HLA-A3: Causes & Reasons

Possible Causes for HLA-A3

HLA A3 as in HA3mochromatosis! [amboss.com]

Br Med J. 1975; 4: 520 Simon M Bourel M Fauchet R Genetet B Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis. [journal-of-hepatology.eu]

Association of HLA-A3 and HLA-B14 antigens with idiopathic hemochromatosis. Gut, 17 (1976), pp. 332-334 [6.] M. Simon, M. Bourel, B. Genetet, et al. [archbronconeumol.org]

Myasthenia Gravis

The histocompatibility complex profile includes HLA-A1, -A3, -B7, -B8, -DRw3, and -DQw2 (though these have not been shown to be associated with the strictly ocular form of [emedicine.com]

However, HLA genotyping is not routinely used in the evaluation of patients suspected to have MG. [emedicine.com]

For example, people with certain human leukocyte antigen (HLA) types have a genetic predisposition to autoimmune diseases. [emedicine.com]

Autosomal Recessive Anterior Segment Dysgenesis

HLA-A3 (35.5%), A4 (41%), B5 (41.2%), DR5 (47%) and DR7 (47%) were the most frequent antigenic types in our patients. [emro.who.int]

Frequencies of different HLA class I antigens in our patients did not differ significantly from those of the general population of Khorasan province (chi-squared P > 0.05) [emro.who.int]

Familial Lichen Planus

There was no increased incidence of the phenotype HLA A3. Lichen ruber und Pityriasis rubra pilaris G. [semanticscholar.org]

Primary Hemochromatosis Type 1

on 6p, close to HLA gene and in linkage disequilibrium with HLA-A3 Common mutation (83% of primary cases) is cysteine to tyrosine at amino acid 282 (C282Y), which inactivates [pathologyoutlines.com]

The gene for HH is closely linked to the HLA-A3 locus on the short arm of chromosome 6 [ PMID 1278715 ]. [snpedia.com]

Association of HLA-A3 and HLA-B14 antigens with idiopathic haemochromatosis. [clinchem.aaccjnls.org]

Arthritis due to Ulcerative Colitis

A Rose-Waaler test was positive 1/128, antinuclear antibody negative, and HLA A3/A24 B7/B38 DRB1*0101/DR14 DQ5. [ard.bmj.com]

Disorder of Iron Metabolism

His Ch6p haplotypes were assumed to be HLA-A3, -B7; C282Y and HLA-A3, -B51; C282Y. [nature.com]

None of these subjects were found to have the A3 or B14 antigens that are associated with HLA-linked hemochromatosis in white populations, but six had B7. [doi.org]

Frequencies of HLA haplotypes in control and primary iron overload populations The HLA-A3, -B7 haplotype, identified in patient 1, is considered by many to be part of the [nature.com]

Familial Enteropathy with Villous Edema and IgG2 Deficiency

The disease is also associated with HLA-A3 and HLA-B14. [quizlet.com]

Neonatal Neutropenia

The study of the mother's and patient's sera showed the presence of anti HNA1a, HPA-3b and HLA antibodies specific for HLA-A3 and HLA-B38 antigens. [ncbi.nlm.nih.gov]

Hyperdibasic Aminoaciduria Type 1

A29 HLA A3 HLA B13 HLA B17 HLA B27 HLA B5 HLA B51 HLA B7 HLA B8 HLA Bw54 HLA CW7 HLA DQ2 HLA DQ8 HLA DR1 HLA DR2 HLA DR3 HLA DR4 HLA DR6 HLA linkages see Human leucocyte [diseaselist.blogspot.com]

A29 HLA A3 HLA B13 HLA B17 HLA B27 HLA B5 HLA B51 HLA B54 see HLA Bw54 HLA B7 HLA B8 HLA Bw54 HLA class 1 deficiency see Major histocompatibility complex class I deficiency [diseasesdatabase.com]

