HLA-A2 Causes & Reasons

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HLA-A2 Symptom Checker: Possible causes include Precursor-Cell Lymphoblastic Leukemia. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Patient File

Sex unknown, Age unknown

Reported Symptoms

HLA-A2,

Negated

None

Unsure

None

Possible Causes

Precursor-Cell Lymphoblastic Leukemia

Med Oncol. 2018 Feb 10;35(3):36. doi: 10.1007/s12032-018-1092-9. Author information 1 Oncohematology Section, Albert Sabin Children Hospital, Ceará, Brazil. 2 Department of Clinical and Toxicological Analysis, Federal University of Ceará, UFC, Ceará, Brazil. 3 Flow Cytometry Section, Clementino Fraga Laboratory, Ceará, Brazil.[…] [ncbi.nlm.nih.gov]

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Demodicosis

CONCLUSIONS: The HLA A2 and Cw2 phenotypes have an important diagnostic, prognostic and pathogenetic significance and could play a role in resistance or susceptibility to [ncbi.nlm.nih.gov]

Individuals who have the HLA A2 phenotype are 2.9 times more resistant to demodicosis. [ncbi.nlm.nih.gov]

Patients were typed for HLA A, B, Bw and Cw using the microlymphocytotoxicity method. [ncbi.nlm.nih.gov]

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Amegakaryocytic Thrombocytopenia

The mothers' sera showed antibody against both pooled random platelets and lymphocytes of type HLA-A2. [ncbi.nlm.nih.gov]

Immune amegakaryocytic thrombocytopenia of the newborn: association with anti-HLA-A2. [jcp.bmj.com]

It is suggested that anti-HLA-A2 may cause neonatal thrombocytopenia by depressing megakaryocytes instead of, or in addition to, any direct effect on platelets. [ncbi.nlm.nih.gov]

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Hypersensitivity

There appears to be a genetic predisposition for atopic diseases and there is evidence for HLA (A2) association. [microbiologybook.org]

Bjorkman PJ, Saper MA, Samraoui B, et al: Structure of the human class I histocompatibility antigen, HLA-A2. Nature 1987;329:506–512. [karger.com]

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Familial Spontaneous Pneumothorax

In our study, we detected the HLA haplotype A2, B61 in three of 4 who had episodes of spontaneous pneumothorax. [ncbi.nlm.nih.gov]

A relationship between the HLA haplotype A2, B40, the alpha 1, antitrypsin phenotype M1 M2 and the occurrence of spontaneous pneumothorax was suggested in this family. [ncbi.nlm.nih.gov]

[…] haplotype A2, B40, alpha 1antitrypsin phenotype M1M2. 15 In our study, there was a positive family history in 9 PSP patients. [jpma.org.pk]

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Infectious Mononucleosis

The risk associated with HLA-A2 haplotypes is higher than any environmental risk posed by diet. [emedicine.medscape.com]

EBV-specific CD8 tetramer staining PBMCs from AIM patients, who screened positive for expression of the HLA A2 allele, were subjected to HLA-peptide tetramer staining performed [doi.org]

Predisposing factors include a diet rich in nitrosamines, salted fish, Chinese race, and the HLA-A2 haplotype. [emedicine.medscape.com]

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Stomatitis

HLA-B51, HLA-Cw7, HLA-A2, HLA-A11, and HLA-DR2 are examples of human leukocyte antigen types associated with aphthous stomatitis.[2][5] However, these HLA types are inconsistently [en.wikipedia.org]

[…] least 40% of people with aphthous stomatitis have a positive family history, suggesting that some people are genetically predisposed to suffering with oral ulceration.[6] HLA-B12 [en.wikipedia.org]

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Food Poisoning

Studies have shown an association between HLA types A2 W15 and DQw3 and hypersensitivity pneumonitis. 19, 20 The prevalence of hypersensitivity pneumonitis in children is [doi.org]

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Food Allergy

Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329 : 506–512, 1987. Crossref PubMed ISI Google Scholar 21. Bjorkman PJ, Saper MA, Samraoui B. [dx.doi.org]

