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253 Possible Causes for HLA-B8

  • Adrenal Insufficiency

    Genetic risk None HLA -B8, -DR3, and -DR4 genes confer risk 2.[]

  • Primary Sclerosing Cholangitis

    Thus, "A HLA association in PSC was first identified for HLA-B8 (i.e. HLA-B*0801) and DR3 (i.e. DRB1*0301)[24,50].[] HLA-B8, HLA-DR3, and HLA-Drw52a alleles have an increased prevalence in patients with PSC, suggesting a genetic predisposition.[] […] the portal circulation and from exposure to toxic bile acids has been postulated. [14] A genetic predisposition has been suggested because of an increased prevalence of HLA-B8[]

  • Graves Disease

    0.3% of men 85% of patients are women (female to male ratio is 4:1), usually ages 20 - 40 years; men are usually older 60% concordance in identical twins; associated with HLA-B8[] An autoimmune disease with stimulating anti-TSH receptor antibodies a type II hypersensitivity anti-microsomal, anti-thyroglobulin antibodies also present Female dominant HLA-B8[] […] and HLA-DR3 Sites Global involvement of thyroid gland Pathophysiology Exact cause is unclear It is believed to involve a combination of genetic and environmental factors[]

  • Systemic Lupus Erythematosus

    Factors leading to SLE include: Genetic predisposition, incuding haplotype HLA-B8, -DR 3 Exposure to sunlight Viral infection , particularly Epstein-Barr virus Hormones Toxins[] ) reveal that HLA-A1, HLA-B8, and HLA-DR3 are more common in persons with SLE than in the general population.[] […] however, it was determined that these loci had a lower significance level and a lower contribution to individual risk for SLE. [ 31 ] Studies of human leukocyte antigens (HLAs[]

  • Herpes Gestationis

    An additional laboratory finding in patients with HG is their increased frequency of the HLA-B8 and HLA-DR3 haplotypes as well as the HLA-DR3, -DR4 paired haplotype.[] In herpes gestationis, immunofluorescence studies were consistently positive, there was a high frequency of HLA-B8 and an association with autoimmune thyrotoxicosis.[] HLA-A1, B8, DR3 is known to be in linkage disequilibrium with a deletion of C4A (the C4 null allele or C4QO).[]

  • Chronic Active Hepatitis B

    The apparent predisposition of individuals with HLA-B8 and DR3 haplotypes to develop IACAH suggests that genetically conditioned abnormalities may have a role in pathogenesis[]

  • Sjogren's Syndrome

    These "histocompatibility antigens" may include HLA-B8 and HLA-DR3.[] […] and HLA-B8 are generally found in Caucasian patients, while HLA-DR5 is related to Greek and Israeli patients. [60] Multiple genome-wide association scans may be conducted[] In white persons, for instance, the condition is linked to human leukocyte antigen (HLA)–DR3, HLA-DQ2, and HLA-B8, [10] whereas the linkage is to HLA-DRB1*15 in Spanish persons[]

  • Myasthenia Gravis

    The early peak shows a female predominance, approximately 3:1, and an association with HLA-B8, HLA-DR3, and HLA-DR1, the latter being more specific for ocular MG.[] This suggests an association of MG with HLA B8 and DR3. In terms of underlying genetic abnormalities, work is ongoing [ 8 ] .[] In people 40 there is a higher incidence of HLA A1, B8, and DRW3 in patients with MG, and in those 40 there is a correlation with HLA A3, B7, and DRW2.[]

  • Autoimmune Hepatitis

    […] day; female 40-60 gm/day (-2 points) Male 80 gm/day; female 60 gm/day (-1 point) Genetic factors Other autoimmune diseases in patient or first-degree relatives (1 point) HLA[] , HLA-B8, HLA-DR3, HLA-DR4) A predominance of T lymphocytes and plasma cells in liver histologic lesions Complex in vitro defects in cellular immunity and immunoregulatory[] AIH is associated with the complement allele C4AQO and with the HLA haplotypes B8, B14, DR3, DR4, and Dw3.[]

  • Dysgammaglobulinemia

    Selective IgA deficiency and the HLA-B8 antigen. Report of two cases with familial data. [Clinical significance of selective deficiency of IgA].[]

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