HLA-A2: Causes & Reasons

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Possible Causes for HLA-A2

Precursor-Cell Lymphoblastic Leukemia

Med Oncol. 2018 Feb 10;35(3):36. doi: 10.1007/s12032-018-1092-9. Author information 1 Oncohematology Section, Albert Sabin Children Hospital, Ceará, Brazil. 2 Department of Clinical and Toxicological Analysis, Federal University of Ceará, UFC, Ceará, Brazil. 3 Flow Cytometry Section, Clementino Fraga Laboratory, Ceará, Brazil.[…] [ncbi.nlm.nih.gov]

Demodicosis

Individuals who have the HLA A2 phenotype are 2.9 times more resistant to demodicosis. [ncbi.nlm.nih.gov]

CONCLUSIONS: The HLA A2 and Cw2 phenotypes have an important diagnostic, prognostic and pathogenetic significance and could play a role in resistance or susceptibility to [ncbi.nlm.nih.gov]

Patients were typed for HLA A, B, Bw and Cw using the microlymphocytotoxicity method. [ncbi.nlm.nih.gov]

Mitochondrial Myopathy with Cataract

The same HLA haplotype (A2-B21) was found in the three patients. Similar articles [A case of mitochondrial myopathy in a family with oculo-pharyngeal myopathy]. [pubmed.ncbi.nlm.nih.gov]

Acute Lymphoblastic Leukemia

WHO. 10 facts about cancer. World Health Organization. World Health Organization; 2014 [cited 2014 Jan 4]. Available from: http://www.who.int/features/factfiles/cancer/en/. Supriyadi E, Widjajanto PH, Purwanto I, Cloos J, Veerman AJP, Sutaryo S. Incidence of childhood leukemia in Yogyakarta, Indonesia, 1998-2009.[…] [msjonline.org]

Immunodeficiency due to Defective Expression of HLA Class 1

[…] demonstrated that HLA-G1 downregulation is Nef-independent and Vpu-dependent, contrasting with the Nef- and Vpu-dependent HLA-A2 downregulation. [jgv.microbiologyresearch.org]

Disease relevance of B2M Stable, recombinant, water-soluble complexes of HLA-A2 and HLA-B27 were reconstituted from 125I-labeled beta 2-microglobulin ( beta 2m ), a synthetic [wikigenes.org]

Together, these results show that the decrease of HLA-A2 and HLA-G1 caused by HIV-1 occurs through distinct mechanisms. †Both authors contributed equally to this work. [jgv.microbiologyresearch.org]

Amegakaryocytic Thrombocytopenia

The mothers' sera showed antibody against both pooled random platelets and lymphocytes of type HLA-A2. [ncbi.nlm.nih.gov]

Immune amegakaryocytic thrombocytopenia of the newborn: association with anti-HLA-A2. [jcp.bmj.com]

It is suggested that anti-HLA-A2 may cause neonatal thrombocytopenia by depressing megakaryocytes instead of, or in addition to, any direct effect on platelets. [ncbi.nlm.nih.gov]

Aphthous Stomatitis

PREDISPOSING FACTORS There is a genetic predisposition shown by a positive family history in about one-third of patients and by an increased frequency of HLA types (HLA-A2 [pocketdentistry.com]

There is increased frequency of HLA-A2, A11, B12 and DR2 in RAS patients. Trauma: orthodontic appliances and thermal injury ('pizza burn'), certain foods. [stmina-monastery.org]

Deafness-Epiphyseal Dysplasia-Short Stature Syndrome

Structure of the human class I histocompatibility antigen, HLA-A2. ‏ [books.google.com]

Hypercatabolic Hypoproteinemia

From Proteopedia Jump to: navigation, search THE ANTIGENIC IDENTITY OF PEPTIDE(SLASH)MHC COMPLEXES: A COMPARISON OF THE CONFORMATION OF FIVE PEPTIDES PRESENTED BY HLA-A2 1hhi [proteopedia.org]

Melkersson-Rosenthal Syndrome

HLA typing may show HLA-A2 or HLA-A11. [16] Crohn disease, sarcoidosis, and OFG may present with similar histologic findings. [emedicine.com]

