HLA-Cw6: Causes & Reasons

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Possible Causes for HLA-Cw6

Psoriasis

Ikaheimo I, Tiilikainen A, Karvonen J, Silvennoinen-Kassinen S (1996) HLA risk haplotype Cw6, DR7, DQA1*0201 and HLA-Cw6 with reference to the clinical picture of psoriasis [doi.org]

Polygenic disorder with strong HLA-association, mainly with HLA-Cw6. [clinicaladvisor.com]

Suomela S, Kainu K, Onkamo P et al (2007) Clinical associations of the risk alleles of HLA-Cw6 and CCHCR1*WWCC in psoriasis. [doi.org]

Geographic Tongue

[…] to determine whether benign migratory glossitis is also associated with HLA-Cw6, the classical association observed in psoriasis. [ncbi.nlm.nih.gov]

[…] associations with benign migratory glossitis and psoriasis in Brazilian patients and particularly to determine whether benign migratory glossitis is also associated with HLA‐Cw6 [onlinelibrary.wiley.com]

Associations with human leukocyte antigen (HLA)–DR5, HLA-DRW6, and HLA-Cw6 have also been reported. [11, 12] Etiology A definitive cause has not been elucidated, but lesions [emedicine.com]

Psoriatic Arthritis

HLA-Cw6-positive and HLA-Cw6-negative patients with psoriasis vulgaris have distinct clinical features. [ard.bmj.com]

No Sacroiliitis Asymmetric Symmetric Stiffness In the morning and/or with immobility Yes Female:male ratio 1:1 1:3 Enthesis Yes No High-titer RF No No HLA association CW6 [discoverpsa.com]

[…] antigens (HLA-B17, HLA-Cw6) in the early onset group were also noted. [ard.bmj.com]

Fissured Tongue

Associations with human leukocyte antigens (HLA)-DR5, HLA-DRW6, and HLA-Cw6 have also been reported. [7] BMG has also been linked to allergies. [jisppd.com]

Gozaga HF, Torres EA, Alchorne MM, Gerbase-Delima M: Both psoriasis and benign migratory glossitis are associated with HLA-CW6. Br J Dermatol 1996;135:368–370. [karger.com]

Some have reported links with various human leukocyte antigens, such as increased incidence of HLA-DR5, HLA-DRW6 and HLA-Cw6 and decreased incidence in HLA-B51. [10] Vitamin [en.wikipedia.org]

Tongue Disease

Associations with human leukocyte antigen (HLA)–DR5, HLA-DRW6, and HLA-Cw6 have also been reported. [11, 12] Etiology A definitive cause has not been elucidated, but lesions [emedicine.medscape.com]

Both psoriasis and benign migratory glossitis are associated with HLA-Cw6. Br J Dermatol. 1996;135(3):368–370. 18. Marks R, Simons MJ. [aafp.org]

Both psoriasis and benign migratory glossitis are associated with HLA-Cw6. Br J Dermatol. 1996 Sep. 135(3):368-70. [Medline]. [emedicine.medscape.com]

Glossitis

Associations with human leukocyte antigen HLA DR5, HLA DRW6 and HLA Cw6 have been reported. Maintaining a good oral hygiene may prevent glossitis. [symptoma.com]

Associations of HLA- Cw6 presents a particularly strong association irrespective of the racial or ethnic group suggesting that Cw6 itself or closely linked gene in strong [ispub.com]

Median Rhomboid Glossitis

Gozaga HF, Torres EA, Alchorne MM, Gerbase-Delima M: Both psoriasis and benign migratory glossitis are associated with HLA-CW6. Br J Dermatol 1996;135:368–370. [karger.com]

Both psoriasis and benign migratory glossitis are associated with HLA-Cw6. Br J Dermatol 1996;135:368-370. 18. Marks R, Simons MJ. [tribune.cz]

Both psoriasis and benign migratory glossitis are associated with HLA-Cw6. Br J Dermatol. 1996;135(3):368–370. 18. Marks R, Simons MJ. [aafp.org]

Genital Psoriasis

Psoriasis is associated with certain human leukocyte antigen (HLA) alleles, the strongest being human leukocyte antigen Cw6 (HLA-Cw6). [emedicine.medscape.com]

Three genes in the PSORS1 locus have a strong association with psoriasis vulgaris: HLA-C variant HLA-Cw6, [32] which encodes a MHC class I protein; CCHCR1, variant WWC, which [en.wikipedia.org]

Meta-Analysis Confirms the LCE3C_LCE3B Deletion as a Risk Factor for Psoriasis in Several Ethnic Groups and Finds Interaction with HLA-Cw6. [emedicine.medscape.com]

Streptococcal Infection

[…] than HLA-Cw6 itself. [jmg.bmj.com]

Psoriasis and HLA-Cw6. Br J Dermatol 1980 ; 102 : 179 –84. [jmg.bmj.com]

