytic syndromes and particularly between the virus-associated hemophagocytic syndrome (VAHS) and the malignant histiocytosis (HM)[] Lymphadenopathy, splenomegaly, hepatomegaly, skin conditions such as rashes and multiple tumors, as well as gastrointestinal and other problems, are also encountered.[]

  • Infectious Mononucleosis

    The patient showed severe hepatomegaly incidentally, and dual positivity of Immunoglobulin (Ig) M to Epstein-Barr virus (EBV) viral capsid antigen (VCA) and cytomegalovirus[] Severe chronic active Epstein-Barr virus infection accompanied by virus-associated hemophagocytic syndrome, cerebellar ataxia and encephalitis.[] Abstract A 38-year-old male was admitted with fever, progressive jaundice, cervical lymphadenopathy, hepatomegaly and acute oliguric renal failure.[]

  • Familial Hemophagocytic Lymphohistiocytosis

    Diagnosis is challenging because it mimics severe sepsis by demonstrating hepatomegaly, splenomegaly, persistent fever, central nervous system involvement, and cytopenias.[] It is concluded that a viral infection cannot serve as the sole criterion for distinguishing a virus-associated hemophagocytic syndrome as an entity separate from familial[] The typical clinical characteristics of FHL are a prolonged fever that is accompanied by hepatomegaly, elevated liver enzymes, cytopenias, and less commonly, a rash and lymphadenopathy[]

  • Chronic Active Hepatitis B

    Clinical signs include liver tenderness, hepatomegaly, and splenomegaly. Acute HBV infection typically lasts two to four months.[] Bone marrow biopsy showed hypocellularity, histiocytic hyperplasia, and hemophagocytosis consistent with a virus-associated hemophagocytic syndrome (VAHS).[] […] may cause nonspecific symptoms, such as fatigue, poor appetite, nausea, vomiting, abdominal pain, low-grade fever, jaundice, and dark urine; and clinical signs, such as hepatomegaly[]

  • Chediak Higashi Syndrome

    […] phagocytes (neutrophils), which thus have poor bactericidal function, leading to susceptibility to infections, abnormalities in nuclear structure of leukocytes, anemia, and hepatomegaly[] In our case, a four-month-old boy, virus-associated hemophagocytic syndrome (VAHS) was suspected from generation of fever, hepatosplenomegaly, and existence of atypical lymphocytes[] Mild hepatomegaly was noted; however, no lymph nodes were palpable. Complete blood count was within normal limits.[]

  • Lymphoma

    Hepatomegaly. Intermediate- and high-grade lymphomas: Most patients present with rapidly growing and bulky lymphadenopathy.[] Hodgkin lymphoma-associated hemophagocytic syndrome: a disorder strongly correlated with Epstein-Barr virus. Clin Infect Dis. 2008 Aug 15. 47(4):531-4. [Medline].[] Intermediate- and high-grade lymphomas may produce the following physical examination findings: Rapidly growing and bulky lymphadenopathy Splenomegaly Hepatomegaly Large abdominal[]

  • Autoimmune Hepatitis

    CT Nonspecific, ranging from normal to hepatomegaly and cirrhosis.[] Virus-, drug- and lymphoma-associated hemophagocytic syndrome (HPS) was ruled out. Therefore, the patient was diagnosed with autoimmune-associated HPS (AAHS).[] Abdominal pain 38% Paleness 26% Other symptoms and signs may include: General discomfort or uneasiness Abdominal distension Pruritis Diarrhea Edema Weight loss Spider angiomata Hepatomegaly[]

  • Hepatosplenic Lymphoma

    It occurs mainly in young adults presenting with splenomegaly and most often with hepatomegaly but without lymphadenopathy.[] In 1 patient, a low level of fibrinogen associated with increased triglyceridemia and ferritinemia suggested hemophagocytic syndrome, which was confirmed by bone marrow examination[] CM Codes (U.S. only) C86.1 Hepatosplenic T-cell lymphoma (effective October 01, 2015) Signs and Symptoms Anemia Drenching night sweats Fatigue Fever (for no known reason) Hepatomegaly[]

  • Hepatosplenomegaly

    Hepatomegaly in the absence of signs of CLD is unlikely to be due to cirrhosis. Consider a malignancy instead.[] T-cell lymphoma and the virus-associated hemophagocytic syndrome. Am J Clin Pathol. 1991; 97 :189–194. [ PubMed ] 16.[] Craig F, Clare N, Sklar J, Banks P (1991) T-cell lymphoma and the virus-associated hemophagocytic syndrome. Am J Clin Pathol 97: 189–194. View Article Google Scholar 16.[]

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