Chronic Epstein-Barr Virus Infection

The risk associated with HLA-A2 haplotypes is higher than any environmental risk posed by diet. [emedicine.medscape.com]

Predisposing factors include a diet rich in nitrosamines, salted fish, Chinese race, and the HLA-A2 haplotype. [emedicine.medscape.com]

Race Epstein-Barr virus infection has no racial predilection; however, HLA-A2 haplotypes, which are more common in people of Chinese origin, are associated with a predisposition [emedicine.medscape.com]

Pharyngeal Carcinoma

 Epstein-Barr Virus (EBV) most immunological finding in nasopharyngeal cancer  Genetic predisposition (genotypes HLA-A2 and HLA-Bsin2).  Nitosamines (smoked meat and [slideshare.net]

Haplotypes that have been associated with the malignancy include certain human leukocyte antigens (HLA), including HLA-A2, HLA-B46 and HLA-B58. 8 Diagnosis HISTORY AND PHYSICAL [aafp.org]

It is common among first-degree relatives of affected patients, and among those with A2 HLA genetic haptotypes. [star2.com]

Panuveitis

Melanocyte lysis by cytotoxic T lymphocytes recognizing the MART-1 melanoma antigen in HLA-A2 patients with Vogt-Koyanagi-Harada disease. Int Immunol. 1996;8:799–803. [ncbi.nlm.nih.gov]

Bothnia Retinal Dystrophy

Structure of the human class I histocompatibility antigen, HLA-A2. ‏ [books.google.com]

Stevens-Johnson Syndrome

Carriage of the following human leukocyte antigens has been associated with increased risk: HLA-B*1502 HLA-B*5801 HLA-B*44 HLA-A29 HLA-B12 HLA-DR7 HLA-A2 HLA-B*5801 HLA-A* [emedicine.medscape.com]

HLA-A29, HLA-B12, and HLA-DR7 are frequently associated with sulfonamide-induced Stevens-Johnson syndrome, while HLA-A2 and HLA-B12 are often encountered in Stevens-Johnson [emedicine.medscape.com]

HLA-B*5801 confers a risk of allopurinol-related reactions. [25] Pretreatment screening is not readily available. [26] Whites with HLA-B*44 appear to be more susceptible to [emedicine.medscape.com]

Nasopharyngeal Neoplasm

In Chinese patients the risk associated with foreign birthplace and occupational exposure increased among those with HLA-A2 and less than two antigens at the B locus, suggesting [nejm.org]

Haplotypes that have been associated with the malignancy include certain human leukocyte antigens (HLA), including HLA-A2, HLA-B46 and HLA-B58. 8 Diagnosis HISTORY AND PHYSICAL [aafp.org]

Synovial Sarcoma

*0201 Species Reactivity: Human Epitope: KASEKIFYV MHC: HLA-A2 Our customer service representatives are available 24 hours a day, from Monday to Sunday. [creativebiolabs.net]

The first is for HLA-A2+ patients with unresectable, metastatic and recurrent synovial sarcoma expressing NY-ESO-1. [mdanderson.org]

Type: Fab Application: ELISA, FuncS Derivation: Mouse Species Reactivity: Human Type: scFv Application: ELISA, IF, FuncS Species Reactivity: Human Epitope: KASEKIFYV MHC: HLA-A [creativebiolabs.net]

Metastatic Adenocarcinoma of the Breast

Abstract We have immunized advanced melanoma patients with a HLA-A2-compatible human melanoma line genetically modified to release interleukin-2 (IL-2), to elicit or increase [liebertpub.com]

Mixed tumor–lymphocyte cultures carried out with different allogeneic HLA-A2-matched melanoma lines as stimulators and targets revealed an increase in the MHC-unrestricted [liebertpub.com]

Advanced melanoma patients were immunized with a HLA-A2-compatible melanoma line genetically modified to release interleukin-2 (IL-2) to elicit or increase an anti-melanoma [liebertpub.com]

Epstein-Barr Virus-Associated Lymphoma

The risk associated with HLA-A2 haplotypes is higher than any environmental risk posed by diet. [emedicine.medscape.com]

Predisposing factors include a diet rich in nitrosamines, salted fish, Chinese race, and the HLA-A2 haplotype. [emedicine.medscape.com]

