Create issue ticket

10 Possible Causes for Hepatosplenomegaly, Lacrimal Gland Enlargement, T-Lymphocyte Count Increased

  • Infectious Mononucleosis

    Both cases involved young adults presenting with fever, pharyngitis, lymphadenopathy, hepatosplenomegaly, and atypical lymphocytosis confirmed by serologic tests, liver biopsy[ncbi.nlm.nih.gov] Third, the frequency of CD4CXCR5ICOSPD1 Tfh subset was significantly higher in lymphadenectasis or hepatosplenomegaly patients, and associated with the level of alanine aminotransferase[ncbi.nlm.nih.gov] She presented with fever, skin rash, lymphadenopathy, and hepatosplenomegaly.[ncbi.nlm.nih.gov]

  • Precursor-Cell Lymphoblastic Leukemia

    Massive hepatosplenomegaly as a presentation of ALL has not been described previously in any patient population.[ncbi.nlm.nih.gov] The increase in the ALC was primarily from activated CTL019 T lymphocytes. Patient 1 was a 7-year-old girl with a second recurrence of ALL.[doi.org] Here, a 16-year-old male presented with complaints of pain abdomen, on and off fever, joint pain, and hepatosplenomegaly for 2 months.[ncbi.nlm.nih.gov]

  • Acute Lymphoblastic Leukemia 

    The most frequent signs are lymphadenopathies, hepatosplenomegaly, fever, signs of haemorrhage, and bone pain.[orpha.net] CT of the chest and abdomen should be done to detect mediastinal masses and lymphadenopathy and may also detect hepatosplenomegaly.[msdmanuals.com] Other findings include abdominal masses due to hepatosplenomegaly, cachexia and lymphadenopathy.[cancertherapyadvisor.com]

  • Waldenstrom Macroglobulinemia

    Most commonly it presents with cytopenia, hepatosplenomegaly, lymphadenopathy, constitutional symptoms, and hyperviscosity syndrome.[ncbi.nlm.nih.gov] Additional tests that may be done include: 24-hour urine protein Total protein Immunofixation in urine T (thymus derived) lymphocyte count Bone x-rays Some people with WM[nlm.nih.gov] The patient had lymphadenopathy and hepatosplenomegaly.[ncbi.nlm.nih.gov]

  • Alcoholic Hepatitis

    B and T lymphocytes are noted in the portal and periportal areas, and natural killer lymphocytes are noted around hyalin-containing hepatocytes.[emedicine.medscape.com] Physical Examination and Laboratory Findings In Alcoholic Liver Disease Physical Examination Constitutional Fever Skin Spider angioma Parotid and lacrimal gland enlargement[clevelandclinicmeded.com] Patients have decreased peripheral lymphocyte counts with an associated increase in the ratio of helper cells to suppressor cells, signifying that lymphocytes are involved[emedicine.medscape.com]

  • Chronic Thyroiditis

    A physical examination may reveal hepatosplenomegaly, peripheral lymphadenopathy, ascites, and pleural effusion. Multicentric CD has a poor prognosis if untreated.[hematologyandoncology.net] It has features of an allergic disorder: abnormally high Th2 cytokines in tissues, raised IgE and increased T-reg lymphocytes in the blood, and raised eosinophil count in[dermnetnz.org] Lacrimal gland enlargement was observed in 8 cases.[ajnr.org]

  • IgG4-Related Retroperitoneal Fibrosis

    A physical examination may reveal hepatosplenomegaly, peripheral lymphadenopathy, ascites, and pleural effusion. Multicentric CD has a poor prognosis if untreated.[hematologyandoncology.net] It has features of an allergic disorder: abnormally high Th2 cytokines in tissues, raised IgE and increased T-reg lymphocytes in the blood, and raised eosinophil count in[dermnetnz.org] Most commonly involved are the pancreas, major salivary glands (sialadenitis, salivary gland enlargement), lacrimal glands (lacrimal gland enlargement and proptosis), retroperitoneal[elynsgroup.com]

  • Alcoholic Liver Disease

    Liver cirrhosis may start asymptomatically, but eventually, severe injury leads to portal hypertension, hepatosplenomegaly, upper gastrointestinal bleeding, ascites, esophageal[symptoma.com] B and T lymphocytes are noted in the portal and periportal areas, and natural killer lymphocytes are noted around hyalin-containing hepatocytes.[emedicine.medscape.com] Physical Examination and Laboratory Findings In Alcoholic Liver Disease Physical Examination Constitutional Fever Skin Spider angioma Parotid and lacrimal gland enlargement[clevelandclinicmeded.com]

  • IgG4-Related Kidney Disease

    This latter study revealed extensive cervical adenopathy (Figure 1) and hepatosplenomegaly. The patient underwent lymph node resection.[elynsgroup.com] It has features of an allergic disorder: abnormally high Th2 cytokines in tissues, raised IgE and increased T-reg lymphocytes in the blood, and raised eosinophil count in[dermnetnz.org] Role of Th2 cells in IgG4-related lacrimal gland enlargement. Int Arch Allergy Immunol. 2010; 152:Suppl 1:47-53. Mattoo H, Mahajan VS, Della Torre E, et al.[rarediseasesjournal.com]

  • IgG4 Syndrome

    A physical examination may reveal hepatosplenomegaly, peripheral lymphadenopathy, ascites, and pleural effusion. Multicentric CD has a poor prognosis if untreated.[hematologyandoncology.net] It has features of an allergic disorder: abnormal high Th2 cytokines (cell messenger proteins) in tissues, raised IgE and increased T-reg lymphocytes in blood and raised eosinophil[dermnetnz.org] Lacrimal gland enlargement was observed in 8 cases.[ajnr.org]

Similar symptoms