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150 Possible Causes for HLA-DQ2

  • Celiac Disease

    The final study group included 553 children who were positive for HLA-DQ2, HLA-DQ8, or both ( Table 1 ).[] We don’t know all the necessary genes to develop celiac disease; however, HLA DQ2 and/or DQ8 are absolutely necessary to develop the disease.[] Genetic susceptibility defines people who possess the gene pair encoding the major histocompatibility complex class II HLA DQ2 or DQ8.[]

  • Childhood Celiac Disease

    Children with typical symptoms of CD, who have a tissue transglutaminase antibody level 10 times the upper limit of normal together with a positive endomysium antibody and are HLA-DQ2[] Ninety percent of affected individuals carry the HLADQ2 haplotype, 5% the DQ8 haplotype, and the remaining 5% carry at least one of the two DQ2 alleles [ 1 , 2 ].[] HLA-DQ2 and HLA-DQ8 Genes 95% of people with celiac disease have either or both of the HLA-DQ2 or HLA-DQ8 genes.[]

  • Wheat Intolerance

    It occurs in people who inherit one or both of the celiac genes (HLA-DQ2 & HLA-DQ8).[] […] or HLA-DQ8 genes.[] […] antibodies, is a must to test for celiac disease: Endomysial antibodies (EMA) Tissue transglutaminase antibodies (tTG) IgG tissue transglutaminase Total IgA antibodies Genotype HLA-DQ2[]

  • Tropical Sprue

    . - However, it is not known whether these antibodies are primary or secondary to the tissue damage. 15. 3) Genetic factor - Patients with coeliac disease express the HLA-DQ2[] More than 95% of celiac patients have the HLA-DQ2 or HLA-DQ8 haplotype ( 1 ), although these haplotypes are not particularly specific for celiac disease.[] In our study HLA DQ2/DQ8 testing was positive.[]

  • Ataxia

    Hadjivassiliou looking at 68 patients with gluten ataxia noted that 78% of those people carried one or both of the primary celiac disease genes , HLA-DQ2 and HLA-DQ8 .[]

  • Congenital Malabsorption of Folic Acid

    Others activate lamina propria T cells in the context of HLA-DQ2 or DQ8 molecules.[] DQ2-negative celiac patients are invariably HLA DQ8 positive (DQA1*0301/DQB1*0302).[] […] the measurement of HLA DQ2 and/or DQ8 has a strong negative predictive value but a very weak positive predictive value for the diagnosis of celiac disease.[]

  • Invasive Pulmonary Aspergillosis

    Patients who have certain HLA alleles, particularly HLA-DR2, have increased susceptibility to ABPA, whereas HLA-DQ2 appears to be protective. [ 17 ] Risk factors involved[]

  • Amyotrophic Lateral Sclerosis

    A vast majority of people with celiac disease have either the HLA-DQ2 or the HLA-DQ8 variant.[] The genetic predisposition to celiac disease is associated with specific HLA antigen molecules expressed in antigen presenting cells of the immune system.[]

  • Celiac Disease, Epilepsy and Cerebral Calcification Syndrome

    It is associated with the HLA-DQ2 and HLA-DQ8 genes.[] Moreover, CEC, as well as CD, is associated with HLA-DQ2 and HLA-DQ8 phenotype and genotype.[] As for isolated CD, CEC is associated with the HLA-DQ2 and HLA-DQ8 genes.[]

  • Chronic Diarrhea with Villous Atrophy

    In this case, there was a high prevalence of patients with two copies of HLA-DQ2 in both groups, but no relationship between the severity of villous atrophy and HLA-DQ2 homozygosity[] HLA-DQ2 ( 95%) or HLA-DQ8 ( 5%) are present in almost all patients with CD (111,112).[] As for isolated CD, CEC is associated with the HLA-DQ2 and HLA-DQ8 genes.[]

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