HLA-A1 Causes & Reasons

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HLA-A1 Symptom Checker: Possible causes include Myasthenia Gravis. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Myasthenia Gravis

In the sequel study, Garchon and coworkers reevaluated the contribution of the extended 8.1 HLA haplotype, including Class I HLA-A1 and B8 loci and Class II HLA-DR3 allele [hindawi.com]

The histocompatibility complex profile includes HLA-A1, -A3, -B7, -B8, -DRw3, and -DQw2 (though these have not been shown to be associated with the strictly ocular form of [emedicine.com]

In addition, HLA-B*08 and -DRB1*03 alleles were shown to be in linkage disequilibrium, thus, forming a haplotype from which the A1 locus appeared to be unexpectedly excluded [hindawi.com]

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Herpes Gestationis

HLA-A1, B8, DR3 is known to be in linkage disequilibrium with a deletion of C4A (the C4 null allele or C4QO). [dermaamin.com]

Immunogenetic studies reveal an increase in HLA antigens DR3 or DR4, and curiously, nearly 50 percent of patients have the simultaneous presence of both. 21 The extended haplotype [dermaamin.com]

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Dermatitis Herpetiformis

The condition seems to have a genetic predisposition with increased expression of the HLA-A1, HLA-B8, HLA-DR3, and HLA-DQ2 haplotypes and IgA deposits in the papillary dermis [symptoma.com]

It is associated with an increased expression of HLA-A1, HLA-B8, and HLA-DR3 antibodies. [fpnotebook.com]

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Labor

Risk factors An increased association of myositis has been found with human leukocyte antigen (HLA) haplotypes A1, B8, and DR3, which also increase the risk for autoimmune [emedicine.medscape.com]

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Birth

Risk factors An increased association of myositis has been found with human leukocyte antigen (HLA) haplotypes A1, B8, and DR3, which also increase the risk for autoimmune [emedicine.medscape.com]

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Puerperium

Risk factors An increased association of myositis has been found with human leukocyte antigen (HLA) haplotypes A1, B8, and DR3, which also increase the risk for autoimmune [emedicine.medscape.com]

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Benign Migratory Glossitis

HLA antigens in geographic tongue. Tissue Antigens. 1980;15:60-2. [ Links ] 50 Fenerli A1, Papanicolaou S, Papanicolaou M, Laskaris G. [scielo.br]

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Cholangitis

Later studies have verified that PSC associations exist also for the other alleles of the AH8.1 (the HLA-A1 allele[51], the HLA-C7 allele[52], the major histocompatibility [psc-literature.org]

Genetic studies have demonstrated the expression of the haplotypes HLA A1-B8-DR3, DR-6, and DR-2 in some cases of PSC. [scielo.br]

Multiple candidate genes have been associated with PSC, including HLA-DRB1*1501-DQB1*602, HLA-DRB1*1301-DQB1*0603 and HLA-A1-B8-DRB1*0301-DQB1*0201 [ 9 ]. [oapublishinglondon.com]

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Thrombocytopenia

"HLA-DRw52a is involved in alloimmunization against PL-A1 antigen". Human Immunology. 27 (2): 73–9. doi : 10.1016/0198-8859(90)90104-w. PMID 2298610. [en.wikipedia.org]

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Diabetes Mellitus

Structures rendered from 1ao7.pdb. 14.4.3 HLA alleles influence the risk of developing type 1 diabetes HLA-DQ Haplotype Relative risk Absolute risk A1: 0301-0302 / B1: 0501 [watcut.uwaterloo.ca]

Therefore, the risk of developing type 1 diabetes varies substantially between different HLA genotypes. [watcut.uwaterloo.ca]

0201 21 6% B1: 0602 0.03 0.01% The alleles and associated risks listed here are just one illustrative example of the influence of HLA genotypes on the risk of contracting [watcut.uwaterloo.ca]

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Cryptogenic Cirrhosis

Regarding HLA haplotypes associated with autoimmune hepatitis,30 11 of 25 patients (44%) had HLA A1 (only 1 of these had an elevated autoimmune score), 6 of 25 (24%) had HLA [hepatitiscentral.com]

Regarding HLA haplotypes associated with autoimmune hepatitis, 30 11 of 25 patients (44%) had HLA A1 (only 1 of these had an elevated autoimmune score), 6 of 25 (24%) had [hepatitiscentral.com]

Only 1 had the extended HLA A1-B8-DR3 haplotype. Laboratory parameters (table 1) were not significantly different between the risk subgroups. [hepatitiscentral.com]

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Dermatitis Vegetans

It is associated with an increased expression of HLA-A1, HLA-B8, and HLA-DR3 antibodies. [fpnotebook.com]

Patients with dermatitis herpetiformis have an increased expression of the HLA-A1, HLA-B8, HLA-DR3, and HLA-DQ2 haplotypes. [emedicine.medscape.com]

Both dermatitis herpetiformis and celiac disease (CD) are associated with an increased expression of HLA-A1, HLA-B8, HLA-DR3, and HLA-DQ2 haplotypes. [emedicine.medscape.com]

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Renal Sarcoidosis

DRB1 and DQ B1 have been associated with acute sarcoidosis and a good prognosis, and HLA A1, B7, B8, B13, DR3, DR5, DR14, DR15 and DRl7 with familial cases 1, 6. [erj.ersjournals.com]

Positive associations were found with HLA-A1, B8, and DR3 markers. Negative associations were identified for HLA-B12 and DR4. [jasn.asnjournals.org]

