HLA-DR3: Causes & Reasons

Possible Causes for HLA-DR3

For example, HLA DR3 positivity only contributes when other antibodies are negative. This calculator correctly scores such circumstances. [web.archive.org]

Transgenic AIH mice carrying HLA-DR3 showed reduced diversity and total load of gut microbiota. [ncbi.nlm.nih.gov]

[…] association HLA DR3/DR4 HLA DR3/DR7 Prognosis Good More aggressive and classically harder to treat; rates of relapse are high Type 1 Type 2 Percentage of all AIH cases 80% [bmb.oxfordjournals.org]

Sjögren Syndrome

We found significantly increased frequency of HLA-DR3 (P less than .001), HLA-DW52a (P less than .001), and HLA-DQA4 (P less than .05), in comparison to normal controls. [ncbi.nlm.nih.gov]

We found significantly increased frequency of HLA‐DR3 ( P < .001), HLA‐DW52a ( P < .001), and HLA‐DQA4 ( P < .05), in comparison to normal controls. [doi.org]

Genetic tests can show an association of Sjögrens syndrome with HLA DR3. [youtube.com]

Childhood Celiac Disease

Children positive for the HLA-DR3 allele and females appear to be at increased risk. [ncbi.nlm.nih.gov]

Kaplan–Meier Estimates of CDA in HLA-DR3–DQ2 Homozygotes, According to Country. [nejm.org]

The genetic susceptibility to celiac disease is conferred by well-identified haplotypes in the human leukocyte antigen (HLA) class II region (ie, DR3 or DR5/DR7 or HLA DR4 [emedicine.medscape.com]

Diabetes Mellitus

There is around 30 to 35% concordance in monozygotic twins. 95% of the patients carry HLA-DR3, HLD-DR4 or both genes. [symptoma.com]

Associated with HLA DR3 and DR4 and islet cell antibodies around the time of diagnosis. Patients always need insulin treatment and are prone to ketoacidosis. [patient.info]

Compared with nonautoimmune T2D patients, autoimmune T2D patients are reportedly more commonly positive for HLA-DR3 and -DR4 and their associated DQβ1 alleles 0201 and 0302 [clinchem.aaccjnls.org]

Celiac Disease

We confirmed the high frequency of HLA-DR3 in this population, and we were also able to demonstrate the additional risk of developing celiac disease imparted by HLA-DR7. [ncbi.nlm.nih.gov]

Altogether 655 schoolchildren (18.1 percent) carried the HLA-DQA1*05-DQB1*02 (HLA-DR3–DQ2) haplotype, and 1411 (39 percent) carried either the HLA-DR3–DQ2 or the HLA-DQ-A1 [nejm.org]

[…] of HLA-DR3-DQ2 and/or DR4-DQ8-positive children. [ncbi.nlm.nih.gov]

Graves Disease

[…] and HLA-DR3 Laboratory Increased T3 / T4, increased uptake of radioactive iodine, decreased TSH Clinical Images Images hosted on other servers: Rodney Dangerfield Marty Feldman [web.archive.org]

[…] and HLA-DR3 Sites Global involvement of thyroid gland Pathophysiology Exact cause is unclear It is believed to involve a combination of genetic and environmental factors [pathologyoutlines.com]

An autoimmune disease with stimulating anti-TSH receptor antibodies a type II hypersensitivity anti-microsomal, anti-thyroglobulin antibodies also present Female dominant HLA-B8 [step2.medbullets.com]

Myasthenia Gravis

People with certain genetic markers (called HLA-B8, DR3) are more likely to develop MG. [umms.org]

In the sequel study, Garchon and coworkers reevaluated the contribution of the extended 8.1 HLA haplotype, including Class I HLA-A1 and B8 loci and Class II HLA-DR3 allele [hindawi.com]

The early peak shows a female predominance, approximately 3:1, and an association with HLA-B8, HLA-DR3, and HLA-DR1, the latter being more specific for ocular MG. [eyewiki.aao.org]

