Hepatosplenomegaly: Causes & Reasons

Warning: Do not use in emergencies, if pregnant, if under 18, or as a substitute for a doctor’s advice or diagnosis. Learn more

Possible Causes for hepatosplenomegaly

Infectious Mononucleosis

Both cases involved young adults presenting with fever, pharyngitis, lymphadenopathy, hepatosplenomegaly, and atypical lymphocytosis confirmed by serologic tests, liver biopsy [ncbi.nlm.nih.gov]

She presented with fever, skin rash, lymphadenopathy, and hepatosplenomegaly. [ncbi.nlm.nih.gov]

Third, the frequency of CD4CXCR5ICOSPD1 Tfh subset was significantly higher in lymphadenectasis or hepatosplenomegaly patients, and associated with the level of alanine aminotransferase [ncbi.nlm.nih.gov]

Chronic Alcoholism

The concept of "structural plasticity" has emerged as a potential mechanism in neurodegenerative and psychiatric diseases such as drug abuse, depression, and dementia. Chronic alcoholism is a progressive neurodegenerative disease while the person continues to abuse alcohol, though clinical and imaging studies show[…] [ncbi.nlm.nih.gov]

Cardiomyopathy

The acute presentation is characterized by dyspnea, fever, myalgia, hepatosplenomegaly, and myocarditis. Chronic infection involves the esophagus, colon, and heart. [emedicine.medscape.com]

Hemochromatosis

Skin hyperpigmentation (like suntan) on both exposed and nonexposed areas; slate gray in late stages (75% of patients with hereditary hemochromatosis) Other manifestations Hepatosplenomegaly [faculty.washington.edu]

[…] of the white population, most are unaffected heterozygotes; 5/1000 of US whites are homozygotes Clinical Fatigue, cold intolerance, edema, cardiac arrhythmias, dyspnea, hepatosplenomegaly [medical-dictionary.thefreedictionary.com]

Mucopolysaccharidosis

In a resource poor setting, we report a case of Hunter syndrome, severe subtype, based on global development delay, coarse facies, short stature, hepatosplenomegaly and dysostosis [ncbi.nlm.nih.gov]

Mucopolysaccharidosis VI, also called as Maroteaux-Lamy syndrome, in its severe form presents with bony lesions, corneal clouding, hepatosplenomegaly, cardiovascular abnormalities [ncbi.nlm.nih.gov]

RESULTS: Hepatosplenomegaly decreased significantly in all patients, and the size of the liver was normal for body weight and age in eight patients by 26 weeks. [ncbi.nlm.nih.gov]

Leukemia

[…] fever, night sweats (unintentional) loss of weight fatigue syndrome (extreme weakness) swollen or bleeding gums nosebleed ( Epistaxis ) Enlargment of liver and spleen ( Hepatosplenomegaly [flexikon.doccheck.com]

[…] lymphocytic leukemia is a rare form of leukemia, caused by clonal proliferation of cytotoxic T-cells, characterized by modest lymphocytosis and cytopenias of other lineage with hepatosplenomegaly [ncbi.nlm.nih.gov]

An additional eight features were present in a third to a half of children: recurrent infections (49%), fatigue (46%), limb pain (43%), hepatosplenomegaly (42%), bruising/ [ncbi.nlm.nih.gov]

Congenital Hepatic Fibrosis

Congenital hepatic fibrosis (CHF) is probably the most common cause of non-icteric hepatosplenomegaly and is encountered mainly in children and young adults. [ncbi.nlm.nih.gov]

We report two unrelated children with Joubert syndrome and hepatosplenomegaly. On histopathological examination, both had congenital hepatic fibrosis. [ncbi.nlm.nih.gov]

This diagnosis should be suspected when these biliary and renal abnormalities are associated with hepatosplenomegaly in a patient with normal liver function. [ncbi.nlm.nih.gov]

