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316 Possible Causes for HLA-DR3

  • Diabetes Mellitus

    There is around 30 to 35% concordance in monozygotic twins. 95% of the patients carry HLA-DR3, HLD-DR4 or both genes.[symptoma.com] Compared with nonautoimmune T2D patients, autoimmune T2D patients are reportedly more commonly positive for HLA-DR3 and -DR4 and their associated DQβ1 alleles 0201 and 0302[clinchem.aaccjnls.org] Associated with HLA DR3 and DR4 and islet cell antibodies around the time of diagnosis. Patients always need insulin treatment and are prone to ketoacidosis.[patient.info]

  • Graves Disease

    […] and HLA-DR3 Laboratory Increased T3 / T4, increased uptake of radioactive iodine, decreased TSH Clinical Images Images hosted on other servers: Rodney Dangerfield Marty Feldman[web.archive.org] […] and HLA-DR3 Sites Global involvement of thyroid gland Pathophysiology Exact cause is unclear It is believed to involve a combination of genetic and environmental factors[pathologyoutlines.com] […] genes, particularly HLA-DR3.[rarediseases.org]

  • Celiac Disease

    We confirmed the high frequency of HLA-DR3 in this population, and we were also able to demonstrate the additional risk of developing celiac disease imparted by HLA-DR7.[ncbi.nlm.nih.gov] Altogether 655 schoolchildren (18.1 percent) carried the HLA-DQA1*05-DQB1*02 (HLA-DR3–DQ2) haplotype, and 1411 (39 percent) carried either the HLA-DR3–DQ2 or the HLA-DQ-A1[nejm.org] […] of HLA-DR3-DQ2 and/or DR4-DQ8-positive children.[ncbi.nlm.nih.gov]

  • Sjogren's Syndrome

    We found significantly increased frequency of HLA-DR3 (P less than .001), HLA-DW52a (P less than .001), and HLA-DQA4 (P less than .05), in comparison to normal controls.[ncbi.nlm.nih.gov] We found significantly increased frequency of HLADR3 ( P .001), HLA‐DW52a ( P .001), and HLA‐DQA4 ( P .05), in comparison to normal controls.[doi.org] It is important to note that the HLA-DQ2 haplotype found in 95 % of celiac patients shares a strong linkage to the HLA-DR3 haplotype associated with AIH [ 52 ].[dx.doi.org]

  • Systemic Lupus Erythematosus

    […] ulna at DRUJ Imaging Studies Radiographs usually no evidence of joint destruction osteonecrosis of hips is common Labs Usually positive for ANA (95%) anti-DNA antibodies HLA-DR3[orthobullets.com] The presence of human leukocyte antigen (HLA)–B8 and HLA-DR3 in the mother may predispose the infant to NLE and congenital heart block.[emedicine.medscape.com] (HLA-B8 was most consistently associated with SLE, but was later found to be in linkage disequilibrium with -DQ2 and -DR3.)[doi.org]

  • Autoimmune Hepatitis

    For example, HLA DR3 positivity only contributes when other antibodies are negative. This calculator correctly scores such circumstances.[web.archive.org] Transgenic AIH mice carrying HLA-DR3 showed reduced diversity and total load of gut microbiota.[ncbi.nlm.nih.gov]

  • Childhood Celiac Disease

    Kaplan–Meier Estimates of CDA in HLA-DR3–DQ2 Homozygotes, According to Country.[nejm.org] HLA -DR, -DQ genotypes of celiac disease patients serologically typed to be non-DR3 and non-DR5/7. Hum Immunol 1992 ; 35 : 188 -192.[clinchem.aaccjnls.org] Methods We studied 6403 children with HLA haplotype DR3–DQ2 or DR4–DQ8 prospectively from birth in the United States, Finland, Germany, and Sweden.[nejm.org]

  • Chronic Active Hepatitis B

    The apparent predisposition of individuals with HLA-B8 and DR3 haplotypes to develop IACAH suggests that genetically conditioned abnormalities may have a role in pathogenesis[hepatitiscentral.com]

  • Myasthenia Gravis

    The early peak shows a female predominance, approximately 3:1, and an association with HLA-B8, HLA-DR3, and HLA-DR1, the latter being more specific for ocular MG.[eyewiki.aao.org] […] abstain from having children. [5] Etiology Genetic studies have revealed a correlation between early-onset myasthenia gravis, which affects women of childbearing age, and the HLA-DR3[emedicine.com] […] and B8 alleles. [6] Additionally, research suggests that certain non-HLA genes affect susceptibility to autoimmune disorders as a whole, thus increasing the risk of myasthenia[emedicine.com]

  • Herpes Gestationis

    An additional laboratory finding in patients with HG is their increased frequency of the HLA-B8 and HLA-DR3 haplotypes as well as the HLA-DR3, -DR4 paired haplotype.[ncbi.nlm.nih.gov] Where HLA typing was possible (in one patient), the combination of HLA-DR3 and HLA-DR4 was found.[ncbi.nlm.nih.gov] It is associated with the class II antigens HLA-DR3 and HLA-DR4, but its potential association with the "class III antigens" C2, C4, and factor B has not previously been studied[ncbi.nlm.nih.gov]

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