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511 Possible Causes for HLA-B27

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  • Spondylitis

    Many HLA-B27 positive don’t get AS, and some people without it do. Prevalence 2-8% (30% in eskimos!)[oxfordmedicaleducation.com] About 90% of people who develop spondyloarthritis will carry the HLA-B27 gene.[spondylitis.ca] Not all allelles of HLA-B27 are at risk for B27 Syndromes, please check the HLA-B27 page for details.[snpedia.com]

  • Psoriatic Arthritis

    While a number of genes are linked to PsA, the highest predictive value is noted with HLA-B27.[spondylitis.org] Genetic defects: HLA-B27 is a genetic marker for the disease. Reduced immune defenses : Helper T cell count is usually low.[symptoma.com] […] osteoclasts are exposed to inflammatory molecules in the psoriatic joint, triggering osteoclast activation and causing osteolysis Associated conditions skin psoriasis other HLA-B27[step2.medbullets.com]

  • Ankylosing Spondylitis

    In literature, although the evidence for association between AS and periodontitis as well as AS and HLA-B27 are there but the association of aggressive periodontitis in HLA-B27[ncbi.nlm.nih.gov] […] spondylitis risk in HLA-B27-positive individuals.[ncbi.nlm.nih.gov] KEYWORDS: Ankylosing spondylitis; HLA-B27; Klebsiella pneumoniae[ncbi.nlm.nih.gov]

  • Reiter's Syndrome

    HLA B27 was present in 11 (61.1%) patients.[ncbi.nlm.nih.gov] A case of a genetically HLA-B27 patient fully investigated by molecular analyses, following a holistic vision and an anamnestic assessment of multi-site ecosystems is repeated[ncbi.nlm.nih.gov] ) acts in concert with HLA-B27 to contribute to disease pathogenesis.[ncbi.nlm.nih.gov]

  • Salmonella Infection

    Human leucocyte antigen (HLA)-B27 was positive in 42% of patients with ReA.[ncbi.nlm.nih.gov] Over two thirds of these patients are HLA-B27 positive.[aafp.org] An HLA-B27 genotype is a predisposing factor in over two thirds of patients with reactive arthritis.[aafp.org]

  • Crohn's Disease

    However, they have only a transient benefit in HLA-B27 transgenic rats[ 24 ].[doi.org] Gastroenterology 128 : A210 84 Dieleman LA et al. (2003) Lactobacillus GG prevents recurrence of colitis in HLA-B27 transgenic rats after antibiotic treatment.[dx.doi.org]

  • Uveitis

    Half of all cases of AAU are HLA-B27 positive.[doi.org] There is a paucity of literature reporting on older individuals with HLA-B27 uveitis. Here, we describe cases of HLA-B27 uveitis presenting initially at age 70.[ncbi.nlm.nih.gov] Four families with HLA-B27‑positive aau patients and their HLA-B27-positive blood relatives were included in the study. peripheral blood monocytes were isolated from the subjects[ncbi.nlm.nih.gov]

  • Anterior Uveitis

    HLA-B27-).[ncbi.nlm.nih.gov] Patients were divided into human leucocyte antigen (HLA)-B27 AS and HLA-B27 AS - group.[ncbi.nlm.nih.gov] The examined material was based on observational studies in which participants were affected by Acute Anterior Uveitis and divided into HLA B27 and HLA B27-.[ncbi.nlm.nih.gov]

  • Enthesitis-Related Arthritis

    […] method permitted identification of common HLA-B27 subtypes (HLA-B*27:01 to HLA-B*27:09).[ncbi.nlm.nih.gov] HLA-B27 subtyping was done by sequencing using a group-specific amplification of the second and third exon region of HLA B27 gene.[acrabstracts.org] Forty patients (75.5%) were positive for HLA-B27. MEFV analysis was performed for patients who were HLA-B27 negative.[ncbi.nlm.nih.gov]

  • Juvenile Ankylosing Spondylitis

    Nine of the 10 patients exhibited the genetic marker HLA B27, but only one patient was homozygous for HLA B27.[ncbi.nlm.nih.gov] HLA-B27 was found in 4 out of 6 cases. This frequency is almost equal to that of adult ankylosing spondylitis patients.[ncbi.nlm.nih.gov] Five (33%) of these three family members had positive HLA-B27 but were asymptomatic; six members(40%) were HLA-B27 negative and symptom-free.[ncbi.nlm.nih.gov]

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