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294 Possible Causes for Hepatosplenomegaly, Hypercellular Bone Marrow

  • Chronic Myeloid Leukemia

    Due to presenting complaint of bleeding diathesis and absence of hepatosplenomegaly, the case was undiagnosed for CML until the patient reported to us.[ncbi.nlm.nih.gov] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] A 59-year-old female with dry cough, referred to our hospital, exhibited hepatosplenomegaly, high basophil count, and high platelet count at admission without any other known[ncbi.nlm.nih.gov]

  • Acute Leukemia

    Physical examination showed jaundice, hepatosplenomegaly, and peripheral facial nerve palsy in addition to dermal nodules.[ncbi.nlm.nih.gov] ALL : Hypercellular bone marrow Numerous tightly packed lymphoblasts with undetectable cytoplasm, round, irregular, cleaved nuclei, dispersed chromatin, small nucleoli B[pathologyoutlines.com] Symptoms include anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, bone pain, lymphadenopathy, hepatosplenomegaly,[medical-dictionary.thefreedictionary.com]

  • Polycythemia Vera

    Physical examination reveals multiple bruises on the bilateral upper and lower extremities and hepatosplenomegaly.[step1.medbullets.com] bone marrow 5.[slideshare.net] No lymphadenopathy or hepatosplenomegaly can be palpated. Other systems, including the cardiac, respiratory, and nervous systems, are normal.[mdedge.com]

  • Myeloproliferative Disease

    Marked myeloid proliferation, anemia, thrombocytopenia and hepatosplenomegaly were present; leukocyte alkaline phosphatase and fetal hemoglobin were moderately elevated.[ncbi.nlm.nih.gov] The chronic myeloproliferative diseases are characterized by relatively effective hematopoiesis, which results in a hypercellular bone marrow and elevation of one or more[clinlabnavigator.com] […] yes; there is effective maturation leading to increased peripheral blood counts Hepatosplenomegaly is common due to extramedullary hematopoiesis What is the spent phase found[quizlet.com]

  • Leukemia

    Hepatosplenomegaly and lymphadenopathy are rare in adults with acute myelogenous leukemia, but are present in about 50% of adults with acute lymphoblastic leukemia. 12 Central[aafp.org] […] and young adults (53% of new cases occur in persons 20 years) Symptoms: fever, lethargy, bleeding, musculoskeletal pain or dysfunction 50 years: 75% 50 years: 25% Signs: hepatosplenomegaly[aafp.org] […] on peripheral smear Adults (accounts for 80% of acute leukemia in adults) Symptoms: fever, fatigue, weight loss, bleeding or bruising 50 years: 55% 50 years: 14% Signs: hepatosplenomegaly[aafp.org]

  • Wiskott Aldrich Syndrome

    Epstein-Barr virus (EBV)-associated post-transplantation lymphoproliferative disorder (PTLD) of donor cell origin and hemophagocytosis syndrome with fever, lymphadenopathy, hepatosplenomegaly[ncbi.nlm.nih.gov] The bone marrow was hypercellular with dysplasia.[ncbi.nlm.nih.gov] […] infections: Candida albicans thrombocytopenia recurrent bleeding , especially in first days of life petechiae purpura easy bruising hematemesis epistaxis hematuria chronic eczema hepatosplenomegaly[medbullets.com]

  • Extramedullary Hematopoiesis

    The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[ncbi.nlm.nih.gov] The spaces were filled with fat and prominent hypercellular bone marrow, with trilineage hematopoiesis with scattered lymphoid aggregates, some showing reactive follicles.[austinpublishinggroup.com] The patient underwent a bone marrow biopsy which revealed hypercellular bone marrow with erythroid hyperplasia.[biomarkerres.biomedcentral.com]

  • Acute Lymphoblastic Leukemia

    Massive hepatosplenomegaly as a presentation of ALL has not been described previously in any patient population.[ncbi.nlm.nih.gov] The leukemic cells of the hypercellular bone marrow then spill into the blood circulation and are visible on routine CBCs .[lecturio.com] We report a 28-year-old male with the B-cell ALL who presented with extensive osteolytic lesions, bone pain, hepatosplenomegaly, and pancytopenia without circulating blasts[ncbi.nlm.nih.gov]

  • Hairy Cell Leukemia

    Abdominal discomfort is a common symptom, resulting from hepatosplenomegaly.[orpha.net] Fig. 2: TRAP ; Fig. 3: hypercellular bone marrow with monotonous "fried egg" lymphocytes with abundant cytoplasm Cytology description Small / intermediate size cells with[pathologyoutlines.com] Symptoms include anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, bone pain, lymphadenopathy, hepatosplenomegaly,[medical-dictionary.thefreedictionary.com]

  • Chronic Phase of Chronic Myeloid Leukemia

    […] blasts plus promyelocytes in the peripheral blood and bone marrow and a platelet count of 100 10 9 per liter or more, with an absence of extramedullary disease except for hepatosplenomegaly[nejm.org] marrow biopsy: Moderately hypercellular bone marrow biopsy with numerous megakaryocytes Increased reticulin fibers (reticulin stain) Marked hypercellularity Myeloblastic[pathologyoutlines.com] It can also present with symptoms indicative of hepatosplenomegaly and the resulting upper quadrant pain this causes.[en.wikipedia.org]

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