HLA-DQ2: Causes & Reasons

Possible Causes for HLA-DQ2

HLA-DQ2 and Presentation of Gliadin Epitopes. [doi.org]

The disease is associated with human HLA-DQ genes encoding HLA-DQ2 and DQ8 proteins. [ncbi.nlm.nih.gov]

Patients undergoing upper endoscopy for any reason and positive for HLA-DQ2 and/or DQ8 haplotypes with or without CD were included. [ncbi.nlm.nih.gov]

Childhood Celiac Disease

HLA-DQ2 and HLA-DQ8 Genes 95% of people with celiac disease have either or both of the HLA-DQ2 or HLA-DQ8 genes. [beyondceliac.org]

Methods We performed a multicenter, randomized, double-blind, placebo-controlled dietary-intervention study involving 944 children who were positive for HLA-DQ2 or HLA-DQ8 [drschaer-institute.com]

The most important genes associated with susceptibility to coeliac disease are HLA DQ2 and HLA DQ8. [coeliac.org.au]

Celiac Disease with Diffuse Intestinal Ulceration

Past genetic testing revealed that this patient carries the HLA-DQ2 allele. The physician suspects that the patient's presentation is dietary in cause. [medbullets.com]

DQ2 or DQ8 expression, dermatitis herpetiformis, hyposplenism Monomorphic variant NOT associated with celiac disease, may represent a distinct entity EATL in situ: refractory [pathologyoutlines.com]

Celiac Disease and HLA-DQ2/DQ8 eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/1790189-overview. Accessed November 2010. [labtestsonline.it]

Chronic Diarrhea with Villous Atrophy

However, as two copies of HLA-DQ2 have been reported to enhance the predisposition to celiac disease [ 14 ], we investigated the number of HLA-DQ2 copies according to the [em-consulte.com]

As for isolated CD, CEC is associated with the HLA-DQ2 and HLA-DQ8 genes. [orpha.net]

[…] olmesartan-associated sprue-like enteropathy is uncertain, the long latency before onset of symptoms, findings of lymphocytic or collagenous colitis, and high association with HLA-DQ2 [medpagetoday.com]

Dermatitis Herpetiformis

No patients had HLA-DQ2 or -DQ8, which is frequently found in Caucasian DH patients. [ncbi.nlm.nih.gov]

It is most common in patients of northern European/northern Indian ancestry, and is associated with the human leukocyte antigen (HLA) haplotype HLA-DQ2 or HLA-DQ8 along with [en.wikipedia.org]

Physiopathology is complex, occurring in HLA DQ2 or DQ8 predisposed patients, and implies gluten, immunological reaction in the intestinal wall then in the skin. [ncbi.nlm.nih.gov]

Autoimmune Polyendocrine Syndrome Type 2

Rather, individuals are at a higher risk when they carry a particular human leukocyte antigen (HLA-DQ2, HLA-DQ8 and HLA-DR4). [en.wikipedia.org]

Symptoms Asplenia[1] Risk factors Human leukocyte antigen (HLA-DQ2, HLA-DQ8 and HLA-DR4)[2] Diagnostic method Ultrasound, MRI[3] Treatment Thyroid-stimulating hormone[4] [en.wikipedia.org]

Autoimmune polyendocrine syndrome type 2 Other names Schmidt's syndrome[1] HLA-DQ2 one of the human leukocyte antigens genotypes responsible for this condition Specialty Endocrinology [en.wikipedia.org]

Enteropathy-Associated T-Cell Lymphoma

Cases with inappropriate HLA-DQ2/8 genotype testing. [doi.org]

Homozygosity for HLA-DQ2 is associated with RCD II and EATL. [ncbi.nlm.nih.gov]

Poor adherence to a gluten-free diet, HLA-DQ2 homozygosity, and late diagnosis of CD are recognized as risk factors for malignant evolution of CD. [ncbi.nlm.nih.gov]

Echinococcus Multilocularis Infection

PBMC from seven HLA-DR3+, DQ2+, B8+ healthy subjects and nine HLA-DR3-, DQ2-, B8- subjects were also studied as controls. [ncbi.nlm.nih.gov]

Influence of the HLA B8, DR3, DQ2 haplotype. Clin Exp Immunol. 2000 Sep. 121(3):491-8. [Medline]. [emedicine.com]

A spontaneous secretion of TNF by HLA DR3+, DQ2+ B8+ AE patients was also found. [ncbi.nlm.nih.gov]

