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86 Possible Causes for HLA-B7

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  • Myasthenia Gravis

    BACKGROUND: Patients with thymoma with immunodeficiency (TWI)/Good's syndrome characteristically have evidence of combined immunodeficiency including low or absent B-cells, hypogammaglobulinemia and defects in T-cell mediated immunity. These patients can present with common or opportunistic infections. CASE[…][ncbi.nlm.nih.gov]

  • Periodontitis

    , ICAM-1, LFA-1, MHC II, CD32 (Ig Fc receptor), CD35 (Receptor for complement component). » ... « Genes for HLA are clustered in MHC located on Chromosome 6: 6p21. » ... «[periobasics.com] […] molecules. » ... « Lymphocytes comprise 20-40% (1000 - 4000 cells/μl) of all leukocytes. » ... « Markers/Receptors on B cells are Surface Immunoglobulin (IgM and IgD), CD40, B7[periobasics.com]

  • Serpiginous Choroiditis

    Of the histocompatibility antigens, HLA-B7 was found more frequently than expected in a Finnish population (54.5% versus 24.3%; P less than 0.05).[ncbi.nlm.nih.gov] Of the histocompatibility antigens, HLA-A2 was found in five and HLA-B7 in 4 of the 6 patients studied.[ncbi.nlm.nih.gov] However, it is known to be associated with certain conditions that include tuberculosis, herpes infection, and HLA-B7 genetic make-up.[dovemed.com]

  • Choroiditis

    Of the histocompatibility antigens, HLA-B7 was found more frequently than expected in a Finnish population (54.5% versus 24.3%; P 0.05).[link.springer.com] However, it is known to be associated with certain conditions that include tuberculosis, herpes infection, and HLA-B7 genetic make-up.[dovemed.com] References Braley RE, Meredith TA, Aaberg TM, Koethe SM, Witkowski JA (1978) The prevalence of HLA-B7 in presumed ocular histoplasmosis.[link.springer.com]

  • Polyarthritis

    It is associated with HLA B7 and HLA A2 hapbtypes anc hasa male predominance (M:F 2:1).[shmabstracts.com] […] association DR 1.4 B7 DR 3.4 Remission Unusual Predictable (3–36 months) Usual (2 years or more) Response to corticoids Frequently incomplete Significant Significant HLA,[academic.oup.com] […] typing demonstrated increased prevalence of B7 for RS3PE but DR4 for polymyalgia, 49-52 pointing toward similar but distinctive syndromes in this elderly population.[ard.bmj.com]

  • Endometriosis

    Further investigation has revealed a possible role for the HLA-B7 allele.[web.archive.org] The expression of HLA-B7 has been shown to inhibit the cytotoxic activity of natural killerlike T lymphocytes, suggesting that the growth of ectopic endometrial cells might[web.archive.org]

  • Hemochromatosis

    Comparison of amino acid sequences of two human histocompatibility antigens, HLA-A2 and HLA-B7: location of putative alloantigenic sites. Proc. Natl.Acad.Sci.[doi.org]

  • Preeclampsia

    Further studies showed that these sHLA class I molecules included classical HLA class I alleles, such as sHLA-A2, -B7, -B51, -B35 and sHLA-A9.[ncbi.nlm.nih.gov]

  • Spondylitis

    Increased prevalence of HLA-B27 in whites or HLA-B7 in blacks supports a genetic predisposition.[msdmanuals.com] The risk of ankylosing spondylitis in 1st-degree relatives with the HLA-B27 allele is about 20%.[msdmanuals.com]

  • Adenomyosis Uteri

    Further investigation has revealed a possible role for the HLA-B7 allele.[web.archive.org] The expression of HLA-B7 has been shown to inhibit the cytotoxic activity of natural killerlike T lymphocytes, suggesting that the growth of ectopic endometrial cells might[web.archive.org]

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