[…] abnormality Histoplasma capsulatum see Histoplasmosis Histoplasmosis Histrelin His-Werner disease see Trench fever HIV cell fusion inhibitors HIV-1 disease Hives see Urticaria HLA [diseaselist.blogspot.com]

Subcutaneous Tissue Disease

If, for example, the lymphocytes from a person being tested for HLA-A3 are destroyed in a well containing antisera for HLA-A3, the test is positive for this antigen group. [medical-dictionary.thefreedictionary.com]

Hypertrophic Lichen Planus

Although the etiology of LP has yet to be fully elucidated, it is thought to be related to autoimmunity and is associated with HLA types-A3, -A5, -B8, -Bw35, and -DR1. [e-ijd.org]

An association has been observed with HLA-A3, A11, A26, A28, B3, B5, B7, B8, DR1, and DRW9.[ 21, 22, 23, 24 ] In Chinese patients, an increase in HLA-DR9 and Te 22 antigens [ncbi.nlm.nih.gov]

150] TNF-α receptor 2 [151] IL-4 (only nonerosive OLP) [147] IL-6 [150] Haplotype IV of IL-10 [152] IL-18 [153] Tumor suppressor genes (e.g., P53) [154, 155] HLA-A3 [hindawi.com]

Porphyria Cutanea Tarda

Kuntz BM, Goerz G, Merk H, Strohmeyer G, Brüster HT (1984) HLA-A3 and -B7 in porphyria cutanea tarda. Tissue Antigens 24:67–69 CrossRef PubMed Google Scholar 9. [link.springer.com]

Kuntz BMW, Goerz G, Merk H, Strohmeyer G, Bruster HT: HLA-A3 and -B7 in porphyria cutanea tarda. Tissue Antigens 1984;24:67–69. [karger.com]

Hypermobility Syndrome

Hemochromatosis is a genetic disease related to human leukocyte antigen (HLA) A3, B7, and B14 histocompatability antigens resulting in increased iron absorption from the gastrointestinal [ncbi.nlm.nih.gov]

Hemochromatosis-Related Cardiomyopathy

This gene is closely linked to the HLA-A3 locus. [en.citizendium.org]

Preexcitation Syndrome

The participation of HLA-A3 antigen was significantly less among patients (P = 0.03), while HLA-B14 antigen was not found in patients with preexcitation. [ncbi.nlm.nih.gov]

There was an increased frequency of HLA-A9 and HLA-B5 (P = 0.026 and 0.0092) in the investigated population as a whole. [ncbi.nlm.nih.gov]

Hairy Cell Leukemia

Based on these observations, we may conclude that a "specific HLA type," A2, Bw4, Bw6 and A3, B7 might have a role in the genetic predisposition for hairy cell leukemia. [ncbi.nlm.nih.gov]

Its specific HLA type was A3 and B7, the type previously reported in a family (Begley CG, Tait B, Crapper RM, Briggs RG, Brodie GN, Mackay IR: Leuk Res 11:1027–1028, 1987) [doi.org]

Its specific HLA type was A3 and B7, the type previously reported in a family (Begley CG, Tait B, Crapper RM, Briggs RG, Brodie GN, Mackay IR: Leuk Res 11:1027-1028, 1987) [ncbi.nlm.nih.gov]

Choroiditis

HLA typing showed the patient to be HLA-A3, -A28, -B51(5), -Bw4, -Bw6, and -B35 positive. Results of serologic testing for syphilis were negative. [jamanetwork.com]

Philadelphia Chromosome Negative Chronic Myeloid Leukemia

Two bcr-abl junction peptides bind HLA-A3 molecules and allow specific induction of human cytotoxic T lymphocytes Leukemia 1996 10 ( 4 ) 693-699 [ PubMed ] [ Google Scholar [ncbi.nlm.nih.gov]

Hepatobiliary Disorder

CD is associated with the HLA-DQ2 allele as well as non-HLA genes, whereas HH is associated with the HLA-A3 and B7 alleles of the MHC region [61]. [hindawi.com]

