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880 Possible Causes for Hepatosplenomegaly, Leukocytosis, Lymphadenopathy

  • Infectious Mononucleosis

    To depict the grey-scale and Doppler features of cervical lymphadenopathy due to infectious mononucleosis (IM) and to compare the findings with other benign conditions and[ncbi.nlm.nih.gov] Leukocytosis is a common feature of infectious mononucleosis and absence of this should suggest an alternative diagnosis.[symptoma.com] Both cases involved young adults presenting with fever, pharyngitis, lymphadenopathy, hepatosplenomegaly, and atypical lymphocytosis confirmed by serologic tests, liver biopsy[ncbi.nlm.nih.gov]

  • Tuberculosis

    He had mild pallor with mild hepatosplenomegaly. He had high inflammatory markers with pancytopenia in a peripheral blood smear.[ncbi.nlm.nih.gov] In conclusion, TB-chylothorax may develop without obvious mediastinal lymphadenopathy and be associated with tubercular empyema alone.[ncbi.nlm.nih.gov] It may also cause leukocytosis and anemia, however, the findings are nonspecific.[symptoma.com]

  • Adult-Onset Still Disease

    Other common manifestations of AOSD are lymphadenopathy, hepatosplenomegaly, muscle aches, and pharyngitis.[symptoma.com] […] systemic inflammatory disease which presents with cardinal symptoms of spiking fever, arthralgia, and characteristic non pruritic evanescent salmon pink rash and neutrophilic leukocytosis[ncbi.nlm.nih.gov] Adult-onset Still disease (AOSD) is a rare autoinflammatory syndrome characterized by recurring fevers, arthralgia, and consistent laboratory abnormalities that include leukocytosis[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[ncbi.nlm.nih.gov] Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[orpha.net] Leukocytosis is occasionally seen in patients with presumptive but undiagnosed myeloproliferative disorders (MPD).[ncbi.nlm.nih.gov]

  • Chronic Lymphocytic Leukemia

    Lymphadenopathy may or may not be present. Stage III: Absolute lymphocytosis with anemia is present. Hepatosplenomegaly and lymphadenopathy may or may not be present.[symptoma.com] We report two cases of biclonal CLL presented with leukocytosis, typical morphological features, and distinct immunophenotype of CLL.[ncbi.nlm.nih.gov] III Lymphocytosis; lymphadenopathy; hepatosplenomegaly, anemia IV Lymphocytosis, lymphadenopathy; hepatosplenomegaly, thrombocytopenia anemia CHRONIC LYMPHOCYTIC LEUKEMIA[medical-dictionary.thefreedictionary.com]

  • Hairy Cell Leukemia

    Based on these findings, we diagnosed the patient with systemic lymphadenopathy due to HCL.[ncbi.nlm.nih.gov] The 3 HCL-v patients had leukocytosis and received chemotherapy with variable outcome.[ncbi.nlm.nih.gov] Abdominal discomfort is a common symptom, resulting from hepatosplenomegaly.[orpha.net]

  • Hodgkin's Disease

    Physical examination revealed a cachectic male with pallor, with enlarged left supraclavicular Virchow's lymph node and hepatosplenomegaly.[ncbi.nlm.nih.gov] Although all the radiological examinations suggested an osseous anomaly, histopathologic evaluation of the pelvic lymphadenopathies provided definite diagnosis of the disease[ncbi.nlm.nih.gov] The joint distribution of white-cell and absolute lymphocyte counts reveals a clear shift of the bivariate distribution away from normal values toward leukocytosis and at[nejm.org]

  • Acute Lymphoblastic Leukemia

    Massive hepatosplenomegaly as a presentation of ALL has not been described previously in any patient population.[ncbi.nlm.nih.gov] The striking nature of these lesions, along with the finding of submandibular lymphadenopathy, prompted further evaluation.[ncbi.nlm.nih.gov] , hematological, and immunocytological) parameters pointed towards a diagnosis of Wilms tumor in our case, the subsequent development of thrombocytopenia and lymphocytic leukocytosis[ncbi.nlm.nih.gov]

  • Cryopyrin-Associated Periodic Syndrome

    Patients may have lymphadenopathy and/or hepatosplenomegaly. The CINCA/NOMID syndrome typically presents shortly after birth.[clevelandclinicmeded.com] Apart from intermittent attacks of fever, the clinical manifestations are bone and muscle pain, arthralgia or arthritis, and lymphadenopathy [ 8 ].[musculoskeletalkey.com] Diagnostic methods Diagnosis is based on clinical manifestations and on laboratory findings revealing generalized leukocytosis and neurophilia along with others elevated acute[orpha.net]

  • Philadelphia Chromosome Positive Chronic Myeloid Leukemia

    A 12 -year -male child with generalized lymphadenopathy and hepatosplenomegaly had a crisis phase of presentation instead of the usual chronic phase of onset of disease.[ajmhs.org] Petechiae, ecchymoses, and lymphadenopathy are remarkable findings on the physical exam in the later stages. The disease progresses towards a blast crisis.[symptoma.com] A previously healthy 11 year-old-white boy presented with persistent mild leukocytosis and a posterior mediastinal mass.[ncbi.nlm.nih.gov]

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