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263 Possible Causes for HLA-B27, Lymphadenopathy

  • Enthesitis-Related Arthritis

    When the disease is active, up to 10% of patients will develop systemic manifestations such as fever, weight loss, fatigue, muscle weakness, muscle atrophy, and lymphadenopathy[symptoma.com] […] method permitted identification of common HLA-B27 subtypes (HLA-B*27:01 to HLA-B*27:09).[ncbi.nlm.nih.gov] Individuals with systemic arthritis may also have a skin rash or enlargement of the lymph nodes (lymphadenopathy), liver (hepatomegaly), or spleen (splenomegaly).Oligoarticular[icdlist.com]

  • Whipple Disease

    We describe 2 patients with Whipple disease whose initial manifestation was lymphadenopathy.[ncbi.nlm.nih.gov] About 30% of patients have HLA-B27. Drugs Mentioned In This Article PLAQUENIL No US brand name ROCEPHIN PERIOSTAT, VIBRAMYCIN[merckmanuals.com] HLA-B27 antigen; HLA-DRB1*13 and DQB1*06 alleles. [ 9 ] Sewage plant workers, farmers and agricultural workers.[patient.info]

  • Influenza

    […] pediatric seasonal influenza include the following: High fever Chills Myalgia Headache Fatigue Sore throat/pharyngitis Nasal congestion Rhinitis Nonproductive cough Cervical lymphadenopathy[emedicine.medscape.com] Structural homologies between two HLA B27-restricted peptides suggest residues important for interaction with HLA B27. Int Immunol 2 : 311 –6. Hughes AL, Nei M. 1988 .[dx.doi.org]

  • Juvenile Onset Stills Disease

    Appearance of rash, hepatosplenomegaly, serositis and generalized lymphadenopathy.[symptoma.com] B27-positivity in males with onset of arthritis after 6 years of age and detection of rheumatoid factor IgM in two test samples taken three months apart.[orpha.net] RF and HLA B27 are useful for classification (HLA B27 is positive in 90% of enthesitis-related JIA).[patient.info]

  • Polyarthritis

    Check major lymph nodes for evidence of lymphadenopathy. Check the skin for rashes (eg, psoriasis, SLE) and evidence of vasculitis.[patient.info] Anti-citrullinated protein antibody (ACPA), rheumatoid factor, human leucocyte antigen (HLA) B27 and imaging are routinely employed for the early diagnosis of RA and spondyloarthritis[ncbi.nlm.nih.gov] Only 39% had lymphadenopathy, 10% had pericarditis, and fewer had hepato-splenomegaly [ 15 ].[pediatrics.imedpub.com]

  • Rubella-associated Arthritis

    […] before the rash postauricular lymphadenopathy is classic may also have posterior cervical and suboccipital lymphadenopathy fine, pink, non-confluent maculopapular rash starts[medbullets.com] Connective tissue disease, especially SLE Seronegative arthritis, especially Ankylosing spondylitis Rheumatoid factor-negative spondylo-arthropathies associated with HLA-B27[rcpa.edu.au] The role of HLA-B27 in this process has been discussed, and the favorite hypothesis is a cross-reaction between microbial structures and HLA-B27, or that HLA-B27 itself might[antimicrobe.org]

  • Arthritis of Inflammatory Bowel Disease

    Systemic JIA is characterized by systemic symptoms such as high fever (spiking fever), skin rash, pericarditis, and lymphadenopathy, as well as joint symptoms; however, polyarticular[jstage.jst.go.jp] The human leukocyte antigen (HLA)-B27 is a well recognised best-known predisposing factor.[ncbi.nlm.nih.gov] Session Time: 9:00AM-11:00AM Background/Purpose: Systemic juvenile idiopathic arthritis (sJIA) is an autoinflammatory disease accompanied by systemic symptoms including lymphadenopathy[acrabstracts.org]

  • Juvenile Seronegative Polyarthritis

    Individuals with systemic arthritis may also have a skin rash or enlargement of the lymph nodes (lymphadenopathy), liver (hepatomegaly), or spleen (splenomegaly).Oligoarticular[icdlist.com] The HLA B27-positive patients contracted amyloidosis on average 5.9 (median 6.7) years earlier than the HLA B27-negative patients ( p 0.038).[link.springer.com] Systemic-onset JRA is characterized by high intermittent fevers and other extra-articular manifestations: lymphadenopathy, rash, pleuritis, and pericarditis.[pedsinreview.aappublications.org]

  • Juvenile Rheumatoid Arthritis

    […] rheumatoid arthritis accompanied by systemic manifestations such as spiking fever, transient rash on the trunk and limbs, enlargement of the liver and spleen, generalized lymphadenopathy[web.archive.org] There is significant correlation between ANA seropositivity and HLA-B27, early erosion, response to treatment, uveitis and subcutaneous nodule.[ncbi.nlm.nih.gov] Physical examination revealed cervical lymphadenopathy and hepatosplenomegaly.[ncbi.nlm.nih.gov]

  • Adult-Onset Still Disease

    Other common manifestations of AOSD are lymphadenopathy, hepatosplenomegaly, muscle aches, and pharyngitis.[symptoma.com] He had a normal ACE level and negative HLA-B27, quantiferon and PPD testing.[archivesofmedicine.com] Adult onset Still's disease (AOSD) is a systemic inflammatory disease characterized by high-fevers, articular involvement, maculopapular rash, hepatosplenomegaly, lymphadenopathy[ncbi.nlm.nih.gov]

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