Arthritis due to Ulcerative Colitis

Ulcerative colitis complicating seronegative HLA-A2-B27 rheumatoid arthritis with sacroilitis. Ann Rheum Dis 1992;51:1009–1011. PubMed Google Scholar 5. [link.springer.com]

Brain Ependymoma

Treatment for Recurrent Ependymomas in Children Using HLA-A2 Restricted Tumor Antigen Peptides in Combination With Imiquimod Protocol Description This research study, initiated [chp.edu]

Study Level: Pilot Eligibility Criteria Eligibility criteria includes being between the ages of 12 months and 21 years, having the HLA-A2 tissue type and being willing to [chp.edu]

Acute Lung Injury

RESULTS: Anti-HLA-A2 antibodies significantly increased PMN activation, with subsequent endothelial dysfunction. [ncbi.nlm.nih.gov]

TRALI work-up revealed antibody formation to HLA A2, A68, B44, and DQA 5 for the LR-RBCs unit administered. [ncbi.nlm.nih.gov]

This study sought to examine the role of anti-HLA-A2 antibodies in polymorphonuclear neutrophil (PMN) activation and thus in endothelial permeability. [ncbi.nlm.nih.gov]

Cardiac Transplant Rejection

الصفحة 19 - WILEY, DC (1987): Structure of the human class I histocompatibility antigen, HLA-A2. ‏ [books.google.com]

Malignant Neoplasm of the Breast

Abstract We have immunized advanced melanoma patients with a HLA-A2-compatible human melanoma line genetically modified to release interleukin-2 (IL-2), to elicit or increase [liebertpub.com]

Mixed tumor–lymphocyte cultures carried out with different allogeneic HLA-A2-matched melanoma lines as stimulators and targets revealed an increase in the MHC-unrestricted [liebertpub.com]

Advanced melanoma patients were immunized with a HLA-A2-compatible melanoma line genetically modified to release interleukin-2 (IL-2) to elicit or increase an anti-melanoma [liebertpub.com]

Infectious Mononucleosis

The risk associated with HLA-A2 haplotypes is higher than any environmental risk posed by diet. [emedicine.medscape.com]

EBV-specific CD8 tetramer staining PBMCs from AIM patients, who screened positive for expression of the HLA A2 allele, were subjected to HLA-peptide tetramer staining performed [doi.org]

Predisposing factors include a diet rich in nitrosamines, salted fish, Chinese race, and the HLA-A2 haplotype. [emedicine.medscape.com]

Uveomeningoencephalitic Syndrome

Sugita S, Sagawa K, Mochizuki M, Shichijo S, Itoh K (1996) Melanocyte lysis by cytotoxic T lymphocytes recognizing the MART-1 melanoma antigen in HLA-A2 patients with Vogt–Koyanagi–Harada [doi.org]

Melanocyte lysis by cytotoxic T lymphocytes recognizing the MART-1 melanoma antigen in HLA-A2 patients with Vogt–Koyanagi–Harada disease. Int Immunol 1996: 8: 799–803. [dermnetnz.org]

Retinitis Pigmentosa 7

Structure of the human class I histocompatibility antigen, HLA-A2. ‏ [books.google.com]

Pili Torti - Developmental Delay - Neurological Abnormalities Syndrome

Parker KC et al (1994) Scheme on ranking potential HLA-A2 binding peptides based on bold binding of specific peptide side-chains. [ddna.org]

Recurrent Oral Ulceration

This is shown by a positive family history in about one-third of patients with RAS; an increased frequency of human leukocyte antigen (HLA) types A2, A11, B12, and DR2; and [emedicine.medscape.com]

HLA-B51, HLA-Cw7, HLA-A2, HLA-A11, and HLA-DR2 are examples of human leukocyte antigen types associated with aphthous stomatitis. [2] [5] However, these HLA types are inconsistently [en.wikipedia.org]

[…] susceptibility to RAS, which segregates in families in association with HLA haplotypes. [emedicine.medscape.com]

Lymphocytic Choriomeningitis

For this reason, we sought to identify HLA-A2 supertype-restricted epitopes from the LCMV proteome and evaluate them as vaccine determinants in HLA transgenic mice. [ncbi.nlm.nih.gov]