HLA-B27: Causes & Reasons

Possible Causes for HLA-B27

A high percentage of people with these diseases share a similar gene called HLA B27. [my.clevelandclinic.org]

The disease is associated with the HLA B27 gene in 50 to 80% of patients. What is enteropathic arthritis? [my.clevelandclinic.org]

It is associated with the HLA B27 gene, but it is unclear why. It is also unclear why ReA is sometimes associated with infection. [my.clevelandclinic.org]

Axial Spondyloarthritis

Table 1 Different populations in non-radiographic axSpA (True) Non-radiographic Pre-radiographic (or early AS) F>M M>F HLA-B27 Neg HLA-B27 Pos MRI-ve MRI+ve CRP-ve (unless [academic.oup.com]

[…] positive with ≥1 SpA-feature or HLA-B27 negative with ≥2 SpA-features. [acrabstracts.org]

However, HLA-B27 is less prevalent among African Americans with axSpA. Read more about the role of HLA-B27 and axSpA. [creakyjoints.org]

Psoriatic Arthritis

While a number of genes are linked to PsA, the highest predictive value is noted with HLA-B27. [spondylitis.org]

The provider may test for a gene called HLA-B27. People with involvement of the back are more likely to have HLA-B27. [nlm.nih.gov]

[…] osteoclasts are exposed to inflammatory molecules in the psoriatic joint, triggering osteoclast activation and causing osteolysis Associated conditions skin psoriasis other HLA-B27 [step2.medbullets.com]

Ankylosing Spondylitis

Linkage analysis with 32 members using three methods and whole-exome sequencing analysis with three HLA-B27 (+) patients, one HLA-B27 (-) patient, and one healthy individual [ncbi.nlm.nih.gov]

In literature, although the evidence for association between AS and periodontitis as well as AS and HLA-B27 are there but the association of aggressive periodontitis in HLA-B27 [ncbi.nlm.nih.gov]

[…] spondylitis risk in HLA-B27-positive individuals. [ncbi.nlm.nih.gov]

Reiter Syndrome

HLA B27 was present in 11 (61.1%) patients. [ncbi.nlm.nih.gov]

Around 90% of the patients with AS are HLA B27 positive. [bdrdiagnostics.com]

Enthesitis-Related Arthritis

[…] method permitted identification of common HLA-B27 subtypes (HLA-B*27:01 to HLA-B*27:09). [ncbi.nlm.nih.gov]

HLA-B27 subtyping was done by sequencing using a group-specific amplification of the second and third exon region of HLA B27 gene. [acrabstracts.org]

The data set included 234 ERA children with a mean age of 11.6 years, and 59% were HLA-B27-positive. [rheumnow.com]

Juvenile Ankylosing Spondylitis

Nine of the 10 patients exhibited the genetic marker HLA B27, but only one patient was homozygous for HLA B27. [ncbi.nlm.nih.gov]

HLA-B27 was found in 4 out of 6 cases. This frequency is almost equal to that of adult ankylosing spondylitis patients. [ncbi.nlm.nih.gov]

This prevalence of homozygosity among HLA B27 positive persons could be expected to occur by chance alone. [ncbi.nlm.nih.gov]

Shigella Enteritis

One of the animals had a major histocompatibility class I allele with some sequence similarity to HLA-B27. [eurekamag.com]

It is thought that HLA-B27 may affect the elimination of the infecting bacteria or an individual’s immune response. [1] HLA-B27 has been shown to be a predisposing factor [about-reactive-arthritis.com]

A subset of HLA-B27 molecules contains peptides much longer than nonamers. [ard.bmj.com]

Rubella-Associated Arthritis

Connective tissue disease, especially SLE Seronegative arthritis, especially Ankylosing spondylitis Rheumatoid factor-negative spondylo-arthropathies associated with HLA-B27 [rcpa.edu.au]

The role of HLA-B27 in this process has been discussed, and the favorite hypothesis is a cross-reaction between microbial structures and HLA-B27, or that HLA-B27 itself might [antimicrobe.org]

Individuals genetically prone to develop autoimmune illness (namely carriers of HLA-DR1, DR4, DR6, or HLA-B27) are more likely to contract post-immunization arthritis. [encognitive.com]

Salmonella Infection

Human leucocyte antigen (HLA)-B27 was positive in 42% of patients with ReA. [ncbi.nlm.nih.gov]

Aho, K., Ahuonen P., Alkio P.: HLA-B27 in reactive arthritis following infection. Ann. Rheum. Dis. 1975, 34 (suppl.), 29–31. Google Scholar 15. [link.springer.com]

Over two thirds of these patients are HLA-B27 positive. [aafp.org]

Inflammatory Bowel Disease Type 1

or elevated CRP) or presence of HLA-B27 and any two other clinical features. [hindawi.com]

