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415 Possible Causes for HLA-B27, Muscle Weakness, Myopathy

  • Dermatomyositis

    Initially, dermatomyositis (DM) was considered because of the erythema, polyarthritis, and muscle weakness.[ncbi.nlm.nih.gov] The exact cause is still unknown, but most people with spondylitis have a genetic marker, known as HLA-B27.[arthritis.about.com] The level of similarity between juvenile and adult myopathies regarding the presence of myositis-specific autoantibodies has not been fully elucidated.[ncbi.nlm.nih.gov]

  • Polymyositis

    Polymyositis is an idiopathic inflammatory myopathy of unknown aetiology that affect skeletal muscles causing symmetrical, proximal muscle weakness, and also other internal[ncbi.nlm.nih.gov] The exact cause is still unknown, but most people with spondylitis have a genetic marker, known as HLA-B27.[arthritis.about.com] Furthermore, glucocorticosteroid (GC) toxicity leads to a significant disability known as steroid myopathy, particularly in elderly patients.[ncbi.nlm.nih.gov]

  • Myasthenia Gravis

    Proximal muscle weakness is more often seen than distal muscle weakness.[symptoma.com] Interestingly, the late peak features a male predominance and an association with HLA-B27 and HLA-DR2.[eyewiki.aao.org] We review the relevant literature and discuss the hypothesis of a mitochondrial myopathy as a pathogenic mechanism in MuSK-antibody positive myasthenia gravis.[ncbi.nlm.nih.gov]

  • Spinal Muscular Atrophy Type 1

    This study described end-of-life care for children affected by spinal muscular atrophy type 1 (SMA1), which is characterised by progressive muscle weakness and develops in[ncbi.nlm.nih.gov] A, B, DR, DQ HLA B27 HMSN Mutatia punctiforma a PMP22 (PMP22) Intoleranta la lactoza (LCT) – (LPH) Maladia Alzheimer familiala (AD3/PSEN1) Maladia Meulengracht (Sindrom Gilbert[galenus.ro] Differential diagnosis Differential diagnoses include SMA2, congenital muscular dystrophies, congenital myopathies, some early-onset mitochondrial disorders, and carbohydrate[orpha.net]

  • Polymyalgia Rheumatica

    There is no true muscle weakness nor evidence of muscle disease on electromyography (EMG) or on biopsy.[healthcentral.com] Rheumatologic markers, and HLA-B27 were checked.[ncbi.nlm.nih.gov] We studied 60 patients who had undergone 18F-FDG PET/CT scans for workup of suspected PMR, arthritis, enthesitis, or myopathy.[ncbi.nlm.nih.gov]

  • Becker Muscular Dystrophy

    A thorough clinical analysis of the carriers, both children (12) and adults (5), revealed in some of them muscle hypotonia (10/17) and/or very mild muscle weakness (9/17),[ncbi.nlm.nih.gov] A, B, DR, DQ HLA B27 HMSN Mutatia punctiforma a PMP22 (PMP22) Intoleranta la lactoza (LCT) – (LPH) Maladia Alzheimer familiala (AD3/PSEN1) Maladia Meulengracht (Sindrom Gilbert[galenus.ro] In a boy with myopathy and an increase of muscle fibres with central nuclei we detected a heterozygous 387G-- T nucleotide transversion in the MYF6 gene (MIM*159991).[ncbi.nlm.nih.gov]

  • Antisynthetase Syndrome

    The patient's presenting symptoms were cough and proximal muscle weakness of the extremities.[ncbi.nlm.nih.gov] Yang paling menonjol dan konsisten adalah hubungan antara HLA B27 dan ankylosing spondylitis .[basmalah9.blogspot.com] We describe the case report of a 53-year-old man who presented with proximal muscle weakness and a history of bilateral hand tremor.[ncbi.nlm.nih.gov]

  • Hydrocortisone

    In the hydrocortisone vs placebo groups, 21.5% vs 16.9% had secondary infections, 8.6% vs 8.5% had weaning failure, 30.7% vs 23.8% had muscle weakness, and 90.9% vs 81.5%[ncbi.nlm.nih.gov] The exact cause is still unknown, but most people with spondylitis have a genetic marker, known as HLA-B27.[arthritis.about.com] The possibility that neuromuscular blockade might predispose to the development of myopathy is discussed.[ncbi.nlm.nih.gov]

  • Graves Disease

    On neurological examination the patient was presented with muscle weakness, muscle atrophy (in face and sternocleidomastoid muscles), features of myotonia and apocamnosis[ncbi.nlm.nih.gov] HLA-B27 is present in 70-80% of patients with reactive arthritis, and HLA-B27 increases the risk of reactive arthritis by 25-fold.[casesjournal.biomedcentral.com] We suggest that lipid storage myopathy is secondary to GD, and it is likely mitochondrial dysfunction or immune dysfunction induced by GD responsible for the myopathy and[ncbi.nlm.nih.gov]

  • MELAS Syndrome

    Increased acidity in the blood can lead to vomiting, abdominal pain, extreme tiredness (fatigue), muscle weakness, loss of bowel control, and difficulty breathing.[en.wikipedia.org] A, B, DR, DQ HLA B27 HMSN Mutatia punctiforma a PMP22 (PMP22) Intoleranta la lactoza (LCT) – (LPH) Maladia Alzheimer familiala (AD3/PSEN1) Maladia Meulengracht (Sindrom Gilbert[galenus.ro] Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a rare neurodegenerative disease caused by the decreased ability of cells[ncbi.nlm.nih.gov]

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