[…] review of literature, we have found that human leukocyte antigen (HLA) genotypes DR 11, 12, 13, 14, 15 and 17 have been reported to confer susceptibility to the disease, HLA [erj.ersjournals.com]

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Suicidal Depression

The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present. [medvik.cz]

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Primary Sclerosing Cholangitis

Later studies have verified that PSC associations exist also for the other alleles of the AH8.1 (the HLA-A1 allele[51], the HLA-C7 allele[52], the major histocompatibility [psc-literature.org]

The underlying cause is unknown but there is thought to be an autoimmune component with a higher prevalence of certain HLA alleles (A1, B8, DR3). [oxfordmedicaleducation.com]

[…] alleles A1, B8, and DR3 in PSC. [11, 12] An autoimmune mechanism is suggested, because approximately 75-90% of patients with PSC have inflammatory bowel disease (IBD). [emedicine.com]

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Neonatal Scleroderma

The ANA- granddaughter (daughter of the proband) was noted to have severe isolated pulmonary hypertension within the first 6 months of life, and had the other maternal HLA-A1 [ncbi.nlm.nih.gov]

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Infectious Colitis

Increased HLA A1 and diminished HLA A3 in lymphocytic colitis compared to controls and patients with collagenous colitis. Dig Dis Sci. 1992;37(4):496–499. [archivesofpathology.org]

A1, DQ2 and DQ1, 3; a decrease in HLA-A3; and increased rates of carriage of the tumor necrosis factor α gene polymorphism (308) in LC patients relative to control patients [archivesofpathology.org]

[…] cellularity of the lamina propria, and the lack of ongoing watery diarrhea after treatment with a gluten-free diet.30 In addition, studies have shown an increased incidence of HLA [archivesofpathology.org]

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Autoimmune Polyendocrine Syndrome Type 2

The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present. [medvik.cz]

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Fibromyalgia

[…] haplotype HLA-DQ2 A1/B1, n (%) 46 (47) 15 (38) 31 (53) 0.214 HLA-DQ2 (-), n (%) 15 (15) 4 (10) 11 (19) 0.381 Serum autoantibodies Anti tTG-2, U/ml, mean (SD) 0.7 (0.6) 0.5 [dx.doi.org]

[…] relatives, n (%) 4 (4) 0 4 (7) 0.248 Gastroduodenal histopathological details IELs, mean (SD) 18 (3) 14 (2) 35 (5) Helicobacter pylori ( ), n (%) 41 (42) 17 (43) 24 (41) 0.426 HLA [dx.doi.org]

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Sacral Radiculopathy

The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present. [medvik.cz]

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Hepatitis

Type 1 AIH in Caucasians is associated with the HLA-DR3 serotype, which is found in linkage disequilibrium with HLA-B8 and HLA-A1 and in HLA-DR3 -negative patients with HLA-DR4 [doi.org]

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Autoimmune Polyendocrine Syndrome

The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present. [fpnotebook.com]

The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present Note générale [idref.fr]

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Prostate Sarcoma

Phase I study of 21 patients with synovial sarcoma, HLA‐A*2402 positive, given SYT‐SSX peptide vaccine (protocol A1 and A2) for synovial cell interferon‐α incomplete Freund [theoncologist.onlinelibrary.wiley.com]

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Secondary Sclerosing Cholangitis

A1-B8-DR3 variant. [almostadoctor.co.uk]

[…] fact, in some cases, it may present before other features of IBD. 5-10% of UC will also have PSC 1% of Crohn’s patients will have PSC Genetic component – associated with HLA [almostadoctor.co.uk]

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Calcific Tendinitis of the Shoulder

However, an increase in HLA-A1 has been observed in patients with this disorder. [clinicaladvisor.com]

[…] phosphorus abnormality in people suffering from calcific tendonitis, although – in those suffering with calcific tendonitis – there does appear to be a higher incidence of the HLA-A1 [perfectbalanceclinic.com]

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Linear IgA Dermatosis

Five of 9 cases carried the haplotype HLA-A1, B8, DR3. [ncbi.nlm.nih.gov]

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Biliary Carcinoma

[…] sonomammography and lateral chest x-ray in patients of breast cancer PI: Dr.Neeti Sharma 16 Protocol title: Phase II Clinical Trial of Immunotherapy with an Allogeneic B7.1/HLA-A1 [education.rajasthan.gov.in]

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Lupus Erythematosus

Etioloģija• Vismaz 35 gēni ir saistīti ar SLE• Biezāk sastopami leikocītu antigēni: HLA-A1, B8, DR3• Arī komplimentu deficīts ( biežāk C4, C2)• Biežāk EBV nēsātājiem• Zems [pt.slideshare.net]

Other contributing factors in the etiology of SLE include association with: Complement deficiency, especially C2 and C4 HLA-A1, B8 and DR3 and other HLA genes DQw1, DQw2 with [ncbi.nlm.nih.gov]

reveal that HLA-A1, HLA-B8, and HLA-DR3 are more common in persons with SLE than in the general population. [emedicine.medscape.com]

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Malignant Angioendotheliomatosis

reveal that HLA-A1, HLA-B8, and HLA-DR3 are more common in persons with SLE than in the general population. [emedicine.medscape.com]

FAM167A-BLK, BANK1 and KIAA1542); however, those loci had a lower significance level and a lower contribution to individual risk for SLE. [34] Studies of human leukocyte antigens (HLAs [emedicine.medscape.com]

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Psychosis

Association between HLA-A1 allele and schizophrenia gene(s) in patients refractory to conventional neuroleptics but responsive to clozapine medication. [ncbi.nlm.nih.gov]

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