Atypical Hemolytic Uremic Syndrome

There was a repeated mis-match for HLA-A3. Both the cytotoxic and the FACS cross-match tests were negative. [austinpublishinggroup.com]

Familial hypocomplementemic hemolytic uremic syndrome with HLA-A3,B7 haplotype. JAMA 245, 602–604 (1981). 62. Warwicker, P. et al. [nature.com]

Familial hypocomplementemic hemolytic uremic syndrome with HLA-A3, B7 haplotype. JAMA. 1981 ; 245 : 602 -604. ↵ Caprioli J, Bettinaglio P, Zipfel PF, et al. [doi.org]

Bazex Syndrome

[…] types (A3 and B8) in many cases of the disease[2][3][4][5] Causes The etiology of Bazex syndrome is still unknown. [wikidoc.org]

[…] types (A3 and B8) in many cases of the disease [ 8, 10 – 12 ]. [ncbi.nlm.nih.gov]

[…] capability to secrete growth factors like TGF-alpha that affects epidermal growth and epithelial differentiation Genetic susceptibility due to the occurrence of the same HLA [wikidoc.org]

Diabetes Mellitus Type 1

Her HLA type was A3, A9, B8, B15, DR3, DR5. [ncbi.nlm.nih.gov]

Primary Progressive Multiple Sclerosis

Epidemiology Onset in younger, often female adults, affecting 1:2500 (US), commonly associated with HLA-A3, B7 and Dw2 haplotypes. [medical-dictionary.thefreedictionary.com]

[…] infiltrating lymphocytes–primarily T cells and macrophages—phagocytose myelin Epidemiology Onset in younger, often ♀ adults, affecting 1:2500 (US), commonly associated with HLA-A3 [medical-dictionary.thefreedictionary.com]

[…] affects women more than men; peak age of onset at 20–45 years; incidence increases with distance of domicile from the Equator, and in tissue types human leukocyte antigen (HLA [medical-dictionary.thefreedictionary.com]

Chronic Active Hepatitis

The increased frequency of HLA-A3 (47.6 % instead of 19.1 % in 266 healthy controls) is significant after correction. The relative risk is 3.83. [karger.com]

Arthropathy

It is widely accepted that the disease occurs secondary to a dominant gene that shows poor penetrance and is intimately linked to histocompatibility antigens HLA-A3, HLA-B7 [appliedradiology.com]

Relapsing-Remitting Multiple Sclerosis

Epidemiology Onset in younger, often female adults, affecting 1:2500 (US), commonly associated with HLA-A3, B7 and Dw2 haplotypes. [medical-dictionary.thefreedictionary.com]

Lichen Planus

In nonfamilial lichen planus, HLA-A3, -A5, -A28, -B8, -B16, and -Bw35 are more common. 5 HLA-B8 is more common in patients with oral lichen planus as a sole manifestation, [accessmedicine.mhmedical.com]

Different HLA haplotypes were reported in familial lichen planus, including HLA-B7, -Aw19, -B18, and -Cw8. [accessmedicine.mhmedical.com]

Autosomal Recessive Ocular Coloboma

HLA-A3 (35.5%), A4 (41%), B5 (41.2%), DR5 (47%) and DR7 (47%) were the most frequent antigenic types in our patients. [emro.who.int]

Frequencies of different HLA class I antigens in our patients did not differ significantly from those of the general population of Khorasan province (chi-squared P > 0.05) [emro.who.int]

Cholecystitis

In other populations, HLA A3, HLA A30, HLA B5, HLA B8 and HLA B14 are associated with this disease [29]. [intechopen.com]

[…] with chronic cholecystitis made the significance of hereditary load in the development of cholecystitis and to identify genetic markers (B (III) blood group), type Hp 1-1, HLA-A3 [intechopen.com]

This demonstrated the role of chromosome 6 in gallbladder disease by HLA typing. Thus, HLA-DRB1*13:01 is significantly higher than control group [28]. [intechopen.com]