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805 Possible Causes for Hepatosplenomegaly, Petechiae

  • Infectious Mononucleosis

    Both cases involved young adults presenting with fever, pharyngitis, lymphadenopathy, hepatosplenomegaly, and atypical lymphocytosis confirmed by serologic tests, liver biopsy[ncbi.nlm.nih.gov] In adolescent and adult patients presenting with sore throat, the presence of posterior cervical, inguinal or axillary adenopathy, palatine petechiae, splenomegaly, or atypical[ncbi.nlm.nih.gov] Third, the frequency of CD4CXCR5ICOSPD1 Tfh subset was significantly higher in lymphadenectasis or hepatosplenomegaly patients, and associated with the level of alanine aminotransferase[ncbi.nlm.nih.gov]

  • Pharyngitis

    Presence of hepatosplenomegaly or lymphadenopathy outside the cervical region should raise suspicions regarding an underlying malignancy.[ncbi.nlm.nih.gov] There may be Pasita lines (petechiae) in the antecubital fossa area. May be accentuated in the underpants area.[pedclerk.bsd.uchicago.edu] When streptococcal pharyngitis is suspected, the physician should listen for the presence of a heart murmur and evaluate the patient for hepatosplenomegaly.[aafp.org]

  • Leukemia

    Hepatosplenomegaly and lymphadenopathy are rare in adults with acute myelogenous leukemia, but are present in about 50% of adults with acute lymphoblastic leukemia. 12 Central[aafp.org] "Petechiae usually appears on the lower extremities," Wadleigh adds.[prevention.com] Petechiae (small red spots under the skin caused by bleeding) iStock/lzf Dr. Crilley describes petechiae as “like someone painted little red dots with a pen.”[rd.com]

  • Relapsing Fever

    Her condition deteriorated a few hours after admission when jaundice, hepatosplenomegaly, and hemorrhage appeared.[jamanetwork.com] Papules (small lumps), petechiae (small red or purple spots due to bleeding into the skin), purpura (bleeding into the skin, includes petechiae and bruises), and facial flushing[dermnetnz.org] […] recurring fever or in those who have traveled to the developing world or who have a history of tick exposure, especially if accompanied by hemolytic anemia, thrombocytopenia, or hepatosplenomegaly[mdedge.com]

  • Wiskott Aldrich Syndrome

    Epstein-Barr virus (EBV)-associated post-transplantation lymphoproliferative disorder (PTLD) of donor cell origin and hemophagocytosis syndrome with fever, lymphadenopathy, hepatosplenomegaly[ncbi.nlm.nih.gov] Thrasher; used with consent given by parents History & Exam Key Factors FHx of WAS easy bruising and petechiae Other Factors serious bleeding recurrent infections serious[online.epocrates.com] […] infections: Candida albicans thrombocytopenia recurrent bleeding , especially in first days of life petechiae purpura easy bruising hematemesis epistaxis hematuria chronic eczema hepatosplenomegaly[step1.medbullets.com]

  • Primary Myelofibrosis

    The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[ncbi.nlm.nih.gov] Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy[orpha.net] Other physical findings include : Petechiae and ecchymosis (20%) Lymphadenopathy (10-20%) Signs of portal hypertension (10-18%) Gout (6%) Tefferi A.[emedicine.medscape.com]

  • Typhus

    Other patients go on to develop a more serious disease, in which encephalitis, pneumonia, and swelling of the liver and spleen (hepatosplenomegaly) occur.[encyclopedia.com] […] myalgia nausea vomiting Physical exam hypotension fever photophobia early rash light rose color and blanches under pressure late rash dull red that does not fade scattered petechiae[step2.medbullets.com]

  • Rocky Mountain Spotted Fever

    Some individuals with RMSF may also develop abnormal enlargement of the liver and/or spleen (hepatosplenomegaly).[rarediseases.org] Areas of petechiae may result in tiny scars. In rare cases, severe necrosis and gangrene may require amputation.[dermnetnz.org] Vasculitis is marked by palpable purpura rather than petechiae. Drug eruptions will have a history of exposure.[visualdx.com]

  • Chronic Lymphocytic Leukemia

    III Lymphocytosis; lymphadenopathy; hepatosplenomegaly, anemia IV Lymphocytosis, lymphadenopathy; hepatosplenomegaly, thrombocytopenia anemia CHRONIC LYMPHOCYTIC LEUKEMIA[medical-dictionary.thefreedictionary.com] Mucocutaneous bleeding and/or petechiae may be due to thrombocytopenia.[emedicine.medscape.com] The most common treatment-related AEs (reported in at least 5 percent of patients) were headache (20 percent), an increased tendency to bruise (12 percent) and petechiae ([curetoday.com]

  • Babesiosis

    Jaundice, hepatosplenomegaly, anemia and conjugated hyperbilirubinemia developed in this preterm infant.[ncbi.nlm.nih.gov] Petechiae (small red or purple spots due to bleeding into the skin) and bruises may occur, most likely due to thrombocytopenia (low platelets , which causes abnormal blood[dermnetnz.org] The signs and symptoms include fever , chills, sweating, myalgias (muscle aches), fatigue , hepatosplenomegaly (enlargement of the liver and spleen) and hemolytic anemia ([medicinenet.com]

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