HLA-A1: Causes & Reasons

Possible Causes for HLA-A1

HLA-A1, B8, DR3 is known to be in linkage disequilibrium with a deletion of C4A (the C4 null allele or C4QO). [accessmedicine.mhmedical.com]

Immunogenetic studies reveal an increase in HLA antigens DR3 or DR4, and curiously, nearly 50 percent of patients have the simultaneous presence of both. 21 The extended haplotype [dermaamin.com]

Immunogenetic studies reveal an increase in HLA antigens DR3 or DR4, and curiously, nearly 50% of patients have the simultaneous presence of both.22 The extended haplotype [accessmedicine.mhmedical.com]

Myasthenia Gravis

In the sequel study, Garchon and coworkers reevaluated the contribution of the extended 8.1 HLA haplotype, including Class I HLA-A1 and B8 loci and Class II HLA-DR3 allele [hindawi.com]

The histocompatibility complex profile includes HLA-A1, -A3, -B7, -B8, -DRw3, and -DQw2 (though these have not been shown to be associated with the strictly ocular form of [emedicine.com]

In addition, HLA-B*08 and -DRB1*03 alleles were shown to be in linkage disequilibrium, thus, forming a haplotype from which the A1 locus appeared to be unexpectedly excluded [hindawi.com]

Dermatitis Herpetiformis

It is associated with an increased expression of HLA-A1, HLA-B8, and HLA-DR3 antibodies. [fpnotebook.com]

The condition seems to have a genetic predisposition with increased expression of the HLA-A1, HLA-B8, HLA-DR3, and HLA-DQ2 haplotypes and IgA deposits in the papillary dermis [symptoma.com]

Autoimmune Polyendocrine Syndrome Type 2

The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present. [medvik.cz]

Autoimmune Polyendocrine Syndrome Type 3

The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present Note générale [idref.fr]

Autoimmune Polyendocrine Syndrome Type 1

The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present Note générale [idref.fr]

The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present. [fpnotebook.com]

Autoimmune Polyendocrine Syndrome

The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present. [fpnotebook.com]

The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present Note générale [idref.fr]

Renal Sarcoidosis

DRB1 and DQ B1 have been associated with acute sarcoidosis and a good prognosis, and HLA A1, B7, B8, B13, DR3, DR5, DR14, DR15 and DRl7 with familial cases 1, 6. [erj.ersjournals.com]

Positive associations were found with HLA-A1, B8, and DR3 markers. Negative associations were identified for HLA-B12 and DR4. [jasn.asnjournals.org]

[…] review of literature, we have found that human leukocyte antigen (HLA) genotypes DR 11, 12, 13, 14, 15 and 17 have been reported to confer susceptibility to the disease, HLA [erj.ersjournals.com]

Neonatal Scleroderma

The ANA- granddaughter (daughter of the proband) was noted to have severe isolated pulmonary hypertension within the first 6 months of life, and had the other maternal HLA-A1 [ncbi.nlm.nih.gov]

Dermatitis Vegetans

It is associated with an increased expression of HLA-A1, HLA-B8, and HLA-DR3 antibodies. [fpnotebook.com]

Patients with dermatitis herpetiformis have an increased expression of the HLA-A1, HLA-B8, HLA-DR3, and HLA-DQ2 haplotypes. [emedicine.medscape.com]

Both dermatitis herpetiformis and celiac disease (CD) are associated with an increased expression of HLA-A1, HLA-B8, HLA-DR3, and HLA-DQ2 haplotypes. [emedicine.medscape.com]

Collagenous Colitis

HLA-A1 is twice as frequent in lymphocytic colitis patients than in normal control patients or those with collagenous colitis. [incytepathology.wordpress.com]

Increased HLA A1 and diminished HLA A3 in lymphocytic colitis compared to controls and patients with collagenous colitis. Dig Dis Sci. 1992 Apr. 37(4):496-9. [Medline]. [emedicine.medscape.com]

