Possible Causes for high density lipoprotein decreased Obesity Trans fats increase low-density lipoprotein (LDL—the bad) cholesterol levels and decrease high-density lipoprotein (HDL—the good) cholesterol levels, and these effects appear [msdmanuals.com] A low-fat diet decreases high density lipoprotein (HDL) cholesterol levels by decreasing HDL apolipoprotein transport rates. [dx.doi.org] Each diet significantly reduced the low-density lipoprotein/high-density lipoprotein (HDL) cholesterol ratio by approximately 10% (all P r 0.60; P r 0.07; P .40). [dx.doi.org] Diabetes Mellitus […] simvastatin (ie, 80 mg daily). 441 Although the benefit of high-intensity statins declines among statin-naïve patients with ACS as a function of decreasing low-density lipoprotein [doi.org] […] of simvastatin (40 mg daily for 1 month followed by 80 mg daily) in the A to Z Trial (Aggrastat to Zocor), 439 and concerns have been raised recently about the safety of high-dose [doi.org] Angina Pectoris The level of low-density lipoprotein-cholesterol decreased from 130.3 25.5 mg/dl to 61.7 16.5 mg/dl (-50 19%: high intensity) in group H (p Copyright 2016 Elsevier Inc. [ncbi.nlm.nih.gov] Statins (eg. simvastatin): these drugs decrease the amount of cholesterol in the blood and increase the percentage of good fats (HDL- high density lipoproteins). [myvmc.com] Coronary Atherosclerosis […] treat many established atherosclerotic risk factors, including elevated blood pressure, insulin resistance and glucose intolerance, elevated triglyceride concentrations, low high-density [doi.org] Although there was complete linkage of LRP6 R611C and hypertension, high low-density lipoprotein (LDL), TG and a prevalence of DM2 in the index kindred, the frequency of LRP6 [doi.org] lipoprotein cholesterol (HDL-C) concentrations, and obesity. [doi.org] Niemann-Pick Disease Type B On laboratory testing, there is a decrease in high-density lipoprotein (HDL)- cholesterol, elevated triglycerides, and an increase in LDL-cholesterol. [medbullets.com] Familial Combined Hyperlipidemia Atorvastatin was significantly more effective in reducing total cholesterol, LDL cholesterol, apolipoprotein B, and non-high-density lipoprotein (HDL) cholesterol. [ncbi.nlm.nih.gov] This condition is characterized by high levels of total cholesterol and triglycerides, decreased high density lipoprotein (HDL) cholesterol concentration, high apoB concentration [symptoma.com] It is characterised by elevated levels of serum total cholesterol (TC), triglycerides (TGs), or both. 1, 2 Decreased high density lipoprotein cholesterol (HDL-C) levels are [nature.com] Familial Hypercholesterolemia PLoS One. 2017 Dec 11;12(12):e0189316. doi: 10.1371/journal.pone.0189316. eCollection 2017. Author information 1 Department of Endocrinology, The Affiliated Hospital of Qingdao University, Qingdao University, Qingdao, China. 2 Department of Endocrinology, Linzi District People's Hospital, Zibo, China. 3 Department of Gerontology,[…] [ncbi.nlm.nih.gov] Lecithin Acyltransferase Deficiency They showed a marked decrease in plasma high density lipoproteins (HDL) and a decrease in the ester ratio of plasma total cholesterol. [ncbi.nlm.nih.gov] This is the first report of lecithin-cholesterol acyltransferase deficiency in Iran.The diagnosis was confirmed by a low high-density lipoprotein cholesterol concentration [ncbi.nlm.nih.gov] Plasma triglycerides are normal to increased, low density lipoprotein (LDL) levels are reduced, and high-density lipoprotein (HDL) levels are markedly decreased. [ommbid.mhmedical.com] Acute Alcohol Intoxication Numerous explanations, including increased high density lipoprotein (HDL) levels and a direct antithrombotic effect, have been suggested. [merckmanuals.com] On the other hand, low to moderate levels of alcohol consumption ( 1 to 2 drinks/day) may decrease the risk of death due to cardiovascular disorders. [merckmanuals.com] Metabolic Syndrome A major problem with the focus on low fat is that high-carbohydrate diets can contribute to increasing triglyceride and decreasing high-density lipoprotein (HDL) concentrations [ncbi.nlm.nih.gov] These include hyperinsulinemia, IGT, increased plasma triglyceride concentration, and decreased high-density lipoprotein cholesterol concentration, all of which are associated [diabetes.diabetesjournals.org] […] in patients with hypertension and the fact that this risk if not reduced