Systemic Lupus Erythematosus

[…] ulna at DRUJ Imaging Studies Radiographs usually no evidence of joint destruction osteonecrosis of hips is common Labs Usually positive for ANA (95%) anti-DNA antibodies HLA-DR3 [orthobullets.com]

It is important to note that the HLA-DQ2 haplotype found in 95 % of celiac patients shares a strong linkage to the HLA-DR3 haplotype associated with AIH [ 52 ]. [dx.doi.org]

Factors leading to SLE include: Genetic predisposition, including haplotype HLA-B8, -DR3 Exposure to sunlight Viral infection, particularly Epstein-Barr virus Hormones Toxins [dermnetnz.org]

Chronic Active Hepatitis B

The apparent predisposition of individuals with HLA-B8 and DR3 haplotypes to develop IACAH suggests that genetically conditioned abnormalities may have a role in pathogenesis [hepatitiscentral.com]

Dermatitis Herpetiformis

There is an association with the genotypes HLA DR3, HLA DQw2, found in 80-90% of cases. [ncbi.nlm.nih.gov]

The disease is strongly associated with the presence of HLA-B8 and HLA-DR3 antigens. [dermis.net]

It is associated with an increased expression of HLA-A1, HLA-B8, and HLA-DR3 antibodies. [fpnotebook.com]

Autoimmune Polyendocrine Syndrome Type 2

Autoimmune polyglandular syndromes Type I (APECED) Type II Genetics AIRE gene mutation; autosomal recessive Polygenic, autosomal dominant with low penetrance, association with HLA-DR3 [academic.oup.com]

Genetic susceptibility to APS-2 Autoimmune Addison's is closely associated with the_ HLA-DR3_ haplotype; the highest risk genotype is HLA-DR3/4-DQ2/8, found in 30% of patients [diapedia.org]

Associated with certain HLA antigens HLA-DR3, HLA-DR4, non HLA gene M-ICA and CTLA-4[2][8]. [hopkinsguides.com]

Herpes Gestationis

Pemphigoid gestationis has a strong association with HLA-DR3 (61%) and HLA-DR4 (52%), or both (43%), [5] and virtually all patients with a history of pemphigoid gestationis [emedicine.medscape.com]

Where HLA typing was possible (in one patient), the combination of HLA-DR3 and HLA-DR4 was found. [ncbi.nlm.nih.gov]

HLA testing (45% have HLA-DR3, HLA-DR4 compared with 3% of the general population). [patient.info]

Punctate Keratitis

Although its exact etiology is controversial, TSPK has a genetic association with HLA-DR3, an antigen associated with immunogenic responses. [ncbi.nlm.nih.gov]

Although TSPK has a genetic association with HLA-DR3, controversy exists regarding its exact etiology. [emedicine.medscape.com]

Thygeson's superficial punctate keratitis: natural history and association with HLA DR3. Trans Am Ophthalmol Soc. 1981. 79:486-516. [Medline]. Jones BR. [emedicine.medscape.com]

Chronic Fibrous Thyroiditis

[…] approximately 4.6% • Estimated prevalence by gender 5.8% for females and 3.4% for males (CDC data) Risk factors • Postpartum state (i.e., postpartum thyroiditis) • Specific alleles (HLA-DR3 [clinicaladvisor.com]

There are reports that polymorphisms in the HLA locus, specifically the HLA-DR3 and HLA-DR5 alleles, are linked to Hashimoto thyroiditis, but the association is weak. [humpath.com]

(goitrous form), HLA-DR3 (atrophic form) May coexist with SLE, rheumatoid arthritis, Sjögren syndrome, pernicious anemia, type 2 diabetes, Graves disease, chronic active [pathologyoutlines.com]

Inclusion Body Myositis

All 6 patients with sIBM/SS carried the HLA-DRB1*0301 allele, or its equivalent HLA-DR3 serological specificity, compared with 83% of other sIBM cases and all carried some [ncbi.nlm.nih.gov]

