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273 Possible Causes for Hepatosplenomegaly, Mediastinal Lymphadenopathy

  • Tuberculosis

    He had mild pallor with mild hepatosplenomegaly. He had high inflammatory markers with pancytopenia in a peripheral blood smear.[] In conclusion, TB-chylothorax may develop without obvious mediastinal lymphadenopathy and be associated with tubercular empyema alone.[] lymphadenopathy on CT imaging.[]

  • Multicentric Castleman's Disease

    Multicentric Castleman's disease (MCD) typically presents with constitutional symptoms, generalized peripheral lymphadenopathy, hepatosplenomegaly, and laboratory markers[] He exhibited an accelerated erythrosedimentation rate, polyclonal hypergammaglobulinemia, and multiple cervical and thoracic mediastinal lymphadenopathies.[] It manifests by fever, diffuse lymphadenopathy, hepatosplenomegaly, Involvement of the respiratory system and increased C-reactive protein.[]

  • Acute Lymphoblastic Leukemia

    Massive hepatosplenomegaly as a presentation of ALL has not been described previously in any patient population.[] Bulky lymphadenopathy, mediastinal involvement, and high white blood cell counts appear to be more common in younger patients than in older ones. 3 Elderly patients are more[] Symptoms related to a large mediastinal mass (eg, shortness of breath), particularly with T-cell lymphoblastic leukemia/lymphoma (T-ALL) Bone pain (can be severe and often[]

  • Primary Myelofibrosis

    The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[] lymphadenopathy and splenomegaly Laboratory values: WBC: 1.9 x 10 3 cells/mm 3 ANC: 1.4 x 10 3 cells/mm 3 Hb: 9.1 gm/dl Platelets: 77,000 cells/mm 3 Bone marrow biopsy: MF[] Most of them had anemia, fever, and hepatosplenomegaly on admission.[]

  • Visceral Larva Migrans

    Snapshot A 2-year-old boy is a dmit ted to t he hospital with a history of wheezing that is found to have hepatosplenomegaly and a prominent peripheral blood eosinophilia.[] We report a case of visceral larva migrans in an adult with fever, night sweats, weight loss, hilar and mediastinal lymphadenopathy, bilateral pleural effusion, and eosinophilia-mimicking[] In this study, the adult patient presented with eosinophilic cellulitis, hepatosplenomegaly, anemia, and a positive ELISA for T. canis.[]

  • Adult-Onset Still Disease

    Other common manifestations of AOSD are lymphadenopathy, hepatosplenomegaly, muscle aches, and pharyngitis.[] CT scan showed enlarged cervical and mediastinal lymphadenopathy.[] […] genetic factors, immune dysfunction and infections Clinical features Systemic inflammatory disease manifesting with spiking fever, sore throat, arthralgia, skin rash and hepatosplenomegaly[]

  • Castleman Disease

    For multicentric disease: multi-region CT bilateral hilar and mediastinal lymphadenopathy centrilobular nodules diffuse abdominal lymphadenopathy hepatosplenomegaly ascites[] Affected patients usually present with mediastinal lymphadenopathy; sometimes other groups of lymph nodes are involved, with or without associated systemic manifestations.[] […] in the groin , neck , or armpit Unintentional loss of weight In some cases fever and weakness Easy fatigue Appetite loss or extremely poor appetite Lymph node enlargement Hepatosplenomegaly[]

  • Coccidioidomycosis

    […] or processes. 6 7 Lumbar spine, lower extremity, and follow-up chest radiographs were obtained to stage progression of her disease revealing increased heart size, massive hepatosplenomegaly[] Computer Tomography revealed multiple bilateral pulmonary nodules with mediastinal lymphadenopathy.[] Liver and spleen involvement may be demonstrated on CT as diffuse hepatosplenomegaly or focal low density parenchymal lesions. 8, 38 A radionuclide liver-spleen scan may demonstrate[]

  • African Histoplasmosis

    On clinical examination, neither hepatosplenomegaly nor lymphadenopathy was found. Examination of other systems revealed no significant abnormality.[] The presence of calcified mediastinal lymphadenopathy is highly suggestive of histoplasmosis in this case.[] The most common physical findings include rales, hepatosplenomegaly and lymphadenopathy.[]

  • Histoplasmosis

    A 48-year-old human immunodeficiency virus (HIV)-negative man with cervical and mediastinal lymphadenopathy, hepatosplenomegaly, adrenal mass, and bone marrow involvement[] In this study we estimate the diagnostic yield of conventional TBNA (cTBNA) and EBUS-TBNA for the diagnosis of histoplasmosis in patients with mediastinal lymphadenopathy.[] The manifestations of disseminated form of histoplasmosis are fever, weakness, weight loss, hepatosplenomegaly, and mucocutaneous lesions.[]

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