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533 Possible Causes for HLA-B27, Lymphadenopathy

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  • Enthesitis-Related Arthritis

    When the disease is active, up to 10% of patients will develop systemic manifestations such as fever, weight loss, fatigue, muscle weakness, muscle atrophy, and lymphadenopathy[] […] method permitted identification of common HLA-B27 subtypes (HLA-B*27:01 to HLA-B*27:09).[] Individuals with systemic arthritis may also have a skin rash or enlargement of the lymph nodes (lymphadenopathy), liver (hepatomegaly), or spleen (splenomegaly).Oligoarticular[]

  • Whipple Disease

    ’s Disease Lymphadenopathy?[] About 30% of patients have HLA-B27. Drugs Mentioned In This Article PLAQUENIL No US brand name ROCEPHIN PERIOSTAT, VIBRAMYCIN[] HLA-B27 antigen; HLA-DRB1*13 and DQB1*06 alleles. [ 9 ] Sewage plant workers, farmers and agricultural workers.[]

  • Adult-Onset Still Disease

    Other common manifestations of AOSD are lymphadenopathy, hepatosplenomegaly, muscle aches, and pharyngitis.[] He had a normal ACE level and negative HLA-B27, quantiferon and PPD testing.[] […] systemic inflammatory disorder characterized clinically by high spiking fever, polyarthralgia/arthritis, a salmon-pink evanescent rash, predominantly neutrophilic leucocytosis, lymphadenopathy[]

  • Salmonella Infection

    This patient had continuous high fever for one month, bronchopneumonia, pancytopenia, mucous bloody diarrhea and generalized lymphadenopathy.[] Human leucocyte antigen (HLA)-B27 was positive in 42% of patients with ReA.[] Aho, K., Ahuonen P., Alkio P.: HLA-B27 in reactive arthritis following infection. Ann. Rheum. Dis. 1975, 34 (suppl.), 29–31. Google Scholar 15.[]

  • Shigella Enteritis

    […] non-Hodgkin's lymphoma (other than primary brain lymphoma), lymphocytic leukemia, multiple myeloma, any other cancer of lymphoreticular or histiocytic tissue, or angioimmunoblastic lymphadenopathy[] Approximately 70% of patients with post-shigellosis reactive arthritis are HLA-B27 positive. [ 28 ] Hemolytic-uremic syndrome (HUS) is a relatively uncommon disease; however[] It is thought that HLA-B27 may affect the elimination of the infecting bacteria or an individual’s immune response. [1] HLA-B27 has been shown to be a predisposing factor[]

  • Polyarthritis

    Check major lymph nodes for evidence of lymphadenopathy. Check the skin for rashes (eg, psoriasis, SLE) and evidence of vasculitis.[] Anti-citrullinated protein antibody (ACPA), rheumatoid factor, human leucocyte antigen (HLA) B27 and imaging are routinely employed for the early diagnosis of RA and spondyloarthritis[] Only 39% had lymphadenopathy, 10% had pericarditis, and fewer had hepato-splenomegaly [ 15 ].[]

  • Muckle Wells Syndrome

    Additional features include severe chronic fatigue, recurrent headaches, cognitive impairment, ocular involvement (conjunctivitis, uveitis, episcleritis), oral aphthosis, lymphadenopathy[] HLA B27-associated juvenile spondyloarthropathies. Sarcoidosis. Malignancies, including leukemia and lymphoma. Acute intermittent porphyria.[] Physical exam Remarkable findings include lymphadenopathy and/or hepatosplenomegaly.[]

  • Juvenile Onset Stills Disease

    Appearance of rash, hepatosplenomegaly, serositis and generalized lymphadenopathy.[] B27-positivity in males with onset of arthritis after 6 years of age and detection of rheumatoid factor IgM in two test samples taken three months apart.[] RF and HLA B27 are useful for classification (HLA B27 is positive in 90% of enthesitis-related JIA).[]

  • Yersinia Enterocolitica

    […] pseudotuberculosis Usually self limited Gram stain: gram negative, polymorphic, coccoid or ovoid mobile bacteria Case reports 46 year old woman with weight loss and abdominal lymphadenopathy[] A case of appendicitis followed by reactive arthritis in an HLA B27-positive, 29-year-old man after infection with Yersinia enterocolitica is reported.[] […] enterocolitica was not isolated from a stool culture; however, he was diagnosed with ReA based on the colonoscopic findings of a high anti-Y. enterocolitica antibody titer and HLA-B27[]

  • Tonsillitis

    Kikuchi-Fujimoto disease is a very rare cause of benign lymphadenopathy affecting mainly young Asiatic females.[] Sacroiliitis, although rare, is described in human leukocyte antigen (HLA)-B27 positive PSRA patients.[] The case emphasises the importance of having a high index of suspicion for Kawasaki syndrome in children presenting with tonsillitis and cervical lymphadenopathy who do not[]

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