Thus, "A HLA association in PSC was first identified for HLA-B8 (i.e. HLA-B*0801) and DR3 (i.e. DRB1*0301)[24,50].
[psc-literature.org]
HLA-B8, HLA-DR3, and HLA-Drw52a alleles have an increased prevalence in patients with PSC, suggesting a genetic predisposition.
[symptoma.com]
Etiology O Immune mediated O Infection O Genetic predisposition HLA-B8, DR3, DR2, and DR4 O Environmental Factors 34. Pathophysiology 35. Pathophysiology 36.
[slideshare.net]
In herpes gestationis, immunofluorescence studies were consistently positive, there was a high frequency of HLA-B8 and an association with autoimmune thyrotoxicosis.
[ncbi.nlm.nih.gov]
An additional laboratory finding in patients with HG is their increased frequency of the HLA-B8 and HLA-DR3 haplotypes as well as the HLA-DR3, -DR4 paired haplotype.
[ncbi.nlm.nih.gov]
[…] day; female 40-60 gm/day (-2 points) Male >80 gm/day; female >60 gm/day (-1 point) Genetic factors Other autoimmune diseases in patient or first-degree relatives (1 point) HLA
[merckmanuals.com]
In the Italian population HLA-B8-DR3-DQ2, in Japan HLA-DRB1*0405 are the most frequent AIH associated haplotypes (12).
[path.upmc.edu]
B8, DR3, and Drw52),73 75-78 and this host related predisposition may result in similar clinical expressions or in transitions between the diseases.79-85 Conversely, HLA
[gut.bmj.com]
These "histocompatibility antigens" may include HLA-B8 and HLA-DR3.
[lupus.org]
The association of Sjögren syndrome with human leukocyte antigen (HLA)–B8, HLA-Dw3, HLA-DR3, and the DQA1*0501 allele supports the notion of genetic susceptibility. [16] An
[emedicine.com]
People with certain genetic markers (called HLA-B8, DR3) are more likely to develop MG.
[umms.org]
The early peak shows a female predominance, approximately 3:1, and an association with HLA-B8, HLA-DR3, and HLA-DR1, the latter being more specific for ocular MG.
[eyewiki.aao.org]
Epidemiology Affects 2% of women in US, 0.3% of men 85% of patients are women, usually ages 20 - 40 years; men are usually older 60% concordance in identical twins; associated with HLA-B8
[web.archive.org]
An autoimmune disease with stimulating anti-TSH receptor antibodies a type II hypersensitivity anti-microsomal, anti-thyroglobulin antibodies also present Female dominant HLA-B8
[step2.medbullets.com]
0.3% of men 85% of patients are women (female to male ratio is 4:1), usually ages 20 - 40 years; men are usually older 60% concordance in identical twins; associated with HLA-B8
[pathologyoutlines.com]
Factors leading to SLE include: Genetic predisposition, including haplotype HLA -B8, -DR 3 Exposure to sunlight Viral infection, particularly Epstein-Barr virus Hormones Toxins
[dermnetnz.org]
Factors leading to SLE include: Genetic predisposition, including haplotype HLA-B8, -DR3 Exposure to sunlight Viral infection, particularly Epstein-Barr virus Hormones Toxins
[dermnetnz.org]
Factors leading to SLE include: Genetic predisposition, incuding haplotype HLA -B8, -DR 3 Exposure to sunlight Viral infection, particularly Epstein-Barr virus Hormones Toxins
[dermnetnz.org]
The apparent predisposition of individuals with HLA-B8 and DR3 haplotypes to develop IACAH suggests that genetically conditioned abnormalities may have a role in pathogenesis
[hepatitiscentral.com]
Abstract Type 2 diabetes mellitus (T2DM) is a growing and serious global health problem. Inhibition of the sodium--glucosecotransporter-2 (SGLT2) can increase urinary glucose excretion and decrease plasma glucose levels in an insulin-independent manner. Ertugliflozin is a highly selective inhibitor of SGLT2, and was[…]
[ncbi.nlm.nih.gov]
We encountered a Japanese case of DH which showed granular IgA and C3 deposits in the papillary dermis and which was associated with gluten-sensitive enteropathy but no HLA-B8
[ncbi.nlm.nih.gov]
The HLA typing revealed no B8/DR3.
