Hepatosplenomegaly Causes & Reasons

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Hepatosplenomegaly Symptom Checker: Possible causes include Infectious Mononucleosis. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Infectious Mononucleosis

Both cases involved young adults presenting with fever, pharyngitis, lymphadenopathy, hepatosplenomegaly, and atypical lymphocytosis confirmed by serologic tests, liver biopsy [ncbi.nlm.nih.gov]

She presented with fever, skin rash, lymphadenopathy, and hepatosplenomegaly. [ncbi.nlm.nih.gov]

Third, the frequency of CD4CXCR5ICOSPD1 Tfh subset was significantly higher in lymphadenectasis or hepatosplenomegaly patients, and associated with the level of alanine aminotransferase [ncbi.nlm.nih.gov]

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Chronic Alcoholism

The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia. Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and imaging studies show[…] [ncbi.nlm.nih.gov]

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Cardiomyopathy

The acute presentation is characterized by dyspnea, fever, myalgia, hepatosplenomegaly, and myocarditis. Chronic infection involves the esophagus, colon, and heart. [emedicine.medscape.com]

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Hemochromatosis

Skin hyperpigmentation (like suntan) on both exposed and nonexposed areas; slate gray in late stages (75% of patients with hereditary hemochromatosis) Other manifestations Hepatosplenomegaly [faculty.washington.edu]

[…] of the white population, most are unaffected heterozygotes; 5/1000 of US whites are homozygotes Clinical Fatigue, cold intolerance, edema, cardiac arrhythmias, dyspnea, hepatosplenomegaly [medical-dictionary.thefreedictionary.com]

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Mucopolysaccharidosis

In a resource poor setting, we report a case of Hunter syndrome, severe subtype, based on global development delay, coarse facies, short stature, hepatosplenomegaly and dysostosis [ncbi.nlm.nih.gov]

Mucopolysaccharidosis VI, also called as Maroteaux-Lamy syndrome, in its severe form presents with bony lesions, corneal clouding, hepatosplenomegaly, cardiovascular abnormalities [ncbi.nlm.nih.gov]

RESULTS: Hepatosplenomegaly decreased significantly in all patients, and the size of the liver was normal for body weight and age in eight patients by 26 weeks. [ncbi.nlm.nih.gov]

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Leukemia

[…] fever, night sweats (unintentional) loss of weight fatigue syndrome (extreme weakness) swollen or bleeding gums nosebleed ( Epistaxis ) Enlargment of liver and spleen ( Hepatosplenomegaly [flexikon.doccheck.com]

[…] lymphocytic leukemia is a rare form of leukemia, caused by clonal proliferation of cytotoxic T-cells, characterized by modest lymphocytosis and cytopenias of other lineage with hepatosplenomegaly [ncbi.nlm.nih.gov]

An additional eight features were present in a third to a half of children: recurrent infections (49%), fatigue (46%), limb pain (43%), hepatosplenomegaly (42%), bruising/ [ncbi.nlm.nih.gov]

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Congenital Hepatic Fibrosis

Congenital hepatic fibrosis (CHF) is probably the most common cause of non-icteric hepatosplenomegaly and is encountered mainly in children and young adults. [ncbi.nlm.nih.gov]

We report two unrelated children with Joubert syndrome and hepatosplenomegaly. On histopathological examination, both had congenital hepatic fibrosis. [ncbi.nlm.nih.gov]

This diagnosis should be suspected when these biliary and renal abnormalities are associated with hepatosplenomegaly in a patient with normal liver function. [ncbi.nlm.nih.gov]

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Syphilis

Among 139 infants with symptomatic congenital syphilis in 3 series, the most common early signs were hepatosplenomegaly (71%), rash (68%), fever (42%), neurosyphylis (23%) [doi.org]

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Primary Immune Deficiency Disorder

Case #2 A 3-month-old Qatari female was admitted due to generalized rash, lymphadenopathy, and hepatosplenomegaly diagnosed by her pediatrician. [hindawi.com]

[…] not absent T-cell function and normal or elevated immunoglobulins Autosomal recessive or X-linked NEMO Common and opportunistic infections, lymphopenia, lymphadenopathy, hepatosplenomegaly [merckmanuals.com]

Radiologic findings are often nonspecific and include hilar and mediastinal adenopathy, hepatosplenomegaly, brain atrophy, diffuse decreased periventricular density on CT, [ajronline.org]

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Angioimmunoblastic Lymphadenopathy

AILD is characterized by generalized lymphadenopathy, hepatosplenomegaly, immunological abnormalities, polyclonal hypergammaglobulinemia and anemia. [ncbi.nlm.nih.gov]

Angioimmunoblastic lymphadenopathy with disproteinemia (AILD) is a systemic lymphoproliferative disorder characterized by constitutional symptoms such as generalized lymphadenopathy, hepatosplenomegaly [ncbi.nlm.nih.gov]

Angioimmunoblastic lymphadenopathy (AILD) is a rare disorder characterised by generalised lymphadenopathy, fever, hepatosplenomegaly, immune hemolytic anemia and polyclonal [ncbi.nlm.nih.gov]