For sufficient power, we would have needed at least 26 patients, but we only had 11 HLA-DR3-positive versus three HLA-DR3-negative patients. [doi.org]

No causal gene has been identified but HLA-DR3 and 8-1 MHC genotypes have been shown to correlate with IBM susceptibility. [orpha.net]

Autoimmune Polyendocrine Syndrome

It is associated with HLA-DR3 and/or HLA-DR4 haplotypes, and the pattern of inheritance is autosomal dominant with variable expressivity. [1, 2] Two other related autoimmune [emedicine.medscape.com]

Echinococcus Multilocularis Infection

PBMC from seven HLA-DR3+, DQ2+, B8+ healthy subjects and nine HLA-DR3-, DQ2-, B8- subjects were also studied as controls. [ncbi.nlm.nih.gov]

Influence of the HLA B8, DR3, DQ2 haplotype. Clin Exp Immunol. 2000 Sep. 121(3):491-8. [Medline]. [emedicine.com]

A spontaneous secretion of TNF by HLA DR3+, DQ2+ B8+ AE patients was also found. [ncbi.nlm.nih.gov]

Subacute Cutaneous Lupus Erythematosus

[…] and HLA-DR3. 10 The antinuclear antibodies (FAN) are positive in 70 to 90% of cases. [scielo.br]

SCLE →HLA-DR3, DQA1*0501, DQB1*0502 haplotype DLE → significant increases of HLA-B7, -B8, -DR2, - DR3, and -DQA0102 → a significant decrease in HLA-A2 17. [slideshare.net]

Genetics have been shown to play an important role in the development of SCLE, specifically in individuals with human leucocyte antigen (HLA) B8, HLA-DR3, HLA-DRw52 and HLA-DQ1 [lupus.bmj.com]

Secondary Sclerosing Cholangitis

HLA-DR3 + leukocytes secrete significantly greater amounts of IL-2, IL-5, IL-12, and IFNγ than do HLA-DR3 − leukocytes, before and after mitogen stimulation in vitro [ 50 [abdominalkey.com]

The most commonly recorded association of the major histocompatibility complex (MHC) with scleroderma is with the HLA B8, DR3-containing haplotype and the high frequency of [jdeonline.in]

Frequent, however, is the association of PAC with HLA-B8 and HLA-DR3 aplotypes.The lymphocytes that are involved in the inflammatory exudate in affected bile ducts are T-lymphocytes [meddean.luc.edu]

Drug-Induced Lupus Erythematosus

B8, HLA-DR4, HLA DR3, and complement C4 allele. 5 DILE was first described in 1945 as resulting from sulfasalazine intake; currently, hundreds of medications are associated [rheumatologyadvisor.com]

Etiology Genetic predisposition : HLA -DR2 and HLA-DR3 commonly found in patients with SLE Hormonal factors : suspected modulatory effect of hormones on immune system Immunological [amboss.com]

There is a genetic predisposition to DISCLE, with increased frequency of HLA-B8 and HLA DR3. [ncbi.nlm.nih.gov]

Hughes-Stovin Syndrome

Diabetes mellitus type 1 [15] Moderate, A IV HLA-DR3, HLA-DR4. [immunologyonline.wordpress.com]

Microscopic colitis Limited, S Ulcerative colitis [15] Limited, A IV Antiphospholipid syndrome [15] Moderate, M, A HLA-DR7, HLA-B8, HLA-DR2, HLA-DR3. [alergianakonline.wordpress.com]

Lambert-Eaton myasthenic syndrome Strong, M, Y HLA-DR3-B8. [immunologyonline.wordpress.com]

Inclusion Body Myopathy

For sufficient power, we would have needed at least 26 patients, but we only had 11 HLA-DR3-positive versus three HLA-DR3-negative patients. [doi.org]

No causal gene has been identified but HLA-DR3 and 8-1 MHC genotypes have been shown to correlate with IBM susceptibility. [orpha.net]