Primary Immune Deficiency Disorder

Case #2 A 3-month-old Qatari female was admitted due to generalized rash, lymphadenopathy, and hepatosplenomegaly diagnosed by her pediatrician. [hindawi.com]

[…] not absent T-cell function and normal or elevated immunoglobulins Autosomal recessive or X-linked NEMO Common and opportunistic infections, lymphopenia, lymphadenopathy, hepatosplenomegaly [merckmanuals.com]

Radiologic findings are often nonspecific and include hilar and mediastinal adenopathy, hepatosplenomegaly, brain atrophy, diffuse decreased periventricular density on CT, [ajronline.org]

Syphilis

Among 139 infants with symptomatic congenital syphilis in 3 series, the most common early signs were hepatosplenomegaly (71%), rash (68%), fever (42%), neurosyphylis (23%) [doi.org]

Juvenile Seronegative Polyarthritis

Migratory salmon colored light pink rash involving the trunk and/or extremities and hepatosplenomegaly are also frequently observed in patients with systemic onset. [radiopaedia.org]

uveitis, rashes, nail changes, lymphadenopathy, hepatosplenomegaly ), laboratory findings, and disease prognosis. [amboss.com]

[…] day best prognosis for long term remission (70%) Systemic (20%) systemic symptoms (rash, fever, multiple joint involvement) anemia, high WBC, elevated ESR, CRP, platelets hepatosplenomegaly [orthobullets.com]

Angioimmunoblastic Lymphadenopathy

AILD is characterized by generalized lymphadenopathy, hepatosplenomegaly, immunological abnormalities, polyclonal hypergammaglobulinemia and anemia. [ncbi.nlm.nih.gov]

Angioimmunoblastic lymphadenopathy with disproteinemia (AILD) is a systemic lymphoproliferative disorder characterized by constitutional symptoms such as generalized lymphadenopathy, hepatosplenomegaly [ncbi.nlm.nih.gov]

Angioimmunoblastic lymphadenopathy (AILD) is a rare disorder characterised by generalised lymphadenopathy, fever, hepatosplenomegaly, immune hemolytic anemia and polyclonal [ncbi.nlm.nih.gov]

Gaucher Disease

We report here the case of a young woman with hepatosplenomegaly, leukopenia, and thrombocytopenia. [ncbi.nlm.nih.gov]

[ncbi.nlm.nih.gov] Less common signs of the disease are hepatosplenomegaly, ichthyosis, arthrogryposis and facial dysmorphy. [symptoma.com]

Type B is a later-onset form with no neurologic involvement but hepatosplenomegaly in many patients. [accessmedicine.mhmedical.com]

Viral Hepatitis

Hepatosplenomegaly and laboratory evidence of mild to moderate hepatic dysfunction are the predominant features, with increased aminotransferases and alkaline phosphatase [doi.org]

Sarcoidosis

The laboratory investigations showed pancytopenia, and imaging tests revealed hepatosplenomegaly and ascites. [ncbi.nlm.nih.gov]

CONCLUSIONS The majority of patients with hepatic sarcoidosis are usually asymptomatic, with only 5-30% presenting with abdominal pain, jaundice, nausea, vomiting, and hepatosplenomegaly [ncbi.nlm.nih.gov]

There were no other palpable lymph nodes, hepatosplenomegaly, fever, night sweats, or constitutional symptoms. [hindawi.com]

Nephroblastoma

Leukemia should be suspected if persistent vague symptoms are accompanied by evidence of abnormal bleeding, bone pain, lymphadenopathy or hepatosplenomegaly. [aafp.org]

Affected males typically have intellectual disability, macrosomia, cardiac, skeletal, gastrointestinal and genitourinary anomalies, hepatosplenomegaly, and distinctive facial [invitae.com]

The physical examination may reveal no abnormalities, but the presence of significant lymphadenopathy or any hepatosplenomegaly should raise suspicion for leukemia. [aafp.org]

