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1,307 Possible Causes for Hepatosplenomegaly, Jaundice

  • Infectious Mononucleosis

    We report a case of infectious mononucleosis in a 72-year old jaundiced gentleman with ferritin level of 2438 that normalised on clinical improvement.[ncbi.nlm.nih.gov] Both cases involved young adults presenting with fever, pharyngitis, lymphadenopathy, hepatosplenomegaly, and atypical lymphocytosis confirmed by serologic tests, liver biopsy[ncbi.nlm.nih.gov] […] patient between 16 and 25 years old who complains of sore throat and fever is more likely to have infectious mononucleosis than another disease; and if - in addition - he is jaundiced[ncbi.nlm.nih.gov]

  • TORCH Syndrome

    They include hepatosplenomegaly (enlargement of the liver and spleen), fever, lethargy, difficulty feeding, anemia, petechiae, purpurae, jaundice, and chorioretinitis.[en.wikipedia.org] Cutaneous manifestations, including petechiae, purpura, jaundice, and dermal erythropoiesis, are commonly seen in toxoplasmosis, rubella, and cytomegalovirus infections.[ncbi.nlm.nih.gov] Other features are: Premature delivery and small for gestational age Deafness Chorioretinitis Psychomotor retardation Hepatosplenomegaly Direct hyperbilirubinaemia Thrombocytopenia[ganfyd.org]

  • Wolman Disease

    LAL is responsible of Wolman disease (WD), a severe systemic disease manifesting in the first days of life with vomiting, diarrhea, failure to thrive, hepatosplenomegaly, jaundice[ncbi.nlm.nih.gov] BACKGROUND: Infant leukemia most commonly present with pallor and hepatosplenomegaly.[ncbi.nlm.nih.gov] Other symptoms that can develop in children include: Jaundice Calcium deposits in the adrenal glands, which causes them to harden The onset of CESD varies, and in some cases[medic8.com]

  • Niemann-Pick Disease Type C

    Abstract A three-month old Chinese male infant was a victim of neonatal hepatitis presenting with prolonged jaundice, poor body weight gain, progressive hepatosplenomegaly[ncbi.nlm.nih.gov] Hepatosplenomegaly and progressive neurological symptoms are the main clinical features.[ncbi.nlm.nih.gov] NP-C) is a lysosomal lipid storage disease (see this term) characterized by variable clinical signs, depending on the age of onset, such as prolonged unexplained neonatal jaundice[orpha.net]

  • Hepatitis A

    The individual remains infective from 15-20 days before the appearance of jaundice to 8 days after jaundice disappears.[symptoma.com] On examination, he had tachypnea, hepatosplenomegaly, ascites and right-sided pleural effusion.[ncbi.nlm.nih.gov] US population has been exposed Epidemiology Contaminated food–eg, shellfish, and other foods prepared by HAV carriers Clinical Fever, nonspecific GI malaise–eg, nausea, hepatosplenomegaly[medical-dictionary.thefreedictionary.com]

  • Progressive Familial Intrahepatic Cholestasis

    RESULTS: Six patients who underwent PBD experienced short-term resolution of jaundice and pruritus.[ncbi.nlm.nih.gov] […] grow at the expected rate (failure to thrive), high blood pressure in the vein that supplies blood to the liver (portal hypertension), and an enlarged liver and spleen (hepatosplenomegaly[ghr.nlm.nih.gov] Physical exam Remarkable findings on examination include: Icterus Hepatosplenomegaly Hyperpigmentation Growth retardation Shiny nails The newborn with unexplainable cholestasis[symptoma.com]

  • Primary Biliary Cirrhosis

    CASE PRESENTATION: A 65-year-old male was admitted to our hospital with jaundice, pruritus, mild abdominal pain and darkening urine.[ncbi.nlm.nih.gov] In addition to typical clinical findings as fever, hepatosplenomegaly, and cachexia, VL is associated with autoimmune phenomena.[ncbi.nlm.nih.gov] Symptomatic individuals usually present with either pruritus or fatigue and, more rarely, with either jaundice or complications of cirrhosis.[ncbi.nlm.nih.gov]

  • Thalassemia

    Clinical description Patients present with moderate to severe anemia, jaundice and splenomegaly.[orpha.net] They have severe anemia and hepatosplenomegaly. Untreated children have severe failure to thrive and shortened life expectancy.[meddean.luc.edu] Diagnostic methods Diagnosis is suspected in infants younger than 2 years of age with severe microcytic anemia, mild jaundice and hepatosplenomegaly.[orpha.net]

  • Gaucher Disease

    Investigations General assessment FBC and differential (assess the degree of pancytopenia); LFTs (minor elevations of liver enzymes are common but jaundice is a poor prognostic[patient.info] Abstract The hematologist is at the forefront of specialists to whom patients with Gaucher disease present because of cytopenia and hepatosplenomegaly.[ncbi.nlm.nih.gov] The gastrointestinal features include hepatosplenomegaly, jaundice , hepatic (liver) failure, and ascites (fluid in the abdomen).[medicinenet.com]

  • Autoimmune Hemolytic Anemia

    Secondary AIHA might not be diagnosed appropriately because the obstructive jaundice observed in type 1 AIP/IgG4-SC can obscure the presence of hemolytic jaundice.[ncbi.nlm.nih.gov] CASE CHARACTERISTICS: A 7-month-old boy, presented with prolonged fever, erythematous rash, severe pallor and hepatosplenomegaly.[ncbi.nlm.nih.gov] Abstract A 48 year old lady presented with jaundice and exertional breathlesness.[ncbi.nlm.nih.gov]

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