Linear IgA Dermatosis

Five of 9 cases carried the haplotype HLA-A1, B8, DR3. [ncbi.nlm.nih.gov]

Calcific Pancreatitis

In the non-alcoholic sub-group of 36 patients, the incidence of HLA-A1 was significantly higher than in controls ( P c =0.0021); whilst HLA-B8 was present in 38.8% of patients [link.springer.com]

When these data are amalgamated with data from Lyon (France), the antigen HLA-A1 is significantly associated with non-alcoholic chronic pancreatitis. [link.springer.com]

In the subgroup of 52 patients with alcohol-related chronic pancreatitis HLA-B21 was significantly increased in frequency compared with 344 local controls ( P c =0.0128). [link.springer.com]

Primary Sclerosing Cholangitis

Later studies have verified that PSC associations exist also for the other alleles of the AH8.1 (the HLA-A1 allele[51], the HLA-C7 allele[52], the major histocompatibility [psc-literature.org]

The underlying cause is unknown but there is thought to be an autoimmune component with a higher prevalence of certain HLA alleles (A1, B8, DR3). [oxfordmedicaleducation.com]

[…] alleles A1, B8, and DR3 in PSC. [11, 12] An autoimmune mechanism is suggested, because approximately 75-90% of patients with PSC have inflammatory bowel disease (IBD). [emedicine.medscape.com]

Selective IgA Immunodeficiency

Biological context of IgA Deficiency Nine of 11 patients with C4A deletion had an HLA haplotype consistent with the MHC supratype HLA-A1, Cw7, B8, C4AQ0, C4B1, BfS, DR3 previously [wikigenes.org]

Haplotypes of the MHC show genetic association with IgAD, notably HLA (HLA) A1-B8-DR3 and B14-DR1 ( 15 – 17 ). [doi.org]

As clearly suggested by investigation of families, the findings could be attributed to high prevalence of the extended major histocompatibility complex (MHC) haplotype [HLA-A1 [wikigenes.org]

Cryptogenic Cirrhosis

Regarding HLA haplotypes associated with autoimmune hepatitis,30 11 of 25 patients (44%) had HLA A1 (only 1 of these had an elevated autoimmune score), 6 of 25 (24%) had HLA [hepatitiscentral.com]

Regarding HLA haplotypes associated with autoimmune hepatitis, 30 11 of 25 patients (44%) had HLA A1 (only 1 of these had an elevated autoimmune score), 6 of 25 (24%) had [hepatitiscentral.com]

Only 1 had the extended HLA A1-B8-DR3 haplotype. Laboratory parameters (table 1) were not significantly different between the risk subgroups. [hepatitiscentral.com]

Focal Segmental Glomerulosclerosis

Three underwent renal biopsy which displayed characteristic features of focal glomerulosclerosis and all shared the HLA alleles HLA-A1, B8, DR3, DR7. [ncbi.nlm.nih.gov]

[…] alleles HLA-A1, B8, DR3, DR7 may increase the predisposition to familial glomerulosclerosis but additional factors are required for disease development and progression. [ncbi.nlm.nih.gov]

The index case received two cadaveric renal transplants from HLA-A1, B8, DR3 donors and developed chronic rejection with no histological evidence of recurrent glomerulonephritis [ncbi.nlm.nih.gov]

Calcific Tendinitis of the Shoulder

However, an increase in HLA-A1 has been observed in patients with this disorder. [clinicaladvisor.com]

[…] phosphorus abnormality in people suffering from calcific tendonitis, although – in those suffering with calcific tendonitis – there does appear to be a higher incidence of the HLA-A1 [perfectbalanceclinic.com]

Subcorneal Pustular Dermatosis

It is associated with an increased expression of hla-a1, hla-b8, and hla-dr3 antibodies. [icd9data.com]

Chronic Hepatic Schistosomiasis

The relative risk to develop hepatosplenomegaly in persons infected with S. mansoni have been reported in correlation with HLA-A1 and B5[ 15 ]. [wjgnet.com]

