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52 Possible Causes for Hepatosplenomegaly, Polychromasia in Peripheral Blood Smear

  • Congenital Dyserythropoietic Anemia Type 1

    Most affected individuals have hepatosplenomegaly and iron does not accumulate in tissues and organs.[] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[] Many affected individuals have yellowing of the skin and eyes ( jaundice ) and an enlarged liver and spleen ( hepatosplenomegaly ).[]

  • Paroxysmal Cold Hemoglobinuria

    Hepatosplenomegaly may complete the clinical picture, as can microthrombosis which is an uncommon manifestation.[] Tests include complete blood count (CBC) and peripheral smear.[] Temporary hepatosplenomegaly and mild hyperbilirubinemia may follow the onset of an attack. paroxysmal cold hemoglobinuria Hematology A disorder that is: (1) Rarely 'paroxysmal[]

  • Autoimmune Hemolytic Anemia

    A 7-month-old boy, presented with prolonged fever, erythematous rash, severe pallor and hepatosplenomegaly.[] Peripheral blood smear showed polychromasia and spherocytosis. Haptoglobin level was 0.06 g/L ( N 0.16-2). Both hemoglobin electrophoresis and G6PD level were normal.[] Computed tomography (CT) of the chest, abdomen and pelvis was remarkable for hepatosplenomegaly.[]

  • African Histoplasmosis

    Severe infections can cause hepatosplenomegaly, lymphadenopathy, and adrenal enlargement. Lesions have a tendency to calcify as they heal.[] Peripheral smear showed microcytic hypochromic red blood cells, anisopoikilocytosis, polychromasia and reduced leucocyte count and toxic granules with no evidence of hemolysis[] On clinical examination, neither hepatosplenomegaly nor lymphadenopathy was found. Examination of other systems revealed no significant abnormality.[]

  • Congenital Dyserythropoietic Anemia

    Most affected individuals do not have hepatosplenomegaly, and iron does not build up in tissues and organs.[] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[] Abstract Congenital dyserythropoietic anemia (CDA) is a rare disorder, which manifests clinically with varying degrees of anemia and hepatosplenomegaly.[]

  • Juvenile Myelomonocytic Leukemia

    We report a case of a 9-month-old child, without a known diagnosis of neurofibromatosis 1, who presented with hepatosplenomegaly, anemia, thrombocytopenia, and multiple cutaneous[] […] cells on peripheral blood smear ( Figure ).[] The cutaneous lesion and hepatosplenomegaly were improved at the time of discharge.[]

  • Pancytopenia

    We present case of two Syrian refugee infants with severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis.[] blood smear examination for which Leishman stain was used.[] He had mild pallor with mild hepatosplenomegaly. He had high inflammatory markers with pancytopenia in a peripheral blood smear.[]

  • Secondary Myelofibrosis

    Anemia and hepatosplenomegaly are common reasons for referring a child to a pediatric hematologist or oncologist.[] The peripheral smear of patients with primary myelofibrosis includes red blood cells of variable shape (including tear drop cells) and size and variable degrees of polychromasia[] PHP was diagnosed together with hepatosplenomegaly and pancytopenia. Bone marrow biopsy revealed grade 3-4 reticulin fibrosis.[]

  • Cold Agglutinin Disease

    Symptoms during hemolytic crises'' may include severe pain in the back and legs, headache, vomiting, diarrhea, dark urine and hepatosplenomegaly.[] Reticulocytes and Spherocytes The results of the reticulocyte count are usually increased in patients with cold agglutinin disease, with polychromasia in the peripheral blood[] Other laboratory findings include reticulocytosis, positive DAT, auto agglutination and/or rouleaux on peripheral blood smear, polychromasia, and mild to moderate anisocytosis[]

  • Acquired Sideroblastic Anemia

    Acute myelosclerosis is an unusual myeloproliferative syndrome characterized by pancytopenia, absence of massive hepatosplenomegaly, and an absence of tear-drop poikilocytes[] Blood Smear Peripheral blood smear images .[] There is usually no palpable hepatosplenomegaly or lymph node enlargement. The clinical course is remarkable short.[]

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