Tropical Sprue

More than 95% of celiac patients have the HLA-DQ2 or HLA-DQ8 haplotype ( 1 ), although these haplotypes are not particularly specific for celiac disease. [merckmanuals.com]

- However, it is not known whether these antibodies are primary or secondary to the tissue damage. 15. 3) Genetic factor - Patients with coeliac disease express the HLA-DQ2 [slideshare.net]

However, given the high sensitivity, testing that fails to show HLA-DQ2 or -DQ8 can effectively rule out celiac disease when biopsy and serologic markers are not concordant [merckmanuals.com]

Wheat Intolerance

It occurs in people who inherit one or both of the celiac genes (HLA-DQ2 & HLA-DQ8). [rebootwithjoe.com]

class II genes, HLA-DQ2 and HLA-DQ8, located on chromosome 6p21. [2] Nearly all CD patients are NLA-DQ2/HLA-DQ8 positive, with 95% HLA-DQ2 and the rest usually HLA-DQ8 [en.wikipedia.org]

DNA-based testing will identify the presence or absence of the genes encoding the gluten recognition immune cell receptors, HLA-DQ2 and DQ8. [precisionpath.us]

Sjögren Syndrome

All were HLA-DQ2 and/or -DQ8-positive. [doi.org]

More than 95 % of those with CD express HLA-DQ2 while the remainder expresses HLA-DQ8. [doi.org]

Studies show an association with HLA-DQ2 and HLA-DQ8, the same HLA haplotypes necessary for the presence of CD [ 18, 20 ]. [doi.org]

Primary T-Cell Immunodeficiency

The role of HLA DQ2 and DQ8 in dissecting celiac-like disease in common variable immunodeficiency. J Clin Immunol. 2013;33(5):909-916. [scielo.org.mx]

Dilated Cardiomyopathy with Woolly Hair - Keratoderma - Tooth Agenesis

Indispensable enviar consentimiento informado CELIAQUÍA HLA DQ2 SANGRE TOTAL CELIAQUÍA HLA DQ2/DQ8 SANGRE TOTAL CELIAQUÍA HLA DQ8 SANGRE TOTAL 122 15066 CETOLISIS, PANEL SECUENCIACIÓN [docplayer.es]

DQ2 SANGRE TOTAL CELIAQUÍA HLA DQ2/DQ8 SANGRE TOTAL CELIAQUÍA HLA DQ8 SANGRE TOTAL CETOLISIS, PANEL SECUENCIACIÓN MASIVA (NGS) GENES ACAT1, SLC16A2, OXCT CGH ARRAY 60K VELLOSIDAD [docplayer.es]

CLASE B, TIPAJE DNA SANGRE TOTAL HLA CLASE C, TIPAJE DNA SANGRE TOTAL HLA Cw*06 RELACIONADO CON PSORIASIS, SANGRE TOTAL HLA DQ (DQB1/DQA1) TIPAJE SANGRE TOTAL HLA DQ2 RELACIONADO [docplayer.es]

Prune Belly Syndrome with Pulmonic Stenosis - Mental Retardation - Deafness

Collagenous Gastritis

Immunosuppression is standard therapy The absence of both HLA-DQ2 and HLA-DQ8 haplotypes essentially excludes the diagnosis The histologic features may persist for years The [pathologyoutlines.com]

Familial Enteropathy with Villous Edema and IgG2 Deficiency

HLA typing for all first-degree relatives; do no further work-up on those who are negative for HLA-DQ2/8. [worldgastroenterology.org]

Others activate lamina propria T cells in the context of HLA-DQ2 or DQ8 molecules. [obgynkey.com]

In one of these studies, 30% of patients with abdominal symptoms suggestive of irritable bowel syndrome having the celiac-like HLA-DQ2 gene but no antibodies to gliadin in [celiac.com]

Complement Receptor Deficiency

The role of HLA DQ2 and DQ8 in dissecting celiac-like disease in common variable immunodeficiency. J Clin Immunol. 2013;33(5):909-916. [scielo.org.mx]

Celiac Disease-Epilepsy-Cerebral Calcification Syndrome

It is associated with the HLA-DQ2 and HLA-DQ8 genes. [radiopaedia.org]

As for isolated Celiac disease, Celiac disease, epilepsy and cerebral calcification syndrome is associated with the HLA-DQ2 and HLA-DQ8 genes. [checkorphan.org]

As for isolated CD, CEC is associated with the HLA-DQ2 and HLA-DQ8 genes. [orpha.net]

