High Forehead: Causes & Reasons

Possible Causes for High Forehead

Symptoms of these disorders include an enlarged liver; characteristic facial features such as a high forehead, underdeveloped eyebrow ridges, and wide-set eyes; and neurological [ninds.nih.gov]

The common clinical findings included high forehead, large fontanelle, shallow orbit ridges, micrognathia, upslanting palebral fissures, epicanthal folds, severe hypotonia [ncbi.nlm.nih.gov]

Infants present with characteristic dysmorphic craniofacial features (flattened facies, large anterior fontanel, split sutures, prominent high forehead, flattened occiput, [orpha.net]

Wolf-Hirschhorn Syndrome

BACKGROUND: Wolf-Hirschhorn syndrome (WHS) is associated with facial dysmorphism including high forehead, high nasal bridge, hypertelorism and severe mental retardation. [ncbi.nlm.nih.gov]

Figure 1: Picture of the baby showing high forehead, low set ears, down turned corners of mouth Click here to view CPAP and inotropic support were gradually weaned off with [mjdrdypu.org]

[…] low birth weight (LBW) (77%), developmental delay, microcephaly (90%), characteristic craniofacial appearance described as “Greek warrior helmet,”[3],[4] which consists of high [mjdrdypu.org]

Chromosome 19q13.11 Deletion Syndrome

forehead 0000348 Hypotrichosis Sparse hair since birth 0001006 Long face Elongation of face Increased height of face Increased length of face Vertical elongation of face [rarediseases.info.nih.gov]

The aborted fetus weighted 402 g and had ambiguous genitalia and facial dysmorphism including long face, high forehead, retrognathia, thin lips, maxillary protrusion, broad [degruyter.com]

On physical examination, craniofacial dysmorphic features such as broad nasal bridge, high forehead with posterior hairline, and upward directed corners of the eyes were noticed [eymj.org]

Multiple Congenital Anomalies - Hypotonia - Seizures Type 3

Dysmorphic features included brachycephaly, high forehead with bitemporal narrowing, depressed nasal bridge, long philtrum with a deep groove, and open mouth due to hypotonia [bio2rdf.org]

PALLISTER KILLIAN SYNDROME (TETRASOMY 12p) This chromosomal abnormality results in dysmorphic features that include a coarsened flat facies, high forehead, reduced scalp hair [epilepsydiagnosis.org]

forehead Muscular hypotonia of the trunk Nephrotic syndrome Abnormality of the pinna Motor delay Bulbous nose Telecanthus Round face Patent foramen ovale Thickened helices [mendelian.co]

Noonan Syndrome

[…] genetic, polymalformative syndrome with increased risk of developing cancer characterized by a Noonan-like phenotype, including typical dysmorphic facial features (i.e. high [orpha.net]

forehead 0000348 High palate Elevated palate Increased palatal height [ more ] 0000218 Hypertelorism Wide-set eyes Widely spaced eyes [ more ] 0000316 Hypogonadotrophic hypogonadism [rarediseases.info.nih.gov]

The Noonan-like (NS) phenotype includes dysmorphic facial features (i.e. high forehead, hypertelorism, downslanting palpebral fissures, ptosis, low-set ears, prominent philtrum [orpha.net]

Rhizomelic Chondrodysplasia Punctata Type 2

[from OMIM] Show allHide all Abnormality of head or neck Anteverted nares Depressed nasal bridge High forehead High palate Wide nasal bridge Abnormality of limbs Rhizomelia [ncbi.nlm.nih.gov]

forehead ; High palate ; Intellectual disability ; Irregular vertebral endplates ; Large fontanelles ; Microcephaly ; Micrognathia ; Muscular hypotonia ; Osteopenia ; Rhizomelia [mousephenotype.org]

forehead, Hepatomegaly, Abnormality of the nasal bridge, Abnormality of the eye, Abnormality of neuronal migration, Large fontanelles, Triangular face, Central hypotonia [fdna.health]

Rapp-Hodgkin Syndrome

—Slightly upslanted eyes, cup-shaped ears, high forehead, a broad nasal root, hypodontia, a thin upper lip, and mid-facial hypoplasia were present. [escholarship.org]