FREQUENTE TRA I GIAPPONESI M:F=1:3 ETA’: 15-44 ANNI CHIAMATI IN CAUSA ALCUNI VIRUS POICHE’ INDUCONO UNA MIOSITE SIMILE A QUELLA AUTOIMMUNE: COXACKIE, ECHOVIRUS, HTLV-1, HIV HLA-DR3 [studocu.com]

Diabetic Enteropathy

Major histocompatibility antigen studies done on patients with either insulin-dependent diabetes mellitus or celiac disease have found HLA-DR3 and HLA-DQB1*0201 expression [semanticscholar.org]

Genetic Aspects Autoimmune Addison's is closely associated with the_ HLA-DR3_ haplotype; the highest risk genotype is HLA-DR3/4-DQ2/8, found in 30% of patients. [diapedia.org]

Both celiac disease and type 1 diabetes are associated with a high frequency of HLA-DR3 genotypes. [journal.diabetes.org]

Lambert-Eaton Syndrome

Non-tumor LEMS has a strong association with HLA-DR3-B8. [ncbi.nlm.nih.gov]

Around 65% of non-paraneoplastic LEMS patients were found to be HLA-B8 positive, and 50% were HLA-A1 positive while the same frequency existed for HLA-DQ2 and HLA-DR3 [9]. [cureus.com]

Genetic predisposition: Non-tumor Lambert-Eaton myasthenic syndrome is associated with HLA-B8 (HLA - class I) and HLA -DR3 and -DQ2 (HLA class II). [statpearls.com]

Juvenile Seronegative Polyarthritis

However, the disease has been associated with HLA class II antigens, HLA DR3 and DRB1*08. [orpha.net]

Atypical Diabetes Mellitus

In addition, associations with HLA DR3 and DR4 and islet cell antibodies around the time of diagnosis have been noted. [news-medical.net]

Autoimmune Oophoritis

[…] mycotoxins, and organic compounds.[3] Genetics[edit] As Autoimmune oophoritis often occurs in the setting of autoimmune polyendocrine syndromes (APS), mutations in AIRE or HLA-DR3 [en.wikipedia.org]

Superficial Punctate Keratopathy Type Thygeson

Although TSPK has a genetic association with HLA-DR3, controversy exists regarding its exact etiology. [emedicine.medscape.com]

Br J Ophthalmol. 2007;91(8):1038-41. ↑ 7.0 7.1 7.2 Darrell RW: Thygeson's superficial punctate keratitis: natural history and association with HLA-DR3, Trans Am Ophthalmol [eyewiki.aao.org]

[…] from eyes with TSPK, providing doubts this virus is a causative agent. [8][9] On the other hand, an immune based etiology has also been proposed, since the presence of the HLA-DR3 [eyewiki.aao.org]

Autoimmune Polyendocrine Syndrome Type 1

HLA-B8, HLA-DR3, HLA-DR4 HLA-B8, HLA-DR3, HLA-DR4 Phenotype Chronic mucocutaneous candidiasis with either hypoparathyroidism or Addison’s disease Addison’s disease with either [edmcasereports.com]

HLA DR3-DR5 Autoimmune thyroiditis HLA DR3-DQ2 Celiac disease HLA DR3-DQ2, DR4-DQ8 (DRB1 * 0404) Addison's disease MICA 4, 5, 6, and 9 GCT repeats (exon 5) Type 1A diabetes [liebertpub.com]

It is associated with human leukocyte antigen (HLA)-DR3 and/or HLA-DR4 haplotypes, and the pattern of inheritance is autosomal dominant with variable expressivity.[ 1 ] The [ncbi.nlm.nih.gov]

Transient Sarcoidosis

[…] positive for HLA-DR3 may be more likely to develop the chronic form of arthritis. [rheumaknowledgy.com]

Etiology Speculative Familial cases – positive association with HLA-1, -B8, -B13, -DR3 and –B27. [slideshare.net]

In nonpersistent disease, a strong genetic association exists with HLA DR3-DQ2. [73] [74] Cardiac sarcoid has been connected to TNFA variants. [75] Infectious agents [ edit [en.wikipedia.org]