Chondrocalcinosis

HLA typing revealed that all affected subjects bore the haplotype A1 B12 DR3. [ncbi.nlm.nih.gov]

[…] that all affected patients carried the haplotype A1 B12 DR3. [cags.org.ae]

The employment of electron microscopy on biopsies of synovium and cartilage of single patient revealed calcium pyrophosphate dehydrogenase crystals, meanwhile HLA typing demonstrated [cags.org.ae]

Cholangitis

Later studies have verified that PSC associations exist also for the other alleles of the AH8.1 (the HLA-A1 allele[51], the HLA-C7 allele[52], the major histocompatibility [psc-literature.org]

The underlying cause is unknown but there is thought to be an autoimmune component with a higher prevalence of certain HLA alleles (A1, B8, DR3). [oxfordmedicaleducation.com]

Genetic studies have demonstrated the expression of the haplotypes HLA A1-B8-DR3, DR-6, and DR-2 in some cases of PSC. [scielo.br]

Secondary Sclerosing Cholangitis

A1-B8-DR3 variant. [almostadoctor.co.uk]

[…] fact, in some cases, it may present before other features of IBD. 5-10% of UC will also have PSC 1% of Crohn’s patients will have PSC Genetic component – associated with HLA [almostadoctor.co.uk]

Narcolepsy-Cataplexy Syndrome

HLA phenotype: A1, A11; Cw5, Cw7; B44, B39; Bw4, Bw6; DR4, DR8; DR53; DQ6, DQ8 and at the gene level: DRB1*0402, DQB1*0302; DRB1*0806, DQB1*0602. [ncbi.nlm.nih.gov]

Bangstad Syndrome

The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present. [hon.ch]

Eales Disease

HLA types A1, B8, B5 (51) and DR 15 (2) were found in 12 out of 32 patients of eales disease and none in controls. [ncbi.nlm.nih.gov]

CONCLUSION: HLA phenotypes HLA DR3, A1, B8, B5 (51) and DR 15 (2) occurred in majority of cases of Eales disease, whereas these were not found in controls which was statistically [ncbi.nlm.nih.gov]

HLA DR3 was found in 20 patients of group-I and none in group-II. [ncbi.nlm.nih.gov]

Drug-Induced Lupus Erythematosus

reveal that HLA-A1, HLA-B8, and HLA-DR3 are more common in persons with SLE than in the general population. [emedicine.medscape.com]

FAM167A-BLK, BANK1 and KIAA1542); however, those loci had a lower significance level and a lower contribution to individual risk for SLE. [33] Studies of human leukocyte antigens (HLAs [emedicine.medscape.com]

Early-Onset Sarcoidosis

HLA analyses of affected families suggest a polygenic mode of inheritance of risk for sarcoidosis; the most commonly found alleles include class I HLA-A1 and B8 and class [emedicine.medscape.com]

II HLA-DR3 in whites. [emedicine.medscape.com]

Chronic Persistent Hepatitis

Second, strong association between HLA-A1 antigen and CPH (Fisher exact = 0.000022). [ncbi.nlm.nih.gov]

Type 1 AIH in Caucasians is associated with the HLA-DR3 serotype, which is found in linkage disequilibrium with HLA-B8 and HLA-A1 and in HLA-DR3 -negative patients with HLA-DR4 [doi.org]

Rubella

[…] frequencies of HLA-A1 (44% v 35%) and HLA-B8 (34% v 27%) antigens, 18 and of the haplotype HLA-A1, B8, DR3 (25% v 4%–6%), compared with the general population. [mja.com.au]

Increased susceptibility to infection might be inherited as there is some indication that HLA-A1 or factors surrounding A1 on extended haplotypes are involved in virus infection [en.wikipedia.org]

Despite other minor non-significant variations in immunoglobulin levels at this review, no subject had clinical problems related to this. 13, 17 HLA testing showed increased [mja.com.au]