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248 Possible Causes for HLA-DQ2

  • Celiac Disease

    HLA-DQ2 and Presentation of Gliadin Epitopes.[] The disease is associated with human HLA-DQ genes encoding HLA-DQ2 and DQ8 proteins.[] Patients undergoing upper endoscopy for any reason and positive for HLA-DQ2 and/or DQ8 haplotypes with or without CD were included.[]

  • Childhood Celiac Disease

    All successfully genotyped screening-detected cases (99%) carried the HLA-DQ2/DQ8 haplotype ( Table 2 ).[] Children with typical symptoms of CD, who have a tissue transglutaminase antibody level 10 times the upper limit of normal together with a positive endomysium antibody and are HLA-DQ2[] HLA-DQ2 and HLA-DQ8 Genes 95% of people with celiac disease have either or both of the HLA-DQ2 or HLA-DQ8 genes.[]

  • Celiac Disease with Diffuse Intestinal Ulceration

    Past genetic testing revealed that this patient carries the HLA-DQ2 allele. The physician suspects that the patient's presentation is dietary in cause.[] DQ2 or DQ8 expression, dermatitis herpetiformis, hyposplenism Monomorphic variant NOT associated with celiac disease, may represent a distinct entity EATL in situ: refractory[] Celiac Disease and HLA-DQ2/DQ8 eMedicine [On-line information]. Available online at through . Accessed November 2010. Klapproth, J. and Yang, V.[]

  • Chronic Diarrhea with Villous Atrophy

    However, as two copies of HLA-DQ2 have been reported to enhance the predisposition to celiac disease [ 14 ], we investigated the number of HLA-DQ2 copies according to the[] As for isolated CD, CEC is associated with the HLA-DQ2 and HLA-DQ8 genes.[] […] olmesartan-associated sprue-like enteropathy is uncertain, the long latency before onset of symptoms, findings of lymphocytic or collagenous colitis, and high association with HLA-DQ2[]

  • Dermatitis Herpetiformis

    No patients had HLA-DQ2 or -DQ8, which is frequently found in Caucasian DH patients.[] It is most common in patients of northern European/northern Indian ancestry, and is associated with the human leukocyte antigen (HLA) haplotype HLA-DQ2 or HLA-DQ8 along with[] BACKGROUND: Dermatitis herpetiformis (DH) and celiac disease (CD) are considered as autoimmune diseases that share a defined trigger (gluten) and a common genetic background (HLA-DQ2[]

  • Enteropathy-Associated T-Cell Lymphoma

    Homozygosity for HLA-DQ2 is associated with RCD II and EATL.[] Cases with inappropriate HLA-DQ2/8 genotype testing.[] Poor adherence to a gluten-free diet, HLA-DQ2 homozygosity, and late diagnosis of CD are recognized as risk factors for malignant evolution of CD.[]

  • Sjögren Syndrome

    All were HLA-DQ2 and/or -DQ8-positive.[] More than 95 % of those with CD express HLA-DQ2 while the remainder expresses HLA-DQ8.[] Studies show an association with HLA-DQ2 and HLA-DQ8, the same HLA haplotypes necessary for the presence of CD [ 18, 20 ].[]

  • Constipation

    HLA typing for all first-degree relatives; do no further work-up on those who are negative for HLA-DQ2/8.[] Celiac disease is associated with HLA-DQ2 and -DQ8; HLA-DQ2 is present in approximately 95% of celiac disease patients of northern European descent, while the rest are carriers[] ELISA/radioimmunoassay-based tests for detecting IgA anti-tTG or IgG anti-DGP should therefore be recommended in settings with low expertise. 5.6 HLA-DQ2/-DQ8 genotyping HLA-DQ2[]

  • Hypersensitivity

    HLA typing for all first-degree relatives; do no further work-up on those who are negative for HLA-DQ2/8.[] […] structure of HLA DQ2 bound to a gluten peptide as a guide [ 135, 201 ].[] Coeliac disease is associated with the HLA-DQ2 (and DQ8) haplotype.[]

  • Dermatitis

    Other tests HLA haplotype, a set of DNA variations, testing may reveal HLA-DQ2 or HLA-DQ8. This is present in almost all patients with DH (and coeliac disease).[] Other tests HLA haplotype, a set of DNA variations, testing may reveal HLA -DQ2 or HLA -DQ8.[] There is a genetic predisposition and association with human leukocyte antigens (HLAs) DQ2 and DQ8.[]

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