[…] age of onset and HLA pattern as suggested by Szczerkowska-Dobosz et al 10 : type Ia/IIa, early/late onset psoriasis without the predisposing HLA antigens Cw6, B57, or B13 [jmg.bmj.com]

Psoriatic Juvenile Idiopathic Arthritis

Type I psoriasis is strongly associated with the major histocompatibility complex (MHC) class I allele HLA-Cw6. [musculoskeletalkey.com]

HLA-B7, HLA-B27, HLA-DR4, HLA-38, and HLA-DR7 ae identified as genetic susceptibility loci for psoriatic arthritis whereas HLA-Cw6, HLA-B13, HLA-B17, HLA-B57, and HLA-B39 [boneandspine.com]

This HLA association differed from that reported in other forms of juvenile arthritis. [ncbi.nlm.nih.gov]

Commissural Lip Fistula

Association with psoriasis (HLA-Cw6) • Patient reassurance; topical steroid; zinc Docsity.com [docsity.com]

Hughes-Stovin Syndrome

CD-8 T-cells, HLA-Cw6, IL-12b, IL-23b, TNFalpha, NF-κB. Systemic scleroderma [35] [37] Limited, R, S COL1A2 and TGF-β1. [immunologyonline.wordpress.com]

CD-8 T-cells, HLA-Cw6, IL-12b, IL-23b, TNFalpha, NF-κB. Systemic scleroderma [35][37] Limited, R, S COL1A2 and TGF-β1. [alergianakonline.wordpress.com]

Fixed Pigmented Erythema

Fixed drug eruption induced by trimethoprim-sulfamethoxazole: Evidence for a link to HLA-A30 B13 Cw6 haplotype Esen Özkaya-Bayazit, MD Uur Akar, MD Istanbul, Turkey J Am Acad [thedoctorsdoctor.com]

Apart from HLA-B22 found generally in FDE, HLA-A30 B13 Cw6 has been significantly linked with trimethoprim - sulfamethoxazole indicating a specific genetic predisposition. [jcsjournal.org]

Karger AG, Basel References Ozkaya-Bayazit E, Akar U: Fixed drug eruption induced by trimethoprim-sulfamethoxazole: evidence for a link to HLA-A30 B13 Cw6 haplotype. [karger.com]

Atrophic Glossitis

Associations of HLA- Cw6 presents a particularly strong association irrespective of the racial or ethnic group suggesting that Cw6 itself or closely linked gene in strong [ispub.com]

Both psoriasis and benign migratory glossitis are associated with HLA-Cw6. Br J Dermatol. 1996;135(3):368–370. 18. Marks R, Simons MJ. [aafp.org]

Both psoriasis and benign migratory glossitis are associated with HLA-Cw6. Brit J Dermatol 1996; 135:368-70. 42. Marks R, Tait B. HLA antigens in geographic tongue. [ispub.com]

Spondylitic Aortitis

[…] psoriasis  5 – 10 % of people with psoriasis get psoriatic arthritis  Family studies suggest a 50-fold increase in the risk of psoriatic arthritis in 1st degree relatives  HLA-Cw6 [slideshare.net]

The disease is autoimmune-mediated with defined HLA associations (HLA-B27, -B17, -CW6, -DR4, -DR7 and others). [patient.info]

> Can occur without obvious rash so check umbilicus, scalp, behind ears, and gluteal folds - Skin disease predates in 60% but arthritis predates skin disease in 20% - HLA-Cw6 [flashcardmachine.com]

Nephrotic Syndrome Type 1

In the patient group, HLA-DR7 and HLA-CW6 were found to be significantly increased, while HLA-DQW1 and HLA-CW4 were significantly reduced. [cags.org.ae]

[…] involving a group of 48 Arab children with steroid responsive childhood nephritic syndrome and a control group consisting of healthy Arab children, to see if there was any HLA [cags.org.ae]

Nephrotic Syndrome Type 8

In the patient group, HLA-DR7 and HLA-CW6 were found to be significantly increased, while HLA-DQW1 and HLA-CW4 were significantly reduced. [cags.org.ae]

[…] involving a group of 48 Arab children with steroid responsive childhood nephritic syndrome and a control group consisting of healthy Arab children, to see if there was any HLA [cags.org.ae]

Immunodeficiency Type 31C

Oral Pathol Oral Radiol Endod 75: 716–722 Google Scholar Gonzage HF, Torres EA, Alchorne MM et al. (1996) Both psoriasis and benign migratory glossitis are associated with HLA-Cw6 [springerlink.com]

Subcorneal Pustular Dermatosis

Recent posts Analysis of personalized genetic testing for HLA-Cw6 to predict secukinumab success just accepted in JEADV (20 Dec 2017) CTI Grant accepted for new skin measurement [navarinilab.com]

