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1,932 Possible Causes for Hepatosplenomegaly

  • Infectious Mononucleosis

    Both cases involved young adults presenting with fever, pharyngitis, lymphadenopathy, hepatosplenomegaly, and atypical lymphocytosis confirmed by serologic tests, liver biopsy[ncbi.nlm.nih.gov] Third, the frequency of CD4CXCR5ICOSPD1 Tfh subset was significantly higher in lymphadenectasis or hepatosplenomegaly patients, and associated with the level of alanine aminotransferase[ncbi.nlm.nih.gov] She presented with fever, skin rash, lymphadenopathy, and hepatosplenomegaly.[ncbi.nlm.nih.gov]

  • Chronic Alcoholism

    Abstract Korsakoff syndrome (KS) is characterized by dense anterograde and retrograde amnesia. There is often a temporal gradient to the retrograde amnesia, with earlier memories more readily recalled than recent memories. Executive functioning has also been found to be impaired in KS. However, research[…][ncbi.nlm.nih.gov]

  • Hemochromatosis

    Skin hyperpigmentation (like suntan) on both exposed and nonexposed areas; slate gray in late stages (75% of patients with hereditary hemochromatosis) Other manifestations Hepatosplenomegaly[faculty.washington.edu]

  • Cardiomyopathy

    Brain Dev. 2018 Jun;40(6):484-488. doi: 10.1016/j.braindev.2018.02.004. Epub 2018 Mar 2. Nishioka M 1 , Inaba Y 2 , Motobayashi M 3 , Hara Y 1 , Numata R 4 , Amano Y 4 , Shingu K 5 , Yamamoto Y 6 , Murayama K 7 , Ohtake A 8 , Nakazawa Y 1 . Author information 1 Department of Pediatrics, Shinshu University School of[…][ncbi.nlm.nih.gov]

  • Leukemia

    […] lymphocytic leukemia is a rare form of leukemia, caused by clonal proliferation of cytotoxic T-cells, characterized by modest lymphocytosis and cytopenias of other lineage with hepatosplenomegaly[ncbi.nlm.nih.gov] An additional eight features were present in a third to a half of children: recurrent infections (49%), fatigue (46%), limb pain (43%), hepatosplenomegaly (42%), bruising[ncbi.nlm.nih.gov] Stage I Stage I CLL is characterized by absolute lymphocytosis with lymphadenopathy without hepatosplenomegaly, anemia, or thrombocytopenia.[web.archive.org]

  • Congenital Hepatic Fibrosis

    Congenital hepatic fibrosis (CHF) is probably the most common cause of non-icteric hepatosplenomegaly and is encountered mainly in children and young adults.[ncbi.nlm.nih.gov] The authors report an unusual case of ARPKD presenting with hepatosplenomegaly and cytopenia mimicking acute leukemia.[ncbi.nlm.nih.gov] This diagnosis should be suspected when these biliary and renal abnormalities are associated with hepatosplenomegaly in a patient with normal liver function.[ncbi.nlm.nih.gov]

  • Syphilis

    Among 139 infants with symptomatic congenital syphilis in 3 series, the most common early signs were hepatosplenomegaly (71%), rash (68%), fever (42%), neurosyphylis (23%)[doi.org]

  • Mucopolysaccharidosis

    In a resource poor setting, we report a case of Hunter syndrome, severe subtype, based on global development delay, coarse facies, short stature, hepatosplenomegaly and dysostosis[ncbi.nlm.nih.gov] Mucopolysaccharidosis VI, also called as Maroteaux-Lamy syndrome, in its severe form presents with bony lesions, corneal clouding, hepatosplenomegaly, cardiovascular abnormalities[ncbi.nlm.nih.gov] RESULTS: Hepatosplenomegaly decreased significantly in all patients, and the size of the liver was normal for body weight and age in eight patients by 26 weeks.[ncbi.nlm.nih.gov]

  • Primary Immune Deficiency Disorder

    […] not absent T-cell function and normal or elevated immunoglobulins Autosomal recessive or X-linked NEMO Common and opportunistic infections, lymphopenia, lymphadenopathy, hepatosplenomegaly[merckmanuals.com] […] reduced activity of RAG1 . [3] Mice bred from this animal exhibited major symptoms of Omenn syndrome, including having high numbers of memory-phenotype T cells, experiencing hepatosplenomegaly[emedicine.medscape.com] Hepatosplenomegaly and lymphadenopathy are frequently found in patients with CVID and cellular immune deficiency.[worldallergy.org]

  • Gaucher Disease

    We report here the case of a young woman with hepatosplenomegaly, leukopenia, and thrombocytopenia.[ncbi.nlm.nih.gov] Abstract The hematologist is at the forefront of specialists to whom patients with Gaucher disease present because of cytopenia and hepatosplenomegaly.[ncbi.nlm.nih.gov] The phenotype was unusually severe with congenital ichthyosis, hepatosplenomegaly, muscular hypotonia, myoclonus and respiratory failure.[ncbi.nlm.nih.gov]

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