HLA-B8, HLA-DR3, and HLA-Drw52a alleles have an increased prevalence in patients with PSC, suggesting a genetic predisposition. … Thus, "A HLA association in PSC was first identified for HLA-B8 (i.e.
Factors leading to SLE include: Genetic predisposition, incuding haplotype HLA-B8, -DR 3 Exposure to sunlight Viral infection , particularly Epstein-Barr virus Hormones Toxins … […] that these loci had a lower significance level and a lower contribution to individual risk for SLE. [ 31 ] Studies of human leukocyte antigens (HLAs) reveal that HLA-A1, HLA-B8
[…] hepatitis), including the following: The presence of serologic immune markers An association with histocompatibility haplotypes common in autoimmune disorders (eg, HLA-B1, HLA-B8 … B8, DR3 haplotype has been associated with a number of autoimmune diseases such as AIH, thyroiditis, celiac disease, and myasthenia gravis. … […] prevalence of HLA antigens B8 and DR3 has been found in patients with PSC. 36 The HLA-DR3, DQ2 heterozygous genotype may be associated with more rapid disease progression. 39 The HLA
The early peak shows a female predominance, approximately 3:1, and an association with HLA-B8, HLA-DR3, and HLA-DR1, the latter being more specific for ocular MG. … This suggests an association of MG with HLAB8 and DR3. … The histocompatibility complex profile includes HLA-B8, HLA-DRw3, and HLA-DQw2 (though these have not been shown to be associated with the strictly ocular form of MG).
The disease is strongly associated with the presence of hla-b8 and hla-dr3 antigens. … It is associated with an increased expression of hla-a1, hla-b8, and hla-dr3 antibodies. … The disease is strongly associated with the presence of HLA-B8 and HLA-DR3 antigens.