Chronic Lymphocytic Leukemia

III Lymphocytosis; lymphadenopathy; hepatosplenomegaly, anemia IV Lymphocytosis, lymphadenopathy; hepatosplenomegaly, thrombocytopenia anemia CHRONIC LYMPHOCYTIC LEUKEMIA [medical-dictionary.thefreedictionary.com]

Stage I : Stage I CLL is characterized by absolute lymphocytosis with lymphadenopathy without hepatosplenomegaly, anemia, or thrombocytopenia. [cancer.unm.edu]

Symptoms include anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, bone pain, lymphadenopathy, hepatosplenomegaly, [medical-dictionary.thefreedictionary.com]

Systemic Candidiasis

[…] broad-spectrum antimicrobials Right upper quadrant pain Abdominal pain and distension Jaundice (rare) Physical examination findings include right upper quadrant tenderness and hepatosplenomegaly [emedicine.medscape.com]

Symptoms include fever, hepatosplenomegaly and increased blood concentrations of alkaline phosphatases. [mycology.adelaide.edu.au]

Adult-Onset Still Disease

Adult onset Still's disease (AOSD) is a systemic inflammatory disease characterized by high-fevers, articular involvement, maculopapular rash, hepatosplenomegaly, lymphadenopathy [ncbi.nlm.nih.gov]

[…] genetic factors, immune dysfunction and infections Clinical features Systemic inflammatory disease manifesting with spiking fever, sore throat, arthralgia, skin rash and hepatosplenomegaly [pathologyoutlines.com]

HLH is also characterized by fever, hepatosplenomegaly, increased ferritin levels all of which are also features of AOSD. [ijpmonline.org]

Cytomegalovirus Infection

We report a case of a term neonate with ventriculomegaly on prenatal ultrasound who presented with low birth weight, small head circumference, hepatosplenomegaly, and purpuric [ncbi.nlm.nih.gov]

[…] should arouse suspicion of intrauterine CMV infection can be distinguished into CNS signs such as ventriculomegaly or microcephaly and extracerebral infection signs such as hepatosplenomegaly [ncbi.nlm.nih.gov]

A newborn symptomatic is defined by the existence of clinical and / or biological signs and / or neonatal imaging, the most frequent clinical signs are: hepatosplenomegaly [ncbi.nlm.nih.gov]

Multiple Myeloma

* 요약 : IgM, no osteolytic lesion * WM-related symptoms : anemia, constitutional symptoms, hyperviscosity, lymphadenopathy, or hepatosplenomegaly 끝. 2018. 10. 13 - SJH [sondoctor.co.kr]

The presenting problem was proteinuria in five patients, thyromegaly in three patients, and hepatosplenomegaly in one patient. [jamanetwork.com]

[…] they reported a progression-free survival of 2, 10 and 46% for the presence of none, one or two risk factors, respectively at 5 years in MGUS. 17 The age, sex, presence of hepatosplenomegaly [doi.org]

Juvenile-Onset Still Disease

Appearance of rash, hepatosplenomegaly, serositis and generalized lymphadenopathy. [symptoma.com]

This characteristic diagnostic triad may also be associated with an adenopathy and hepatosplenomegaly. [orpha.net]

It is distinguished from other forms of JIA by extra-articular symptoms such as fever, hepatosplenomegaly, lymphadenopathy and serositis. [symptoma.com]

Thalassemia

Hypertrichosis, erythrodontia and reddish-colored urine are often present, as well as hemolytic anemia accompanied by hepatosplenomegaly. [ncbi.nlm.nih.gov]

They have severe anemia and hepatosplenomegaly. Untreated children have severe failure to thrive and shortened life expectancy. [meddean.luc.edu]

Hb-Bart's hydrops fetalis syndrome (most severe variant of alpha thalassemia) Intrauterine ascites and hydrops fetalis;, severe hepatosplenomegaly, and often cardiac and skeletal [amboss.com]