Type 1 is usually associated with HLA-B27, HLA-B35, and HLA-DR103, while type 2 is associated with HLA-B44 (27). [tp.amegroups.com]

However, they have only a transient benefit in HLA-B27 transgenic rats[ 24 ]. [doi.org]

Polyarthritis

Diagnostic methods Diagnosis is based on recognition of the clinical triad and blood tests revealing HLA-B27 positivity (about 75% of the patients are HLA-B27-positive). [orpha.net]

Anti-citrullinated protein antibody (ACPA), rheumatoid factor, human leucocyte antigen (HLA) B27 and imaging are routinely employed for the early diagnosis of RA and spondyloarthritis [ncbi.nlm.nih.gov]

[…] with syndesmophytes, peripheral enthesopathy with calcifications of tendons and ligaments, destructive bone lesions at DIP joints. - Negative rheumatoid factor, positive HLA-B27 [tcd.ie]

Uveitis

Half of all cases of AAU are HLA-B27 positive. [doi.org]

There is a paucity of literature reporting on older individuals with HLA-B27 uveitis. Here, we describe cases of HLA-B27 uveitis presenting initially at age ≥70. [ncbi.nlm.nih.gov]

Four families with HLA-B27‑positive aau patients and their HLA-B27-positive blood relatives were included in the study. peripheral blood monocytes were isolated from the subjects [ncbi.nlm.nih.gov]

Retinitis Pigmentosa

Background The name retinitis pigmentosa (RP) was first applied by Dr Donders in 1857. It is the phenotypic description of several related, yet distinct, hereditary, progressive dystrophies of the photoreceptors of the retina and of the pigment epithelium (which lies just underneath the photoreceptors). Patients[…] [patient.info]

Anterior Uveitis

HLA-B27-). [ncbi.nlm.nih.gov]

Acute anterior uveitis and HLA-B27. Surv Ophthalmol. 2005;50:364-88. Wakefield D. Management of HLA-B27 acute anterior uveitis. [eyewiki.org]

Patients were divided into human leucocyte antigen (HLA)-B27 + AS + and HLA-B27 + AS - group. [ncbi.nlm.nih.gov]

Polyarticular Juvenile Idiopathic Arthritis

Human leukocyte antigen B27 (HLA-B27)- HLA-B27 is a marker for seronegative spondyloarthropathies, which can also cause uveitis in young patients. [eyewiki.aao.org]

HLA-B27 is present more commonly in enthesitis-related arthritis. [merckmanuals.com]

The male patients HLA-B27 +ve patients may have severe inflammation, redness, pain, and hypopyon as seen in association with HLA-B27. These patients are usually older. [eyewiki.aao.org]

Juvenile Idiopathic Arthritis

There is significant correlation between ANA seropositivity and HLA-B27, early erosion, response to treatment, uveitis and subcutaneous nodule. [ncbi.nlm.nih.gov]

It appears to have association with HLA alleles other than B27 (e.g. HLA-DR5). [pathophys.org]

RF and HLA B27 are useful for classification (HLA B27 is positive in 90% of enthesitis-related JIA). [patient.info]

Anterior Spinal Artery Syndrome

an inflammatory arthritis associated with HLA B27. [eyewiki.aao.org]

A detailed explanation of HLA-B27 and those diseases associated with HLA-B27 is found elsewhere on this website, but the most common association with AAU is ankylosing spondylitis [eyewiki.aao.org]

[…] of known risk factors (HLA-B27), with exclusion of other possible causes. [eyewiki.aao.org]

Oligoarthritis

HLA B27 antigen was studied and family history was reexamined in 2006. Five patients had sacroiliitis. [ncbi.nlm.nih.gov]

He was haplotyped as HLA-B27 antigen-positive. The colitis and arthritis promptly abated after treatment with oral vancomycin hydrochloride. [experts.umn.edu]

Spondyloarthritis Nature Reviews Rheumatology volume 8, page184(2012)Cite this article 4 Accesses 0 Altmetric Metrics details Although bone marrow edema and HLA-B27 predict [nature.com]

Viral Arthritis

Having the HLA-B27 gene could also make you more likely to have further episodes of reactive arthritis in the future. [arthritisresearchuk.org]

Some patients with reactive arthritis carry a gene called HLA-B27. Patients who test positive for HLA-B27 often have a more sudden and severe onset of symptoms. [rheumatology.org]

Syphilitic Arthritis

The value of HLA-B27 testing is unclear and should not be implemented for all patients. [rheumatologyadvisor.com]

This is owing to the high frequency of the HLA-B27 gene in the white population. [8] [9] It can occur in epidemic form. [en.wikipedia.org]

[…] absence of HLA-B27. [what-when-how.com]

