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12 Possible Causes for Highly Variable Severity, Lower Limb Vibratory Sense Decreased, Spasticity - Hyperreflexia

  • Autosomal Dominant Spastic Paraplegia Type 4

    Hereditary spastic paraplegias (HSP) comprise a genetically and clinically heterogeneous group of neurodegenerative disorders characterized by progressive spasticity and hyperreflexia[ncbi.nlm.nih.gov] Disease severity was highly variable among patients (Table 3 ).[academic.oup.com] sense in lower limbs Decreased vibratory sense in the lower extremities Decreased vibratory sense in the lower limbs Diminished vibratory sensation in the legs [ more ] 0002166[rarediseases.info.nih.gov]

  • Autosomal Dominant Spastic Paraplegia Type 17

    Central Nervous System: spasticity hyperreflexia clonus difficulty standing walking on tiptoes more Clinical features from OMIM: 607584 UMLS symptoms related to Spastic Paraplegia[malacards.org] Disease severity was highly variable among patients (Table 3 ).[academic.oup.com] limbs Decreased lower limb vibratory sense Decreased vibratory sense in lower limbs Decreased vibratory sense in the lower extremities Decreased vibratory sense in the lower[rarediseases.info.nih.gov]

  • Autosomal Dominant Spastic Paraplegia Type 8

    24, Autosomal Recessive Symptoms via clinical synopsis from OMIM: 57 Neurologic Central Nervous System: spasticity hyperreflexia clonus difficulty standing walking on tiptoes[malacards.org] Additional symptoms may be present and severity is highly variable.[rarediseases.org] Symptoms include hyperreflexia, extensor plantar responses, degeneration of the lateral corticospinal tracts, decreased vibratory sense in the lower limbs, pes cavus and atrophy[cags.org.ae]

  • Autosomal Dominant Spastic Paraplegia Type 13

    Hereditary spastic paraplegia 8 (SPG8) is a pure hereditary spastic paraplegia characterized by slowly progressive spastic paraplegia of the lower limbs (i.e., hyperreflexia[ncbi.nlm.nih.gov] Additional symptoms may be present and severity is highly variable.[rarediseases.org] Symptoms include hyperreflexia, extensor plantar responses, degeneration of the lateral corticospinal tracts, decreased vibratory sense in the lower limbs, pes cavus and atrophy[cags.org.ae]

  • Autosomal Dominant Spastic Paraplegia Type 36

    Central Nervous System: spasticity hyperreflexia clonus difficulty standing walking on tiptoes more Clinical features from OMIM: 607584 UMLS symptoms related to Spastic Paraplegia[malacards.org] Disease severity was highly variable among patients (Table 3 ).[academic.oup.com] The essential clinical findings are slowly progressive and often include severe spasticity, hyperreflexia, and weakness in a pyramidal distribution, noticeably in both lower[emedicine.medscape.com]

  • Autosomal Recessive Spastic Paraplegia Type 46

    Affiliated tissues include brain, and related phenotypes are nystagmus and hyperreflexia Disease Ontology : 12 A hereditary spastic paraplegia that has material basis in mutation[malacards.org] The severity of the disease is highly variable, the visual acuity ranging from normal to legal blindness.[ncbi.nlm.nih.gov] limbs Decreased lower limb vibratory sense Decreased vibratory sense in lower limbs Decreased vibratory sense in the lower extremities Decreased vibratory sense in the lower[rarediseases.info.nih.gov]

  • Autosomal Dominant Spastic Paraplegia Type 19

    […] paraplegia 8 is a neurologic disorder characterized by severe lower limb spasticity and weakness.[cags.org.ae] Additional symptoms may be present and severity is highly variable.[rarediseases.org] Disease severity was highly variable among patients (Table 3 ).[academic.oup.com]

  • Autosomal Dominant Spastic Paraplegia Type 37

    Seizures Milia Spasticity Hyperreflexia SOURCES: DOID GARD OMIM MESH MONDO ORPHANET UMLS More info about SPASTIC PARAPLEGIA 6, AUTOSOMAL DOMINANT; SPG6 Low match SPASTIC[mendelian.co] Disease severity was highly variable among patients (Table 3 ).[academic.oup.com] limbs Decreased lower limb vibratory sense Decreased vibratory sense in lower limbs Decreased vibratory sense in the lower extremities Decreased vibratory sense in the lower[rarediseases.info.nih.gov]

  • Autosomal Dominant Spastic Paraplegia Type 31

    24, Autosomal Recessive Symptoms via clinical synopsis from OMIM: 57 Neurologic Central Nervous System: spasticity hyperreflexia clonus difficulty standing walking on tiptoes[malacards.org] The average age at onset is highly variable, but the diagnosis is usually made around the age of 20 years.[neuroweb.us] limb weakness and spasticity, sphincter dysfunction, decreased vibratory sense at the ankles and with additional manifestations including optical neuropathy, nystagmus, strabismus[mendelian.co]

  • Spastic Paraplegia - Ataxia - Mental Retardation

    These sibs did not have overt spasticity, but had some pyramidal signs, such as hyperreflexia.[findzebra.com] Primary torsion dystonia (PTD) or Ziehen-Oppenheim disease: PTD is highly variable, ranging from severe disabling generalized dystonia in childhood to mild focal dystonia[neuroweb.us] Hereditary spastic paraplegias (HSP) comprise a genetically and clinically heterogeneous group of neurodegenerative disorders characterized by progressive spasticity and hyperreflexia[monarchinitiative.org]

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