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Influenza

Similarly, two changes in M2, at residues 51 and 56, map to an HLA-A11-restricted CTL epitope, while residue 82 of NS1 maps to an HLA-A2-restricted CTL epitope [ 58 ]. [dx.doi.org]

Another change between clade A and B viruses, at residue 226 of PA, also maps to an HLA-A2-restricted CTL epitope [ 58 ]. [dx.doi.org]

Three further changes, at residues 172, 199, and 307, map to antigenic sites [ 20 ], while a change at residue 18 has been mapped as an HLA-A2-restricted CTL epitope [ 58 [dx.doi.org]

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Malignant Neoplasm of the Breast

Abstract We have immunized advanced melanoma patients with a HLA-A2-compatible human melanoma line genetically modified to release interleukin-2 (IL-2), to elicit or increase [liebertpub.com]

Mixed tumor–lymphocyte cultures carried out with different allogeneic HLA-A2-matched melanoma lines as stimulators and targets revealed an increase in the MHC-unrestricted [liebertpub.com]

Advanced melanoma patients were immunized with a HLA-A2-compatible melanoma line genetically modified to release interleukin-2 (IL-2) to elicit or increase an anti-melanoma [liebertpub.com]

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Vitiligo

An HLA-A2-restricted tyrosinase antigen on melanoma cells results from posttranslational modification and suggests a novel pathway for processing of membrane proteins. [ncbi.nlm.nih.gov]

Association of vitiligo with HLA-A2: a meta-analysis. J. Eur. Acad. Dermatol. [dx.doi.org]

Cytotoxic T lymphocyte reactivity to gp100, MelanA/MART-1, and tyrosinase, in HLA-A2-positive vitiligo patients. J. Invest. [dx.doi.org]

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Sarcoma of the Lung

The first is for HLA-A2 patients with unresectable, metastatic and recurrent synovial sarcoma expressing NY-ESO-1. [mdanderson.org]

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Asthma

Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329 : 506–512, 1987. Crossref PubMed ISI Google Scholar 21. Bjorkman PJ, Saper MA, Samraoui B. [dx.doi.org]

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Aphthous Stomatitis

PREDISPOSING FACTORS There is a genetic predisposition shown by a positive family history in about one-third of patients and by an increased frequency of HLA types (HLA-A2 [pocketdentistry.com]

There is increased frequency of HLA-A2, A11, B12 and DR2 in RAS patients. Trauma: orthodontic appliances and thermal injury ('pizza burn'), certain foods. [stmina-monastery.org]

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Brain Ependymoma

Treatment for Recurrent Ependymomas in Children Using HLA-A2 Restricted Tumor Antigen Peptides in Combination With Imiquimod Protocol Description This research study, initiated [chp.edu]

Study Level: Pilot Eligibility Criteria Eligibility criteria includes being between the ages of 12 months and 21 years, having the HLA-A2 tissue type and being willing to [chp.edu]

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Arthritis due to Ulcerative Colitis

Ulcerative colitis complicating seronegative HLA-A2-B27 rheumatoid arthritis with sacroilitis. Ann Rheum Dis 1992;51:1009–1011. PubMed Google Scholar 5. [link.springer.com]

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Pyelonephritis

Donor-specific antibody (DSA) returned positive with high intensity anti-HLA-A2 antibody. [ncbi.nlm.nih.gov]

Cross-match test was negative but she had remote history of anti-HLA-A2 antibody corresponding with the donor HLA. Surgery concluded without any major events. [ncbi.nlm.nih.gov]

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Adenocarcinoma of the Breast

Abstract We have immunized advanced melanoma patients with a HLA-A2-compatible human melanoma line genetically modified to release interleukin-2 (IL-2), to elicit or increase [liebertpub.com]

Mixed tumor–lymphocyte cultures carried out with different allogeneic HLA-A2-matched melanoma lines as stimulators and targets revealed an increase in the MHC-unrestricted [liebertpub.com]

Advanced melanoma patients were immunized with a HLA-A2-compatible melanoma line genetically modified to release interleukin-2 (IL-2) to elicit or increase an anti-melanoma [liebertpub.com]

