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22 Possible Causes for High Oxygen Affinity Hemoglobinopathy

  • Polycythemia Vera

    Familial polycythemias can be caused by hemoglobinopathies with high-oxygen affinities leading to less oxygen release from the hemoglobin as it transits the juxtaglomerular[clinicaladvisor.com]

  • Hemoglobin Chesapeake

    What should patients know about their high-oxygen-affinity hemoglobinopathy?[mdedge.com] Not all high-oxygen-affinity hemoglobinopathies are associated with erythrocytosis.[mdedge.com] In patients being evaluated for a high-oxygen-affinity hemoglobinopathy, a two-step approach has been outlined. 13 The first involves measuring the oxygen-binding properties[mdedge.com]

  • Secondary Polycythemia

    High oxygenaffinity hemoglobinopathies are very rare.[msdmanuals.com] Causes of congenital erythrocytosis Associated with decreased P50 High-oxygen-affinity hemoglobinopathies High-oxygen-affinity hemoglobins release oxygen at a lower-than-normal[nature.com] Familial polycythemias can be caused by hemoglobinopathies with high-oxygen affinities leading to less oxygen release from the hemoglobin as it transits the juxtaglomerular[clinicaladvisor.com]

  • Erythrocytosis

    […] sensing (for example, mutations involving the von Hippel-Lindau tumor suppressor gene) or decreased P50 (for example, high-oxygen-affinity hemoglobinopathy).[mayoclinic.pure.elsevier.com] High oxygenaffinity hemoglobinopathies are very rare.[msdmanuals.com] Causes of congenital erythrocytosis Associated with decreased P50 High-oxygen-affinity hemoglobinopathies High-oxygen-affinity hemoglobins release oxygen at a lower-than-normal[nature.com]

  • Myeloproliferative Disease

    The aim of the present study was to examine the relationship between peripheral CD34 and bone marrow CD34 levels and the clinicopathologic characteristics and laboratory parameters of myeloproliferative disease (MPD) patients. A total of 103 MPD patients were enrolled in this study. We examined the relationship[…][ncbi.nlm.nih.gov]

  • Methemoglobinemia

    Causes of congenital erythrocytosis Associated with decreased P50 High-oxygen-affinity hemoglobinopathies High-oxygen-affinity hemoglobins release oxygen at a lower-than-normal[nature.com] Conditions that shift the oxygen dissociation curve to the left can be associated with erythrocytosis and include high-oxygen-affinity hemoglobinopathies and low levels of[nature.com] […] sensing (for example, mutations involving the von Hippel-Lindau tumor suppressor gene) or decreased P50 (for example, high-oxygen-affinity hemoglobinopathy).[nature.com]

  • Stress Polycythemia

    High oxygen-affinity hemoglobinopathy or 2,3-diphosphoglycerate mutase deficiency are possible when the PaO2-50 is depressed.[thebigl.co] Hemoglobinopathies with certain amino acid substitutions may result in an increased affinity for oxygen, producing tissue hypoxia and a compensatory erythrocytosis.[medtextfree.wordpress.com] Chronic carbon monoxide poisoning is an important but generally unappreciated cause of mild polycythemia.48 Polycythemia Secondary to Abnormal (High-Affinity) Hemoglobins[medtextfree.wordpress.com]

  • Polycythemia

    High oxygen affinity hemoglobinopathy can be detected by hemoglobin electrophoresis and a P50 hemoglobin-oxygen dissociation curve.[clinlabnavigator.com] This illustrates the importance of properly investigating hereditary hemoglobinopathies in cases of erythrocytosis because in some populations variants with high oxygen affinity[scielo.br] High-affinity hemoglobinopathies are also rare; history, if available, would show this is a lifelong finding.[captodayonline.com]

  • Autosomal Recessive Myeloproliferative Disease

    Any high oxygen affinity hemoglobinopathy puts patient at risk of EPO ramp up and thus polycythemia -RBCs always use glycolysis. [And HMP shunt. NO TCA.[quizlet.com] Also consider hemoglobin mutations (chesapeake and Kempsey) that have higher affinities for oxygen due to other mutations.[quizlet.com] ( ) to Ser (less binding pocket of Hemoglobin) 2,3 BPG is NEGATIVE, so this defect limits 2,3 BPG binding and thus causes a leftward shift, with hemoglobin holding onto oxygen[quizlet.com]

  • Polycythemia Type Chuvash

    Causes of congenital erythrocytosis Associated with decreased P50 High-oxygen-affinity hemoglobinopathies High-oxygen-affinity hemoglobins release oxygen at a lower-than-normal[nature.com] High-oxygen-affinity hemoglobinopathy ii. 2,3-bisphosphoglycerate iii. Methemoglobinemia b. Associated with normal P50 i. VHL gene mutations including Chuvash ii.[mrmjournal.biomedcentral.com] affinity hemoglobinopathies stimulating increased Epo production.[findmeacure.com]

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