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386 Possible Causes for HLA-DR4

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  • Diabetes Mellitus

    DQB1*0201, HLA-DR4 DQB1*0302, or both.[emedicine.com] Approximately 95% of patients with type 1 DM have either HLA-DR3 or HLA-DR4.[emedicine.com] HLA-DQs are also considered specific markers of type 1 DM susceptibility.[emedicine.com]

  • Rheumatoid Arthritis

    Interestingly, although RA is common and sometimes severe in groups of American Indians, it is not associated with HLA-DR4, as it is in whites. The evil weed?[medscape.com] It is generally considered that a genetic predisposition (HLA-DR B1 which is the most common allele of HLA-DR4 involved in RA) and an environmental trigger (Epstein-Barr virus[radiopaedia.org]

  • Autoimmune Hepatitis

    (DRB1*0301) and HLA-DR4 (DRB1*0401) China / Japan: HLA-DR4 (DRB1*0405) Clinical features Most patients have nonspecific symptoms: fatigue, anorexia, nausea, weight loss,[pathologyoutlines.com] Race-, sex-, and age-related differences in incidence The disease is most common in whites of northern European ancestry with a high frequency of HLA-DR3 and HLA-DR4 markers[emedicine.com] […] years Etiology Etiology unknown; genetic and environmental factors may play roles in pathogenesis ( J Hepatol 2015;62:S100 ) Genetic predisposition: North America / Europe: HLA-DR3[pathologyoutlines.com]

  • Systemic Lupus Erythematosus

    ) DR3 or DR4 [ 24 ].[omicsonline.org] This particular phenomenon has been observed with HLA-B40 among an Australian population. 55 Likewise, the presence of DR4 in a Japanese population has been reported as a[doi.org] […] levels of liver enzymes, hypergammaglobulinemia, the presence of autoantibodies and typical histological changes [ 25 ], and association with the Human Leukocyte Antigens (HLA[omicsonline.org]

  • Pernicious Anemia

    A 81-year-old woman was diagnosed as having diabetes mellitus (DM) at 58 years of age. She started insulin therapy the following year, but her blood sugar levels were poorly controlled. At the age of 75, she tested positive for the anti-GAD antibody (7.8 U/ml) and was diagnosed as having slowly progressive type 1[…][ncbi.nlm.nih.gov]

  • Juvenile Seronegative Polyarthritis

    DR4 and HLA DW4.[en.wikipedia.org] Other HLA-DR4 molecules (eg, HLA-DR beta *0402) lack this epitope and do not confer this risk.[emedicine.medscape.com] […] ophthalmologist. [23] Rheumatoid factor may be positive, i.e. seropositive, in children with polyarticular JIA occurring between 9 and 16 years of age and is associated with HLA[en.wikipedia.org]

  • Uveomeningoencephalitic Syndrome

    Included studies met the following pre-specified criteria: 1) Association study of HLA-DR4/ HLA-DRB1*04 or its sub-alleles with VKH; 2) The number or percentage of HLA-DR4[nature.com] VKH has been linked to human leukocyte antigen DR4 (HLA-DR4) and HLA-Dw53, with strongest associated risk for HLA-DRB1*0405 haplotype.[ncbi.nlm.nih.gov] Table 2: Assessment of potential bias in included studies Association of HLA-DR4/DRB1*04with VKH In 19 case-control studies investigating the association of HLA-DR4/ HLA-DRB1[nature.com]

  • Rheumatic Fever

    No significant association with class-I human leukocyte antigens (HLAs) has been found, but an increase in class-II HLA antigens DR2 and DR4 has been found in black and white[emedicine.com] […] antigens (DR2 in blacks and DR4 in whites) and ARF has been reported. [5] No general clear-cut sex predilection for ARF has been reported, but certain of its manifestations[emedicine.com] […] patients, respectively. [5] Evidence suggests that elevated immune-complex levels in blood samples from patients with ARF are associated with HLA-B5. [6] In a study of 15[emedicine.com]

  • Relapsing Polychondritis

    Susceptibility to relapsing polychondritis was significantly associated with HLA-DR4 (p 0.001).[ncbi.nlm.nih.gov] There is a significant association of RP with the antigen HLA-DR4.[ncbi.nlm.nih.gov] HLA-DR4, a known susceptibility allele in Germans, showed a trend of susceptibility association without significance (P 0.067).[ncbi.nlm.nih.gov]

  • Polymyalgia Rheumatica

    For example, a person with a certain gene for an MHC class II molecule, also called a human leukocyte antigen, or HLADR4, is more likely to develop the disease especially[osmosis.org] "Polymyalgia rheumatica: a syndrome associated with HLA-DR4 antigen." Arthritis Rheum 31.5 May 1988: 678-682. Cutolo, M., M.A. Cimmino, and A. Sulli.[medicinenet.com]

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