[ncbi.nlm.nih.gov]
The disease is strongly associated with the presence of HLA-B8 and HLA-DR3 antigens.
[dermis.net]
Five of 9 cases carried the haplotype HLA-A1, B8, DR3.
[ncbi.nlm.nih.gov]
Linear IgA dermatosis in children has been reported in association with human leukocyte antigen B8 (HLA-B8), but the significance of this finding is unknown.
[emedicine.medscape.com]
There is a lesser association with HLA B8. Both variants arise from the binding of IgA to two dermal antigens.
[thedoctorsdoctor.com]
Association of HLA-B8 has been reported with Schmidt syndrome.
[ncbi.nlm.nih.gov]
Many of the component endocrine disorders are associated with certain HLA antigens - especially HLA-B8 and HLA-Dw3.
[gpnotebook.com]
The screening of family members can be also assumed relevant, as there is a role of HLA antigens (namely HLA B8-DW-DR3) in predisposing individuals to the polyglandular autoimmune
[news-medical.net]
PBMC from seven HLA-DR3+, DQ2+, B8+ healthy subjects and nine HLA-DR3-, DQ2-, B8- subjects were also studied as controls.
[ncbi.nlm.nih.gov]
Influence of the HLA B8, DR3, DQ2 haplotype. Clin Exp Immunol. 2000 Sep. 121(3):491-8. [Medline].
[emedicine.com]
A spontaneous secretion of TNF by HLA DR3+, DQ2+ B8+ AE patients was also found.
[ncbi.nlm.nih.gov]
HLA-DR6 and DR2 in nitrofurantoin hepatitis, HLA-B8 in clometacin hepatitis).
[ncbi.nlm.nih.gov]
The prevalences of HLA-DR2, DR6, and B8 were similar in the 71 patients and in controls.
[ncbi.nlm.nih.gov]
In this study the HLA haplotype was determined in 71 patients with idiosyncratic hepatitis due to different drugs.
[ncbi.nlm.nih.gov]
Frequent, however, is the association of PAC with HLA-B8 and HLA-DR3 aplotypes.The lymphocytes that are involved in the inflammatory exudate in affected bile ducts are T-lymphocytes
[meddean.luc.edu]
The most commonly recorded association of the major histocompatibility complex (MHC) with scleroderma is with the HLA B8, DR3-containing haplotype and the high frequency of
[jdeonline.in]
[…] among HLA-B8, MICA*008, TNFα promoter (TNFA*2), and a yet unidentified susceptibility allele.
[abdominalkey.com]
The association of HLA-B8, B 51, DR 2, and multiple sclerosis in pars planitis.
[nature.com]
Malinowski SM, Pulido JS, Goeken NE et al (1993) The association of HLA-B8, B51, DR2, and multiple sclerosis in pars planitis.
[link.springer.com]
HLA associations have been reported in IU. HLA-DR is the most significant occurring in 67-72% of patients; others include HLA-B8 and HLA-B51.
[eyewiki.aao.org]
Both genetic and environmental risk factors seem to have a role in the cause of juvenile dermatomyositis; HLA B8-DRB1*0301 ancestral haplotype is a strong immunogenetic risk
[ncbi.nlm.nih.gov]
B8-DRB1*0301-DQA1*0501 is the chief risk factor for JDM in Caucasian patients, with DQA1*0301 an additional risk factor for JDM. 8-10 Group A beta-hemolytic streptococci
[obgynkey.com]
The peak age of onset is 5 to 14 years, and it is associated genetically with the major histocompatibility complex HLA-B8 and DR-3 alleles.
[rheumaknowledgy.com]
Genetic predisposition: Non-tumor Lambert-Eaton myasthenic syndrome is associated with HLA-B8 (HLA - class I) and HLA -DR3 and -DQ2 (HLA class II).
[statpearls.com]
The genetic association with HLA–B8–DR 3 haplotype is present in about 65% of young patients with NT–L EMS.
[statpearls.com]
It has been suggested that patients with sarcoidosis carrying the HLA-B8 allele may be more prone to develop erythema nodosum and acute arthritis, whereas patients with sarcoidosis
[rheumaknowledgy.com]
Etiology Speculative Familial cases – positive association with HLA-1, -B8, -B13, -DR3 and –B27.
[slideshare.net]
[…] positive for HLA-DR3 may be more likely to develop the chronic form of arthritis.