with antihypertensive treatment are due to the clustering of risk factors for CAD, in addition to high [diabetes.diabetesjournals.org] Menopause […] levels of low-density lipoprotein cholesterol. [35] Moreover, women with higher concentrations of 25OHD3 had higher levels of high-density lipoprotein cholesterol but lower [emedicine.medscape.com] […] triglyceride levels. [35] Raloxifene is an SERM that acts directly on estrogen receptors in the bone to decrease resorption. [emedicine.medscape.com] Calcium/Vitamin D Trial, they found that daily supplementation with 1,000 mg of elemental calcium and 400 IU of vitamin D3 significantly increased concentrations of 25OHD3 and decreased [emedicine.medscape.com] Hypertension Ramipril treatment resulted in a significant plausible modification in high-density lipoprotein (HDL) (P .0390), glucose (P .0213), and hsCRP (P .0053) concentrations [ncbi.nlm.nih.gov] lipoprotein triglycerides; (5) decreased high-density lipoprotein cholesterol; and (6) hypertension. [doi.org] as well as decreased SI (P .0009) value, while nebivolol treatment showed no such benefits. [ncbi.nlm.nih.gov] Insulin Resistance These include hyperinsulinemia, IGT, increased plasma triglyceride concentration, and decreased high-density lipoprotein cholesterol concentration, all of which are associated [diabetes.diabetesjournals.org] […] and, sometimes, a decreased low-density lipoprotein cholesterol level. 8 Insulin resistance has been found in persons with low levels of high-density lipoprotein. 9 Insulin [aafp.org] […] in patients with hypertension and the fact that this risk if not reduced with antihypertensive treatment are due to the clustering of risk factors for CAD, in addition to high [diabetes.diabetesjournals.org] Tonsillitis Statins (eg. simvastatin): these drugs decrease the amount of cholesterol in the blood and increase the percentage of good fats (HDL- high density lipoproteins). [healthengine.com.au] lipoprotein (HDL). [emedicine.medscape.com] […] factors include LV hypertrophy, obesity, and elevated serum levels of homocysteine, lipoprotein (a), plasminogen activator inhibitor, fibrinogen, serum triglycerides, or low high-density [emedicine.medscape.com] Hyperuricemia […] synthesis of high-density lipoprotein. [ncbi.nlm.nih.gov] […] association between homocysteine and atherosclerosis include stimulating smooth muscle cell growth, reducing endothelial cell growth and endothelial cell relaxation, and decreasing [ncbi.nlm.nih.gov] Hypoglycemia lipoprotein Actos linked to decreased triglycerides Convenient dosing Increased risk of heart failure Causes an average of 5–10 pounds weight gain Associated with higher [en.wikipedia.org] Expensive Thiazolidinediones (Pioglitazone, Rosiglitazone) Reduce insulin resistance by activating PPAR-γ in fat and muscle Lower risk of hypoglycemia Slight increase in high-density [en.wikipedia.org] Periodontitis Periodontitis decreases the antiatherogenic potency of high density lipoprotein. J Lipid Res. 2004; 45 : 139–147. [doi.org] Hypogonadism High-density lipoprotein (HDL) cholesterol levels were also found to decrease in patients that were on oral testosterone therapy [57, 113]. [hindawi.com] In a meta-analysis study, the high-density lipoprotein (HDL) cholesterol levels were significantly lower in the testosterone-treated group than the control group [110]. [hindawi.com] There is some evidence that after an initial decrease, HDL cholesterol levels then return to baseline [105]. [hindawi.com] Polycystic Ovary Syndrome Elevation in triglycerides, total cholesterol, and low-density lipoprotein levels, as well as decrease in high density lipoprotein level in serum of women with WHR value 0.8 [ncbi.nlm.nih.gov] lipoprotein (LDL)-cholesterol levels and/or decreased high-density lipoprotein cholesterol (HDL-C) levels. [obgyn.ucla.edu] […] for future cardiovascular disease and may likewise require lifestyle management, along with oral statins and other medications to correct increased triglyceride and low-density [obgyn.ucla.edu] Arthritis The Brasilia Heart Study Group indicates that changes in high-density lipoprotein (HDL) during an MI may alter the antiatherogenic function of HDL to transport lipids from [emedicine.medscape.com] […] arterial walls. [16] The investigators noted a simultaneous decrease in lipid transfer to HDL and in the capacity of HDL to efflux cholesterol from cells occurs