HLA-A9: Causes & Reasons

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Possible Causes for HLA-A9

Thromboangiitis Obliterans

Genetic factors implicated Autoimmune component which is not fully understood Chronic anaerobic periodontal infection Genetics Greater prevalence of HLA-A54, HLA-A9, and HLA-B5 [unboundmedicine.com]

They also show a higher prevalence of human leukocyte antigen (HLA)–A9, HLA-A54, and HLA-B5, suggesting a genetic component to the disease. [emedicine.com]

Bilateral Sensorineural Hearing Loss

HLA A9 and B15 are associated with the generalized form, but not the localized form, of early-onset periodontal diseases. [article.sapub.org]

Cogan Syndrome

HLA-B17, HLA-A9, HLA-Bw35, and HLA-Cw4 have been correlated with an increased incidence of Cogan’s syndrome. [webeye.ophth.uiowa.edu]

Intestinal Lymphoma

HLA gene frequency was particularly increased in the HLA-A9 antigen. [ncbi.nlm.nih.gov]

AW19, A9, and B12, and the B blood group has been described ref1, ref2. [ufrgs.br]

[…] infection can explain the high incidence of IPSID in young adults versus Burkitt lymphoma, which is EBV related in children. genetic : a striking association of IPSID with HLAs [ufrgs.br]

Trichuris Trichiura

However, HLA-A9 positive individuals with high worm burden had significantly lower levels of sHLA-I in their plasma compared with HLA-A9 positive subjects with low worm burden [ncbi.nlm.nih.gov]

The results confirmed previous findings showing increased levels of sHLA-I in HLA-A9, and in this case HLA-A23 positive individuals. [ncbi.nlm.nih.gov]

These results suggest that the intensity of T. trichiura infection influences the ability of HLA-A9 positive subjects to maintain high levels of sHLA-I. [ncbi.nlm.nih.gov]

Cataract - Ataxia - Deafness

HLA-B17, HLA-A9, HLA-Bw35, and HLA-Cw4 have been correlated with an increased incidence of Cogan’s syndrome. [webeye.ophth.uiowa.edu]

Aggressive Periodontitis

Several studies have examined this association, and despite the inconclusive results, the antigens HLA‐A9 and HLA‐B15 have been found to be consistently associated with the [aap.onlinelibrary.wiley.com]

HLA-A9, B-15 are found in high frequency in rapidly progressive periodontitis patients [36], [37] and HLA-DQB1 plays a crucial role in pathogenesis of AP. [38] Miscellaneous [jicdro.org]

Ile polymorphism showed a protective effect against AP. [34] TNFA gene polymorphism (1031, 863,857, 308, and 238) was not associated with aggressive periodontitis. [35] HLA-DR4 [jicdro.org]

Preexcitation Syndrome

There was an increased frequency of HLA-A9 and HLA-B5 (P = 0.026 and 0.0092) in the investigated population as a whole. [ncbi.nlm.nih.gov]

The results of the frequency of HLA system antigens were compared to the results of the control group of a Croatian population consisting of 175 people. [ncbi.nlm.nih.gov]

Interstitial Keratitis

HLA-B17, HLA-A9, HLA-Bw35, and HLA-Cw4 have been correlated with an increased incidence of Cogan’s syndrome. [webeye.ophth.uiowa.edu]

Scleritis and Episcleritis

HLA-B17, HLA-A9, HLA-Bw35, and HLA-Cw4 have been correlated with an increased incidence of Cogan’s syndrome. [webeye.ophth.uiowa.edu]

Herpes Gestationis

The more serious case (widespread cutaneous involvement, repeated fetal deaths) had a very powerful anti-HLA-A9 +anti-HLA-B5 antibody (titre 1/1000); the other had less severe [ncbi.nlm.nih.gov]

Palindromic Rheumatism

Their identical HLA locus was A9,Aw19(29); B12,Bw22; Cw1; DR1, DR4. [ncbi.nlm.nih.gov]

Cogan Syndrome

HLA-B17, HLA-A9, HLA-Bw35, and HLA-Cw4 have been correlated with an increased incidence of Cogan’s syndrome. [webeye.ophth.uiowa.edu]

Diabetes Mellitus Type 1

Her HLA type was A3, A9, B8, B15, DR3, DR5. [ncbi.nlm.nih.gov]

Biliary Atresia

We found, especially in those without associated malformations, a significantly higher frequency of HLA -B12, of haplotypes A9-B5 and A28-B35, and of their disequilibrium [journals.lww.com]

To test the hypothesis that susceptibility to this disease would be influenced by host genetic factors, we studied the human leukocyte antigen ( HLA ) system in 55 patients [journals.lww.com]

Intestinal Disease

AW19, A9, and B12, and the B blood group has been described ref1, ref2. [ufrgs.br]

A striking association of IPSID with human leukocyte antigens (HLAs) AW19, A9, and B12, and the B blood group has been described. 54, 55 Genetic predisposition is further [bloodjournal.org]

[…] infection can explain the high incidence of IPSID in young adults versus Burkitt lymphoma, which is EBV related in children. genetic : a striking association of IPSID with HLAs [ufrgs.br]

Myeloproliferative Disease

HLA-typing disclosed the same haplotype (A2, A9, B5, B21, C5) in both patients. [ncbi.nlm.nih.gov]

Preeclampsia

Further studies showed that these sHLA class I molecules included classical HLA class I alleles, such as sHLA-A2, -B7, -B51, -B35 and sHLA-A9. [ncbi.nlm.nih.gov]

Limited Cutaneous Systemic Scleroderma

The HLA phenotype was A1, A9, B17, Bw4, Cw4, Cw6, DR5, DR52, DR8, DQ4, DQ7. A chest x ray was normal and a radiograph of the hands revealed subcutaneous calcinosis. [bjo.bmj.com]

Cystinosis

However, positive association was found with HLA-B7 and negative association with HLA-A9. The haplotypes A3B7 and A1B7 were significantly increased. [ncbi.nlm.nih.gov]

HLA association of a mendelian disorder without linkage is a phenomenon not previously noted, according to Steinherz et al. (1981). [ncbi.nlm.nih.gov]

From study of 5 families, Steinherz et al. (1981) concluded that linkage with HLA is unlikely; all lod scores were negative (-2.04 at theta 0.01). [ncbi.nlm.nih.gov]

Squamous Cell Carcinoma of the Head and Neck

These cytokines augmented expression of HLA-class I, HLA-class II, and intercellular adhesion molecule I, but not squamous cell carcinoma-associated antigens, E7 and A9, on [ncbi.nlm.nih.gov]

Lytic Bone Lesion

HLA typing was done in a previous study (6) and showed A9, AIO, B8, B27 in the mother, and A14, B8 in 1 son. [docslide.com.br]

Thus, in each of the 2 families that have been HLA typed, both mother and son share 1 similar locus; HLA-B14 in our patients family and HLA-B8 in the family studied by Elias [docslide.com.br]

Neuroblastoma

BM-infiltrating NB cells also expressed CD271 and HLA-G. We have identified proteins specifically expressed by BM-infiltrating NB cells. [ncbi.nlm.nih.gov]

BM-infiltrating NB cells expressed indeed the proteins encoded by the top-ranked genes, S100A8 and A9 (calprotectin), CD177 and CD3, and secreted the CXCL7 chemokine. [ncbi.nlm.nih.gov]

Immunosuppressive Therapy

There is some consensus that HLA A9 (or its A24 subspecificity) may confer an increased risk of schizophrenia.21 Wright et al.21 concluded that ‘there is some evidence that [nature.com]