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603 Possible Causes for Hepatosplenomegaly, Leukocytosis, Splenomegaly

  • Infectious Mononucleosis

    Both cases involved young adults presenting with fever, pharyngitis, lymphadenopathy, hepatosplenomegaly, and atypical lymphocytosis confirmed by serologic tests, liver biopsy[ncbi.nlm.nih.gov] Clinical estimates of splenomegaly are fallible.[ncbi.nlm.nih.gov] Sprunt, Frank Alexander Evans (1889-1956): Mononuclear leukocytosis in reaction to acute infection (infectious mononucleosis).[whonamedit.com]

  • Adult-Onset Still Disease

    […] clinically by high spiking fever, polyarthralgia/arthritis, a salmon-pink evanescent rash, predominantly neutrophilic leucocytosis, lymphadenopathy, liver dysfunction, and splenomegaly[ncbi.nlm.nih.gov] […] systemic inflammatory disease which presents with cardinal symptoms of spiking fever, arthralgia, and characteristic non pruritic evanescent salmon pink rash and neutrophilic leukocytosis[ncbi.nlm.nih.gov] Other common manifestations of AOSD are lymphadenopathy, hepatosplenomegaly, muscle aches, and pharyngitis.[symptoma.com]

  • Primary Myelofibrosis

    The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[ncbi.nlm.nih.gov] We report a patient with very advanced myelofibrosis and huge splenomegaly who showed a complete hematological response to low dose thalidomide with reversal of splenomegaly[ncbi.nlm.nih.gov] Leukocytosis is occasionally seen in patients with presumptive but undiagnosed myeloproliferative disorders (MPD).[ncbi.nlm.nih.gov]

  • Myeloproliferative Disease

    Marked myeloid proliferation, anemia, thrombocytopenia and hepatosplenomegaly were present; leukocyte alkaline phosphatase and fetal hemoglobin were moderately elevated.[ncbi.nlm.nih.gov] CML: demonstrates increased production of neutrophils and marked splenomegaly.[ncbi.nlm.nih.gov] […] a Philadelphia (Ph) chromosome without DNA breakpoints in the M-bcr region; (3) the spontaneous loss of detectable Ph-positive cells, 5 years after the first finding of leukocytosis[ncbi.nlm.nih.gov]

  • Leukemia

    […] lymphocytic leukemia is a rare form of leukemia, caused by clonal proliferation of cytotoxic T-cells, characterized by modest lymphocytosis and cytopenias of other lineage with hepatosplenomegaly[ncbi.nlm.nih.gov] Five features were present in 50% of children: hepatomegaly (64%), splenomegaly (61%), pallor (54%), fever (53%) and bruising (52%).[ncbi.nlm.nih.gov] Evaluation Step 0: Leukocytosis ( White Blood Cell Count 11,000/mm3) Confirmed with a second Complete Blood Count with differential No other obvious cause for Leukocytosis[fpnotebook.com]

  • Polycythemia Vera

    […] symptoms in the phase 3 RESPONSE study of patients with polycythemia vera with splenomegaly who experienced an inadequate response to or adverse effects from hydroxyurea.[ncbi.nlm.nih.gov] During multivariable analysis, leukocytosis 15 10 9 /l, palpable splenomegaly and grade 1 BM reticulin fibrosis remained significant.[ncbi.nlm.nih.gov] Interferon alfa has been demonstrated in small anecdotal studies to possibly be useful in patients who have relapsed or progressed into AMM or with large hepatosplenomegaly[apicareonline.com]

  • Chronic Lymphocytic Leukemia

    III Lymphocytosis; lymphadenopathy; hepatosplenomegaly, anemia IV Lymphocytosis, lymphadenopathy; hepatosplenomegaly, thrombocytopenia anemia CHRONIC LYMPHOCYTIC LEUKEMIA[medical-dictionary.thefreedictionary.com] One month later, he presented with progressive leukocytosis (mostly neutrophilia) and splenomegaly.[ncbi.nlm.nih.gov] In the physical examination, generalized lymphadenopathy and hepato- and/or splenomegaly may be noted.[symptoma.com]

  • Thalassemia

    Hypertrichosis, erythrodontia and reddish-colored urine are often present, as well as hemolytic anemia accompanied by hepatosplenomegaly.[ncbi.nlm.nih.gov] Approach to the adult patient with splenomegaly and other splenic disorders. . Accessed June 14, 2016. Splenomegaly. Merck Manual Professional Version. .[mayoclinic.org] While thrombocytic counts are generally unaltered, leukocytosis may be detected.[symptoma.com]

  • Chronic Myeloid Leukemia

    Due to presenting complaint of bleeding diathesis and absence of hepatosplenomegaly, the case was undiagnosed for CML until the patient reported to us.[ncbi.nlm.nih.gov] Three of 4 TKI-treated patients did not reach complete hematologic response due to the persistence of thrombocytosis and/or splenomegaly.[ncbi.nlm.nih.gov] Her disease was managed during pregnancy using interferon-α alone despite persistent leukocytosis.[ncbi.nlm.nih.gov]

  • Juvenile Onset Stills Disease

    Appearance of rash, hepatosplenomegaly, serositis and generalized lymphadenopathy.[symptoma.com] […] one of the following manifestations: skin rash (evanescent, non-fixed erythematous rash that accompanies fever spikes), generalized lymphadenopathy, hepatomegaly and/or splenomegaly[stillsdisease.org] Lymphadenopathy, splenomegaly, hepatomegaly, and sore throat are also common.[slideshare.net]

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