Question

    23 Possible Causes for HLA DQ2 in USA

    • Celiac Disease
      HLA-DQ2

      What is the meaning of HLA DQ2/DQ8? … We don’t know all the necessary genes to develop celiac disease; however, HLA DQ2 and/or DQ8 are absolutely necessary to develop the disease. … Most people with coeliac bear a two-gene HLA-DQ2 haplotype referred to as DQ2.5 haplotype.[1] [2]

    • Childhood Celiac Disease
      HLA-DQ2
    • Schmidt Syndrome

      Rather, individuals are at a higher risk when they carry a particular human leukocyte antigen (HLA-DQ2, HLA-DQ8 and HLA-DR4). … […] that autoimmune polyendocrine syndrome type 2 has an autosomal dominant(and recessive) inheritance Furthermore, the human leukocyte antigen involved in this condition are HLA-DQ2 … Here, haplotypes comprising HLA-DR3, HLA-DR4, HLA-DQ2, and HLA-DQ8 are associated with a high risk for adrenal insufficiency.[3] [4]

    • Dyspepsia

      Moreover, most patients in this study with clinically-confirmed enteropathy (84.1%) had the genetic locus for celiac disease susceptibility (HLA DQ2 or -DQ8), indicating the … […] clinically verified enteropathy they performed typical blood tests for celiac disease (e.g. anti-tissue transglutiminase IgA antibodies), as well as genetic testing for the HLA-DQ2 … […] stool frequency and gastrointestinal symptom score returned to normal values in 60% of diarrhea predominant IBS patients who were positive and in 12% who were negative for HLA-DQ2[5]

    • Dermatitis Herpetiformis

      It is most common in patients of northern European ancestry, and is associated with the HLA-DQ2 haplotype along with celiac disease and gluten sensitivity. https://en.wikipedia.org … Other tests HLA haplotype, a set of DNA variations, testing may reveal HLA-DQ2 or HLA-DQ8. … There is a genetic predisposition and association with human leukocyte antigens (HLAs) DQ2 and DQ8.[6] [7]

    • Tropical Sprue

      Also associated with HLA-DQ2 and HLA-DQ8. … . - However, it is not known whether these antibodies are primary or secondary to the tissue damage. 15. 3) Genetic factor - Patients with coeliac disease express the HLA-DQ2[8] [9]

    • Hookworm Infection

      In addition, a recent investigation of the fecal microbiota of infants at either high- or low- genetic risk of developing CeD (HLA-DQ2 carriers and non-HLA-DQ2 carriers, respectively … The HLA-DQ2 genotype selects for early intestinal microbiota composition in infants at high risk of developing coeliac disease . … Trial design Eight otherwise healthy volunteers with HLA-DQ2   or HLA-DQ8   CeD on a strict GFD ( 5 years) ( Trial subjects) were infected percutaneously with 20 infective[10]

    • Amyotrophic Lateral Sclerosis

      A vast majority of people with celiac disease have either the HLA-DQ2 or the HLA-DQ8 variant.[11]

    • Telangiectasis

      […] intestinal mucosa,and the classic histologic finding of absent villi and hyperplastic crypts.There is a strong genetic component, with more than 95% of patients expressingthe HLA-DQ2[12]

    • Addison's Disease

      Both diseases share the same genetic risk factors (HLA-DQ2 and HLA-DQ8 haplotypes).[13]

    Further symptoms

    Similar symptoms

    References

    1. Coeliac disease, https://en.wikipedia.org/wiki/Coeliac_disease
    2. Celiac Disease FAQ | Center for Celiac Research, http://www.massgeneral.org/children/services/ce…
    3. Autoimmune polyendocrine syndrome type 2, https://en.wikipedia.org/wiki/Autoimmune_polyen…
    4. Schmidt Syndrome, https://www.symptoma.com/en/info/schmidt-syndrome
    5. Wheat As A Common Cause of Dyspepsia and Irritable Bowel, http://www.greenmedinfo.com/blog/wheat-common-c…
    6. Gluten Free Has Never Tasted So Good ®, https://www.kinnikinnick.com/index/content/dh
    7. Dermatitis herpetiformis | DermNet New Zealand, http://www.dermnetnz.org/immune/dermatitis-herp…
    8. Celiac's DIsease, Whipple's Disease, Tropical Sprue and Abetalipoproteinemia for USMLE, https://www.youtube.com/watch?v=XWBqNw6bfj8
    9. Malabsorption in tropical sprue & coeliac disease, http://www.slideshare.net/autumnpianist/malabso…
    10. Experimental hookworm infection and escalating gluten challenges are associated with increased microbial richness in celiac subjects, http://www.nature.com/articles/srep13797
    11. Celiac Disease And Amyotrophic Lateral Sclerosis – Is There a Link?, http://brainblogger.com/2015/09/26/celiac-disea…
    12. Idiopathic Juxtafoveal Telangiectasis in Association With Celiac Sprue | JAMA Ophthalmology, http://archopht.jamanetwork.com/article.aspx?ar…
    13. Addison's disease, https://en.wikipedia.org/wiki/Addison%27s_disease