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1,138 Possible Causes for Hepatosplenomegaly, Jaundice, Pallor

  • Thalassemia

    Diagnostic methods Diagnosis is suspected in infants younger than 2 years of age with severe microcytic anemia, mild jaundice and hepatosplenomegaly.[orpha.net] Hypertrichosis, erythrodontia and reddish-colored urine are often present, as well as hemolytic anemia accompanied by hepatosplenomegaly.[ncbi.nlm.nih.gov] Clinical description Patients present with moderate to severe anemia, jaundice and splenomegaly.[orpha.net]

  • Autoimmune Hemolytic Anemia

    Secondary AIHA might not be diagnosed appropriately because the obstructive jaundice observed in type 1 AIP/IgG4-SC can obscure the presence of hemolytic jaundice.[ncbi.nlm.nih.gov] A 7-month-old boy, presented with prolonged fever, erythematous rash, severe pallor and hepatosplenomegaly.[ncbi.nlm.nih.gov] An otherwise seemingly normal girl, who had developed limping at the age of 11 months old, referred to Namazi Hospital, Shiraz, Iran, due to pallor and latitude at the age[ncbi.nlm.nih.gov]

  • Cooley's Anemia

    Children develop life-threatening anemia, have failure to thrive, and may develop jaundice.[secure.ssa.gov] Karimi M et al Prevalence of hepatosplenomegaly in beta thalassemia minor subjects in Iran. Eur J Radiol. 2007. doi: 10.1016/j.ejrad.2007.09.027 Google Scholar 8.[link.springer.com] The anemia surfaces in the first few months after birth and becomes progressively more severe leading to pallor and easy fatigability, failure to thrive (grow), bouts of fever[medicinenet.com]

  • Gaucher Disease

    Investigations General assessment FBC and differential (assess the degree of pancytopenia); LFTs (minor elevations of liver enzymes are common but jaundice is a poor prognostic[patient.info] We report here the case of a young woman with hepatosplenomegaly, leukopenia, and thrombocytopenia.[ncbi.nlm.nih.gov] […] reactions, occurring in 2 or more patients, included abdominal pain, agitation, fever, chills, diarrhea, eczema, edema, hypertension, irritability, laryngeal edema, nausea, pallor[aetna.com]

  • Malaria

    Abstract A 5-year-old immunocompetent girl presented with fever, jaundice, hepatosplenomegaly and pancytopenia.[ncbi.nlm.nih.gov] Infant presented with pallor, jaundice and massive spleen. Laboratory tests revealed anaemia, thrombocytopenia and bilirubinemia.[ncbi.nlm.nih.gov] Common physical findings include jaundice, hepatosplenomagaly and pallor.[clinicaladvisor.com]

  • ALK+ Histiocytosis

    Jaundice has been reported. Laboratory analyses of blood samples may reveal increased levels of alanine aminotransferase, aspartate aminotransferase, and bilirubin.[symptoma.com] General pathology Genetic and developmental anomalies ALK histiocytosis See also histiocytoses ALK immunoreactivity Clinical synopsis pallor massive hepatosplenomegaly anemia[humpath.com] Case; sex/age Case 1; F/neonate Case 2; F/3 mo Case 3; F/3 mo Presentation Pallor; failure to thrive; abdominal distension; ascites; lower limb edema Pallor; mild jaundice[ashpublications.org]

  • T-Cell Acute Lymphoblastic Leukemia

    Obstructive jaundice: an unusual initial manifestation of intra-abdominal non-Hodgkin lymphoma in a child.[journals.lww.com] A 6-year-old male presented with a testicular mass, hepatosplenomegaly, and a pleural effusion while undergoing maintenance chemotherapy for treatment of T-cell acute lymphoblastic[ncbi.nlm.nih.gov] There was moderate pallor, bilateral, multiple, discrete, soft cervical lymph nodes with largest measuring up to 2 cm.[henrypublishinggroups.com]

  • Babesiosis

    Jaundice, hepatosplenomegaly, anemia and conjugated hyperbilirubinemia developed in this preterm infant.[ncbi.nlm.nih.gov] Physical examination may reveal fever, splenomegaly, hepatomegaly, and pallor or jaundice. The diagnosis is confirmed with laboratory testing (see below).[clinicaladvisor.com] During hospitalization, the patient developed pancytopenia and jaundice and became progressively more ill.[ncbi.nlm.nih.gov]

  • Paroxysmal Cold Hemoglobinuria

    Should the kidneys be affected as well, the condition may progress to the renal dysfunction that presents with oliguria or even anuria in extreme circumstances; jaundice and[symptoma.com] Following an episode, affected individuals usually develop the signs of hemolysis including yellowing of the skin, whites of the eyes and mucous membranes (jaundice).[rarediseases.org] Temporary hepatosplenomegaly and mild hyperbilirubinemia may follow the onset of an attack. paroxysmal cold hemoglobinuria Hematology A disorder that is: (1) Rarely 'paroxysmal[medical-dictionary.thefreedictionary.com]

  • Congenital Dyserythropoietic Anemia

    , Neonatal/diagnosis Jaundice, Neonatal/etiology Jaundice, Neonatal/therapy Microscopy, Electron Phototherapy Pregnancy[ncbi.nlm.nih.gov] Most affected individuals do not have hepatosplenomegaly, and iron does not build up in tissues and organs.[ncbi.nlm.nih.gov] Age at onset of pallor ranged from birth to 9 years. Blood transfusion requirements varied from nil to monthly. This is the first report of CDA type I from India.[ncbi.nlm.nih.gov]

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