Question

    36 Possible Causes for HLA B8 in USA

    • Primary Sclerosing Cholangitis
      HLA-B8

      HLA-B8, HLA-DR3, and HLA-Drw52a alleles have an increased prevalence in patients with PSC, suggesting a genetic predisposition. … Thus, "A HLA association in PSC was first identified for HLA-B8 (i.e.[1] [2]

    • Systemic Lupus Erythematosus
      HLA-B8

      Factors leading to SLE include: Genetic predisposition, incuding haplotype HLA-B8, -DR 3 Exposure to sunlight Viral infection , particularly Epstein-Barr virus Hormones Toxins … […] that these loci had a lower significance level and a lower contribution to individual risk for SLE. [ 31 ] Studies of human leukocyte antigens (HLAs) reveal that HLA-A1, HLA-B8[3] [4]

    • Autoimmune Hepatitis
      HLA-B8

      […] hepatitis), including the following: The presence of serologic immune markers An association with histocompatibility haplotypes common in autoimmune disorders (eg, HLA-B1, HLA-B8B8, DR3 haplotype has been associated with a number of autoimmune diseases such as AIH, thyroiditis, celiac disease, and myasthenia gravis. … […] prevalence of HLA antigens B8 and DR3 has been found in patients with PSC. 36 The HLA-DR3, DQ2 heterozygous genotype may be associated with more rapid disease progression. 39 The HLA[5] [6]

    • Sjogren's Syndrome
      HLA-B8

      HLA-DQ2 and HLA-B8 are generally found in Caucasian patients, while HLA-DR5 is related to Greek and Israeli patients.[7]

    • Myasthenia Gravis
      HLA-B8

      The early peak shows a female predominance, approximately 3:1, and an association with HLA-B8, HLA-DR3, and HLA-DR1, the latter being more specific for ocular MG. … This suggests an association of MG with HLA B8 and DR3. … The histocompatibility complex profile includes HLA-B8, HLA-DRw3, and HLA-DQw2 (though these have not been shown to be associated with the strictly ocular form of MG).[8] [9] [10]

    • Diabetes Mellitus
      HLA-B8
    • Chronic Active Hepatitis B
      HLA-B8
    • Herpes Gestationis
      HLA-B8

      In herpes gestationis, immunofluorescence studies were consistently positive, there was a high frequency of HLA-B8 and an association with autoimmune thyrotoxicosis.[11]

    • Graves Disease
      HLA-B8

      The first genetic factor to be associated with Graves’ disease was HLA-B8 [123], a Class I major histocompatibility component (MHC).[12]

    • Dermatitis Herpetiformis

      The disease is strongly associated with the presence of hla-b8 and hla-dr3 antigens. … It is associated with an increased expression of hla-a1, hla-b8, and hla-dr3 antibodies. … The disease is strongly associated with the presence of HLA-B8 and HLA-DR3 antigens.[13] [14]

    Further symptoms

    Similar symptoms

    References

    1. Primary Sclerosing Cholangitis, https://www.symptoma.com/en/info/primary-sclero…
    2. Frequently Asked Questions (FAQ), Primary Sclerosing Cholangitis Literature, http://www.psc-literature.org/FAQ.htm
    3. Systemic lupus erythematosus | DermNet New Zealand, http://www.dermnetnz.org/immune/sle.html
    4. Systemic Lupus Erythematosus (SLE): Practice Essentials, Background, Pathophysiology, http://emedicine.medscape.com/article/332244-overview
    5. Overview of Chronic Hepatitis - Hepatic and Biliary Disorders, http://www.merckmanuals.com/professional/hepati…
    6. Modern Pathology - Autoimmune liver disease: overlap and outliers, http://www.nature.com/modpathol/journal/v20/n1s…
    7. Sjögren syndrome, https://en.wikipedia.org/wiki/Sj%C3%B6gren_syndrome
    8. Myasthenia Gravis - EyeWiki, http://eyewiki.aao.org/Myasthenia_Gravis
    9. Myasthenia Gravis. Autoimmune disease, myasthenic syndrome, https://patient.info/doctor/myasthenia-gravis-pro
    10. Myasthenia Gravis: Practice Essentials, Background, Anatomy, http://emedicine.medscape.com/article/1171206-overview
    11. Herpes gestationis (Pemphigoid gestationis), http://www.thedoctorsdoctor.com/diseases/herpes…
    12. Graves' Disease and the Manifestations of Thyrotoxicosis, http://www.thyroidmanager.org/chapter/graves-di…
    13. 2017 ICD-10-CM Diagnosis Code L13.0 : Dermatitis herpetiformis, http://www.icd10data.com/ICD10CM/Codes/L00-L99/…
    14. Dermatitis Herpetiformis, http://www.fpnotebook.com/derm/Blister/DrmtsHrp…