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52 Possible Causes for Hepatosplenomegaly, Polychromasia in Peripheral Blood Smear

  • Congenital Dyserythropoietic Anemia Type 1

    Most affected individuals have hepatosplenomegaly and iron does not accumulate in tissues and organs.[ivami.com] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[unboundmedicine.com] Many affected individuals have yellowing of the skin and eyes ( jaundice ) and an enlarged liver and spleen ( hepatosplenomegaly ).[rarediseases.info.nih.gov]

  • Paroxysmal Cold Hemoglobinuria

    Hepatosplenomegaly may complete the clinical picture, as can microthrombosis which is an uncommon manifestation.[symptoma.com] Tests include complete blood count (CBC) and peripheral smear.[emedicine.com] Temporary hepatosplenomegaly and mild hyperbilirubinemia may follow the onset of an attack. paroxysmal cold hemoglobinuria Hematology A disorder that is: (1) Rarely 'paroxysmal[medical-dictionary.thefreedictionary.com]

  • Autoimmune Hemolytic Anemia

    A 7-month-old boy, presented with prolonged fever, erythematous rash, severe pallor and hepatosplenomegaly.[ncbi.nlm.nih.gov] Peripheral blood smear showed polychromasia and spherocytosis. Haptoglobin level was 0.06 g/L ( N 0.16-2). Both hemoglobin electrophoresis and G6PD level were normal.[jahjournal.org] Computed tomography (CT) of the chest, abdomen and pelvis was remarkable for hepatosplenomegaly.[doi.org]

  • African Histoplasmosis

    Severe infections can cause hepatosplenomegaly, lymphadenopathy, and adrenal enlargement. Lesions have a tendency to calcify as they heal.[en.wikipedia.org] Peripheral smear showed microcytic hypochromic red blood cells, anisopoikilocytosis, polychromasia and reduced leucocyte count and toxic granules with no evidence of hemolysis[ijstd.org] On clinical examination, neither hepatosplenomegaly nor lymphadenopathy was found. Examination of other systems revealed no significant abnormality.[atmph.org]

  • Congenital Dyserythropoietic Anemia

    Most affected individuals do not have hepatosplenomegaly, and iron does not build up in tissues and organs.[ncbi.nlm.nih.gov] Anisopoikilocytosis with tear-drop forms, polychromasia, basophilic stippling in peripheral blood smear, erythroid hyperplasia with megaloblastoid changes, binucleated cells[ncbi.nlm.nih.gov] Abstract Congenital dyserythropoietic anemia (CDA) is a rare disorder, which manifests clinically with varying degrees of anemia and hepatosplenomegaly.[ncbi.nlm.nih.gov]

  • Juvenile Myelomonocytic Leukemia

    We report a case of a 9-month-old child, without a known diagnosis of neurofibromatosis 1, who presented with hepatosplenomegaly, anemia, thrombocytopenia, and multiple cutaneous[ncbi.nlm.nih.gov] […] cells on peripheral blood smear ( Figure ).[consultant360.com] The cutaneous lesion and hepatosplenomegaly were improved at the time of discharge.[ncbi.nlm.nih.gov]

  • Pancytopenia

    We present case of two Syrian refugee infants with severe vitamin B12 deficiency with pancytopenia, hepatosplenomegaly and leukoerythroblastosis.[ncbi.nlm.nih.gov] blood smear examination for which Leishman stain was used.[mjdrdypu.org] He had mild pallor with mild hepatosplenomegaly. He had high inflammatory markers with pancytopenia in a peripheral blood smear.[ncbi.nlm.nih.gov]

  • Secondary Myelofibrosis

    Anemia and hepatosplenomegaly are common reasons for referring a child to a pediatric hematologist or oncologist.[ncbi.nlm.nih.gov] The peripheral smear of patients with primary myelofibrosis includes red blood cells of variable shape (including tear drop cells) and size and variable degrees of polychromasia[mpncanada.com] PHP was diagnosed together with hepatosplenomegaly and pancytopenia. Bone marrow biopsy revealed grade 3-4 reticulin fibrosis.[ncbi.nlm.nih.gov]

  • Cold Agglutinin Disease

    Symptoms during hemolytic crises'' may include severe pain in the back and legs, headache, vomiting, diarrhea, dark urine and hepatosplenomegaly.[web.archive.org] Reticulocytes and Spherocytes The results of the reticulocyte count are usually increased in patients with cold agglutinin disease, with polychromasia in the peripheral blood[web.archive.org] Other laboratory findings include reticulocytosis, positive DAT, auto agglutination and/or rouleaux on peripheral blood smear, polychromasia, and mild to moderate anisocytosis[keralamedicaljournal.com]

  • Acquired Sideroblastic Anemia

    Acute myelosclerosis is an unusual myeloproliferative syndrome characterized by pancytopenia, absence of massive hepatosplenomegaly, and an absence of tear-drop poikilocytes[ncbi.nlm.nih.gov] Blood Smear Peripheral blood smear images .[imagebank.hematology.org] There is usually no palpable hepatosplenomegaly or lymph node enlargement. The clinical course is remarkable short.[ncbi.nlm.nih.gov]

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