Fine hair * Pili canaliculi * Small nails * Missing teeth * Small teeth * Conical teeth * Low nasal bridge * Narrow nose * Hypoplastic nostrils * Maxillary hypoplasia * High [checkorphan.org]

forehead, cone-shaped incisors and enamel hypoplasia (thin or absent tooth enamel), microdontia (decreased width of tooth), hypodontia (failure of development of between [xpertdox.com]

X-linked Mental Retardation Type Cabezas

forehead 0000348 Hypospadias 0000047 Intellectual disability Mental deficiency Mental retardation Mental retardation, nonspecific Mental-retardation [ more ] 0001249 Joint [rarediseases.info.nih.gov]

[…] bridge Flat, nasal bridge Flattened nasal bridge Low nasal bridge Low nasal root [ more ] 0005280 Generalized hypotonia Decreased muscle tone Low muscle tone [ more ] 0001290 High [rarediseases.info.nih.gov]

Chromosome 16q22 Deletion Syndrome

Clinical features Imported from Human Phenotype Ontology (HPO) Abnormality of head or neck Blepharophimosis Epicanthus Frontal bossing High forehead High palate Hypertelorism [familydiagnosis.com]

forehead, diastasis of the cranial sutures, broad nasal bridge, hypertelorism, low-set abnormal ears, and short neck. [malacards.org]

[…] palate Wide anterior fontanel Epicanthus Hypertelorism Micrognathia High forehead Posteriorly rotated ears Low-set ears Abnormality of the pinna Wide nasal bridge Short neck [familydiagnosis.com]

15q24 Deletion Syndrome

Children and adults with this rare condition may also have typical facial features such as a high forehead and microcephally (small head), as well as changes to the structure [thinkgenetic.com]

[…] nasal bridge flaring of nasal alae wide, short nose Genitourinary External Genitalia Male: cryptorchidism hypospadias microphallus Head And Neck Head: microcephaly high forehead [malacards.org]

downslanting palpebral fissures, broad nasal base with flaring of alae nasi, long, smooth philtrum and full lower lip High forehead, broad medial eyebrows, deep set eyes [academic.oup.com]

17q12 Microdeletion Syndrome

Müllerian aplasia in females, macrocephaly, mild facial dysmorphism (high forehead, deep set eyes and chubby cheeks) and transient hypercalcaemia have also been reported. [mendelian.co]

High forehead Tall forehead An abnormally increased height of the forehead. [rarediseases.oscar.ncsu.edu]

Chondrodysplasia with Joint Dislocations Type gPAPP

[from SNOMEDCT_US] Show allHide all Abnormality of head or neck Coronal craniosynostosis Flat face High forehead Micrognathia Narrow mouth Short nose Wide nasal bridge Abnormality [ncbi.nlm.nih.gov]

[…] developmental, genetic Phenotypes Autosomal recessive inheritance ; Brachydactyly ; Cleft palate ; Coronal craniosynostosis ; Flat face ; Genu valgum ; Hearing impairment ; High [mousephenotype.org]

Epicanthus High forehead Broad forehead Finger syndactyly Coarse facial features Thin vermilion border Camptodactyly of finger Increased bone mineral density Craniosynostosis [mendelian.co]

Chromosome 17p13.1 Deletion Syndrome

forehead 0000348 Highly arched eyebrow Arched eyebrows Broad, arched eyebrows High, rounded eyebrows High-arched eyebrows Thick, flared eyebrows [ more ] 0002553 Hydrocephalus [rarediseases.info.nih.gov]

Typical facial characteristics include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge [mendelian.co]

Seckel Syndrome

We report on a 3-year-old boy with prenatal onset of proportionate dwarfism, postnatal severe microcephaly, high forehead with receded hairline, sparse scalp hair, beaked [ncbi.nlm.nih.gov]

low hair growth on the forehead, high roof of the mouth, microgenia, muscular hypertonus, contractures in the elbow joints without pathological reflexes (Fig. 1). [bmcmedgenomics.biomedcentral.com]

She also displayed high-pitched voice. The age of menarche was 15 years. She had regular menstrual cycles. [termedia.pl]