Oral Mucosal Disorder

Both psoriasis and benign migratory glossitis are associated with HLA Cw6. Br J Dermatol 1996 ;135:368 70. 12. Ramírez Amador VA, Esquivel Pedraza L, Orozco Topete R. [jdrr.org]

Both psoriasis and benign migratory glossitis are associated with HLA?Cw6. Br J Dermatol 1996;135:368?70. Tomb R, Hajj H, Nehme E. Oral lesions in psoriasis. [amhsr.org]

The association of HLA? [amhsr.org]

Limited Cutaneous Systemic Scleroderma

HLA-Cw6 were associated with CREST-PBC overlap syndrome (p CONCLUSION: It was suggested that there was a genetic difference between CREST syndrome alone and CREST-PBC overlap [ncbi.nlm.nih.gov]

The HLA phenotype was A1, A9, B17, Bw4, Cw4, Cw6, DR5, DR52, DR8, DQ4, DQ7. A chest x ray was normal and a radiograph of the hands revealed subcutaneous calcinosis. [bjo.bmj.com]

Pustular Psoriasis

Participation of HLA genes has been studied being greater the co-relation found with the HLA-Cw6. 6 As for this report the patient presented family history of similar lesions [scielo.br]

Psoriasis susceptibility (PSOR1) on chromosome 6, also known as the HLA-Cw6 allele, has been strongly associated with the development of psoriasis (up to 10-fold increase [clinicaladvisor.com]

Impetigo Herpetiformis

Since C4A and C4B genes are conjugated with HLA Cw6 gene which seems to be attributed to psoriasis vulgaris, differences in their allels expresion may contribute to better [kundoc.com]

Lingual Papillitis

Some have reported links with various human leukocyte antigens, such as increased incidence of HLA-DR5, HLA-DRW6 and HLA-Cw6 and decreased incidence in HLA-B51. [10] Vitamin [readtiger.com]

Isolated Toenail Dystrophy

HLA-Cw6 and HLA-DRB1FNx0107 together are associated with less severe joint disease in psoriatic arthritis. Ann Rheum Dis 2007;66:807-11. 17. [e-ijd.org]

studies have shown that type 1 psoriasis which usually affects the skin is strongly associated with HLA-Cw6 [13] and these patients have an earlier onset of disease which [e-ijd.org]

[…] is also more extensive and severe, whereas, type 2 psoriasis that predominantly damages the nails and the joints is not associated with HLA Cw6 suggesting a different immunopathology [e-ijd.org]

Chorioretinitis

However, several alleles were increased in MCP, although not significantly: HLA-A31; HLA-B57, HLA-B62; HLA-Cw3, HLA-Cw6; HLA-DR4, HLA-DR7, and HLA-DR8. · Conclusions: MCP [link.springer.com]

Immunogenetically significant reduced frequencies of HLA-B7 and HLA-DR1 were found; also HLA-DR15(2) was reduced. [link.springer.com]

Nephrotic Syndrome Type 9

In the patient group, HLA-DR7 and HLA-CW6 were found to be significantly increased, while HLA-DQW1 and HLA-CW4 were significantly reduced. [cags.org.ae]

[…] involving a group of 48 Arab children with steroid responsive childhood nephritic syndrome and a control group consisting of healthy Arab children, to see if there was any HLA [cags.org.ae]

Pure Red Cell Aplasia

B, and C antigens that was transfected with HLA-Cw6. [content.nejm.org]

A B-cell line deficient in class I HLA-A, B, and C antigens was transfected with the HLA-Cw6 gene. [content.nejm.org]

The inhibitory effect of the HLA-Cw6 allele was due to the presence of the p58.1 killer-cell inhibitory receptor (which binds to HLA-Cw6) on the patient's γ/δ T cells, whereas [content.nejm.org]

Streptococcus Pyogenes

Although this particular phenotype of psoriasis is usually associated with streptococcal throat infections and mainly occurs in HLA-Cw6(+) patients, the specific immunologic [ncbi.nlm.nih.gov]

Moreover, a higher TH17 response was observed in cells isolated from patients with flares associated with a streptococcal tonsillitis and with the HLA-Cw6 allele (cohort 1 [ncbi.nlm.nih.gov]

Acrodermatitis Continua of Hallopeau

[…] typing (commonly for B13, B17, B37, Cw4, and Cw6), and exclusion of other causes.1,11,24 Studies have shown that HLA-Cw6 correlates with generalised plaque psoriasis, while [emjreviews.com]

Cw6 allele.1 The subgroup of non-pustular psoriasis includes psoriasis vulgaris or chronic plaque, guttate psoriasis, erythrodermic psoriasis, palmoplantar psoriasis, inverse [emjreviews.com]

[…] aetiology of this skin disorder is multifactorial, with a strong hereditary and genetic component, particularly regarding the PSORS1 gene and the human leukocyte antigen (HLA [emjreviews.com]