Mooren's Ulcer

The same study found that only one out of 10 patients with another form of destructive sclerokeratitis expressed the HLA-DR17 allele and three expressed HLA-DQ2. [eyewiki.aao.org]

One study suggested that 83% of patients (n=12) with Mooren's ulcer were HLA-DR17 positive, and 83% were HLA-DQ2 positive, as compared to control populations where frequencies [eyewiki.aao.org]

HLA-DQ5 has also been found in increased frequencies in patients with Mooren's ulcer [7]. [eyewiki.aao.org]

Immunodeficiency Type 60

The role of HLA DQ2 and DQ8 in dissecting celiac-like disease in common variable immunodeficiency. J Clin Immunol. 2013;33(5):909-916. [scielo.org.mx]

CD79B Deficiency

The role of HLA DQ2 and DQ8 in dissecting celiac-like disease in common variable immunodeficiency. J Clin Immunol. 2013;33(5):909-916. [scielo.org.mx]

Polycystic Lipomembranous Osteodysplasia-Sclerosing Leukoencephalopathy Syndrome Type 2

Collagenous Sprue

Genetic testing for HLA-DQ2 and HLA DQ-8 was negative. Colonoscopy revealed a grossly normal appearing mucosa. [journals.lww.com]

None of the patients had ever shown celiac-specific antibodies, and all were negative for HLA-DQ2 and HLA-DQ8 phenotype. [celiac.com]

[…] a) Refer the patient for a dietary review b) Request a clonal analysis of the intraepithelial lymphocytes c) Refer for HLA DQ2/DQ8 testing d) Refer the patient for capsule [ueg.eu]

Transient Hypogammaglobulinemia

The role of HLA DQ2 and DQ8 in dissecting celiac-like disease in common variable immunodeficiency. J Clin Immunol. 2013;33(5):909-916. [scielo.org.mx]

Gluten Allergy

Thus, HLA-DQ2 or HLA-DQ8 is necessary for disease development but is not sufficient for disease development. [allergycliniclondon.co.uk]

“The vaccine is designed to target the 90 percent of celiac disease patients with the HLA-DQ2 genetic form of disease. [wellandgood.com]

DQ2 and HLA DQ8) Intestinal biopsy (for celiacs) I want to mention that one potential problem with testing is that gluten is made up of several hundred peptides and gliadin [amymyersmd.com]

Yao Syndrome

Genetic testing for celiac disease was negative for the HLA-DQ2/DQ8 haplotypes. Plasma cytokine (IL-1, IL-6 and TNFα) levels were normal. [the-rheumatologist.org]

Selective IgA Immunodeficiency

Fifty-four out of 58 biopsy verified CD patients carried HLA-DQ2/DQ8 (one DNA sample was not available). [journals.plos.org]

Celiac Disease and HLA-DQ2/DQ8 eMedicine [On-line information]. Available online at http://emedicine.medscape.com/article/1790189-overview. Accessed November 2010. [labtestsonline.it]

[…] disorder, triggered by gluten and related prolamines present in wheat, barley and rye, that occur in genetically susceptible individuals, who have the human leukocyte antigen HLA-DQ2 [medcraveonline.com]

Autosomal Recessive Agammaglobulinemia Type 2

The role of HLA DQ2 and DQ8 in dissecting celiac-like disease in common variable immunodeficiency. J Clin Immunol. 2013;33(5):909-916. [scielo.org.mx]

Autoimmune Enteropathy

The patients were HLA-DQ2 positive. IgA antigliadin and antiendomysial antibodies were not found in any of the patients. [ncbi.nlm.nih.gov]

Four patients had the celiac HLA-DQ2/DQ8 susceptibility genotype. [journals.plos.org]

HLA DQ2/DQ8 can bind gluten peptides after their prior modification by the CD autoantigen, tissue transglutaminase (TG2). [readbyqxmd.com]

Allergic Bronchopulmonary Aspergillosis

Previous HLA typing revealed that the patient was HLA-DR2+, DRB*1501, HLA-DQ2-, a pattern associated with increased risk of ABPA. [ncbi.nlm.nih.gov]

Additional studies indicated that the presence of HLA-DQ2 (especially HLA-DQB1*0201) provided protection from the development of ABPA. [clinicaladvisor.com]

Genetic Factors Involved in Pathogenesis of ABPA HLA associations: HLA-DR molecules (DR2, DR5, and possibly, DR4 or DR7) associated with susceptibility HLA-DQ2 molecules associated [slideshare.net]