[rheumaknowledgy.com]
RESULTS: HLA-B8 was present in 15 (37.5%) of 40 patients versus 85 (19.7%) of 431 controls (relative risk, 2.44; P = 0.011).
[ncbi.nlm.nih.gov]
The association of HLA-B8, B51, DR2 and multiple sclerosis in pars planitis. Ophthalmology 1993; 100: 1199–1205. Google Scholar Graham EM, Edelsten C.
[link.springer.com]
The association of HLA-B8, B 51, DR 2, and multiple sclerosis in pars planitis. Ophthalmology 1993; 100 :1199–205. 3.
[nature.com]
B8, HLA-DR4, HLA DR3, and complement C4 allele. 5 DILE was first described in 1945 as resulting from sulfasalazine intake; currently, hundreds of medications are associated
[rheumatologyadvisor.com]
There is a genetic predisposition to DISCLE, with increased frequency of HLA-B8 and HLA DR3.
[ncbi.nlm.nih.gov]
The study on her HLA type did not provide any significant information; for example HLA-DR2, DR3 and B8 (usually present in patients affected by LES) were absent.
[academic.oup.com]
The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present Note générale
[idref.fr]
Multiple autoimmune manifestations in a splenectomized subject with HLA-B8. Arch Intern Med, 1983, 143, 1987–1989. PubMed Google Scholar 25.
[link.springer.com]
Second, higher frequency of ocular myasthenia in autoimmune thyroid disease could be attributed to genetic linkage.[ 5 ] Human leukocyte antigen (HLA) specificity (B8, DR3
[ncbi.nlm.nih.gov]
[…] associations have been connected with disease susceptibility and outcome—for example, HLA-B8 and DR-3 with Löfgren's syndrome (acute systemic disease with fever, polyarthritis
[bjo.bmj.com]
[…] relation with a causative agent.2 Genetic factors might also be involved since familial incidence in certain populations as high as 19% has been noted and, further, specific HLA
[bjo.bmj.com]
More than 50% of patients have human leukocyte antigen (HLA) B27 (HLA-B27) or HLA-B8 and the many diseases associated with them. Trauma is a common cause.
[emedicine.com]
We found: i) an increased frequency of HLA-B8 (21.4% versus 7.1%) and a decreased frequency of HLA-B12 (2.9% versus 18.2%) in Graves' disease when compared with controls;
[ncbi.nlm.nih.gov]
Familial predisposition associated with HLA-B8, DR3 What is the classic triad in Grave's Disease? 1. Diffuse toxic thyroid enlargement (goiter) 2. Hyperthyroidism 3.
[quizlet.com]
There is an underlying genetic predisposition, because of an increased frequency of haplotypes human leukocyte antigen (HLA)-B8 and HLA-DRw3 in white patients, HLA-Bw36 in
[entokey.com]
It is associated with an increased expression of HLA-A1, HLA-B8, and HLA-DR3 antibodies.
[fpnotebook.com]
Patients with dermatitis herpetiformis have an increased expression of the HLA-A1, HLA-B8, HLA-DR3, and HLA-DQ2 haplotypes.
[emedicine.medscape.com]
The disease is strongly associated with the presence of HLA-B8 and HLA-DR3 antigens.
[fpnotebook.com]
HLA-B8, HLA-DR3, HLA-DR4 HLA-B8, HLA-DR3, HLA-DR4 Phenotype Chronic mucocutaneous candidiasis with either hypoparathyroidism or Addison’s disease Addison’s disease with either
[edmcasereports.com]
The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present Note générale
[idref.fr]
The type II syndrome differs from type I in that it is associated with HLA-A1 and B8 haplotypes, onset is usually in adulthood, and candidiasis is not present.
[fpnotebook.com]
Prospective analysis suggests susceptibility genes for deficiencies of IgA and several other immunoglobulins on the [HLA-B8, SC01, DR3] conserved extended haplotype.
[emedicine.medscape.com]
F1C30, and DR3 in a Spanish Basque population [11] and HLA-B8, SC01, DR3 in white subjects in an American study. [12] A 2008 report noted that depletion of circulating IgD
[emedicine.medscape.com]
[…] ongoing. [5, 6, 7, 8] Low serum IgD levels are not distributed in a normal gaussian fashion. [9, 10] IgD deficiency is associated with the specific human leukocyte antigens HLA-B18
[emedicine.medscape.com]
