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867 Possible Causes for Hepatosplenomegaly, Pancytopenia

  • Infectious Mononucleosis

    Both cases involved young adults presenting with fever, pharyngitis, lymphadenopathy, hepatosplenomegaly, and atypical lymphocytosis confirmed by serologic tests, liver biopsy[ncbi.nlm.nih.gov] […] infection as an adult is a risk factor for the development of multiple sclerosis. [1, 2] Hematologic complications can include development of autoimmune hemolytic anemia, pancytopenia[emedicine.medscape.com] She presented with fever, skin rash, lymphadenopathy, and hepatosplenomegaly.[ncbi.nlm.nih.gov]

  • Familial Myelofibrosis

    The illness presented with pallor, haemorrhagic symptoms, and hepatosplenomegaly, and the blood picture was that of pancytopenia and leucoerythroblastosis.[ncbi.nlm.nih.gov] Hepatosplenomegaly may cause irritability, feeding difficulties, loss of appetite and weight. Children may complain about abdominal pain.[symptoma.com] The illness presented with pallor, haemorrhagic symptoms, and hepatosplenomegaly, and the blood picture was that of pancytopenia and leucoerythroblastosis.[ncbi.nlm.nih.gov]

  • Hepatosplenic T-cell Lymphoma

    Abstract We report a case of a man presenting with an unexplained fever, pancytopenia and hepatosplenomegaly without lymphadenopathy.[ncbi.nlm.nih.gov] Patients presented with fatigue, hepatosplenomegaly, and pancytopenia.[ncbi.nlm.nih.gov] Initial blood work showed mild pancytopaenia and imaging studies revealed hepatosplenomegaly.[ncbi.nlm.nih.gov]

  • Malignant Histiocytosis

    Abstract A 70-year-old woman was admitted for evaluation of hepatosplenomegaly, fever and elevated serum LDH levels.[ncbi.nlm.nih.gov] […] pancreas at initial presentation is exceptional, this entity should be included in the differential diagnosis of acute pancreatitis, especially when hepatosplenomegaly and pancytopenia[ncbi.nlm.nih.gov] Her clinical course was complicated in the last year by several infectious and noninfectious events, and after pancytopenia, fever, and extremely high levels of lactate dehydrogenase[ncbi.nlm.nih.gov]

  • Visceral Leishmaniasis

    The infant suffered from intermittent fever for 5 weeks, and hepatosplenomegaly and pancytopenia, and was successfully treated with a short course of liposomal amphotericin[ncbi.nlm.nih.gov] We present an unusual case of febrile pancytopenia in a nonagenarian who was diagnosed with visceral leishmaniasis.[ncbi.nlm.nih.gov] Infection is characterized by pancytopenia (anemia, thrombocytopenia, neutropenia), hepatosplenomegaly, fever, and severe immunosuppression that can lead to fatal opportunistic[symptoma.com]

  • Niemann-Pick Disease

    These patients may have mild hepatosplenomegaly, but the central nervous system is profoundly affected.[ncbi.nlm.nih.gov] Patients with type B NPD have minimal neurologic involvement but pancytopenia is common.[symptoma.com] Pancytopenia is common.[msdmanuals.com]

  • Hairy Cell Leukemia

    Abdominal discomfort is a common symptom, resulting from hepatosplenomegaly.[orpha.net] We should keep in mind other reasons for vasculitis such as lymphoproliferative disease, especially whose who have hematological abnormalities such as pancytopenia. 2014 Asia[ncbi.nlm.nih.gov] […] than 5% and reduction of more than 50% of HCs in the bone marrow, (3) normalization of peripheral blood counts, and (4) more than 50% reduction of abnormal adenopathy or hepatosplenomegaly[doi.org]

  • Aggressive Systemic Mastocytosis

    The patient was a 37-week-old male, born by caesarean section owing to hepatosplenomegaly and ascites diagnosed in utero, who exhibited extensive cutaneous and systemic manifestations[ncbi.nlm.nih.gov] […] organomegaly and organ dysfunction, impairment of hematopoietic function (which may result in disruption of the blood count ranging from isolated cytopenia to more or less marked pancytopenia[orpha.net] Respective clinical findings (so called C-Findings) include cytopenias, osteolysis (or osteoporosis) with pathologic fractures, hepatosplenomegaly with impaired liver function[ncbi.nlm.nih.gov]

  • Systemic Mastocytosis

    We report the case of a 48-year old male patient who presented with hepatosplenomegaly for 12 years, yellow-brown colored maculopapular pigmentation on the skin and pancytopenia[sciforschenonline.org] The disease progressed rapidly and severe pancytopenia and recurrent upper gastrointestinal bleeding became the dominant problem.[ncbi.nlm.nih.gov] […] organomegaly and organ dysfunction, impairment of hematopoietic function (which may result in disruption of the blood count ranging from isolated cytopenia to more or less marked pancytopenia[orpha.net]

  • Multicentric Castleman's Disease

    It manifests by fever, diffuse lymphadenopathy, hepatosplenomegaly, Involvement of the respiratory system and increased C-reactive protein.[orpha.net] Diffuse lymph-node enlargement, splenomegaly and pancytopenia were detected. Induction with Rituximab was made because pancytopenia was present.[ncbi.nlm.nih.gov] Multicentric Castleman's disease (MCD) typically presents with constitutional symptoms, generalized peripheral lymphadenopathy, hepatosplenomegaly, and laboratory markers[ncbi.nlm.nih.gov]

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