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Polyarthritis

It is associated with HLA B7 and HLA A2 hapbtypes anc hasa male predominance (M:F 2:1). [shmabstracts.com]

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Synovial Sarcoma

Non-Randomized Intervention Model: Parallel Assignment Primary Purpose: Treatment Official Title: A Pilot Study of Genetically Engineered NY-ESO-1 Specific NY-ESO-1ᶜ²⁵⁹T in HLA-A2 [clinicaltrials.gov]

The first is for HLA-A2 patients with unresectable, metastatic and recurrent synovial sarcoma expressing NY-ESO-1. [mdanderson.org]

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Medial Sclerosis

A possible association with the HLA-A2 antigen suggests that there may be a genetic component to the development of the disease. [pulmonologyadvisor.com]

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Metastatic Adenocarcinoma of the Breast

Abstract We have immunized advanced melanoma patients with a HLA-A2-compatible human melanoma line genetically modified to release interleukin-2 (IL-2), to elicit or increase [liebertpub.com]

Mixed tumor–lymphocyte cultures carried out with different allogeneic HLA-A2-matched melanoma lines as stimulators and targets revealed an increase in the MHC-unrestricted [liebertpub.com]

Advanced melanoma patients were immunized with a HLA-A2-compatible melanoma line genetically modified to release interleukin-2 (IL-2) to elicit or increase an anti-melanoma [liebertpub.com]

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Hemochromatosis

Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites. Proc. Natl.Acad.Sci. [doi.org]

Structure of the human class I histocompatibility antigen, HLA-A2. Nature 329, 506–512 (1987). 50 De Sousa, M. et al. Iron overload in β2-microglobulin-deficient mice. [doi.org]

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Liver Cirrhosis

A2 in the Japanese population [ 178 ], or HLA DRB1*11 in the Caucasian population [ 179 ]. [dx.doi.org]

Patients who developed Type 1 DM were genetically restricted to HLA DRB1-DQB1 haplotype [ 177 ], while IFN-induced autoimmune thyroiditis had genetic susceptibility to HLA [dx.doi.org]

The emergence of these autoantibodies was restricted to the specific HLA haplotypes. [dx.doi.org]

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Carcinoma of the Breast

The two melanoma lines also maintained susceptibility to lysis by lymphokine-activated killer (LAK) cells and by a HLA-A2-restricted melanoma-specific cytotoxic T lymphocyte [liebertpub.com]

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Preeclampsia

Further studies showed that these sHLA class I molecules included classical HLA class I alleles, such as sHLA-A2, -B7, -B51, -B35 and sHLA-A9. [ncbi.nlm.nih.gov]

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Drug Eruptions

RESULTS: The carrier frequency of HLA serotype A2 was significantly higher in the TAT-induced EDE patients than in the general Han Chinese study participants from the human [ncbi.nlm.nih.gov]

Particularly, the carrier frequency of three A2 alleles, including HLA-A*02:01, HLA-A*02:06, and HLA-A*02:07, is significantly higher than that of the control group (OR 14.40 [ncbi.nlm.nih.gov]

Furthermore, the HLA-A2 serotype, especially three alleles A*02:01, A*02:06, and A*02:07, was identified to be associated with the TAT-induced EDE in the Han Chinese population [ncbi.nlm.nih.gov]

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Hashimoto Thyroiditis

In Japanese, associations with DRB4*0101, HLA-A2 and DRw53 were demonstrated, while in Chinese patients association with DRw9 was observed (Hawkins, Lam et al. 1987, Honda [intechopen.com]

In Caucasians, associations of different forms of HT with various HLA alleles were reported, including DR3, DR5, DQ7, DQB1*03, DQw7 or DRB1*04-DQB1*0301 haplotype. [intechopen.com]

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Pseudogout

HLA typing of 38 patients suffering from calcific periarthritis (hydroxyapatite rheumatism) showed an increased prevalence of HLA A2 (66 per cent) and HLA BW35 (34 per cent [wikigenes.org]

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