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199 Possible Causes for Hereditary Spherocytosis, Lactate Dehydrogenase Increased

  • Hereditary Elliptocytosis

    Diagnostic tests Key laboratory studies comprise a complete blood count (CBC), reticulocyte count, bilirubin, haptoglobin, lactate dehydrogenase (LDH), Coombs test, potassium[] Hereditary elliptocytosis (HE), its aggravated form hereditary pyropoikilocytosis (HPP), and hereditary spherocytosis (HS) designate a set of congenital hemolytic syndromes[] Numerous mutations have allowed to reclassify hereditary elliptocytosis (HE) and poikilocytosis (HP), and, more recently, hereditary spherocytosis (HS) into well defined subsets[]

  • Autoimmune Hemolytic Anemia

    Unconjugated bilirubin is usually, but not always, elevated and urine urobilinogen is increased. Lactate dehydrogenase is usually elevated into the thousands.[] spherocytosis) Urinalysis hemoglobinuria hemosiderinuria Differential Diagnosis Treatment Warm agglutinin from best initial therapy to further steps in treatment ladder glucocorticoids[] Increased serum unconjugated bilirubin, increased lactate dehydrogenase (LDH) and reduced or absent haptoglobin. Increased urinary urobilinogen, haemosiderinuria.[]

  • Hereditary Spherocytosis

    Reticulocytosis, increased bilirubin, increased lactate dehydrogenase, increased urinary and fecal urobilinogen, and decreased haptoglobin, reflect increased erythrocyte production[] These changes are also seen in non-hereditary spherocytosis, but they are typically more pronounced in hereditary spherocytosis.[] Other biochemical changes of hemolysis also are also present, including: increased lactate dehydrogenase (LDH) increased unconjugated bilirubin decreased serum haptoglobin[]

  • Acquired Toxic Hemolytic Anemia

    Breakdown of RBCs releases lactate dehydrogenase and potassium, leading to elevation of both in serum.[] spherocytosis - paroxymal nocturnal hemoglobinuria (PNH) - hemoglobinopathia - auto-immunhemolytic anemia (AIHA) - pernicious anemia[] Recognize clinical findings associated with hereditary spherocytosis.[]

  • Paroxysmal Nocturnal Hemoglobinuria

    The effect of eculizumab on intravascular hemolysis was demonstrated by a reduction in lactate dehydrogenase levels at all measurements after baseline.[] A 76-year-old man with paroxysmal nocturnal hemoglobinuria and hereditary spherocytosis was started on deferoxamine for iron overload secondary to previous blood transfusions[] After approximately 2 years, apart from normalization of the lactate dehydrogenase (LDH) level, there was an increase in glycosylphosphatidylinositol (GPI) negative red cells[]

  • Hemolytic Uremic Syndrome

    Following an increase in the dose of eculizumab to 1,500 mg every 2 weeks, lactate dehydrogenase (LDH), proteinuria, and creatinine decreased, and CH50 assay showed 0%.[] […] hemolytic anemias D58.0 Hereditary spherocytosis D58.1 Hereditary elliptocytosis D58.2 Other hemoglobinopathies D58.8 Other specified hereditary hemolytic anemias D58.9 Hereditary[] Neurological symptoms occurred at the same time as there was an increase of lactate dehydrogenase and creatinine and the nadir of the platelet count occurred before the onset[]

  • Microangiopathic Hemolytic Anemia

    Laboratory abnormalities Anemia Increased lactate dehydrogenase. Increased indirect bilirubin. Decreased haptoglobin. Increased urine urobilinogen.[] We’ve gone through the main hereditary hemolytic anemias: hereditary spherocytosis (and its less-common counterpart, hereditary elliptocytosis ), glucose-6-phosphate dehydrogenase[] Characteristic laboratory data are a negative direct antiglobulin (Coombs) test, an increased lactate dehydrogenase (LDH) level, increased indirect bilirubin, and low haptoglobin[]

  • Nonimmune Hemolysis

    Increased serum unconjugated bilirubin, increased lactate dehydrogenase (LDH) and reduced or absent haptoglobin. Increased urinary urobilinogen, haemosiderinuria.[] Hereditary Spherocytosis is the result of what? ankyrin, spectrin, other membrane proteins -membranopathies Hereditary Spherocytosis is what type of inheritance?[] […] or normal as a reaction to an infectious process, thereby masking hemolysis Lactate dehydrogenase ( LDH ) : nonspecific parameter that simply indicates increased cellular[]

  • Obstructive Jaundice

    Lactate dehydrogenase is raised in haemolysis. LFTs : Alkaline phosphatase: considerably increased with either extrahepatic or intrahepatic biliary disease.[] Risk factors for pigment stones include chronic hameolysis (red blood cell breakdown) -hereditary spherocytosis, sickle cell disease , as well as liver cirrhosis .[]

  • Blackwater Fever

    Hemolysis is associated with a release of RBC lactate dehydrogenase (LDH).[] The Red Blood Cell Membrane and Its Disorders: Hereditary Spherocytosis, Elliptocytosis, and Related Diseases.[] Hemoglobin released from damaged RBCs leads to an increase in indirect bilirubin and urobilinogen levels.[]

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