Giacheti Syndrome

Head And Neck Face: long face Head And Neck Eyes: hypotelorism Growth Height: tall stature (>97th centile) Skeletal Hands: long hands Head And Neck Head: high forehead Neurologic [malacards.org]

High forehead MedGen UID: 65991 •Concept ID: C0239676 • Finding An abnormally increased height of the forehead. [ncbi.nlm.nih.gov]

Patient 1 has a high and narrow forehead, a high and broad nose, a short philtrum, and facial asymmetry (Panel A). [nejm.org]

Mosaic Variegated Aneuploidy Syndrome Type 1

Physical examination showed facial dysmorphim: “coarse” face with flat profile and high forehead, hypertelorism, upslanting palpebral fissures, and a broad, flat nasal bridge [latunisiemedicale.com]

ocular hypertelorism, upslanting palpebral fissures, bilateral epicanthus, prominent nasal bridge with hypoplastic nares, large ears, prominent upper incisors, a high palate [karger.com]

At 3 years and 4 months, he presented with hypotonia, growth and speech delay, severe psychomotor developmental delay, microcephaly, an elongated face, narrow and sloping forehead [karger.com]

Syndromic Microphthalmia Type 6

forehead ; High palate ; Hypospadias ; Hypothyroidism ; Inferior vermis hypoplasia ; Lambdoidal craniosynostosis ; Low-set ears ; Macrotia ; Malar flattening ; Microcephaly [mousephenotype.org]

forehead 0000348 Macrotia Large ears 0000400 Malar flattening Zygomatic flattening 0000272 Midface retrusion Decreased size of midface Midface deficiency Underdevelopment [rarediseases.info.nih.gov]

[…] myelination ; Facial asymmetry ; Failure to thrive ; Female hypogonadism ; Finger syndactyly ; Flexion contracture of thumb ; Global developmental delay ; Hearing impairment ; High [mousephenotype.org]

MEDNIK Syndrome

Patients with MEDNIK exhibit distinct dysmorphic features, including high forehead, upslanting palpebral fissures, depressed nasal bridge, and low-set ears, as well as growth [ncbi.nlm.nih.gov]

forehead, upslanting palpebral fissures, a depressed nasal bridge, low-set ears, growth retardation, and brain atrophy apparent upon imaging.[4] The disorder was discovered [en.wikipedia.org]

All patients showed peculiar dysmorphic features (high forehead, mongoloid facial appearance, depressed nasal bridge, low set ears, growth retardation) moderate to severe [academic.oup.com]

Developmental and Epileptic Encephalopathy Type 18

Affiliated tissues include brain, and related phenotypes are high forehead and downslanted palpebral fissures UniProtKB/Swiss-Prot : 75 Epileptic encephalopathy, early infantile [malacards.org]

Prieto Syndrome

[…] growth * Skin dimple in lower back * Clinodactyly * Partially dislocated knee * Subcortical cerebral atrophy * Abnormal walk * Low set ears * Abnormal dermatoglyphics * High [checkorphan.org]

forehead 0000348 Hypertelorism Wide-set eyes Widely spaced eyes [ more ] 0000316 Inguinal hernia 0000023 Intellectual disability Mental deficiency Mental retardation Mental [rarediseases.info.nih.gov]

forehead * Broad nose * Wide set eyes * Reduced muscle tone * Small jaw * Seizures * Coxa valga * Extra teeth * Speech defect * Underdeveloped ear lobe * Undescended testes [checkorphan.org]

Kyphomelic Dysplasia

Dumbbell-shaped humerus Dumbbell-shaped long bone in upper arm 0005009 Femoral bowing Bowed thighbone 0002980 Flared metaphysis Flared wide portion of long bone 0003015 High [rarediseases.info.nih.gov]

This girlhad a flat face, a high forehead, and a severemicromelia(photographs of the patient are unavailable). [docslide.net]

forehead 0000348 Limitation of joint mobility Decreased joint mobility Decreased mobility of joints Limited joint mobility Limited joint motion [ more ] 0001376 Low-set ears [rarediseases.info.nih.gov]

Methylmalonic Acidemia with Homocystinuria Type cblC

forehead, large, flappy, and low-set ears, and a flat philtrum) often develop as the patients grow (8). [ajnr.org]

