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221 Possible Causes for HLA-B8

  • Diabetes Mellitus

    Intensive diabetes therapy aimed at achieving near normoglycemia reduces the risk of microvascular and neurologic complications of type 1 diabetes. We studied whether the use of intensive therapy as compared with conventional therapy during the Diabetes Control and Complications Trial (DCCT) affected the long-term[…][ncbi.nlm.nih.gov]

  • Graves Disease

    Epidemiology Affects 2% of women in US, 0.3% of men 85% of patients are women, usually ages 20 - 40 years; men are usually older 60% concordance in identical twins; associated with HLA-B8[web.archive.org] An autoimmune disease with stimulating anti-TSH receptor antibodies a type II hypersensitivity anti-microsomal, anti-thyroglobulin antibodies also present Female dominant HLA-B8[step2.medbullets.com] 0.3% of men 85% of patients are women (female to male ratio is 4:1), usually ages 20 - 40 years; men are usually older 60% concordance in identical twins; associated with HLA-B8[pathologyoutlines.com]

  • Primary Sclerosing Cholangitis

    HLA-B8, HLA-DR3, and HLA-Drw52a alleles have an increased prevalence in patients with PSC, suggesting a genetic predisposition.[symptoma.com] Etiology O Immune mediated O Infection O Genetic predisposition HLA-B8, DR3, DR2, and DR4 O Environmental Factors 34. Pathophysiology 35. Pathophysiology 36.[slideshare.net] […] the portal circulation and from exposure to toxic bile acids has been postulated. [14] A genetic predisposition has been suggested because of an increased prevalence of HLA-B8[emedicine.medscape.com]

  • Systemic Lupus Erythematosus

    Factors leading to SLE include: Genetic predisposition, including haplotype HLA -B8, -DR 3 Exposure to sunlight Viral infection, particularly Epstein-Barr virus Hormones Toxins[dermnetnz.org] Factors leading to SLE include: Genetic predisposition, incuding haplotype HLA -B8, -DR 3 Exposure to sunlight Viral infection , particularly Epstein-Barr virus Hormones Toxins[dermnetnz.org] The presence of human leukocyte antigen (HLA)–B8 and HLA-DR3 in the mother may predispose the infant to NLE and congenital heart block.[emedicine.medscape.com]

  • Sjogren's Syndrome

    The association of Sjögren syndrome with human leukocyte antigen (HLA)–B8, HLA-Dw3, HLA-DR3, and the DQA1*0501 allele supports the notion of genetic susceptibility. [16] An[emedicine.medscape.com] Pathophysiology A genetic predisposition in SS-associated dry eye disease exists, as is evidenced by the high prevalence of human leukocyte antigen B8 (HLA-B8) haplotype in[emedicine.com]

  • Autoimmune Hepatitis

    […] day; female 40-60 gm/day (-2 points) Male 80 gm/day; female 60 gm/day (-1 point) Genetic factors Other autoimmune diseases in patient or first-degree relatives (1 point) HLA[merckmanuals.com] , HLA-B8, HLA-DR3, HLA-DR4) A predominance of T lymphocytes and plasma cells in liver histologic lesions Complex in vitro defects in cellular immunity and immunoregulatory[merckmanuals.com] AIH is associated with the complement allele C4AQO and with the HLA haplotypes B8, B14, DR3, DR4, and Dw3.[patient.info]

  • Chronic Active Hepatitis B

    The apparent predisposition of individuals with HLA-B8 and DR3 haplotypes to develop IACAH suggests that genetically conditioned abnormalities may have a role in pathogenesis[hepatitiscentral.com]

  • Myasthenia Gravis

    This suggests an association of MG with HLA B8 and DR3. In terms of underlying genetic abnormalities, work is ongoing [ 8 ].[patient.info] The early peak shows a female predominance, approximately 3:1, and an association with HLA-B8, HLA-DR3, and HLA-DR1, the latter being more specific for ocular MG.[eyewiki.aao.org]

  • Herpes Gestationis

    All three patients possessed the human lymphocyte antigen HLA-B8.[ncbi.nlm.nih.gov] In herpes gestationis, immunofluorescence studies were consistently positive, there was a high frequency of HLA-B8 and an association with autoimmune thyrotoxicosis.[ncbi.nlm.nih.gov] An additional laboratory finding in patients with HG is their increased frequency of the HLA-B8 and HLA-DR3 haplotypes as well as the HLA-DR3, -DR4 paired haplotype.[ncbi.nlm.nih.gov]

  • Dermatitis Herpetiformis

    We encountered a Japanese case of DH which showed granular IgA and C3 deposits in the papillary dermis and which was associated with gluten-sensitive enteropathy but no HLA-B8[ncbi.nlm.nih.gov] The HLA typing revealed no B8/DR3.[ncbi.nlm.nih.gov] The disease is strongly associated with the presence of HLA-B8 and HLA-DR3 antigens.[hon.ch]

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