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894 Possible Causes for Hepatosplenomegaly, Pallor

  • Familial Myelofibrosis

    The illness presented with pallor, haemorrhagic symptoms, and hepatosplenomegaly, and the blood picture was that of pancytopenia and leucoerythroblastosis.[ncbi.nlm.nih.gov] Hepatosplenomegaly may cause irritability, feeding difficulties, loss of appetite and weight. Children may complain about abdominal pain.[symptoma.com] The illness presented with pallor, haemorrhagic symptoms, and hepatosplenomegaly, and the blood picture was that of pancytopenia and leucoerythroblastosis.[ncbi.nlm.nih.gov]

  • Gaucher Disease

    Abstract The hematologist is at the forefront of specialists to whom patients with Gaucher disease present because of cytopenia and hepatosplenomegaly.[ncbi.nlm.nih.gov] […] reactions, occurring in 2 or more patients, included abdominal pain, agitation, fever, chills, diarrhea, eczema, edema, hypertension, irritability, laryngeal edema, nausea, pallor[aetna.com] The phenotype was unusually severe with congenital ichthyosis, hepatosplenomegaly, muscular hypotonia, myoclonus and respiratory failure.[ncbi.nlm.nih.gov]

  • ALK+ Histiocytosis

    Anemia, thrombocytopenia, and hepatosplenomegaly are the hallmarks of ALK H.[symptoma.com] General pathology Genetic and developmental anomalies ALK histiocytosis See also histiocytoses ALK immunoreactivity Clinical synopsis pallor massive hepatosplenomegaly anemia[humpath.com] The patients presented with pallor, massive hepatosplenomegaly, anemia, and thrombocytopenia.[ncbi.nlm.nih.gov]

  • Aggressive Systemic Mastocytosis

    The patient was a 37-week-old male, born by caesarean section owing to hepatosplenomegaly and ascites diagnosed in utero, who exhibited extensive cutaneous and systemic manifestations[ncbi.nlm.nih.gov] In fact, bone marrow failure is associated with cytopenias and patients suffering from anemia, leukopenia, or thrombocytopenia may present with pallor, weakness, and fatigue[symptoma.com] Respective clinical findings (so called C-Findings) include cytopenias, osteolysis (or osteoporosis) with pathologic fractures, hepatosplenomegaly with impaired liver function[ncbi.nlm.nih.gov]

  • Autoimmune Hemolytic Anemia

    CASE CHARACTERISTICS: A 7-month-old boy, presented with prolonged fever, erythematous rash, severe pallor and hepatosplenomegaly.[ncbi.nlm.nih.gov] Computed tomography (CT) of the chest, abdomen and pelvis was remarkable for hepatosplenomegaly.[dx.doi.org] CASE PRESENTATION: An otherwise seemingly normal girl, who had developed limping at the age of 11 months old, referred to Namazi Hospital, Shiraz, Iran, due to pallor and[ncbi.nlm.nih.gov]

  • Thalassemia

    They have severe anemia and hepatosplenomegaly. Untreated children have severe failure to thrive and shortened life expectancy.[meddean.luc.edu] Clinical description Onset is during infancy with severe anemia, failure to thrive and progressive pallor.[orpha.net] Some infants become progressively pale (pallor).[rarediseases.org]

  • Primary Myelofibrosis

    The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[ncbi.nlm.nih.gov] Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[orpha.net] Skin pallor (caused by anemia) may also be noticeable.[aoporphan.com]

  • Acute Lymphoblastic Leukemia

    Massive hepatosplenomegaly as a presentation of ALL has not been described previously in any patient population.[ncbi.nlm.nih.gov] […] leukemia that is marked by an abnormal increase in the number of lymphoblasts, that is characterized by rapid onset and progression of symptoms which include fever, anemia, pallor[merriam-webster.com] Physical examination reveals pallor and multiple ecchymoses on his arms, legs, and trunk.[doi.org]

  • Acute Leukemia

    Physical examination showed jaundice, hepatosplenomegaly, and peripheral facial nerve palsy in addition to dermal nodules.[ncbi.nlm.nih.gov] The first case is a 4-year-old girl who presented with pallor and abdominal enlargement.[ncbi.nlm.nih.gov] Symptoms include anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, bone pain, lymphadenopathy, hepatosplenomegaly,[medical-dictionary.thefreedictionary.com]

  • Waldenstrom Macroglobulinemia

    Clinical features include anemia, thrombocytopenia, hepatosplenomegaly, lymphadenopathy, and rarely hyperviscosity.[ncbi.nlm.nih.gov] However, the patient also reported a one-year history of painful pallor in his digits; therefore, further rheumatologic workup for presumed Raynaud’s phenomenon was requested[the-rheumatologist.org] The patient had lymphadenopathy and hepatosplenomegaly.[ncbi.nlm.nih.gov]

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