HLA-Cw6 Causes & Reasons

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HLA-Cw6 Symptom Checker: Possible causes include Psoriasis. Check the full list of possible causes and conditions now! Talk to our Chatbot to narrow down your search.

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Possible Causes

Psoriasis

Ikaheimo I, Tiilikainen A, Karvonen J, Silvennoinen-Kassinen S (1996) HLA risk haplotype Cw6, DR7, DQA1*0201 and HLA-Cw6 with reference to the clinical picture of psoriasis [doi.org]

This illness is closely linked with some human leukocyte antigen alleles (HLA alleles) especially the human leukocyte antigen Cw6 (HLA-Cw6). [symptoma.com]

Suomela S, Kainu K, Onkamo P et al (2007) Clinical associations of the risk alleles of HLA-Cw6 and CCHCR1*WWCC in psoriasis. [doi.org]

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Benign Migratory Glossitis

[…] to determine whether benign migratory glossitis is also associated with HLA-Cw6, the classical association observed in psoriasis. [ncbi.nlm.nih.gov]

[…] associations with benign migratory glossitis and psoriasis in Brazilian patients and particularly to determine whether benign migratory glossitis is also associated with HLA‐Cw6 [onlinelibrary.wiley.com]

Both psoriasis and benign migratory glossitis are associated with HLA-Cw6. Br J Dermatol. 1996;135:368–370. [PubMed] [Google Scholar] 6. [ncbi.nlm.nih.gov]

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Streptococcal Infection

[…] than HLA-Cw6 itself. [jmg.bmj.com]

Psoriasis and HLA-Cw6. Br J Dermatol 1980 ; 102 : 179 –84. [jmg.bmj.com]

[…] age of onset and HLA pattern as suggested by Szczerkowska-Dobosz et al 10 : type Ia/IIa, early/late onset psoriasis without the predisposing HLA antigens Cw6, B57, or B13 [jmg.bmj.com]

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Psoriatic Arthritis

[…] antigens (HLA-B17, HLA-Cw6) in the early onset group were also noted. [ard.bmj.com]

HLA-B38, HLA-B39, HLA-Cw6, HLA-DR4, and HLA-DR7. [emedicine.com]

HLA-Cw6-positive and HLA-Cw6-negative patients with psoriasis vulgaris have distinct clinical features. J Invest Dermatol 2002 ; 118 : 362 –5. [ard.bmj.com]

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Metabolic Syndrome

In normal-weight individuals with HLA-Cw6 positivity the risk of psoriasis was 8.33 times greater than for persons with HLA-Cw6 negativity [ 58 ]. [dx.doi.org]

Obese patients with the HLA-Cw6 gene were 35 times more likely to develop psoriasis than patients of normal weight without the HLA-Cw6 gene [ 58 ]. [dx.doi.org]

We know that HLA-Cw6, a major psoriasis susceptibility gene, is also associated with obesity. [dx.doi.org]

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Tongue Disease

Associations with human leukocyte antigen (HLA)–DR5, HLA-DRW6, and HLA-Cw6 have also been reported. [11, 12] Etiology A definitive cause has not been elucidated, but lesions [emedicine.medscape.com]

Both psoriasis and benign migratory glossitis are associated with HLA-Cw6. Br J Dermatol. 1996;135(3):368–370. 18. Marks R, Simons MJ. [aafp.org]

Both psoriasis and benign migratory glossitis are associated with HLA-Cw6. Br J Dermatol. 1996 Sep. 135(3):368-70. [Medline]. [emedicine.medscape.com]

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Streptococcus Pyogenes

Although this particular phenotype of psoriasis is usually associated with streptococcal throat infections and mainly occurs in HLA-Cw6( ) patients, the specific immunologic [ncbi.nlm.nih.gov]

Moreover, a higher TH17 response was observed in cells isolated from patients with flares associated with a streptococcal tonsillitis and with the HLA-Cw6 allele (cohort 1 [ncbi.nlm.nih.gov]

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Juvenile Psoriatic Arthritis

Type I psoriasis is strongly associated with the major histocompatibility complex (MHC) class I allele HLA-Cw6. [musculoskeletalkey.com]

This HLA association differed from that reported in other forms of juvenile arthritis. [ncbi.nlm.nih.gov]

HLA-B7, HLA-B27, HLA-DR4, HLA-38, and HLA-DR7 ae identified as genetic susceptibility loci for psoriatic arthritis whereas HLA-Cw6, HLA-B13, HLA-B17, HLA-B57, and HLA-B39 [boneandspine.com]