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Juvenile Seronegative Polyarthritis

Migratory salmon colored light pink rash involving the trunk and/or extremities and hepatosplenomegaly are also frequently observed in patients with systemic onset. [radiopaedia.org]

uveitis, rashes, nail changes, lymphadenopathy, hepatosplenomegaly ), laboratory findings, and disease prognosis. [amboss.com]

[…] day best prognosis for long term remission (70%) Systemic (20%) systemic symptoms (rash, fever, multiple joint involvement) anemia, high WBC, elevated ESR, CRP, platelets hepatosplenomegaly [orthobullets.com]

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Gaucher Disease

We report here the case of a young woman with hepatosplenomegaly, leukopenia, and thrombocytopenia. [ncbi.nlm.nih.gov]

[ncbi.nlm.nih.gov] Less common signs of the disease are hepatosplenomegaly, ichthyosis, arthrogryposis and facial dysmorphy. [symptoma.com]

Laboratory studies that show anemia and other hematological abnormalities, together with marked hepatosplenomegaly will usually indicate a bone marrow biopsy, which will show [symptoma.com]

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Viral Hepatitis

Hepatosplenomegaly and laboratory evidence of mild to moderate hepatic dysfunction are the predominant features, with increased aminotransferases and alkaline phosphatase [doi.org]

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Nephroblastoma

Leukemia should be suspected if persistent vague symptoms are accompanied by evidence of abnormal bleeding, bone pain, lymphadenopathy or hepatosplenomegaly. [aafp.org]

Affected males typically have intellectual disability, macrosomia, cardiac, skeletal, gastrointestinal and genitourinary anomalies, hepatosplenomegaly, and distinctive facial [invitae.com]

The physical examination may reveal no abnormalities, but the presence of significant lymphadenopathy or any hepatosplenomegaly should raise suspicion for leukemia. [aafp.org]

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Chronic Lymphocytic Leukemia

III Lymphocytosis; lymphadenopathy; hepatosplenomegaly, anemia IV Lymphocytosis, lymphadenopathy; hepatosplenomegaly, thrombocytopenia anemia CHRONIC LYMPHOCYTIC LEUKEMIA [medical-dictionary.thefreedictionary.com]

Lymphadenopathy, hepatosplenomegaly and anemia may or may not be present. There is no known prevention of this disease. [symptoma.com]

Stage I : Stage I CLL is characterized by absolute lymphocytosis with lymphadenopathy without hepatosplenomegaly, anemia, or thrombocytopenia. [cancer.unm.edu]

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Adult-Onset Still Disease

Other common manifestations of AOSD are lymphadenopathy, hepatosplenomegaly, muscle aches, and pharyngitis. [symptoma.com]

Adult onset Still's disease (AOSD) is a systemic inflammatory disease characterized by high-fevers, articular involvement, maculopapular rash, hepatosplenomegaly, lymphadenopathy [ncbi.nlm.nih.gov]

[…] genetic factors, immune dysfunction and infections Clinical features Systemic inflammatory disease manifesting with spiking fever, sore throat, arthralgia, skin rash and hepatosplenomegaly [pathologyoutlines.com]

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Systemic Candidiasis

[…] broad-spectrum antimicrobials Right upper quadrant pain Abdominal pain and distension Jaundice (rare) Physical examination findings include right upper quadrant tenderness and hepatosplenomegaly [emedicine.medscape.com]

Symptoms include fever, hepatosplenomegaly and increased blood concentrations of alkaline phosphatases. [mycology.adelaide.edu.au]

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Cytomegalovirus Infection

We report a case of a term neonate with ventriculomegaly on prenatal ultrasound who presented with low birth weight, small head circumference, hepatosplenomegaly, and purpuric [ncbi.nlm.nih.gov]

[…] should arouse suspicion of intrauterine CMV infection can be distinguished into CNS signs such as ventriculomegaly or microcephaly and extracerebral infection signs such as hepatosplenomegaly [ncbi.nlm.nih.gov]

A newborn symptomatic is defined by the existence of clinical and / or biological signs and / or neonatal imaging, the most frequent clinical signs are: hepatosplenomegaly [ncbi.nlm.nih.gov]

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Multiple Myeloma

* 요약 : IgM, no osteolytic lesion * WM-related symptoms : anemia, constitutional symptoms, hyperviscosity, lymphadenopathy, or hepatosplenomegaly 끝. 2018. 10. 13 - SJH [sondoctor.co.kr]

The presenting problem was proteinuria in five patients, thyromegaly in three patients, and hepatosplenomegaly in one patient. [jamanetwork.com]

Lymphadenopathy and hepatosplenomegaly are unusual. [merckmanuals.com]

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Thalassemia

Hypertrichosis, erythrodontia and reddish-colored urine are often present, as well as hemolytic anemia accompanied by hepatosplenomegaly. [ncbi.nlm.nih.gov]

They have severe anemia and hepatosplenomegaly. Untreated children have severe failure to thrive and shortened life expectancy. [meddean.luc.edu]

