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199 Possible Causes for Hereditary Spherocytosis, Lactate Dehydrogenase Increased

  • Hereditary Elliptocytosis

    Diagnostic tests Key laboratory studies comprise a complete blood count (CBC), reticulocyte count, bilirubin, haptoglobin, lactate dehydrogenase (LDH), Coombs test, potassium[symptoma.com] Hereditary elliptocytosis (HE), its aggravated form hereditary pyropoikilocytosis (HPP), and hereditary spherocytosis (HS) designate a set of congenital hemolytic syndromes[ncbi.nlm.nih.gov] Numerous mutations have allowed to reclassify hereditary elliptocytosis (HE) and poikilocytosis (HP), and, more recently, hereditary spherocytosis (HS) into well defined subsets[ncbi.nlm.nih.gov]

  • Autoimmune Hemolytic Anemia

    Unconjugated bilirubin is usually, but not always, elevated and urine urobilinogen is increased. Lactate dehydrogenase is usually elevated into the thousands.[clinlabnavigator.com] spherocytosis) Urinalysis hemoglobinuria hemosiderinuria Differential Diagnosis Treatment Warm agglutinin from best initial therapy to further steps in treatment ladder glucocorticoids[step1.medbullets.com] Increased serum unconjugated bilirubin, increased lactate dehydrogenase (LDH) and reduced or absent haptoglobin. Increased urinary urobilinogen, haemosiderinuria.[patient.info]

  • Hereditary Spherocytosis

    Reticulocytosis, increased bilirubin, increased lactate dehydrogenase, increased urinary and fecal urobilinogen, and decreased haptoglobin, reflect increased erythrocyte production[clinicaladvisor.com] These changes are also seen in non-hereditary spherocytosis, but they are typically more pronounced in hereditary spherocytosis.[en.wikipedia.org] Other biochemical changes of hemolysis also are also present, including: increased lactate dehydrogenase (LDH) increased unconjugated bilirubin decreased serum haptoglobin[steadyhealth.com]

  • Acquired Toxic Hemolytic Anemia

    Breakdown of RBCs releases lactate dehydrogenase and potassium, leading to elevation of both in serum.[accessmedicine.mhmedical.com] spherocytosis - paroxymal nocturnal hemoglobinuria (PNH) - hemoglobinopathia - auto-immunhemolytic anemia (AIHA) - pernicious anemia[thieme-connect.com] Recognize clinical findings associated with hereditary spherocytosis.[pedsinreview.aappublications.org]

  • Paroxysmal Nocturnal Hemoglobinuria

    The effect of eculizumab on intravascular hemolysis was demonstrated by a reduction in lactate dehydrogenase levels at all measurements after baseline.[ncbi.nlm.nih.gov] A 76-year-old man with paroxysmal nocturnal hemoglobinuria and hereditary spherocytosis was started on deferoxamine for iron overload secondary to previous blood transfusions[ncbi.nlm.nih.gov] After approximately 2 years, apart from normalization of the lactate dehydrogenase (LDH) level, there was an increase in glycosylphosphatidylinositol (GPI) negative red cells[nejm.org]

  • Hemolytic Uremic Syndrome

    Following an increase in the dose of eculizumab to 1,500 mg every 2 weeks, lactate dehydrogenase (LDH), proteinuria, and creatinine decreased, and CH50 assay showed 0%.[ncbi.nlm.nih.gov] […] hemolytic anemias D58.0 Hereditary spherocytosis D58.1 Hereditary elliptocytosis D58.2 Other hemoglobinopathies D58.8 Other specified hereditary hemolytic anemias D58.9 Hereditary[icd10data.com] Neurological symptoms occurred at the same time as there was an increase of lactate dehydrogenase and creatinine and the nadir of the platelet count occurred before the onset[bmcresnotes.biomedcentral.com]

  • Microangiopathic Hemolytic Anemia

    Laboratory abnormalities Anemia Increased lactate dehydrogenase. Increased indirect bilirubin. Decreased haptoglobin. Increased urine urobilinogen.[clinicaladvisor.com] We’ve gone through the main hereditary hemolytic anemias: hereditary spherocytosis (and its less-common counterpart, hereditary elliptocytosis ), glucose-6-phosphate dehydrogenase[pathologystudent.com] Characteristic laboratory data are a negative direct antiglobulin (Coombs) test, an increased lactate dehydrogenase (LDH) level, increased indirect bilirubin, and low haptoglobin[springerplus.springeropen.com]

  • Nonimmune Hemolysis

    Increased serum unconjugated bilirubin, increased lactate dehydrogenase (LDH) and reduced or absent haptoglobin. Increased urinary urobilinogen, haemosiderinuria.[patient.info] Hereditary Spherocytosis is the result of what? ankyrin, spectrin, other membrane proteins -membranopathies Hereditary Spherocytosis is what type of inheritance?[quizlet.com] […] or normal as a reaction to an infectious process, thereby masking hemolysis Lactate dehydrogenase ( LDH ) : nonspecific parameter that simply indicates increased cellular[amboss.com]

  • Obstructive Jaundice

    Lactate dehydrogenase is raised in haemolysis. LFTs : Alkaline phosphatase: considerably increased with either extrahepatic or intrahepatic biliary disease.[patient.info] Risk factors for pigment stones include chronic hameolysis (red blood cell breakdown) -hereditary spherocytosis, sickle cell disease , as well as liver cirrhosis .[myvmc.com]

  • Blackwater Fever

    Hemolysis is associated with a release of RBC lactate dehydrogenase (LDH).[emedicine.medscape.com] The Red Blood Cell Membrane and Its Disorders: Hereditary Spherocytosis, Elliptocytosis, and Related Diseases.[emedicine.medscape.com] Hemoglobin released from damaged RBCs leads to an increase in indirect bilirubin and urobilinogen levels.[emedicine.medscape.com]

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