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34 Possible Causes for Hepatosplenomegaly, Polyclonal Hyperglobulinemia

  • Castleman Disease

    For multicentric disease: multi-region CT bilateral hilar and mediastinal lymphadenopathy centrilobular nodules diffuse abdominal lymphadenopathy hepatosplenomegaly ascites[radiopaedia.org] The disease is characterized by fever, weight loss, anemia, polyclonal hyperglobulinemia, splenomegaly, thrombocytosis and peripheral lymphadenopathy.[ncbi.nlm.nih.gov] , hypoalbuminemia, polyclonal hypergammaglobulinemia, leukocytosis, thrombocytosis or splenomegaly. 1,4 In contrast to the localized form, the clinical course of the multicentric[scielo.br]

  • Multicentric Castleman's Disease

    A 46-year-old man presented with a high-grade fever, multiple lymphadenopathies, hepatosplenomegaly and human immunodeficiency virus (HIV) seropositivity, without severe immunosuppression[ncbi.nlm.nih.gov] hyperglobulinemia, elevated transaminases and renal disease. 2 , 5 , 7 Dispenzieri et al. 8 analyzed the clinical spectrum of Castleman’s disease in 113 patients.[pagepress.org] Multicentric Castleman's disease (MCD) typically presents with constitutional symptoms, generalized peripheral lymphadenopathy, hepatosplenomegaly, and laboratory markers[ncbi.nlm.nih.gov]

  • Angioimmunoblastic Lymphadenopathy

    AILD is characterized by generalized lymphadenopathy, hepatosplenomegaly, immunological abnormalities, polyclonal hypergammaglobulinemia and anemia.[ncbi.nlm.nih.gov] In one series, other symptoms included weight loss (58%), hepatomegaly (60%), polyclonal hyperglobulinemia (65%), and generalized adenopathy (87%).[emedicine.medscape.com] Angioimmunoblastic lymphadenopathy with disproteinemia (AILD) is a systemic lymphoproliferative disorder characterized by constitutional symptoms such as generalized lymphadenopathy, hepatosplenomegaly[ncbi.nlm.nih.gov]

  • Primary Myelofibrosis

    The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever.[ncbi.nlm.nih.gov] Polyclonal hyperglobulinemia may be present. Patients with sporadic idiopathic or familial pulmonary hypertension have significant marrow fibrosis.[patient-help.com] Hepatosplenomegaly may cause upper abdominal pain, portal hypertension and ascites.[symptoma.com]

  • Pediatric Chronic Granulomatous Disease

    In addition, septicopyemia, thrush, and hepatosplenomegaly were also commonly observed, accounting for 23%, 23%, and 40% of the cases.[ncbi.nlm.nih.gov] Polyclonal hyperglobulinemia 3. Elevated acute phase reactants such as ESR or CRP 4. Normal studies of T and B lymphocyte immunity Diagnostic test 1.[clinicalmolecularallergy.biomedcentral.com] Multifocal and recurrent unusual osteomyelitis, recurrent hepatic abscesses, hepatosplenomegaly, and lymphadenitis.[radiopaedia.org]

  • H Syndrome

    H syndrome refers to the major clinical findings of hyperpigmentation, hypertrichosis, hepatosplenomegaly, heart anomalies, hearing loss, hypogonadism, low height, and occasionally[orpha.net] In addition, patients displayed short stature, sensorineural hearing loss, cardiac anomalies, hepatosplenomegaly, and scrotal masses.[ncbi.nlm.nih.gov] 612391) is a recently described autosomal recessive genodermatosis characterized by indurated, hyperpigmented, and hypertrichotic skin and systemic manifestations including hepatosplenomegaly[ncbi.nlm.nih.gov]

  • Autosomal Dominant Autoimmune Lymphoproliferative Syndrome Type 1

    Patients with ALPS can develop a myriad of clinical manifestations including lymphadenopathy, hepatosplenomegaly, autoimmunity and increased rates of malignancy.[ncbi.nlm.nih.gov] NOS ( R77.1 ) monoclonal gammopathy (of undetermined significance) ( D47.2 ) Excludes2 transplant failure and rejection ( T86 .-) D89.0 Polyclonal hypergammaglobulinemia[icd10coded.com] […] autoimmune lymphoproliferative syndrome (ALPS) or Canale-Smith syndrome is a recently described clinical entity consisting of chronic, non-malignant lymphadenopathy and hepatosplenomegaly[ncbi.nlm.nih.gov]

  • Rosai-Dorfman Disease

    Abdomen Hepatosplenomegaly Laboratory Findings Leukocytosis Elevated erythrocyte sedimentation rate ( ESR ) Polyclonal hypergammaglobulinemia References[wikidoc.org] hyperglobulinemia.[ncbi.nlm.nih.gov] A neck-chest-abdomen CT scan showed multiple bilateral cervical lymphadenopathies and homogenous hepatosplenomegaly.[omicsonline.org]

  • Chronic Granulomatous Disease

    Multifocal and recurrent unusual osteomyelitis, recurrent hepatic abscesses, hepatosplenomegaly, and lymphadenitis.[radiopaedia.org] Polyclonal hyperglobulinemia 3. Elevated acute phase reactants such as ESR or CRP 4. Normal studies of T and B lymphocyte immunity Diagnostic test 1.[clinicalmolecularallergy.biomedcentral.com] In addition, septicopyemia, thrush, and hepatosplenomegaly were also commonly observed, accounting for 23%, 23%, and 40% of the cases.[ncbi.nlm.nih.gov]

  • Autoimmune Pancreatitis

    Here, we report an interesting case of a 45-year-old male who presented with haematemesis, melena, and fever, accompanied by hepatosplenomegaly, systemic lymphadenopathy,[ncbi.nlm.nih.gov] hyperglobulinemia.[hematologyandoncology.net] A physical examination may reveal hepatosplenomegaly, peripheral lymphadenopathy, ascites, and pleural effusion. Multicentric CD has a poor prognosis if untreated.[hematologyandoncology.net]

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