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1,201 Possible Causes for Hepatosplenomegaly, Pancytopenia

  • Tuberculosis

    He had mild pallor with mild hepatosplenomegaly. He had high inflammatory markers with pancytopenia in a peripheral blood smear.[ncbi.nlm.nih.gov] Extrapulmonary tuberculosis can present with various hematological manifestations, including pancytopenia.[ncbi.nlm.nih.gov] He had high inflammatory markers with pancytopenia in a peripheral blood smear. His chest radiograph was unremarkable, and he had a negative Mantoux test result.[ncbi.nlm.nih.gov]

  • Niemann-Pick Disease

    Hepatosplenomegaly is a hallmark of both types of NPD and lymphadenopathy may occur in patients with type B.[symptoma.com] Pancytopenia is common.[msdmanuals.com] These patients may have mild hepatosplenomegaly, but the central nervous system is profoundly affected.[ncbi.nlm.nih.gov]

  • Leukemia

    Hepatosplenomegaly and lymphadenopathy are rare in adults with acute myelogenous leukemia, but are present in about 50% of adults with acute lymphoblastic leukemia. 12 Central[aafp.org] Bone marrow examination Histochemical studies, cytogenetics, immunophenotyping, and molecular biology studies Imaging CBC and peripheral smear are the first tests done; pancytopenia[merckmanuals.com] […] familial exposure to radiation during cancer treatment and strategies to help limit incidental contact with potentially harmful byproducts. more » A 47-Year-Old Woman with Pancytopenia[cancertherapyadvisor.com]

  • Brucellosis

    Brucellosis is a systemic zoonotic infectious disease that may cause fever, fatigue, sweating, arthritis, hepatosplenomegaly, cytopenia, and lymphadenopathy.[ncbi.nlm.nih.gov] Pancytopenia improved with treatment of brucellosis on all patients.[ncbi.nlm.nih.gov] The diagnostic criteria include fever, hepatosplenomegaly, bicytopenia, high serum ferritin level, decreased natural killer cell activity, elevated soluble CD25 level, high[ncbi.nlm.nih.gov]

  • T-cell Acute Lymphoblastic Leukemia

    A 6-year-old male presented with a testicular mass, hepatosplenomegaly, and a pleural effusion while undergoing maintenance chemotherapy for treatment of T-cell acute lymphoblastic[ncbi.nlm.nih.gov] The patient was a 16-year-old boy who presented with septic shock and pancytopenia, likely precipitated by an acute parvovirus B19 infection.[ncbi.nlm.nih.gov] In comparison, patients 16 to 60 years old (n 21) more commonly had an anterior mediastinal mass (8 [38%]), hepatosplenomegaly (10 [48%]), and lymphadenopathy (16 [76%]).[academic.oup.com]

  • Primary Myelofibrosis

    The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[ncbi.nlm.nih.gov] Primary myelofibrosis is a unique entity among BCR-ABL-negative myeloproliferative diseases, manifesting as bone marrow fibrosis and pancytopenia.[ncbi.nlm.nih.gov] This is then followed by pancytopenia (a reduction in the number of red and white blood cells, as well as platelets).[aoporphan.com]

  • Acute Leukemia

    Physical examination showed jaundice, hepatosplenomegaly, and peripheral facial nerve palsy in addition to dermal nodules.[ncbi.nlm.nih.gov] Pancytopenia in her secondary MF phase responded well to the therapy of corticosteroids, which indicated that the immune mechanism was involved in the pathogenesis of MF.[ncbi.nlm.nih.gov] Symptoms include anemia, fatigue, weight loss, easy bruising, thrombocytopenia, granulocytopenia with bacterial infections, bone pain, lymphadenopathy, hepatosplenomegaly,[medical-dictionary.thefreedictionary.com]

  • Malignant Histiocytosis

    A 70-year-old woman was admitted for evaluation of hepatosplenomegaly, fever and elevated serum LDH levels.[ncbi.nlm.nih.gov] […] pancreas at initial presentation is exceptional, this entity should be included in the differential diagnosis of acute pancreatitis, especially when hepatosplenomegaly and pancytopenia[ncbi.nlm.nih.gov] Her clinical course was complicated in the last year by several infectious and noninfectious events, and after pancytopenia, fever, and extremely high levels of lactate dehydrogenase[ncbi.nlm.nih.gov]

  • Chronic Lymphocytic Leukemia

    III Lymphocytosis; lymphadenopathy; hepatosplenomegaly, anemia IV Lymphocytosis, lymphadenopathy; hepatosplenomegaly, thrombocytopenia anemia CHRONIC LYMPHOCYTIC LEUKEMIA[medical-dictionary.thefreedictionary.com] The symptoms of this infection range from a silent infection to fever, enlargement of the liver and spleen, weight loss, and pancytopenia.[ncbi.nlm.nih.gov] Brentuximab vedotin had a transient effect, but the patient died of sepsis due to residual PTCL and pancytopenia.[ncbi.nlm.nih.gov]

  • Visceral Leishmaniasis

    VL should be considered in the differential diagnosis in returning travellers presenting with prolonged fever, hepatosplenomegaly and/or pancytopenia.[ncbi.nlm.nih.gov] We present an unusual case of febrile pancytopenia in a nonagenarian who was diagnosed with visceral leishmaniasis.[ncbi.nlm.nih.gov] The disease presented with fatigue, anemia, and hepatosplenomegaly in a 61-year-old man with human immunodeficiency virus (HIV) infection who was receiving antiretroviral[ncbi.nlm.nih.gov]

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