Create issue ticket

22 Possible Causes for High Oxygen Affinity Hemoglobinopathy

  • Myeloproliferative Disease

    The myeloproliferative disorders comprise a group of related diseases, including polycythemia vera, essential thrombocythemia, chronic myelogenous leukemia, myelofibrosis, and myeloid metaplasia. An increase in circulating platelets is associated with thrombotic phenomena affecting the arterial and venous circulation. In[…][ncbi.nlm.nih.gov]

  • Polycythemia Vera

    Familial polycythemias can be caused by hemoglobinopathies with high-oxygen affinities leading to less oxygen release from the hemoglobin as it transits the juxtaglomerular[clinicaladvisor.com]

  • Erythrocytosis

    High oxygenaffinity hemoglobinopathies are very rare.[msdmanuals.com] […] sensing (for example, mutations involving the von Hippel-Lindau tumor suppressor gene) or decreased P50 (for example, high-oxygen-affinity hemoglobinopathy).[mayoclinic.pure.elsevier.com] Causes of congenital erythrocytosis Associated with decreased P50 High-oxygen-affinity hemoglobinopathies High-oxygen-affinity hemoglobins release oxygen at a lower-than-normal[nature.com]

  • Secondary Polycythemia

    High oxygenaffinity hemoglobinopathies are very rare.[msdmanuals.com] Causes of congenital erythrocytosis Associated with decreased P50 High-oxygen-affinity hemoglobinopathies High-oxygen-affinity hemoglobins release oxygen at a lower-than-normal[nature.com] Familial polycythemias can be caused by hemoglobinopathies with high-oxygen affinities leading to less oxygen release from the hemoglobin as it transits the juxtaglomerular[clinicaladvisor.com]

  • Stress Polycythemia

    High oxygen-affinity hemoglobinopathy or 2,3-diphosphoglycerate mutase deficiency are possible when the PaO2-50 is depressed.[thebigl.co] Hemoglobinopathies with certain amino acid substitutions may result in an increased affinity for oxygen, producing tissue hypoxia and a compensatory erythrocytosis.[medtextfree.wordpress.com] Chronic carbon monoxide poisoning is an important but generally unappreciated cause of mild polycythemia.48 Polycythemia Secondary to Abnormal (High-Affinity) Hemoglobins[medtextfree.wordpress.com]

  • Hemoglobin Chesapeake

    What should patients know about their high-oxygen-affinity hemoglobinopathy?[mdedge.com] Not all high-oxygen-affinity hemoglobinopathies are associated with erythrocytosis.[mdedge.com] In patients being evaluated for a high-oxygen-affinity hemoglobinopathy, a two-step approach has been outlined. 13 The first involves measuring the oxygen-binding properties[mdedge.com]

  • Polycythemia

    High oxygen affinity hemoglobinopathy can be detected by hemoglobin electrophoresis and a P50 hemoglobin-oxygen dissociation curve.[clinlabnavigator.com] This illustrates the importance of properly investigating hereditary hemoglobinopathies in cases of erythrocytosis because in some populations variants with high oxygen affinity[scielo.br] High-affinity hemoglobinopathies are also rare; history, if available, would show this is a lifelong finding.[captodayonline.com]

  • Posthemorrhagic Anaemia of the Newborn

    NOS Hereditary persistence of fetal hemoglobin [HPFH] Unstable hemoglobin hemolytic disease Excludes: familial polycythemia (289.6) hemoglobin M [Hb-M] disease (289.7) high-oxygen-affinity[theodora.com] […] hemoglobinopathies Abnormal hemoglobin NOS Congenital Heinz-body anemia Disease: hemoglobin C [Hb-C] hemoglobin D [Hb-D] hemoglobin E [Hb-E] hemoglobin Zurich [Hb-Zurich] Hemoglobinopathy[theodora.com]

  • Leukoerythroblastic Anemia

    NOS Hereditary persistence of fetal hemoglobin [HPFH] Unstable hemoglobin hemolytic disease Excludes: familial polycythemia (289.6) hemoglobin M [Hb-M] disease (289.7) high-oxygen-affinity[theodora.com] […] hemoglobinopathies Abnormal hemoglobin NOS Congenital Heinz-body anemia Disease: hemoglobin C [Hb-C] hemoglobin D [Hb-D] hemoglobin E [Hb-E] hemoglobin Zurich [Hb-Zurich] Hemoglobinopathy[theodora.com]

  • Congenital Intrinsic Factor Deficiency

    NOS Hereditary persistence of fetal hemoglobin [HPFH] Unstable hemoglobin hemolytic disease Excludes: familial polycythemia (289.6) hemoglobin M [Hb-M] disease (289.7) high-oxygen-affinity[theodora.com] […] hemoglobinopathies Abnormal hemoglobin NOS Congenital Heinz-body anemia Disease: hemoglobin C [Hb-C] hemoglobin D [Hb-D] hemoglobin E [Hb-E] hemoglobin Zurich [Hb-Zurich] Hemoglobinopathy[theodora.com]

Further symptoms