Hb-Bart's hydrops fetalis syndrome (most severe variant of alpha thalassemia) Intrauterine ascites and hydrops fetalis;, severe hepatosplenomegaly, and often cardiac and skeletal [amboss.com]

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Juvenile-Onset Still Disease

Appearance of rash, hepatosplenomegaly, serositis and generalized lymphadenopathy. [symptoma.com]

This characteristic diagnostic triad may also be associated with an adenopathy and hepatosplenomegaly. [orpha.net]

[…] considered by many to be the most severe JIA subtype. sJIA typically presents with fever of unknown origin and arthritis, together with evanescent skin rash, serositis, hepatosplenomegaly [clinicaltrials.gov]

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Primary Myelofibrosis

The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever. [ncbi.nlm.nih.gov]

Hepatosplenomegaly may cause upper abdominal pain, portal hypertension and ascites. [symptoma.com]

Most of them had anemia, fever, and hepatosplenomegaly on admission. [ncbi.nlm.nih.gov]

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Niemann-Pick Disease Type C

Hepatosplenomegaly and progressive neurological symptoms are the main clinical features. [ncbi.nlm.nih.gov]

We report the case of an infant who presented with hepatosplenomegaly without neurological abnormalities. [ncbi.nlm.nih.gov]

A galactose-free and lactose-free diet resulted in achievement of a normal galactose level, but hepatosplenomegaly and cholestatic signs persisted. [ncbi.nlm.nih.gov]

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Mucopolysaccharidosis 2

Enzyme replacement therapy (ERT) using idursulfase (Elaprase ) was conducted to the patient and it improved hepatosplenomegaly, white blood cells and platelets number, and [ncbi.nlm.nih.gov]

Most children with MPS2 have a severe form with early somatic abnormalities including skeletal deformities, hepatosplenomegaly, and progressive cardiopulmonary deterioration [uniprot.org]

Initial manifestations include: frequent respiratory tract infections (in particular otitis media); umbilical and inguinal hernia; intractable diarrhea; hepatosplenomegaly [orpha.net]

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Castleman Disease

For multicentric disease: multi-region CT bilateral hilar and mediastinal lymphadenopathy centrilobular nodules diffuse abdominal lymphadenopathy hepatosplenomegaly ascites [radiopaedia.org]

[…] in the groin, neck, or armpit Unintentional loss of weight In some cases fever and weakness Easy fatigue Appetite loss or extremely poor appetite Lymph node enlargement Hepatosplenomegaly [epainassist.com]

[…] clinical presentation due to the systemic inflammation, with symptoms such as fevers, night sweats, fatigue, and weight loss, and clinical signs of generalized lymphadenopathy, hepatosplenomegaly [radiopaedia.org]

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Myeloproliferative Disease

Marked myeloid proliferation, anemia, thrombocytopenia and hepatosplenomegaly were present; leukocyte alkaline phosphatase and fetal hemoglobin were moderately elevated. [ncbi.nlm.nih.gov]

[…] yes; there is effective maturation leading to increased peripheral blood counts Hepatosplenomegaly is common due to extramedullary hematopoiesis What is the spent phase found [quizlet.com]

Patients with isolated splenomegaly or hepatosplenomegaly might need ultrasonography and other imaging studies to evaluate the size of these two organs and plan possible surgical [lecturio.com]

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Systemic Lupus Erythematosus

Hepatosplenomegaly can come and go with disease activity. [ojrd.biomedcentral.com]

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Acute Myeloid Leukemia

In all three patients, radionuclide imaging with technetium-99m sulfur colloid showed hepatosplenomegaly, decreased liver uptake, and increased splenic activity. [ncbi.nlm.nih.gov]

Symptoms include anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, bone pain, lymphadenopathy, hepatosplenomegaly, [medical-dictionary.thefreedictionary.com]

The major clinical manifestations of malaise, hepatosplenomegaly, anemia, and leukocytosis are related to abnormal, excessive, unrestrained overgrowth of granulocytes in the [medical-dictionary.thefreedictionary.com]

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Cryopyrin-Associated Periodic Syndrome

Abdominal CT revealed hepatosplenomegaly with inguinal and retroperitoneal adenopathies measuring less than 1cm. [elsevier.es]

Patients may have lymphadenopathy and/or hepatosplenomegaly. The CINCA/NOMID syndrome typically presents shortly after birth. [clevelandclinicmeded.com]

Other manifestations include short stature, hepatosplenomegaly, leukocytosis, and an elevation in serum levels of amyloid A and C-reactive protein and in the erythrocyte sedimentation [doi.org]

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Multicentric Castleman's Disease

A 46-year-old man presented with a high-grade fever, multiple lymphadenopathies, hepatosplenomegaly and human immunodeficiency virus (HIV) seropositivity, without severe immunosuppression [ncbi.nlm.nih.gov]

Multicentric Castleman's disease (MCD) typically presents with constitutional symptoms, generalized peripheral lymphadenopathy, hepatosplenomegaly, and laboratory markers [ncbi.nlm.nih.gov]

It manifests by fever, diffuse lymphadenopathy, hepatosplenomegaly, Involvement of the respiratory system and increased C-reactive protein. [orpha.net]

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