Create issue ticket

388 Possible Causes for High Pain Threshold, Microcephaly (2-3 SD), Poor Coordination of the Lower Extremity

Did you mean: High Pain Threshold, Microcephaly (2-3 SD, Poor Coordination of the Lower Extremity

  • Acute Alcohol Intoxication

    Symptoms at lower doses may include mild sedation and poor coordination. At higher doses, there may be slurred speech, trouble walking, and vomiting.[en.wikipedia.org] Extreme doses may result in a decreased effort to breathe (respiratory depression), coma, or death.[en.wikipedia.org]

    Missing: Microcephaly (2-3 SD)
  • Peripheral Neuropathy

    Peripheral neuropathy, often shortened to neuropathy, is a general term describing disease affecting the peripheral nerves, meaning nerves beyond the brain and spinal cord. Damage to peripheral nerves may impair sensation, movement, gland or organ function depending on which nerves are affected; in other words,[…][en.wikipedia.org]

    Missing: Microcephaly (2-3 SD)
  • Phencyclidine Intoxication

    Abstract Phencyclidine (PCP) is a dissociative anesthetic whose abuse is a growing problem. Historically, its effects have been considered remarkably like those of the schizophrenic state, but in vitro and in vivo neuropharmacologic data are somewhat inconsistent with the dopaminergic hypothesis of schizophrenia. The[…][ncbi.nlm.nih.gov]

    Missing: Microcephaly (2-3 SD)
  • Autosomal Dominant Mental Retardation Type 24

    A common finding in microcephaly is also short stature, typically between -1 SD and -2 SD and in Seckel syndrome it ranges between -4 and -12 SD 3.[centogene.com] SCA8 SCA-8 is a slowly progressive ataxia resulting in poor coordination of limbs, especially lower extremities, and poor coordination of gait and speech.[ataxiacenter.umn.edu] More severe cognitive impairment has been observed in individuals with Seckel syndrome and in those with isolated microcephaly with brain malformations 3.[centogene.com]

  • Overdose

    J Anal Toxicol. 2018 May 1;42(4):255-264. doi: 10.1093/jat/bkx111. Author information 1 Service de Toxicologie, Hôpital Lariboisière, AP-HP, 2 Rue Ambroise Paré, Paris 75010, France. 2 Service Mobile d'Urgence et de Réanimation (SMUR), Hôpital Robert Debré, AP-HP, 48 Boulevard Sérurier, Paris 75019, France. 3 Service de[…][ncbi.nlm.nih.gov]

    Missing: Microcephaly (2-3 SD) Poor Coordination of the Lower Extremity
  • Syringomyelia

    Syringomyelia is a generic term referring to a disorder in which a cyst or cavity forms within the spinal cord. This cyst, called a syrinx, can expand and elongate over time, destroying the spinal cord. The damage may result in loss of feeling, paralysis, weakness, and stiffness in the back, shoulders, and extremities.[…][en.wikipedia.org]

    Missing: Microcephaly (2-3 SD) Poor Coordination of the Lower Extremity
  • Dysequilibrium Syndrome

    Microcephaly (-3 to -4 SD below the mean) has been reported in a few affected individuals. Life span.[ncbi.nlm.nih.gov] Short stature (height just below the 2 nd centile) is a feature in a few affected individuals. Deep tendon reflexes in the lower extremities tend to be brisk.[ncbi.nlm.nih.gov]

    Missing: High Pain Threshold
  • Alcohol Hallucinosis

    AIMS: The aim of this study was to compare the efficacy and safety of valproate (Depakine-Chrono) versus placebo for the treatment of acute alcohol hallucinosis. METHODS: 10 days' randomized, double-blind, parallel study was conducted; 40 patients with an ICD-10 diagnosis of acute alcohol hallucinosis were[…][ncbi.nlm.nih.gov]

    Missing: Microcephaly (2-3 SD) Poor Coordination of the Lower Extremity
  • Channelopathy-Associated Congenital Insensitivity to Pain

    These high threshold stimuli are detected by specialised peripheral sensory neurons known as nociceptors which are abundant in the Peripheral Pain Pathway.[neurosciencefundamentals.unsw.wikispaces.net] ., 2007). 2.2 Physiological Mechanisms The perception of pain is usually evoked at pressures and temperatures extreme enough to cause potential tissue damage and also by toxic[neurosciencefundamentals.unsw.wikispaces.net]

    Missing: Microcephaly (2-3 SD) Poor Coordination of the Lower Extremity
  • Diabetic Peripheral Neuropathy

    We propose in this study to examine whether sensory testing to determine mechanical pain threshold [MPT] or heat pain threshold [HPT] will predict the subject's response to[clinicaltrials.gov] This combination of decreased pain threshold, abnormally high foot pressures, and repetitive stress (such as from walking) can lead to calluses and ulcerations in the high-pressure[health.am] We hypothesize that people with painful DPN who have high MPT or HPT are more likely to respond to lidocaine treatment.[clinicaltrials.gov]

    Missing: Microcephaly (2-3 SD) Poor Coordination of the Lower Extremity