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60 Possible Causes for HLA-B12

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  • Peptic Ulcer

    Stress in mammals triggers a neuroendocrine response mediated by the hypothalamic-pituitary-adrenal axis and the autonomic nervous system. Increased activity of these two systems induces behavioural, cardiovascular, endocrine and metabolic cascades that enable the individual to fight or flee and cope with the[…][ncbi.nlm.nih.gov]

  • Myasthenia Gravis

    BACKGROUND: Patients with thymoma with immunodeficiency (TWI)/Good's syndrome characteristically have evidence of combined immunodeficiency including low or absent B-cells, hypogammaglobulinemia and defects in T-cell mediated immunity. These patients can present with common or opportunistic infections. CASE[…][ncbi.nlm.nih.gov]

  • Stomatitis

    Nutritional deficiencies (iron, folate, ferritin, vitamin B 6, vitamin B 12 ) Tobacco cessation Medications, for example, methotrexate, NSAIDS, phenobarbital Immunologic: HLA-B12[unboundmedicine.com]

  • Toxic Nodular Goiter

    We found: i) an increased frequency of HLA-B8 (21.4% versus 7.1%) and a decreased frequency of HLA-B12 (2.9% versus 18.2%) in Graves' disease when compared with controls;[ncbi.nlm.nih.gov] […] ii) no differences in the distribution of HLA-A, -B antigens in TNG, when compared with either controls or Graves' disease.[ncbi.nlm.nih.gov]

  • Recurrent Oral Ulceration

    These results suggest that HLA-B12, B5, DR7 and DR2 might in some way be associated with tissue localization of disease.[ncbi.nlm.nih.gov] This is shown by a positive family history in about one-third of patients with RAS; an increased frequency of human leukocyte antigen (HLA) types A2, A11, B12, and DR2; and[emedicine.medscape.com] Alternatively, since patients with HLA-B12 show a significantly greater ratio of IgG:IgA circulating immune complexes than those with B5/DR7/DR2, tissue localization might[ncbi.nlm.nih.gov]

  • Open Angle Glaucoma

    The prevalence of HLA-B12 and HLA-B7 antigens in primary open-angle glaucoma. Arch Ophthalmol 1977; 95: 224–5. Google Scholar 24.[link.springer.com]

  • Birdshot Chorioretinopathy

    The HLA-B12 (B44) antigen was also significantly associated with the disease, but this antigen is known to be in linkage disequilibrium with the antigen HLA-A29.[ncbi.nlm.nih.gov] Positivity for the HLA-B12 antigen may also be linked to Birdshot Chorioretinopathy, although this causation has not been confirmed.[raregenomics.org] (HLA-B12), which has been confirmed by several other authors. [5] The link to HLA-B12 is less strong, with a relative risk ratio from 2.7 to 7.[emedicine.medscape.com]

  • Aphthous Stomatitis

    HLA-B12, HLA-B51, HLA-Cw7, HLA-A2, HLA-A11, and HLA-DR2 are examples of human leukocyte antigen types associated with aphthous stomatitis.[en.wikipedia.org] People genetically predisposed to aphthous stomatitis include those with HLA-B12, HLA-B51, HLA-Cw7, HLA-A2, HLA-A11, and HLA-DR2 human leukocyte antigen types.[standardofcare.com] , A11, B12 and DR2).[pocketdentistry.com]

  • Thromboangiitis Obliterans

    De Moerloose et al. (1979) found a deficiency of HLA-B12 in patients with Buerger disease (2.2% vs 28% in controls).[omim.org] HLA-B12 antigen may be associated resistance to disease.[unboundmedicine.com] De Moerloose et al. [ 21 ] found a marked decrease in frequency of the HLA-B12 antigen in patients with Buerger's disease (2.2% vs. 28% in controls).[ojrd.com]

  • Adrenal Insufficiency

    Links to HLA DR3 and DR4.[patient.info] Chronic atrophic gastritis and vitamin B12 deficiency. Coeliac disease. Hypoparathyroidism. Inheritance : Autosomal recessive. Complex genetic factors.[patient.info]

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