Seronegative Arthritis

[…] not associated with HLA-B27. [emedicine.medscape.com]

Patients who test positive for HLA-B27 are more frequently affected by the disease, when compared to those who test negative. [symptoma.com]

HLA-B27 is present in approximately 6-8 % of the normal population in the Indian subcontinent. [ncbi.nlm.nih.gov]

Septic Arthritis of Pelvic Region

Up to 96% of the patients with ankylosing spondylitis are HLA-B27 positive. [lecturio.com]

Fungal arthritis (Medical Encyclopedia) HLA-B27 antigen (Medical Encyclopedia) Reactive arthritis (Medical Encyclopedia) Septic arthritis (Medical Encyclopedia) Viral arthritis [icdlist.com]

This is owing to the high frequency of the HLA-B27 gene in the white population. [8] [9] It can occur in epidemic form. [en.wikipedia.org]

Arthritis due to Ulcerative Colitis

[…] associated with HLA-B27 positivity. [patient.info]

Unlike rheumatoid arthritis, arthritis associated with IBD may affect the lower spine, especially the sacroiliac joints, and is associated with a certain gene (called HLA-B27 [health.harvard.edu]

HLA-B27 related arthritis and bowel inflammation. Part 2. Ileocolonoscopy and bowel histology in patients with HLA-B27 related arthritis. J Rheumatol 1985;12:294-8. 3. [cjhr.org]

Psoriatic Juvenile Idiopathic Arthritis

A statistically significant association with HLA-B27 was observed. [jrheum.org]

[…] arthritis (23%), family history of psoriasis limited to second-degree relatives (16%), fulfillment of criteria for >1 subtype of juvenile idiopathic arthritis (JIA) (5%), and HLA-B27 [ncbi.nlm.nih.gov]

The photograph below shows enthesitis and tenosynovitis (arrowed) in ERA The photograph below shows a red eye in acute uveitis in HLA B27 positive ERA Polyarticular JIA (20% [pmmonline.org]

Reactive Arthritis

S. enteritidis did not co-localize with NRAMP1 and LAMP1/2 in HLA-B27 cells. S. enteritidis did not co-exist with transferrin or dextran within HLA-B27 and A2 cells. [ncbi.nlm.nih.gov]

High resolution and sensitivity mass spectrometry was used to identify HLA-B27 ligands endogenously processed and presented by HLA-B27 from three chlamydial proteins for which [ncbi.nlm.nih.gov]

Khan et al., The pathogenetic role of HLA-B27 and its subtypes. Autoimmun Rev. 6, 183 (2007) M. [charite.de]

Juvenile Seronegative Polyarthritis

The HLA B27-positive patients contracted amyloidosis on average 5.9 (median 6.7) years earlier than the HLA B27-negative patients ( p =0.038). [link.springer.com]

RF and HLA B27 are useful for classification (HLA B27 is positive in 90% of enthesitis-related JIA). [patient.info]

Laboratory tests such as ESR, rheumatoid factor ( RF ), antinuclear antibodies ( ANA ), and the HLA-B27 antigen test are used to classify and determine the prognosis of JIA [amboss.com]

Idiopathic Anterior Uveitis

In the sera only IL-1α was statistically higher in the HLA-B27 associated AAU in comparison to the control. [ncbi.nlm.nih.gov]

RESULTS: As expected, the frequency of HLA-B27 was significantly higher in the patient group than the control group (63.33% versus 15.83%; Pearson's P CONCLUSION: This study [ncbi.nlm.nih.gov]

[…] info:ndljp/pid/284696/ir.library.osaka-u.ac.jp/metadb/up/LIBLSK001/JJRS-53-4-387-394.pdf 詳細表示タイトル (title) 急性前部ブドウ膜炎を併発した強直性脊椎炎 : HLA-B27と臨床症状，骨関節所見との関連 : HLA-B27と急性前部ぶどう膜炎 [dl.ndl.go.jp]

Iritis

Therefore, a uveitis workup might include the following studies: Lyme’s Disease: Anti-Borrelia burgdorferi antibodies Syphilis: RPR, FT-ab HLA-B27: HLA-B27 Genotype testing [morancore.utah.edu]

Recurrences are fairly common, especially in patients who are HLA-B27 positive. Iritis left eye: Typical ciliary injection around the limbus. [ophthalmologytraining.com]

It is the most common form of uveitis with an annual incidence of 12 per 100,000 populations. 90% of the cases are over the age of 20 years 50% of the patients are HLA-B27 [gpnotebook.com]

Spondylitic Aortitis

HLA-B27 antigen. Social class. [iritis.org]

Increased prevalence of HLA-B27 in whites or HLA-B7 in blacks supports a genetic predisposition. [msdmanuals.com]

HLA-B27 allele develop AS Family History. [hss.edu]