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Glossitis

Associations with human leukocyte antigen HLA DR5, HLA DRW6 and HLA Cw6 have been reported. Maintaining a good oral hygiene may prevent glossitis. [symptoma.com]

Associations of HLA- Cw6 presents a particularly strong association irrespective of the racial or ethnic group suggesting that Cw6 itself or closely linked gene in strong [ispub.com]

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Vitiligo

Celiac disease-associated antibodies in patients with psoriasis and correlation with HLA Cw6. [ncbi.nlm.nih.gov]

DR7, and Cw6.[ 10 ] Jin et al. reported the linkage signals on chromosomes 1, 7, and 17 in Caucasian families with generalized vitiligo and associated autoimmune diseases [ncbi.nlm.nih.gov]

[…] disease due to the positive association with some diseases such as thyroiditis, diabetes mellitus and alopecia areata.1 There has also been reported a relationship with HLA [scielo.br]

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Hughes-Stovin Syndrome

CD-8 T-cells, HLA-Cw6, IL-12b, IL-23b, TNFalpha, NF-κB. Systemic scleroderma [35] [37] Limited, R, S COL1A2 and TGF-β1. [immunologyonline.wordpress.com]

CD-8 T-cells, HLA-Cw6, IL-12b, IL-23b, TNFalpha, NF-κB. Systemic scleroderma [35][37] Limited, R, S COL1A2 and TGF-β1. [dokterindonetcom.wordpress.com]

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Median Rhomboid Glossitis

Gozaga HF, Torres EA, Alchorne MM, Gerbase-Delima M: Both psoriasis and benign migratory glossitis are associated with HLA-CW6. Br J Dermatol 1996;135:368–370. [karger.com]

Both psoriasis and benign migratory glossitis are associated with HLA-Cw6. Br J Dermatol 1996;135:368-370. 18. Marks R, Simons MJ. [tribune.cz]

Both psoriasis and benign migratory glossitis are associated with HLA-Cw6. Br J Dermatol. 1996;135(3):368–370. 18. Marks R, Simons MJ. [aafp.org]

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Acrodermatitis Continua of Hallopeau

[…] typing (commonly for B13, B17, B37, Cw4, and Cw6), and exclusion of other causes.1,11,24 Studies have shown that HLA-Cw6 correlates with generalised plaque psoriasis, while [emjreviews.com]

Cw6 allele.1 The subgroup of non-pustular psoriasis includes psoriasis vulgaris or chronic plaque, guttate psoriasis, erythrodermic psoriasis, palmoplantar psoriasis, inverse [emjreviews.com]

[…] aetiology of this skin disorder is multifactorial, with a strong hereditary and genetic component, particularly regarding the PSORS1 gene and the human leukocyte antigen (HLA [emjreviews.com]

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Drug Eruptions

Fixed drug eruption induced by trimethoprim-sulfamethoxazole: Evidence for a link to HLA-A30 B13 Cw6 haplotype Esen Özkaya-Bayazit, MD Uur Akar, MD Istanbul, Turkey J Am Acad [thedoctorsdoctor.com]

In addition, HLA-B22 was increased in patients with FDE caused by a drug other than feprazone. [thedoctorsdoctor.com]

HLA-B55 (split of B22) was present exclusively in trimethoprim-sulfamethoxazole-induced FDE, and in higher frequency than in control subjects. [thedoctorsdoctor.com]

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Spondylitic Aortitis

[…] psoriasis  5 – 10 % of people with psoriasis get psoriatic arthritis  Family studies suggest a 50-fold increase in the risk of psoriatic arthritis in 1st degree relatives  HLA-Cw6 [slideshare.net]

The disease is autoimmune-mediated with defined HLA associations (HLA-B27, -B17, -CW6, -DR4, -DR7 and others). [patient.info]

PsA -- Can occur without obvious rash so check umbilicus, scalp, behind ears, and gluteal folds - Skin disease predates in 60% but arthritis predates skin disease in 20% - HLA-Cw6 [flashcardmachine.com]

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Proliferating Angioendotheliomatosis

eczema, hay fever, HLA-Cw6, LP, normal persons, oral lithium treatment, psoriasis Gorlin-Goltz s.astrocytoma, BCC, craniopharyngioma, medulloblastoma, meningioma granuloma [dermadvocate.net]

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Limited Cutaneous Systemic Scleroderma

HLA-Cw6 were associated with CREST-PBC overlap syndrome (p CONCLUSION: It was suggested that there was a genetic difference between CREST syndrome alone and CREST-PBC overlap [ncbi.nlm.nih.gov]

The HLA phenotype was A1, A9, B17, Bw4, Cw4, Cw6, DR5, DR52, DR8, DQ4, DQ7. A chest x ray was normal and a radiograph of the hands revealed subcutaneous calcinosis. [bjo.bmj.com]