in the acute [emedicine.medscape.com] Hypercholesterolemia Traditionally, risk factors for cardiovascular disease in adults have included elevated levels of low-density lipoprotein (LDL), decreased levels of high-density lipoprotein [pediatricheartspecialists.com] Plasma levels of high-density lipoprotein cholesterol were decreased, and levels of triglyceride, very low—density lipoproteins, and intermediate-density lipoproteins were [jamanetwork.com] However, blood total cholesterol, low-density lipoprotein cholesterol, and hepatic cholesterol were elevated by the HCD compared to ND, and those concentrations were decreased [ncbi.nlm.nih.gov] Polyps The Brasilia Heart Study Group indicates that changes in high-density lipoprotein (HDL) during an MI may alter the antiatherogenic function of HDL to transport lipids from [emedicine.medscape.com] […] arterial walls. [16] The investigators noted a simultaneous decrease in lipid transfer to HDL and in the capacity of HDL to efflux cholesterol from cells occurs in the acute [emedicine.medscape.com] Alzheimer Disease The decreased serum high-density lipoprotein (HDL) cholesterol in diabetic rats was also reversed toward normalization after the treatment ( Murugan and Pari, 2006 ). [ncbi.nlm.nih.gov] Cardiac Arrhythmia Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. [doi.org] Polyarticular Juvenile Idiopathic Arthritis The primary lipoprotein risk factor was decreased high-density lipoprotein cholesterol (57%), followed by elevated levels of low-density lipoprotein cholesterol (18%), triglycerides [ncbi.nlm.nih.gov] The male patients had decreased high-density lipoprotein cholesterol levels than the female patients (p 5 years) disease duration. [ncbi.nlm.nih.gov] CONCLUSIONS: Dyslipoproteinemia is highly prevalent in patients with polyarticular juvenile idiopathic arthritis and is primarily related to decreased high-density lipoprotein [ncbi.nlm.nih.gov] Coagulation Abnormalities lipoprotein and ApoB, as well as decreased serum high-density lipoproteins and ApoA1, has been reported in coronary artery disease. 62 Against this background, ApoA1 may [healio.com] […] cholesterol in peripheral tissues is carried back to the liver for excretion. 58 ApoA1 levels are reportedly higher in women than men. 61 An association of elevated serum low-density [healio.com] Diabetes Mellitus Type 2 (LDL‐C) ‐ despite overall increases in total LDL‐C ‐ and increases in the levels of high density lipoprotein‐cholesterol (HDL‐C). [doi.org] In clinical studies in patients with type 2 diabetes mellitus, rosiglitazone has been associated with reductions in the levels of small dense low density lipoprotein‐cholesterol [doi.org] Diastolic and systolic blood pressure are thought to be decreased after rosiglitazone treatment. [doi.org] Stroke In 1999/2000, 2001/2002, and 2003/2004, statins were being used by 19.6%, 27.3%, and 35.9% of US adults with high low-density lipoprotein cholesterol levels, respectively [doi.org] Moderate alcohol intake, increased levels of high-density lipoprotein and its subfractions, and decreased risk of myocardial infarction. [doi.org] ( P trend P trend 10 In addition, cross-sectional population-based surveys over the past 20 years in Minnesota revealed that 1 blood pressure decreased and awareness, treatment [doi.org] Hypoalphalipoproteinemia Abstract A 16-year-old boy presented with bilateral arcus cornealis and markedly decreased plasma high density lipoprotein cholesterol. [ncbi.nlm.nih.gov] Familial Hypoalphalipoproteinemia (main mutations) FHA Signs/symptoms: Decreased high density lipoprotein (HDL) cholesterol. [diagene.ch] Adenovirus-mediated expression of apoA-I(FIN) decreased apoA-I and high density lipoprotein cholesterol concentrations in both wild-type C57BL/6J mice and in apoA-I-deficient [ncbi.nlm.nih.gov] Hypothyroidism […] the liver. 93 The high-density lipoprotein (HDL) levels are normal or even elevated in severe hypothyroidism because of decreased activity of cholesteryl-ester transfer protein [stroke.ahajournals.org] The activity of cholesterol ester transfer protein is decreased in hypothyroidism: a possible contribution to alterations in high-density lipoproteins. [ncbi.nlm.nih.gov] The lipid profile is presented as a marked increase in LDL and apolipoprotein B because of a decreased fractional clearance of LDL by a reduced number of LDL receptors in [stroke.ahajournals.org]