Mild facial anomalies have also been described in cblC patients; features included a long face, high forehead, large, floppy, and low-set ears, and flat philtrum. [scielo.br]

[…] permission from Springer, Berlin Infants with early-onset MMA-HC present with gastrointestinal, hematologic, and neurologic problems; minor facial anomalies (such as long face, high [ajnr.org]

Cloverleaf Skull

Facial anomalies exopthalmos. hypertelorism. downward displaced ears. flat nasal root. high forehead. mid- facial hypoplasia. [fetalultrasound.com]

Facial malformations include high forehead, severe proptosis, or exophthalmoses, beaked nose, and downward displacement of ears. [prince.org]

forehead * Beaked nose Note that Kleeblattschaedel syndrome symptoms usually refers to various symptoms known to a patient, but the phrase Kleeblattschaedel syndrome signs [checkorphan.org]

Pseudo-Zellweger Syndrome

Neurol India 2007;55:93 Zellweger syndrome (cerebro-hepato-renal syndrome) is associated with generalized hypotonia, high forehead with flattened facies, hepatomegaly and [neurologyindia.com]

Some have macrocephaly, abnormally large fontanelles, as well as unusual facial features such as a high forehead, retrognathism, low set ears and widely spaced eyes. [alextlc.org]

Individuals with D-bifunctional protein deficiency may have unusual facial features, including a high forehead, widely spaced eyes (hypertelorism), a lengthened area between [rarediseases.oscar.ncsu.edu]

Dubowitz Syndrome

It is primarily diagnosed through the distinctive facial features of affected individuals, including a small triangular-shaped face with a high forehead and wide-set, slitted [ncbi.nlm.nih.gov]

They have a small triangular-shaped face with a high forehead and wide-set, slitted eyes. [poandpo.com]

The forehead is high, broad, and sloping. Eyebrows and hair are thin or absent. The ears may be abnormally shaped or placed. [poandpo.com]

Saethre-Chotzen Syndrome

Other symptions include: Head/Face: abnormally shaped head a high forehead a low frontal hair line facial asymmetry palatal anomalies [4] Eyes/Nose/Ears: droopy eyes (ptosis [pfond.cmmt.ubc.ca]

forehead (56 percent), ptosis (53 percent), and prominent auricular crura (56 percent). [ncbi.nlm.nih.gov]

forehead and facial asymmetry. [symptoma.com]

Mowat-Wilson Syndrome

Abstract Mowat-Wilson syndrome (MWS) is a multiple congenital anomaly syndrome characterized by a distinct facial phenotype (high forehead, frontal bossing, large eyebrows [ncbi.nlm.nih.gov]

Clinical description The typical characteristic facies of MWS includes a high forehead, frontal bossing, large eyebrows that are medially flaring and sparse in the middle [orpha.net]

The distinctive facial features include a high forehead, broad eyebrows, wide spaced eyes, small nose and the prominent pointed chin. [mybiosource.com]

Pallister-Killian Syndrome

forehead with frontal bossing a coarse face an abnormally wide space between the eyes broad nasal bridge highly arched palate epicanthal folds large ears with lobes that [en.wikibooks.org]

Patients also exhibit a distinctive facial structure, characterized by high foreheads, sparse hair on the temple, a wide space between the eyes, epicanthal folds and a flat [popflock.com]

The syndrome presents with a recognizable pattern of findings including pigmentary skin changes, coarse face, high forehead, sparse anterior scalp hair, hypertelorism, seizures [ncbi.nlm.nih.gov]

Glutaric Aciduria Type 2

They usually have dysplastic kidneys with multiple cysts and may also have facial dysmorphism (low-set ears, high forehead, hypertelorism and hypoplastic midface), rocker-bottom [orpha.net]

Trisomy 12p

His phenotype was similar to that of the "trisomy 12p syndrome", characterized by developmental delays and craniofacial abnormalities including a high forehead, a short nose [investigadores.uandes.cl]

forehead, prominent glabella, ocular hypertelorism, dysplastic ears and peri-auricular tags). [epilepsydiagnosis.org]