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Rheumatoid Arthritis

Gudjonsson, Andrew Johnston and Helgi Valdimarsson, HLA-Cw6 homozygosity in plaque psoriasis is associated with streptococcal throat infections and pronounced improvement [doi.org]

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Erythroderma Desquamativum

[…] associations include -Cw6, -B57, and -DR7 for early onset and -Cw2 for late onset psoriasis epidemiology Equal frequency in both sexes Mean age of onset is 27 years, range [slideserve.com]

[…] associations include -Cw6, -B57, and -DR7 for early onset and -Cw2 for late onset psoriasis 41 It is believed also that any individual that has –B13 or –B17 has a fivefold [slideplayer.com]

Heredity is of significance in some cases Evidence that susceptibility to psoriasis is linked to class I and II major histocompatibility complex on human chromosome 6 (17q) HLA [slideserve.com]

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Seronegative Arthritis

PSOR6, PSOR7), transcription factor RUNX1 Psoriatic arthritis: HLA-B7, HLA-B27, HLA-DR4, HLA-38, and HLA-DR7 Psoriasis and psoriatic arthritis: HLA-Cw6, HLA-B13, HLA-B17, [emedicine.medscape.com]

[…] and psoriatic arthritis is not yet clear) [18, 24, 25, 26, 27, 28, 29, 30] : Early-onset psoriasis: HLA-Cw6, HLA-B57, HLA-DR7, and HLA-B17, with HLA-Cw*0602 variant found [emedicine.medscape.com]

[…] to be highly associated Psoriasis: HLA-Cw6 (or psoriasis susceptibility 1 [PSOR1] on chromosome 6) and 6 other psoriasis susceptibility loci (PSOR2, PSOR3, PSOR4, PSOR5, [emedicine.medscape.com]

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Arthropathy

The disease is autoimmune-mediated with defined HLA associations (HLA-B27, -B17, -CW6, -DR4, -DR7 and others). [patient.info]

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Chorioretinitis

However, several alleles were increased in MCP, although not significantly: HLA-A31; HLA-B57, HLA-B62; HLA-Cw3, HLA-Cw6; HLA-DR4, HLA-DR7, and HLA-DR8. · Conclusions: MCP [link.springer.com]

Immunogenetically significant reduced frequencies of HLA-B7 and HLA-DR1 were found; also HLA-DR15(2) was reduced. [link.springer.com]

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Pustular Psoriasis

Participation of HLA genes has been studied being greater the co-relation found with the HLA-Cw6. 6 As for this report the patient presented family history of similar lesions [scielo.br]

Psoriasis susceptibility (PSOR1) on chromosome 6, also known as the HLA-Cw6 allele, has been strongly associated with the development of psoriasis (up to 10-fold increase [clinicaladvisor.com]

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Addison's Disease

Celiac disease-associated antibodies in patients with psoriasis and correlation with HLA Cw6. [ncbi.nlm.nih.gov]

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Commissural Lip Fistula

Association with psoriasis (HLA-Cw6) • Patient reassurance; topical steroid; zinc Docsity.com [docsity.com]

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Fissured Tongue

Gozaga HF, Torres EA, Alchorne MM, Gerbase-Delima M: Both psoriasis and benign migratory glossitis are associated with HLA-CW6. Br J Dermatol 1996;135:368–370. [karger.com]

Some have reported links with various human leukocyte antigens, such as increased incidence of HLA-DR5, HLA-DRW6 and HLA-Cw6 and decreased incidence in HLA-B51. [10] Vitamin [en.wikipedia.org]

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Overlap Syndrome

Cw6. 60 Scleroderma and RA may be seen as part of an overlap syndrome. [jcp.bmj.com]

[…] serologically by the presence of autoantibodies directed against the pyruvate dehydrogenase complex (M2), centromere, and Ro/SSA and/or La/SSB and genetically by an association with HLA [jcp.bmj.com]

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Systemic Lupus Erythematosus

Celiac disease-associated antibodies in patients with psoriasis and correlation with HLA Cw6. [ncbi.nlm.nih.gov]

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Impetigo Herpetiformis

Since C4A and C4B genes are conjugated with HLA Cw6 gene which seems to be attributed to psoriasis vulgaris, differences in their allels expresion may contribute to better [kundoc.com]

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Lingual Papillitis

Some have reported links with various human leukocyte antigens, such as increased incidence of HLA-DR5, HLA-DRW6 and HLA-Cw6 and decreased incidence in HLA-B51. [10] Vitamin [readtiger.com]

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