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163 Possible Causes for HLA-DQ2

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  • Celiac Disease

    The disease is associated with human HLA-DQ genes encoding HLA-DQ2 and DQ8 proteins.[ncbi.nlm.nih.gov] Celiac disease (CD) occurs in subjects positive for HLA-DQ2 and/or DQ8 gene loci at any age following ingestion of gluten-containing food.[ncbi.nlm.nih.gov] HLA-DQ2 was less frequent in UC patients (P 0.0287), and HLA-DQ8 in CD (P 0.0217).[ncbi.nlm.nih.gov]

  • Childhood Celiac Disease

    Children with typical symptoms of CD, who have a tissue transglutaminase antibody level 10 times the upper limit of normal together with a positive endomysium antibody and are HLA-DQ2[journals.lww.com] HLA-DQ2 and HLA-DQ8 Genes 95% of people with celiac disease have either or both of the HLA-DQ2 or HLA-DQ8 genes.[beyondceliac.org] Ninety percent of affected individuals carry the HLADQ2 haplotype, 5% the DQ8 haplotype, and the remaining 5% carry at least one of the two DQ2 alleles [ 1 , 2 ].[intechopen.com]

  • Ataxia

    Hadjivassiliou looking at 68 patients with gluten ataxia noted that 78% of those people carried one or both of the primary celiac disease genes , HLA-DQ2 and HLA-DQ8 .[verywell.com]

  • Congenital Malabsorption of Folic Acid

    Others activate lamina propria T cells in the context of HLA-DQ2 or DQ8 molecules.[clinicalgate.com] DQ2-negative celiac patients are invariably HLA DQ8 positive (DQA1*0301/DQB1*0302).[clinicalgate.com] […] the measurement of HLA DQ2 and/or DQ8 has a strong negative predictive value but a very weak positive predictive value for the diagnosis of celiac disease.[clinicalgate.com]

  • Amyotrophic Lateral Sclerosis

    A vast majority of people with celiac disease have either the HLA-DQ2 or the HLA-DQ8 variant.[brainblogger.com] The genetic predisposition to celiac disease is associated with specific HLA antigen molecules expressed in antigen presenting cells of the immune system.[brainblogger.com]

  • Spleen Disease

    […] predicting celiac disease Why patients with hyposplenism should get tested for celiac disease 25-75% of celiac patients have hyposplenism Look for red blood cell abnormality HLA-DQ2[glutenfreern.com] […] and HLA-DQ8 genes indicate predisposition for celiac disease Antibody test available from EnteroLab or Cyrex Laboratories Ask for total IgA, IgG Other autoimmune diseases[glutenfreern.com]

  • Eales Disease

    HLA DQ2 and DR52 was found in 28 cases of group-I as compared to 18 cases of group-II (p .005).[ncbi.nlm.nih.gov] Similarly, HLA DQ2, DR52 and Bw6 was found in higher frequency in Eales patients and thus strongly associated with it.[ncbi.nlm.nih.gov] HLA phenotypes HLA DR3, A1, B8, B5 (51) and DR 15 (2) occurred in majority of cases of Eales disease, whereas these were not found in controls which was statistically significant[ncbi.nlm.nih.gov]

  • Helicobacter Pylori Infection

    Celiac disease (CD) occurs in subjects positive for HLA-DQ2 and/or DQ8 gene loci at any age following ingestion of gluten-containing food.[ncbi.nlm.nih.gov] Patients undergoing upper endoscopy for any reason and positive for HLA-DQ2 and/or DQ8 haplotypes with or without CD were included.[ncbi.nlm.nih.gov]

  • Tropical Sprue

    . - However, it is not known whether these antibodies are primary or secondary to the tissue damage. 15. 3) Genetic factor - Patients with coeliac disease express the HLA-DQ2[slideshare.net] More than 95% of celiac patients have the HLA-DQ2 or HLA-DQ8 haplotype ( 1 ), although these haplotypes are not particularly specific for celiac disease.[merckmanuals.com] However, given the high sensitivity, testing that fails to show HLA-DQ2 or -DQ8 can effectively rule out celiac disease when biopsy and serologic markers are not concordant[merckmanuals.com]

  • Wheat Intolerance

    It occurs in people who inherit one or both of the celiac genes (HLA-DQ2 & HLA-DQ8).[rebootwithjoe.com] ) class II genes, HLA-DQ2 and HLA-DQ8 , located on chromosome 6p21 . [2] Nearly all CD patients are NLA-DQ2/HLA-DQ8 positive, with 95% HLA-DQ2 and the rest usually HLA-DQ8[en.wikipedia.org] At the moment, the most important factor found to have a significant impact on the development of CeD is possession of 2 copies of the HLA-DQ2 allele (the high-risk HLA genotype[journals.lww.com]

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