Primary Myelofibrosis

The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever. [ncbi.nlm.nih.gov]

Most of them had anemia, fever, and hepatosplenomegaly on admission. [ncbi.nlm.nih.gov]

He has hepatosplenomegaly with a palpable spleen of 6 cm below the left costal margin and a liver size of 2.5 cm below the right costal margin. [ncbi.nlm.nih.gov]

Niemann-Pick Disease Type C

Hepatosplenomegaly and progressive neurological symptoms are the main clinical features. [ncbi.nlm.nih.gov]

We report the case of an infant who presented with hepatosplenomegaly without neurological abnormalities. [ncbi.nlm.nih.gov]

A galactose-free and lactose-free diet resulted in achievement of a normal galactose level, but hepatosplenomegaly and cholestatic signs persisted. [ncbi.nlm.nih.gov]

Mucopolysaccharidosis Type 2

Enzyme replacement therapy (ERT) using idursulfase (Elaprase ) was conducted to the patient and it improved hepatosplenomegaly, white blood cells and platelets number, and [ncbi.nlm.nih.gov]

Most children with MPS2 have a severe form with early somatic abnormalities including skeletal deformities, hepatosplenomegaly, and progressive cardiopulmonary deterioration [uniprot.org]

Initial manifestations include: frequent respiratory tract infections (in particular otitis media); umbilical and inguinal hernia; intractable diarrhea; hepatosplenomegaly [orpha.net]

Castleman Disease

For multicentric disease: multi-region CT bilateral hilar and mediastinal lymphadenopathy centrilobular nodules diffuse abdominal lymphadenopathy hepatosplenomegaly ascites [radiopaedia.org]

[…] in the groin, neck, or armpit Unintentional loss of weight In some cases fever and weakness Easy fatigue Appetite loss or extremely poor appetite Lymph node enlargement Hepatosplenomegaly [epainassist.com]

[…] clinical presentation due to the systemic inflammation, with symptoms such as fevers, night sweats, fatigue, and weight loss, and clinical signs of generalized lymphadenopathy, hepatosplenomegaly [radiopaedia.org]

Myeloproliferative Disease

Marked myeloid proliferation, anemia, thrombocytopenia and hepatosplenomegaly were present; leukocyte alkaline phosphatase and fetal hemoglobin were moderately elevated. [ncbi.nlm.nih.gov]

[…] yes; there is effective maturation leading to increased peripheral blood counts Hepatosplenomegaly is common due to extramedullary hematopoiesis What is the spent phase found [quizlet.com]

Patients with isolated splenomegaly or hepatosplenomegaly might need ultrasonography and other imaging studies to evaluate the size of these two organs and plan possible surgical [lecturio.com]

Acute Myeloid Leukemia

In all three patients, radionuclide imaging with technetium-99m sulfur colloid showed hepatosplenomegaly, decreased liver uptake, and increased splenic activity. [ncbi.nlm.nih.gov]

The major clinical manifestations of malaise, hepatosplenomegaly, anemia, and leukocytosis are related to abnormal, excessive, unrestrained overgrowth of granulocytes in the [medical-dictionary.thefreedictionary.com]

Systemic Lupus Erythematosus

Hepatosplenomegaly can come and go with disease activity. [ojrd.biomedcentral.com]

Cryopyrin-Associated Periodic Syndrome

Abdominal CT revealed hepatosplenomegaly with inguinal and retroperitoneal adenopathies measuring less than 1cm. [elsevier.es]

Patients may have lymphadenopathy and/or hepatosplenomegaly. The CINCA/NOMID syndrome typically presents shortly after birth. [clevelandclinicmeded.com]

Other manifestations include short stature, hepatosplenomegaly, leukocytosis, and an elevation in serum levels of amyloid A and C-reactive protein and in the erythrocyte sedimentation [doi.org]